Catherine Lawrence

2025

MRI detects blood-brain barrier alterations in a rat model of Alzheimer’s disease and lung infection

Ohene, Y., Morrey, W. J., Powell , E., Smethers, K. F., Luka, N., South, K., Berks, M., Lawrence, C. B., Parker, G. J. M., Parkes, L. M., Boutin, H. & Dickie, B. R., 4 Mar 2025, (E-pub ahead of print) In: npj Imaging. 3

Research output: Contribution to journal › Article › peer-review

Open Access

2024

Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome

Mcmahon, E., El Sayed, S., Green, J., Hoyle, C., Fitzpatrick, L., Jones, E., Corrie, E., Kelly, R., Challinor, M., Freeman, S., Bryce, R., Lawrence, C. B., Brough, D. & Kasher, P., 16 Feb 2024, In: iScience. 27, 2, 108968.

Research output: Contribution to journal › Article

Open Access

C9orf72 dipeptides activate the NLRP3 inflammasome

Rivers-Auty, J., Hoyle, C., Pointer, A., Lawrence, C., Pickering-Brown, S., Brough, D. & Ryan, S., 20 Aug 2024, In: Brain Communications. fcae282.

Research output: Contribution to journal › Article › peer-review

Open Access

The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome.

Gleeson, T. A., Kaiser, C., Lawrence, C. B., Brough, D., Allan, S. M. & Green, J. P., 22 May 2024, In: Disease Models & Mechanisms.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

A Multi-disciplinary Commentary on Preclinical Research to investigate Vascular Contributions to Dementia

Sri, S., Greenstein, A., Granata, A., Collcutt, A., Jochems, A. C. C., Mccoll, B. W., Castro, B. D., Webber, C., Reyes, C. A., Hall, C., Lawrence, C., Hawkes, C., Pegasiou-Davies, C.-M., Gibson, C., Crawford, C. L., Smith, C., Vivien, D., Mclean, F. H., Wiseman, F. & Brezzo, G. & 37 others, Lalli, G., Pritchard, H., Markus, H. S., Bravo-Ferrer, I., Taylor, J., Leiper, J., Berwick, J., Gan, J., Gallacher, J., Moss, J., Goense, J., Mcmullan, L., Work, L., Evans, L., Stringer, M. S., Ashford, M., Abulfadl, M., Conlon, N., Malhotra, P., Bath, P., Canter, R., Brown, R., Ince, S., Anderle, S., Young, S., Quick, S., Szymkowiak, S., Hill, S., Allan, S., Wang, T., Quinn, T., Procter, T., Farr, T. D., Zhao, X., Yang, Z., Hainsworth, A. H. & Wardlaw, J. M., 30 Oct 2023, In: Cerebral Circulation - Cognition and Behavior. 5, 100189.

Research output: Contribution to journal › Article › peer-review

Open Access

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Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection

Ohene, Y., Harris, W. J., Powell, E., Wycech, N. W., Smethers, K. F., Lasič, S., South, K., Coutts, G., Sharp, A., Lawrence, C. B., Boutin, H., Parker, G. J. M., Parkes, L. M. & Dickie, B. R., 1 Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 25.

Research output: Contribution to journal › Article › peer-review

Open Access

Intracerebral administration of a novel self-assembling peptide hydrogel is safe and supports cell proliferation in experimental intracerebral haemorrhage

Bolan, F., Dickie, B. R., Cook, J. R., Thomas, J. M., Pinteaux, E., Allan, S. M. & Lawrence, C. B., 18 Oct 2023, In: Translational stroke research.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Characterisation of C101248: a novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome

Lawrence, C. B., Harte, M., Brough, D. & et al., 7 Nov 2022, (Accepted/In press) In: Neuropharmacology.

Research output: Contribution to journal › Article › peer-review

Looking into the IL-1 of the storm: Are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes?

Gleeson, T., Nordling, E., Kaiser, C., Lawrence, C. B., Brough, D., Green, J. & Allan, S., 24 Aug 2022, (Accepted/In press) In: Discovery Immunology.

