Research output per year
Research output per year
Personal profile
Overview
I hold a honorary academic post at the Lydia Becker Institute of Immunology and Inflammation. Currently, I am a NIHR Academic Clinical Lecturer at the School of Cellular and Molecular Medicine (University of Bristol), while undertaking Paediatric Rheumatology subspecialty training at the Bristol Royal Hospital for Children.
I am interested in exploring how we can design better treatments for autoimmune conditions through understanding the origin and function of immune cells residing in primary tissue that undergo inflammation during disease. I became fascinated by the function of kidney macrophages for their diverse role in maintaining tissue health and significant involvement in autoimmune disease, whilst studying for a PhD (Versus Arthritis Clinical Research Fellowship) in the laboratories of Professor Tracy Hussell and Professor Rachel Lennon.
My research investigates how immune cells in tissue are maintained during health and the pathways that lead to resolution after inflammation. A specific focus of my research is paediatric uveitis, a chronic sight-threatening eye disease affecting a third of children and adolescents with juvenile idiopathic arthritis (JIA), which is difficult to diagnose and challenging to treat.
My current research in paediatric uveitis is funded by grants from NIHR CRN Children/Versus Arthritis Paediatric Clinical Studies Group and FAIR UK.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Medicine, PhD, The University of Manchester
Award Date: 1 Jul 2021
Master of Research, Medical Sciences (Distinction)
Award Date: 1 Jan 2016
MRCPCH, Royal College of Paediatrics & Child Health
Award Date: 1 Jan 2016
Bachelor of Science, The University of Manchester
Award Date: 1 Jul 2011
Bachelor of Medicine and Bachelor of Surgery, MBChB, The University of Manchester
Award Date: 1 Jul 2011
Keywords
- immunology
- inflammation
- rheumatology
- arthritis
- children
Fingerprint
Dive into the research topics where Christine Chew is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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Juvenile idiopathic inflammatory myositis: an update on pathophysiology and clinical care
Papadopoulou, C., Chew, C., Wilkinson, M. G. L., McCann, L. & Wedderburn, L. R., 1 Jun 2023, In: Nature Reviews Rheumatology. 19, 6, p. 343-362 20 p.Research output: Contribution to journal › Review article › peer-review
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Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort
Chew, C., 1 Oct 2021, In: Rheumatology (Oxford). 60, 10, p. 4737-4747 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile23 Downloads (Pure) -
Longitudinal immune profiling reveals distinct features of COVID-19 pathogenesis
Respiratory TRC, CIRCO, Mann, E. R., Menon, M., Knight, S. B., Konkel, J. E., Jagger, C., Shaw, T. N., Krishnan, S., Rattray, M., Ustianowski, A., Bakerly, N. D., Dark, P., Lord, G., Simpson, A., Felton, T., Ho, L. P., Feldmann, M., Grainger, J. R. & Hussell, T., 1 Jun 2020, medRxiv, 30 p.Research output: Preprint/Working paper › Preprint
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Severity-stratified and longitudinal analysis of VWF/ADAMTS13 imbalance, altered fibrin crosslinking and inhibition of fibrinolysis as contributors to COVID-19 coagulopathy
CIRCO, 21 Aug 2020, medRxiv, (medRxiv).Research output: Preprint/Working paper › Working paper
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Basement membrane defects in genetic kidney diseases
Lennon, R. & Chew, C., 2018, In: Frontiers in pediatrics. 6, 16 p., 11.Research output: Contribution to journal › Article › peer-review
Open Access
Prizes
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Best Oral Abstract Presentation (1 of 3) at the British Society of Matrix Biology Conference
Chew, C. (Recipient), Aug 2020
Prize: Prize (including medals and awards)
Thesis
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Macrophage response within the unique microenvironment of the kidneys in health and disease
Chew, C. (Author), Lennon, R. (Supervisor) & Hussell, T. (Supervisor), 1 Aug 2021Student thesis: Phd
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