Personal profile
Biography
Research associate working in the PRECISE group. My main research interests are in the cellular responses to radiotherapy and proton therapy through micronuclei production, rupture and the cGAS/STING pathway. I am currently working on the movement of double strand breaks following radiation and the production of chromosome aberrations.
I have an MSc in Molecular Cell Biology and an MSc in Bioinformatics and Systems Biology. My PhD thesis evaluated the cellular responses to proton beam therapy using wet lab and computational techniques with a focus on micronuclei and cell cycle.
Education/Academic qualification
Master in Science, Bioinformatics & Systems Biology, The University of Manchester
Award Date: 31 Aug 2018
Bachelor of Science, Molecular Cell Biology, University of York
Award Date: 31 Aug 2015
Areas of expertise
- QR180 Immunology
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre
Keywords
- Bioinformatics
- Proton Therapy
- Radiobiology
- Immunology
- cGAS/STING
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Collaborations and top research areas from the last five years
Research output
- 3 Article
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The suitability of micronuclei as markers of relative biological effect
Heaven, C. J., Wanstall, H. C., Henthorn, N. T., Warmenhoven, J.-W., Ingram, S. P., Chadwick, A. L., Santina, E., Honeychurch, J., Schmidt, C. K., Kirkby, K. J., Kirkby, N. F., Burnet, N. G. & Merchant, M. J., 2 Apr 2022, In: Mutagenesis. 37, 1, p. 3-12 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Unravelling the Impact of Linear Energy Transfer on Micronuclei induction from proton and photon irradiation
Heaven, C. J., Warmenhoven, J., Chadwick, A., Santina, E., Honeychurch, J., Schmidt, C., Kirkby, K., Merchant, M. & Henthorn, N., 30 Jun 2025, (Accepted/In press) In: Scientific Reports.Research output: Contribution to journal › Article › peer-review
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Modelling Heterogeneous Anomalous Dynamics of Radiation-Induced Double-Strand Breaks in DNA during Non-Homologous End-Joining Pathway
Korabel, N., Warmenhoven, J. W., Henthorn, N. T., Ingram, S., Fedotov, S., Heaven, C. J., Kirkby, K. J., Taylor, M. J. & Merchant, M. J., 8 Jun 2024, In: Entropy. 26, 6, 502.Research output: Contribution to journal › Article › peer-review
Open Access
Thesis
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Experimental and computational analysis of the cellular responses to proton beam therapy
Heaven, C. (Author), Schmidt, C. (Co Supervisor), Honeychurch, J. (Co Supervisor), Chadwick, A. (Co Supervisor), Kirkby, K. (Co Supervisor), Santina, E. (Co Supervisor), Warmenhoven, J. (Main Supervisor) & Henthorn, N. (Co Supervisor), 20 Jun 2024Student thesis: Phd
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