Research output: Contribution to journal › Article › peer-review

LRRC8A is dispensable for a variety of microglial functions and response to acute stroke

Cook, J. R., Gray, A. L., Lemarchand, E., Schiessl, I., Green, J. P., Newland, M. C., Dyer, D. P., Brough, D. & Lawrence, C. B., 12 Feb 2022, In: GLIA.

Research output: Contribution to journal › Article › peer-review

Open Access

Measurement of Protein Synthesis Rate in Rat by [11C]Leucine PET Imaging: Application to the TgF344-AD Model of Alzheimer’s Disease

Bochicchio, D., Christie, L., Lawrence, C. B., Herholz, K., Parker, C. A., Hinz, R. & Boutin, H., 20 Dec 2022, (E-pub ahead of print) In: Molecular Imaging and Biology. 10 p.

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Open Access

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The Two pore Potassium Channel THIK-1 Regulates NLRP3 Inflammasome Activation

Drinkall, S., Lawrence, C. B., Ossola, B., Russell, S., Bender, C., Brice, N. B., Dawson, L. A., Harte, M. & Brough, D., 30 Mar 2022, In: GLIA.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease

Hadjidemetriou, M., Rivers-Auty, J., Papafilippou, L., Eales, J., Kellett, K. A. B., Hooper, N. M., Lawrence, C. B. & Kostarelos, K., 27 Apr 2021, In: ACS Nano. 15, 4, p. 7357-7369 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Regenerative Potential of Hydrogels for Intracerebral Hemorrhage: Lessons from Ischemic Stroke and Traumatic Brain Injury Research

Thomas, J., Louca, I., Bolan, F., Sava, O. R., Allan, S., Lawrence, C. B. & Pinteaux, E., 17 Jun 2021, (Accepted/In press) In: Advanced Healthcare Materials.

Research output: Contribution to journal › Article › peer-review

Response to correspondence on "Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation"

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M.-C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., DeMambro, V., D'Hont, J., Dibb, K. & Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N.-C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X.-D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majeweska, L., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y.-I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J.-F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., 7 Apr 2021, In: Genome Biology. 22, 1, p. 99

Research output: Contribution to journal › Article › peer-review

Zinc status alters Alzheimer's disease progression through NLRP3-dependent inflammation

Lawrence, C. B., Rivers-Auty, J., Tapia Olivares, V., White, C., Daniels, M., Drinkall, S., Kennedy, P., Spence, H., Yu Shi, A., Green, J., Hoyle, C., Cook, J., Bradley, A., Mather, A., Peters, R., Tzeng, T.-C., Gordon, M. J., Beattie, J. H., Brough, D. & Lawrence, C. B., 31 Mar 2021, In: Journal of Neuroscience. 41 , 13, p. 3025–3038

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A hyperacute immune map of ischaemic stroke patients reveals alterations to circulating innate and adaptive cells

Krishnan, S., O'Boyle, C., Smith, C., Hulme, S., Allan, S., Grainger, J. & Lawrence, C. B., 18 Nov 2020, (E-pub ahead of print) In: Clinical and experimental immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Downloads (Pure)

Anti-inflammatories in Alzheimer’s disease - potential therapy or spurious correlate?

Rivers-Auty, J., Mather, A., Peters, R., Lawrence, C. B. & Brough, D., 14 Jul 2020, (Accepted/In press) In: Brain Communications.

Research output: Contribution to journal › Article › peer-review

Comorbidity and age in the modelling of stroke: are we still failing to consider the characteristics of stroke patients?

McCann, S. K. & Lawrence, C. B., 24 Feb 2020, (E-pub ahead of print) In: BMJ Open Science.

