Search results

  • 2023

    RAC1B function is essential for breast cancer stem cell maintenance and chemoresistance of breast tumor cells

    Chen, F., Gurler, S. B., Novo, D., Selli, C., Alferez, D. G., Eroglu, S., Pavlou, K., Zhang, J., Sims, A. H., Humphreys, N. E., Adamson, A., Campbell, A., Sansom, O. J., Tournier, C., Clarke, R. B., Brennan, K., Streuli, C. H. & Ucar, A., 24 Feb 2023, In: Oncogene. 42, p. 679-692 14 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2022

    Inhibiting ERK5 Overcomes Breast Cancer Resistance to Anti-HER2 Therapy By Targeting the G1–S Cell-Cycle Transition

    Zhang, J., Pearson, A. J., Sabherwal, N., Telfer, B. A., Ali, N., Kan, K., Xu, Q., Zhang, W., Chen, F., Li, S., Wang, J., Gray, N. S., Risa-Ebrí, B., Finegan, K. G., Cross, M. J., Giurisato, E., Whitmarsh, A. J. & Tournier, C., 10 Mar 2022, In: Cancer Research Communications. 2, 3, p. 131-145 15 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2021

    The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion

    Xu, Q., Zhang, J., Telfer, B. A., Zhang, H., Ali, N., Chen, F., Risa, B., Pearson, A. J., Zhang, W., Finegan, K. G., Ucar, A., Giurisato, E. & Tournier, C., 10 Jun 2021, In: Oncogene. 40, 23, p. 3929-3941 13 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2020

    Discovery of a gatekeeper residue in the C-terminal tail of the extracellular signal-regulated protein kinase 5 (ERK5)

    Pearson, A. J., Fullwood, P., Tapia, G. T., Prise, I., Smith, M. P., Xu, Q., Jordan, A., Giurisato, E., Whitmarsh, A. J., Francavilla, C. & Tournier, C., 1 Feb 2020, In: International Journal of Molecular Sciences. 21, 3, 929.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Open Access
  • Open Access
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  • 2018

    Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition

    Giurisato, E., Xu, Q., Lonardi, S., Telfer, B., Russo, I., Pearson, A., Finegan, K., Wang, W., Wang, J., Gray, N. S., Vermi, W., Xia, Z. & Tournier, C., 5 Mar 2018, In: Proceedings of the National Academy of Sciences. 115, 12, p. E2801-E2810

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2017

    Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5

    Gilbert, A. S., Seoane, P. I., Sephton-Clark, P., Bojarczuk, A., Hotham, R., Giurisato, E., Sarhan, A. R., Hillen, A., Velde, G. V., Gray, N. S., Alessi, D. R., Cunningham, D. L., Tournier, C., Johnston, S. A. & May, R. C., 16 Aug 2017, In: Science Advances. 3, 8, p. e1700898 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2016

    Can tumor cells proliferate without ERK5?

    Giurisato, E. & Tournier, C., Jan 2016, In: Cell cycle (Georgetown, Tex.). 15, 5, p. 619-20 2 p.

    Research output: Contribution to journalArticlepeer-review

  • Fibroblast Growth Factor 21 Mediates Glycemic Regulation by Hepatic JNK

    Vernia, S., Cavanagh-Kyros, J., Barrett, T., Tournier, C. & Davis, R. J., 15 Mar 2016, In: Cell Reports. 14, 10, p. 2273-80 8 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • 2015

    A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis.

    Wu, L., Chen, X., Zhao, J., Martin, B., Zepp, J. A., Ko, J. S., Gu, C., Cai, G., Ouyang, W., Sen, G., Stark, G. R., Su, B., Vines, C. M., Tournier, C., Hamilton, T. A., Vidimos, A., Gastman, B., Liu, C. & Li, X., 21 Sept 2015, In: The Journal of experimental medicine. 212, 10

    Research output: Contribution to journalArticlepeer-review

  • Dual role of ERK5 in the regulation of T cell receptor expression at the T cell surface.

    Rovira-Clavé, X., Angulo-Ibáñez, M., Tournier, C., Reina, M. & Espel, E., 24 Aug 2015, In: Journal of leukocyte biology.

    Research output: Contribution to journalArticlepeer-review

  • ERK5 is a critical mediator of inflammation-driven cancer.

