Research output per year
Research output per year
Personal profile
Biography
Catherine Lawrence is currently a lecturer in the Faculty of Life Sciences.
Catherine obtained a BSc honours degree in Pharmacology (1992) and her PhD (1996) from the University of Manchester. During her PhD, which was under the supervision of Professor Nancy Rothwell, she was interested in how pro-inflammatory cytokines affect neuronal injury. However, after completing her PhD she then gained over two years experience in the commercial sector working as a Clinical Research Associate in the pharmaceutical industry.
In 1998 she returned to academic research and obtained a post-doctoral position (funded by AstraZenca) working with Dr Simon Luckman in the School of Biological Sciences at the University of Manchester. Her interest at this time was the involvement of novel neuropeptides in energy homeostasis. In 2004 she left the University of Manchester to secure a position as a Senior Research Scientist at AstraZeneca, but then returned to the Faculty of Life Sciences in 2005 when she was awarded an RCUK fellowship. In 2010 she became a lecturer, a senior lecturer in 2015 and a Professor in Neuoscience in 2024.
Research interests
Her current research interests focus around brain diseases including stroke, Alzheimer’s disease and vascular dementia, and the role of inflammation. These brain diseases often affect the elderly and usually people who have many other conditions also known as co-morbidities (e.g. high-blood pressure, high cholesterol, diabetes, obesity, infection). She and others have shown that co-morbidities influence the development and/or severity of stroke and Alzheimer’s disease and her research group is trying to understand why this is.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Dementia@Manchester
- Lydia Becker Institute
- Manchester Institute for Collaborative Research on Ageing
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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25-hydroxycholesterol dysregulates brain endothelial cell function and exacerbates cerebral haemorrhage
Tapia, V. S., Withers, S., Zhou, R., Bennington, A., Hedley, F., El Khouja, A., Luka, N., Massimo, M., Crilly, S., Long, K., Lawrence, C. B. & Kasher, P., 10 May 2024, Cold Spring Harbor Laboratory Press, (bioRxiv).Research output: Preprint/Working paper › Preprint
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Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome
Mcmahon, E., El Sayed, S., Green, J., Hoyle, C., Fitzpatrick, L., Jones, E., Corrie, E., Kelly, R., Challinor, M., Freeman, S., Bryce, R., Lawrence, C. B., Brough, D. & Kasher, P., 16 Feb 2024, In: iScience. 27, 2, 108968.Research output: Contribution to journal › Article
Open Access -
C9orf72 dipeptides activate the NLRP3 inflammasome
Rivers-Auty, J., Hoyle, C., Pointer, A., Lawrence, C., Pickering-Brown, S., Brough, D. & Ryan, S., 20 Aug 2024, In: Brain Communications. fcae282.Research output: Contribution to journal › Article › peer-review
Open Access -
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome.
Gleeson, T. A., Kaiser, C., Lawrence, C. B., Brough, D., Allan, S. M. & Green, J. P., 22 May 2024, In: Disease Models & Mechanisms.Research output: Contribution to journal › Article › peer-review
Open Access -
A Multi-disciplinary Commentary on Preclinical Research to investigate Vascular Contributions to Dementia
Sri, S., Greenstein, A., Granata, A., Collcutt, A., Jochems, A. C. C., Mccoll, B. W., Castro, B. D., Webber, C., Reyes, C. A., Hall, C., Lawrence, C., Hawkes, C., Pegasiou-Davies, C.-M., Gibson, C., Crawford, C. L., Smith, C., Vivien, D., Mclean, F. H., Wiseman, F. & Brezzo, G. & 37 others, , 30 Oct 2023, In: Cerebral Circulation - Cognition and Behavior. 5, 100189.Research output: Contribution to journal › Article › peer-review
Open Access32 Downloads (Pure)
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Brain disorders
Allan, S. (Researcher), Baines, R. (Researcher), Bromley, R. (Researcher), Brough, D. (Researcher), Burns, A. (Researcher), Doig, A. (Researcher), Gigg, J. (Researcher), Green, J. (Researcher), Hooper, N. (Researcher), Kasher, P. (Researcher), Lawrence, C. (Researcher), Milosavljevic, N. (Researcher), Miyan, J. (Researcher), Pinteaux, E. (Researcher), Roncaroli, F. (Researcher), Rothwell, N. (Researcher), Schiessl, I. (Researcher), South, K. (Researcher), Verkhratsky, A. (Researcher), Wykes, R. (Researcher) & Ryan, S. (Researcher)
Project: Research
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Neuroinflammation
Allan, S. (Researcher), Brough, D. (Researcher), Green, J. (Researcher), Kasher, P. (Researcher), Lawrence, C. (Researcher), Ryan, S. (Researcher), Pinteaux, E. (Researcher), Rothwell, N. (Researcher), Schiessl, I. (Researcher), South, K. (Researcher) & Youshani, A. (Researcher)
Project: Research
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Identifying a New Drug Target for the Treatment of Alzheimer's Disease.