Research output: Contribution to journal › Article › peer-review

Open Access

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors

Nizami, S., Arunasalam, K., Green, J., Cook, J., Lawrence, C. B., Zarganes-Tzitzikas, T., Davis, J. B., Daniel, E. D. & Brough, D., 20 Sept 2020, In: Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

Green, J., Swanton, T., Morris, L., El-Sharkawy, L., Cook, J., Yu Shi, A., Beswick, J., Adamson, A., Humphreys, N., Bryce, R., Freeman, S., Lawrence, C. B. & Brough, D., 20 Nov 2020, In: eLife. 2020, 9, e59704.

Research output: Contribution to journal › Article › peer-review

Open Access

Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl- channel modulation

Swanton, T., Beswick, J., Hammadi, H., Morris, L., Williams, D., De Cesco, S., El-sharkawy, L., Yu, S., Green, J., Davis, J., Lawrence, C., Brough, D. & Freeman, S., 12 Oct 2020, In: Chemical Science. 11, 43, p. 11720-11728 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis

Thomas, J., Cunningham, C., Lawrence, C. B., Pinteaux, E. & Allan, S., 24 Feb 2020, (E-pub ahead of print) In: BMJ Open Science.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice

O'Boyle, C., Haley, M. J., Lemarchand, E., Smith, C. J., Allan, S. M., Konkel, J. E. & Lawrence, C. B., 2019, In: International Journal of Stroke.

Research output: Contribution to journal › Article › peer-review

Open Access

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Old Dog New Tricks; Revisiting How Stroke Modulates the Systemic Immune Landscape

Krishnan, S. & Lawrence, C. B., 2 Jul 2019, (E-pub ahead of print) In: Frontiers in Neurology. 10

Research output: Contribution to journal › Article › peer-review

Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake

Banerjee, S., Andrew, R. J., Duff, C. J., Fisher, K., Jackson, C. D., Lawrence, C. B., Maeda, N., Greenspan, D. S., Kellett, K. & Hooper, N., 6 Aug 2019, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

Gurumurthy, C. B., O'Brien, A. R., Quadros, R. M., Adams, J., Alcaide, P., Ayabe, S., Ballard, J., Batra, S. K., Beauchamp, M.-C., Becker, K. A., Bernas, G., Brough, D., Carrillo-Salinas, F., Chan, W., Chen, H., Dawson, R., Demambro, V., D'Hont, J., Dibb, K. M. & Eudy, J. D. & 93 others, Gan, L., Gao, J., Gonzales, A., Guntur, A. R., Guo, H., Harms, D. W., Harrington, A., Hentges, K. E., Humphreys, N., Imai, S., Ishii, H., Iwama, M., Jonasch, E., Karolak, M., Keavney, B., Khin, N.-C., Konno, M., Kotani, Y., Kunihiro, Y., Lakshmanan, I., Larochelle, C., Lawrence, C. B., Li, L., Lindner, V., Liu, X.-D., Lopez-Castejon, G., Loudon, A., Lowe, J., Jerome-Majewska, L. A., Matsusaka, T., Miura, H., Miyasaka, Y., Morpurgo, B., Motyl, K., Nabeshima, Y.-I., Nakade, K., Nakashiba, T., Nakashima, K., Obata, Y., Ogiwara, S., Ouellet, M., Oxburgh, L., Piltz, S., Pinz, I., Ponnusamy, M. P., Ray, D., Redder, R. J., Rosen, C. J., Ross, N., Ruhe, M. T., Ryzhova, L., Salvador, A. M., Alam, S. S., Sedlacek, R., Sharma, K., Smith, C., Staes, K., Starrs, L., Sugiyama, F., Takahashi, S., Tanaka, T., Trafford, A. W., Uno, Y., Vanhoutte, L., Vanrockeghem, F., Willis, B. J., Wright, C. S., Yamauchi, Y., Yi, X., Yoshimi, K., Zhang, X., Zhang, Y., Ohtsuka, M., Das, S., Garry, D. J., Hochepied, T., Thomas, P., Parker-Thornburg, J., Adamson, A. D., Yoshiki, A., Schmouth, J.-F., Golovko, A., Thompson, W. R., Lloyd, K. C. K., Wood, J. A., Cowan, M., Mashimo, T., Mizuno, S., Zhu, H., Kasparek, P., Liaw, L., Miano, J. M. & Burgio, G., 2019, In: Genome biology. 20, 1, 171.