    Finegan, K., Perez Madrigal, D., Hitchin, J., Davies, C., Jordan, A. & Tournier, C., 15 Feb 2015, In: Cancer Research. 75, 4, p. 742-753

    Research output: Contribution to journalArticlepeer-review

  • Pathological axonal death through a MAPK cascade that triggers a local energy deficit.

    Yang, J., Wu, Z., Renier, N., Simon, D. J., Uryu, K., Park, D. S., Greer, P. A., Tournier, C., Davis, R. J. & Tessier-Lavigne, M., 15 Jan 2015, In: Cell. 160, 1-2, p. 161-176

    Research output: Contribution to journalArticlepeer-review

  • 2014

    Impaired JNK signaling cooperates with KrasG12D expression to accelerate pancreatic ductal adenocarcinoma

    Mcmahon, R., Tournier, C., Davies, C. C., Harvey, E., Finegan, K. G., Connor, F., Davis, R. J., Tuveson, D. A. & Tournier, C., 15 Jun 2014, In: Cancer Research. 74, 12, p. 3344-3356 12 p.

    Research output: Contribution to journalArticlepeer-review

  • ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates.

    Itoh, T., Horiuchi, M., Ikeda, R. H., Xu, J., Bannerman, P., Pleasure, D., Penninger, J. M., Tournier, C. & Itoh, A., 6 Aug 2014, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 34, 32

    Research output: Contribution to journalArticlepeer-review

  • 2013

    The 2 Faces of JNK Signaling in Cancer

    Tournier, C., Sept 2013, In: Genes and Cancer. 4, 9-10, p. 397-400 3 p.