Brough, D. (PI), Allan, S. (CoI), Freeman, S. (CoI) & Lawrence, C. (CoI)
18/09/17 → 17/09/20
Project: Research
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Does obesity affect the susceptibility to infection after experimental stroke and influence outcome?
Lawrence, C. (PI), Allan, S. (CoI), Hopkins, S. (CoI) & Smith, C. (CoI)
1/09/14 → 31/08/17
Project: Research
Activities
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Invited speaker at Wellcome Trust meeting
Lawrence, C. (Speaker)
11 Jun 2019Activity: Talk or presentation › Invited talk › Research
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Invited speaker at BNA conference
Lawrence, C. (Speaker)
14 Apr 2019Activity: Talk or presentation › Invited talk › Research
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Seminar speaker at St George's University London
Lawrence, C. (Discussant)
5 Dec 2018Activity: Talk or presentation › Invited talk › Research
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Frontiers in Neurology (Journal)
Lawrence, C. (Member of editorial board)
1 Jan 2018 → …Activity: Publication peer-review and editorial work › Editorial work › Research
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Seminar speaker at Centre for Neurodegeneration
Lawrence, C. (Invited speaker)
13 Nov 2017Activity: Talk or presentation › Invited talk › Research
Datasets
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CCDC 1563191: Experimental Crystal Structure Determination
Baldwin, A. (Contributor), Rivers-Auty, J. (Contributor), Daniels, M. (Contributor), White, C. (Contributor), Schwalbe, C. H. (Contributor), Schilling, T. (Contributor), Hammadi, H. (Contributor), Jaiyong, P. (Contributor), Spencer, N. G. (Contributor), England, H. (Contributor), Luheshi, N. M. (Contributor), Kadirvel, M. (Contributor), Lawrence, C. (Contributor), Rothwell, N. (Contributor), Harte, M. (Contributor), Bryce, R. (Contributor), Allan, S. M. (Contributor), Eder, C. (Contributor), Freeman, S. (Contributor) & Brough, D. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2017
DOI: 10.5517/ccdc.csd.cc1pgmj9, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1pgmj9&sid=DataCite
Dataset
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CCDC 1563192: Experimental Crystal Structure Determination
Baldwin, A. (Contributor), Rivers-Auty, J. (Contributor), Daniels, M. (Contributor), White, C. (Contributor), Schwalbe, C. H. (Contributor), Schilling, T. (Contributor), Hammadi, H. (Contributor), Jaiyong, P. (Contributor), Spencer, N. G. (Contributor), England, H. (Contributor), Luheshi, N. M. (Contributor), Kadirvel, M. (Contributor), Lawrence, C. (Contributor), Rothwell, N. (Contributor), Harte, M. (Contributor), Bryce, R. (Contributor), Allan, S. M. (Contributor), Eder, C. (Contributor), Freeman, S. (Contributor) & Brough, D. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2017
DOI: 10.5517/ccdc.csd.cc1pgmkb, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccdc.csd.cc1pgmkb&sid=DataCite
Dataset