Research output: Contribution to journal › Article › peer-review

Open Access

Stroke Induces Prolonged Changes in Lipid Metabolism, the Liver and Body Composition in Mice

Haley, M. J., White, C. S., Roberts, D., O’Toole, K., Cunningham, C. J., Rivers-Auty, J., O’Boyle, C., Lane, C., Heaney, O., Allan, S. M. & Lawrence, C. B., 21 Dec 2019, (E-pub ahead of print) In: Translational stroke research.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Chloride regulates dynamic NLRP3-dependent ASC oligomerisation and inflammasome priming

Green, J., Yu, S., Martín-Sánchez, F., Pelegrin, P., Lopez-Castejon, G., Lawrence, C. B. & Brough, D., 2 Oct 2018, In: Proceedings of the National Academy of Sciences. 115, 40, p. E9371-E9380

Research output: Contribution to journal › Article › peer-review

Open Access

File

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Is targeting the inflammasome a way forward for neuroscience drug discovery?

Swanton, T., Cook, J., Beswick, J., Freeman, S., Lawrence, C. B. & Brough, D., 2018, In: SLAS Discovery.

Research output: Contribution to journal › Article › peer-review

Open Access

File

171 Downloads (Pure)

2017

Acute high-fat feeding leads to disruptions in glucose homeostasis and worsens stroke outcome

Haley, M., Krishnan, S., Burrows, D., de Hogg, L., Thakrar, J., Schiessl, I., Allan, S. & Lawrence, C. B., 2017, In: Journal of Cerebral Blood Flow and Metabolism.

Research output: Contribution to journal › Article › peer-review

Open Access

Adipose tissue, metabolic and inflammatory responses to stroke are altered in obese mice

Haley, M., Mullard, G., Hollywood, K., Cooper, G. J., Dunn, W. B. & Lawrence, C. B., 2017, In: DMM Disease Models and Mechanisms.

Research output: Contribution to journal › Article › peer-review

Open Access

Boron based inhibitors of the NLRP3 inflammasome

Baldwin, A., Rivers-Auty, J., Daniels, M., White, C., Schwalbe, C. H., Schilling, T., Hammadi, H., Jaiyong, P., Spencer, N. G., England, H., Luheshi, N. M., Kadirvel, M., Lawrence, C. B., Rothwell, N., Harte, M., Bryce, R., Allen, S., Eder, C., Freeman, S. & Brough, D., 16 Nov 2017, In: Cell Chemical Biology. 24, 11, p. 1321-1335 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

Withers, S., Forman, R., Meza-Perez, S., Sorobetea, D., Sitnik, K., Hopwood, T., Lawrence, C., W. Agace, W., Else, K., Heagerty, A., Svensson-Frej, M. & Cruickshank, S., 17 Mar 2017, In: Scientific Reports. 7, 44571.

Research output: Contribution to journal › Article › peer-review

Open Access

Inflammasomes as therapeutic targets for Alzheimer's disease

White, C. S., Lawrence, C. B., Brough, D. & Rivers-Auty, J., Mar 2017, In: Brain Pathology. 27, 2, p. 223-234 12 p.

Research output: Contribution to journal › Article › peer-review

The blood-brain barrier after stroke: structural studies and the role of transcytotic vesicles

Haley, M. J. & Lawrence, C. B., 1 Feb 2017, In: Journal of Cerebral Blood Flow and Metabolism. 37, 2, p. 456-470 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer's disease: metabolic basis for dementia

Xu, J., Begley, P., Church, S., Patassini, S., Mcharg, S., Kureishy, N., Hollywood, K., Waldvogel, H. J., Liu, H., Zhang, S., Lin, W., Herholz, K., Turner, C., Synek, B. J., Curtis, M. A., Rivers-Auty, J., Lawrence, C., Kellett, K., Hooper, N. & Vardy, E. R. L. C. & 5 others, Wu, D., Unwin, R., Faull, R. L. M., Dowsey, A. & Cooper, G., 9 Jun 2016, In: Scientific Reports. 6, 12 p., 27524.