    Research output: Contribution to journalArticlepeer-review

  • 2012
  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J., & 1,248 othersAleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M. K., Choi, D., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., De Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Er Eng, K., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B., Il Kang, K., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H., Kim, J. C., Kim, J. K., Kim, P. K., Kim, S. W., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C. B., Koch, J. C., Koga, H., Koh, J. Y., Koh, Y. H., Koike, M., Komatsu, M., Kominami, E., Kong, H. J., Kong, W. J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kouri Flores, J. B., Kovács, A. L., Kraft, C., Krainc, D., Krämer, H., Kretz-Remy, C., Krichevsky, A. M., Kroemer, G., Krüger, R., Krut, O., Ktistakis, N. T., Kuan, C. Y., Kucharczyk, R., Kumar, A., Kumar, R., Kumar, S., Kundu, M., Kung, H. J., Kurz, T., Kwon, H. J., La Spada, A. R., Lafont, F., Lamark, T., Landry, J., Lane, J. D., Lapaquette, P., Laporte, J. F., László, L., Lavandero, S., Lavoie, J. N., Layfield, R., Lazo, P. A., Le, W., Le Cam, L., Ledbetter, D. J., Lee, A. J. X., Lee, B. W., Lee, G. M., Lee, J., Lee, J. H., Lee, M., Lee, M. S., Lee, S. H., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H. Y., Lei, Q. Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. S., Lev, D., Levenson, V. V., Levine, B., Levy, E., Li, F., Li, J. L., Li, L., Li, S., Li, W., Li, X. J., Li, Y. B., Li, Y. P., Liang, C., Liang, Q., Liao, Y. F., Liberski, P. P., Lieberman, A., Lim, H. J., Lim, K. L., Lim, K., Lin, C. F., Lin, F. C., Lin, J., Lin, J. D., Lin, K., Lin, W. W., Lin, W. C., Lin, Y. L., Linden, R., Lingor, P., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, B., Liu, C. F., Liu, K., Liu, L., Liu, Q. A., Liu, W., Liu, Y. C., Liu, Y., Lockshin, R. A., Lok, C. N., Lonial, S., Loos, B., Lopez-Berestein, G., López-Otín, C., Lossi, L., Lotze, M. T., Lõw, P., Lu, B., Lu, B., Lu, B., Lu, Z., Luciano, F., Lukacs, N. W., Lund, A. H., Lynch-Day, M. A., Ma, Y., Macian, F., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Maiuri, M. C., Malagoli, D., Malicdan, M. C. V., Malorni, W., Man, N., Mandelkow, E. M., Manon, S., Manov, I., Mao, K., Mao, X., Mao, Z., Marambaud, P., Marazziti, D., Marcel, Y. L., Marchbank, K., Marchetti, P., Marciniak, S. J., Marcondes, M., Mardi, M., Marfe, G., Mariño, G., Markaki, M., Marten, M. R., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Masini, M., Matarrese, P., Matsuo, S., Matteoni, R., Mayer, A., Mazure, N. M., McConkey, D. J., McConnell, M. J., McDermott, C., McDonald, C., McInerney, G. M., McKenna, S. L., McLaughlin, B., McLean, P. J., McMaster, C. R., McQuibban, G. A., Meijer, A. J., Meisler, M. H., Meléndez, A., Melia, T. J., Melino, G., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F. S., Menon, M. B., Menzies, F. M., Mercer, C. A., Merighi, A., Merry, D. E., Meschini, S., Meyer, C. G., Meyer, T. F., Miao, C. Y., Miao, J. Y., Michels, P. A. M., Michiels, C., Mijaljica, D., Milojkovic, A., Minucci, S., Miracco, C., Miranti, C. K., Mitroulis, I., Miyazawa, K., Mizushima, N., Mograbi, B., Mohseni, S., Molero, X., Mollereau, B., Mollinedo, F., Momoi, T., Monastyrska, I., Monick, M. M., Monteiro, M. J., Moore, M. N., Mora, R., Moreau, K., Moreira, P. I., Moriyasu, Y., Moscat, J., Mostowy, S., Mottram, J. C., Motyl, T., Moussa, C. E. H., Müller, S., Muller, S., Münger, K., Münz, C., Murphy, L. O., Murphy, M. E., Musarò, A., Mysorekar, I., Nagata, E., Nagata, K., Nahimana, A., Nair, U., Nakagawa, T., Nakahira, K., Nakano, H., Nakatogawa, H., Nanjundan, M., Naqvi, N. I., Narendra, D. P., Narita, M., Navarro, M., Nawrocki, S. T., Nazarko, T. Y., Nemchenko, A., Netea, M. G., Neufeld, T. P., Ney, P. A., Nezis, I. P., Nguyen, H. P., Nie, D., Nishino, I., Nislow, C., Nixon, R. A., Noda, T., Noegel, A. A., Nogalska, A., Noguchi, S., Notterpek, L., Novak, I., Nozaki, T., Nukina, N., Nürnberger, T., Nyfeler, B., Obara, K., Oberley, T. D., Oddo, S., Ogawa, M., Ohashi, T., Okamoto, K., Oleinick, N. L., Oliver, F. J., Olsen, L. J., Olsson, S., Opota, O., Osborne, T. F., Ostrander, G. K., Otsu, K., Ou, J. H. J., Ouimet, M., Overholtzer, M., Ozpolat, B., Paganetti, P., Pagnini, U., Pallet, N., Palmer, G. E., Palumbo, C., Pan, T., Panaretakis, T., Pandey, U. B., Papackova, Z., Papassideri, I., Paris, I., Park, J., Park, O. K., Parys, J. B., Parzych, K. R., Patschan, S., Patterson, C., Pattingre, S., Pawelek, J. M., Peng, J., Perlmutter, D. H., Perrotta, I., Perry, G., Pervaiz, S., Peter, M., Peters, G. J., Petersen, M., Petrovski, G., Phang, J. M., Piacentini, M., Pierre, P., Pierrefite-Carle, V., Pierron, G., Pinkas-Kramarski, R., Piras, A., Piri, N., Platanias, L. C., Pöggeler, S., Poirot, M., Poletti, A., Poüs, C., Pozuelo-Rubio, M., Prætorius-Ibba, M., Prasad, A., Prescott, M., Priault, M., Produit-Zengaffinen, N., Progulske-Fox, A., Proikas-Cezanne, T., Przedborski, S., Przyklenk, K., Puertollano, R., Puyal, J., Qian, S. B., Qin, L., Qin, Z. H., Quaggin, S. E., Raben, N., Rabinowich, H., Rabkin, S. W., Rahman, I., Rami, A., Ramm, G., Randall, G., Randow, F., Rao, V. A., Rathmell, J. C., Ravikumar, B., Ray, S. K., Reed, B. H., Reed, J. C., Reggiori, F., Régnier-Vigouroux, A., Reichert, A. S., Reiners, J. J., Reiter, R. J., Ren, J., Revuelta, J. L., Rhodes, C. J., Ritis, K., Rizzo, E., Robbins, J., Roberge, M., Roca, H., Roccheri, M. C., Rocchi, S., Rodemann, H. P., De Córdoba, S. R., Rohrer, B., Roninson, I. B., Rosen, K., Rost-Roszkowska, M. M., Rouis, M., Rouschop, K. M. A., Rovetta, F., Rubin, B. P., Rubinsztein, D. C., Ruckdeschel, K., Rucker, E. B., Rudich, A., Rudolf, E., Ruiz-Opazo, N., Russo, R., Rusten, T. E., Ryan, K. M., Ryter, S. W., Sabatini, D. M., Sadoshima, J., Saha, T., Saitoh, T., Sakagami, H., Sakai, Y., Salekdeh, G. H., Salomoni, P., Salvaterra, P. M., Salvesen, G., Salvioli, R., Sanchez, A. M. J., Sánchez-Alcázar, J. A., Sánchez-Prieto, R., Sandri, M., Sankar, U., Sansanwal, P., Santambrogio, L., Saran, S., Sarkar, S., Sarwal, M., Sasakawa, C., Sasnauskiene, A., Sass, M., Sato, K., Sato, M., Schapira, A. H. V., Scharl, M., Schätzl, H. M., Scheper, W., Schiaffino, S., Schneider, C., Schneider, M. E., Schneider-Stock, R., Schoenlein, P. V., Schorderet, D. F., Schüller, C., Schwartz, G. K., Scorrano, L., Sealy, L., Seglen, P. O., Segura-Aguilar, J., Seiliez, I., Seleverstov, O., Sell, C., Seo, J. B., Separovic, D., Setaluri, V., Setoguchi, T., Settembre, C., Shacka, J. J., Shanmugam, M., Shapiro, I. M., Shaulian, E., Shaw, R. J., Shelhamer, J. H., Shen, H. M., Shen, W. C., Sheng, Z. H., Shi, Y., Shibuya, K., Shidoji, Y., Shieh, J. J., Shih, C. M., Shimada, Y., Shimizu, S., Shintani, T., Shirihai, O. S., Shore, G. C., Sibirny, A. A., Sidhu, S. B., Sikorska, B., Simmons, A., Simon, A. K., Simon, H. U., Simone, C., Simonsen, A., Sinclair, D. A., Singh, R., Sinha, D., Sinicrope, F. A., Sirko, A., Siu, P. M., Sivridis, E., Skop, V., Skulachev, V. P., Slack, R. S., Smaili, S. S., Smith, D. R., Soengas, M. S., Soldati, T., Song, X., Sood, A. K., Soong, T. W., Sotgia, F., Spector, S. A., Spies, C. D., Springer, W., Srinivasula, S. M., Stefanis, L., Steffan, J. S., Stendel, R., Stenmark, H., Stephanou, A., Stern, S. T., Sternberg, C., Stork, B., Strålfors, P., Subauste, C. S., Sui, X., Sulzer, D., Sun, J., Sun, S. Y., Sun, Z. J., Sung, J. J. Y., Suzuki, K., Suzuki, T., Swanson, M. S., Swanton, C., Sweeney, S. T., Sy, L. K., Szabadkai, G., Tabas, I., Taegtmeyer, H., Tafani, M., Takács-Vellai, K., Takano, Y., Takegawa, K., Takemura, G., Takeshita, F., Talbot, N. J., Tan, K. S. W., Tanaka, K., Tanaka, K., Tang, D., Tang, D., Tanida, I., Tannous, B. A., Tavernarakis, N., Taylor, G. S., Taylor, G. A., Taylor, J. P., Terada, A. S., Terman, A., Tettamanti, G., Thevissen, K., Thompson, C. B., Thorburn, A., Thumm, M., Tian, F., Tian, Y., Tocchini-Valentini, G., Tolkovsky, A. M., Tomino, Y., Tönges, L., Tooze, S. A., Tournier, C., Tower, J., Towns, R., Trajkovic, V., Travassos, L. H., Tsai, T. F., Tschan, M. P., Tsubata, T., Tsung, A., Turk, B., Turner, L. S., Tyagi, S. C., Uchiyama, Y., Ueno, T., Umekawa, M., Umemiya-Shirafuji, R., Unni, V. K., Vaccaro, M. I., Valente, E. M., Van Den Berghe, G., Van Der Klei, I. J., Van Doorn, W. G., Van Dyk, L. F., Van Egmond, M., Van Grunsven, L. A., Vandenabeele, P., Vandenberghe, W. P., Vanhorebeek, I., Vaquero, E. C., Velasco, G., Vellai, T., Vicencio, J. M., Vierstra, R. D., Vila, M., Vindis, C., Viola, G., Viscomi, M. T., Voitsekhovskaja, O. V., Von Haefen, C., Votruba, M., Wada, K., Wade-Martins, R., Walker, C. L., Walsh, C. M., Walter, J., Wan, X. B., Wang, A., Wang, C., Wang, D., Wang, F., Wang, F., Wang, G., Wang, H., Wang, H. G., Wang, H. D., Wang, J., Wang, K., Wang, M., Wang, R. C., Wang, X., Wang, X., Wang, Y. J., Wang, Y., Wang, Z., Wang, Z. C., Wang, Z., Wansink, D. G., Ward, D. M., Watada, H., Waters, S. L., Webster, P., Wei, L., Weihl, C. C., Weiss, W. A., Welford, S. M., Wen, L. P., Whitehouse, C. A., Whitton, J. L., Whitworth, A. J., Wileman, T., Wiley, J. W., Wilkinson, S., Willbold, D., Williams, R. L., Williamson, P. R., Wouters, B. G., Wu, C., Wu, D. C., Wu, W. K. K., Wyttenbach, A., Xavier, R. J., Xi, Z., Xia, P., Xiao, G., Xie, Z., Xie, Z., Xu, D. Z., Xu, J., Xu, L., Xu, X., Yamamoto, A., Yamamoto, A., Yamashina, S., Yamashita, M., Yan, X., Yanagida, M., Yang, D. S., Yang, E., Yang, J. M., Yang, S. Y., Yang, W., Yang, W. Y., Yang, Z., Yao, M. C., Yao, T. P., Yeganeh, B., Yen, W. L., Yin, J. J., Yin, X. M., Yoo, O. J., Yoon, G., Yoon, S. Y., Yorimitsu, T., Yoshikawa, Y., Yoshimori, T., Yoshimoto, K., You, H. J., Youle, R. J., Younes, A., Yu, L., Yu, L., Yu, S. W., Yu, W. H., Yuan, Z. M., Yue, Z., Yun, C. H., Yuzaki, M., Zabirnyk, O., Silva-Zacarin, E., David Zacks, E., Zacksenhaus, L., Zaffaroni, N., Zakeri, Z., Zeh, H. J., Zeitlin, S. O., Zhang, H., Zhang, H. L., Zhang, J., Zhang, J. P., Zhang, L., Zhang, L., Zhang, M. Y., Zhang, X. D., Zhao, M., Zhao, Y. F., Zhao, Y., Zhao, Z. J., Zheng, X., Zhivotovsky, B., Zhong, Q., Zhou, C. Z., Zhu, C., Zhu, W. G., Zhu, X. F., Zhu, X., Zhu, Y., Zoladek, T., Zong, W. X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 2012, In: Autophagy. 8, 4, p. 445-544 99 p.