Research output: Contribution to journal › Article › peer-review

Open Access

49 Downloads (Pure)

Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

Daniels, M. J. D., Rivers-Auty, J., Schilling, T., Spencer, N. G., Watremez, W., Fasolino, V., Booth, S. J., White, C. S., Baldwin, A. G., Freeman, S., Wong, R., Latta, C., Yu, S., Jackson, J., Fischer, N., Koziel, V., Pillot, T., Bagnall, J., Allan, S. M. & Paszek, P. & 5 others, Galea, J., Harte, M. K., Eder, C., Lawrence, C. B. & Brough, D., 11 Aug 2016, In: Nature Communications. 7, p. 12504 12504.

Research output: Contribution to journal › Article › peer-review

Open Access

146 Downloads (Pure)

Mitochondrial Abnormalities and Synaptic Loss Underlie Memory Deficits Seen in Mouse Models of Obesity and Alzheimer's Disease

Martins, I. V. A., Rivers-Auty, J., Allan, S. M. & Lawrence, C. B., 6 Dec 2016, In: Journal of Alzheimer's disease : JAD. 55, 3, p. 915-932 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Obesity and stroke: Can we translate from rodents to patients?

Haley, M. & Lawrence, C., 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 12

Research output: Contribution to journal › Article › peer-review

Open Access

Systemic Inflammation Affects Reperfusion Following Transient Cerebral Ischaemia

Burrows, F., Haley, M., Scott, E., Coutts, G., Lawrence, C., Allan, S. & Schiessl, I., Mar 2016, In: Experimental neurology. 277, p. 252-60 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke

Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., Mccoll, B. & Lawrence, C., 4 Aug 2015, In: Journal of Neuroinflammation. 12, 140, p. 1-12 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2014

High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology.

Knight, E. M., Martins, I. V. A., Gumusgoz, S., Allan, S. M. & Lawrence, C. B., Aug 2014, In: Neurobiology of Aging. 35, 8, p. 1821-1832 11 p., 24630364.

Research output: Contribution to journal › Article › peer-review

Maternal high-fat diet worsens memory deficits in the triple-transgenic (3xTgAD) mouse model of Alzheimer's disease

Martin, S. A. L., Jameson, C. H., Allan, S. M. & Lawrence, C. B., 11 Jun 2014, In: PLoS ONE. 9, 6, e99226.

Research output: Contribution to journal › Article › peer-review

Zinc depletion regulates the processing and secretion of IL-1β.

Pedrosa Mendes, P., Summersgill, H., England, H., Lopez-Castejon, G., Lawrence, C. B., Luheshi, N. M., Pahle, J., Mendes, P. & Brough, D., 2014, In: CELL DEATH & DISEASE. 5

Research output: Contribution to journal › Article › peer-review

Open Access

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2013

Age-related changes in core body temperature and activity in triple-transgenic Alzheimer's disease (3xTgAD) mice

Knight, E. M., Brown, T. M., Gümüsgöz, S., Smith, J. C. M., Waters, E. J., Allan, S. M. & Lawrence, C. B., Jan 2013, In: DMM Disease Models and Mechanisms. 6, 1, p. 160-170 10 p.

Research output: Contribution to journal › Article › peer-review

The immune system in stroke: Clinical challenges and their translation to experimental research

Smith, C. J., Lawrence, C. B., Rodriguez-Grande, B., Kovacs, K. J., Pradillo, J. M. & Denes, A., Sept 2013, In: Journal of Neuroimmune Pharmacology. 8, 4, p. 867-887 20 p.

Research output: Contribution to journal › Article › peer-review

2012

Catherine Lawrence, BSc, PhD

Research output

Search results