    Research output: Contribution to journalArticlepeer-review

  • JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate

    Hübner, A., Mulholland, D. J., Standen, C. L., Karasarides, M., Cavanagh-Kyros, J., Barrett, T., Chi, H., Greiner, D. L., Tournier, C., Sawyers, C. L., Flavell, R. A., Wu, H. & Davis, R. J., 24 Jul 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 30, p. 12046-12051 5 p.

    Research output: Contribution to journalArticlepeer-review

  • P90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction

    Le, N. T., Takei, Y., Shishido, T., Woo, C. H., Chang, E., Heo, K. S., Lee, H., Lu, Y., Morrell, C., Oikawa, M., McClain, C., Wang, X., Tournier, C., Molina, C. A., Taunton, J., Yan, C., Fujiwara, K., Patterson, C., Yang, J. & Abe, J. I., 17 Feb 2012, In: Circulation research. 110, 4, p. 536-550 14 p.

    Research output: Contribution to journalArticlepeer-review

  • REST and its downstream molecule Mek5 regulate survival of primordial germ cells

    Okamura, D., Mochizuki, K., Taniguchi, H., Tokitake, Y., Ikeda, M., Yamada, Y., Tournier, C., Yamaguchi, S., Tada, T., Schöler, H. R. & Matsui, Y., 15 Dec 2012, In: Developmental Biology. 372, 2, p. 190-202 12 p.

    Research output: Contribution to journalArticlepeer-review

  • Targeted deletion of ERK5 MAP kinase in the developing nervous system impairs development of GABAergic interneurons in the main olfactory bulb and behavioral discrimination between structurally similar odorants

    Zou, J., Pan, Y. W., Wang, Z., Chang, S. Y., Wang, W., Wang, X., Tournier, C., Storm, D. R. & Xia, Z., 21 Mar 2012, In: Journal of Neuroscience. 32, 12, p. 4118-4132 14 p.

    Research output: Contribution to journalArticlepeer-review

  • The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs)

    Perez-Madrigal, D., Finegan, K. G., Paramo, B. & Tournier, C., Dec 2012, In: Cellular Signalling. 24, 12, p. 2360-2368 8 p.

    Research output: Contribution to journalArticlepeer-review

  • 2011

    Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing peroxisome proliferator-activated receptor γ2 expression

    Ahn, Y. H., Yang, Y., Gibbons, D. L., Creighton, C. J., Yang, F., Wistuba, I. I., Lin, W., Thilaganathan, N., Alvarez, C. A., Roybal, J., Goldsmith, E. J., Tournier, C. & Kurie, J. M., Nov 2011, In: Molecular and Cellular Biology. 31, 21, p. 4270-4285 15 p.

    Research output: Contribution to journalArticlepeer-review

  • The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo

    Mazzitelli, S., Xu, P., Ferrer, I., Davis, R. J. & Tournier, C., 23 Nov 2011, In: Journal of Neuroscience. 31, 47, p. 16969-16976 7 p.

    Research output: Contribution to journalArticlepeer-review

  • The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy

    Lee, E. J. & Tournier, C., Jul 2011, In: Autophagy. 7, 7, p. 689-695 6 p.

    Research output: Contribution to journalArticlepeer-review

  • 2010

    Alternative ERK5 regulation by phosphorylation during the cell cycle

    Iñesta-Vaquera, F. A., Campbell, D. G., Tournier, C., Gómez, N., Lizcano, J. M. & Cuenda, A., Dec 2010, In: Cellular Signalling. 22, 12, p. 1829-1837 8 p.

    Research output: Contribution to journalArticlepeer-review

  • The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer

    Finegan, K. G. & Tournier, C., 15 Jul 2010, In: Cancer Research. 70, 14, p. 5797-5806 9 p.

    Research output: Contribution to journalArticlepeer-review

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  • 2009

    Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5

    Finegan, K. G., Wang, X., Lee, E. J., Robinson, A. C. & Tournier, C., 2009, In: Cell Death and Differentiation. 16, 5, p. 674-683 9 p.

    Research output: Contribution to journalArticlepeer-review

  • 2008

    ERK5 regulation in naïve T-cell activation and survival

    Ananieva, O., Macdonald, A., Wang, X., McCoy, C. E., McIlrath, J., Tournier, C. & Arthur, J. S. C., Sept 2008, In: European journal of immunology. 38, 9, p. 2534-2547 13 p.

    Research output: Contribution to journalArticlepeer-review

  • Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4

    Yang, T. T. C., Yu, R. Y. L., Agadir, A., Gao, G. J., Campos-Gonzalez, R., Tournier, C. & Chow, C. W., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3489-3501 12 p.

    Research output: Contribution to journalArticlepeer-review

  • 2007

    Physiological roles of MKK4 and MKK7: Insights from animal models

    Wang, X., Destrument, A. & Tournier, C., Aug 2007, In: Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 8, p. 1349-1357 8 p.

    Research output: Contribution to journalArticlepeer-review

  • Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death

    Wang, X., Nadarajah, B., Robinson, A. C., McColl, B. W., Jin, J. W., Dajas-Bailador, F., Boot-Handford, R. P. & Tournier, C., Nov 2007, In: Molecular and Cellular Biology. 27, 22, p. 7935-7946 11 p.

    Research output: Contribution to journalArticlepeer-review

  • 2006

    Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress

    Wang, X., Finegan, K. G., Robinson, A. C., Knowles, L., Khosravi-Far, R., Hinchliffe, K. A., Boot-Handford, R. P. & Tournier, C., Dec 2006, In: Cell Death and Differentiation. 13, 12, p. 2099-2108 9 p.

    Research output: Contribution to journalArticlepeer-review

  • Regulation of cellular functions by the ERK5 signalling pathway

    Wang, X. & Tournier, C., Jun 2006, In: Cellular Signalling. 18, 6, p. 753-760 7 p.

    Research output: Contribution to journalArticlepeer-review

  • The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway

    Papadakis, E. S., Finegan, K. G., Wang, X., Robinson, A. C., Guo, C., Kayahara, M. & Tournier, C., 20 Feb 2006, In: FEBS Letters. 580, 5, p. 1320-1326 6 p.

    Research output: Contribution to journalArticlepeer-review

  • 2005

    Activation of integrin α5β1 delays apoptosis of Ntera2 neuronal cells

    Gibson, R. M., Craig, S. E., Heenan, L., Tournier, C. & Humphries, M. J., Mar 2005, In: Molecular and Cellular Neuroscience. 28, 3, p. 588-598 10 p.

    Research output: Contribution to journalArticlepeer-review

  • Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway

    Wang, X., Merritt, A. J., Seyfried, J., Guo, C., Papadakis, E. S., Finegan, K. G., Kayahara, M., Dixon, J., Boot-Handford, R. P., Cartwright, E. J., Mayer, U. & Tournier, C., Jan 2005, In: Molecular and Cellular Biology. 25, 1, p. 336-345 9 p.

    Research output: Contribution to journalArticlepeer-review

  • 2001

    MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines

    Tournier, C., Dong, C., Turner, T. K., Jones, S. N., Flavell, R. A. & Davis, R. J., 2001, In: Genes and development. 15, 11, p. 1419-1426 7 p.

    Research output: Contribution to journalArticlepeer-review

  • 2000

    JNK is required for effector T-cell function but not for T-cell activation

    Tournier, C., Dong, C., Yang, D. D., Tournler, C., Whitmarsh, A. J., Xu, J., Davis, R. J. & Flavell, R. A., 4 May 2000, In: Nature. 405, 6782, p. 91-94 3 p.

    Research output: Contribution to journalArticlepeer-review

  • Requirement of JNK for stress-induced activation of the cytochrome c- mediated death pathway

    Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A. & Davis, R. J., 5 May 2000, In: Science. 288, 5467, p. 870-874 4 p.

    Research output: Contribution to journalArticlepeer-review

  • 1999

    Molecular basis of T-cell differentiation

    Flavell, R. A., Li, B., Dong, C., Lu, H. T., Yang, D. D., Enslen, H., Tournier, C., Whitmarsh, A., Wysk, M., Conze, D., Rincon, M. & Davis, R. J., 1999, In: Cold Spring Harbor Symposia on Quantitative Biology. 64, p. 563-71 9 p.

    Research output: Contribution to journalArticlepeer-review

  • The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases

    Tournier, C., Whitmarsh, A. J., Cavanagh, J., Barrett, T. & Davis, R. J., Feb 1999, In: Mol Cell Biol. 19, 2, p. 1569-81 13 p.

    Research output: Contribution to journalArticlepeer-review

  • 1998

    A mammalian scaffold complex that selectively mediates MAP kinase activation

    Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J. & Davis, R. J., 11 Sept 1998, In: Science. 281, 5383, p. 1671-4 4 p.

    Research output: Contribution to journalArticlepeer-review

  • 1997

    Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

    Tournier, C., Whitmarsh, A. J., Cavanagh, J., Barrett, T. & Davis, R. J., 8 Jul 1997, In: Proceedings of the National Academy of Sciences. 94, 14, p. 7337-42 6 p.

    Research output: Contribution to journalArticlepeer-review