Genome Stability Lab (GSL)

Research in the group aims to better understand how cells maintain stable genomes and how genomically instable cancers can be detected and targeted in novel ways. Specifically, we are working on two topics to improve strategies of preventing and treating diseases of unmet need in the future.

1. How do ubiquitylation pathways regulate the DNA damage response and associated processes? To address this, we are integrating cell biology, biochemistry, bioinformatics and high through-put/high-content quantitative microscopy/microarray techniques. The importance of ubiquitylation and DNA damage response pathways is illustrated by a declining ubiquitin system and accumulating DNA damage giving rise to various human disorders such as cancer and neurodegenerative diseases.

2. Ovarian cancer displays rampant genomic instability and has low long-term survival rates with less than 30 percent of women outliving the disease for more than ten years, mainly due to a lack of early detection methods. We are establishing cutting-edge nanotechnology, cell biology, molecular biology, biochemistry and advanced microscopy methods to develop innovative biohybrid drug-delivery vehicles to detect and target the disease earlier.

Christine completed postdoctoral positions in Prof. Stephen Jackson's group at the Gurdon Institute/University of Cambridge between 2011 and 2016, and Dr Tom Misteli's group at the National Cancer Institute, National Institutes of Health, USA, between 2009 and 2011. She was awarded her PhD in Dr Frank Uhlmann's group at the CRUK London Research Institute/University College London where she performed her studies between 2004 and 2009.

BBSRC David Phillips Fellowship (awarded in 2016)

FBMH Dean's Prize Early Career Research Development Award (awarded in 2016)

Cambridge Nanoforum Fellowship (awarded in 2012)

FEBS Return-to-Europe Fellowship (awarded in 2011)

EMBO Long-term Fellowship (awarded in 2008)

Read about our work on engineering human spermbots for improving ovarian cancer care here:

• https://bruntwood.co.uk/blog/ones-to-watch-in-precision-medicine-2021/

Media coverage of our 2016 ACS Nano paper 'Molecular Insights into Division of Single Human Cancer Cells in On-Chip Transparent Microtubes'.

ACS (June 2016)

Sciencenews (June 2016)

Nature Cell Biology News & Views article referring to our 2015 Nature Cell Biology paper 'Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair'.

Nature Cell Biology News & Views (October 2015)

Front cover art of our 2014 NANOLetters paper 'Rolled-up functionized nanomembranes as three-dimensional cavities for single cell studies'.

NANOLetters front Cover Art (August 2014)

Postdoctoral researchers

Sarah Harbach (since September 2024)

[email protected]

Sarah completed her BSc in Biochemistry from the University of York in 2018. During her degree, she undertook an industrial placement at AstraZeneca (Cambridge) developing LC-MS/MS methods to analyse lipid nanoparticle biodistribution. She moved to the University of Manchester in 2018 for her doctoral studies under the supervision of Prof. Tracy Hussell, identifying novel early biomarkers of lung cancer using nasal swabs using shotgun proteomics, for which she has a patent pending, and investigating nasal proteomic changes during acute SARS-CoV-2 infection and recovery. She continued her research at the Doherty Institute at the University of Melbourne in Australia, developing nasal and intestinal organoid models of infectious disease, including SARS-CoV-2. Sarah joined the lab in September 2024 as a Postdoctoral Research Associate, working in the NEMO (Novel Early Markers for Ovarian Cancer) consortium to identify potential biomarkers for ovarian cancer detection.

Benjamin Foster (since July 2023)

[email protected]

Ben completed his Masters (MSci) in Natural Sciences from the University of Cambridge, with his thesis project focussing on the function of a ubiquitin-related modifier, Urm1, in Archaea. He moved to the MRC London Institute of Medical Sciences (LMS) in 2013 for his doctoral research with Till Bartke, investigating the role of combinatorial chromatin modifications and how they are written and read. He continued this research at the Institute of Functional Epigenetics (IFE) at the Helmholtz Zentrum in Munich, focussing on how UHRF1 ubiquitylates histone H3 in its role for maintaining DNA methylation after replication. At the end of 2018, Ben moved to the Department of Biochemistry at the University of Oxford to investigate the function and activity of deubiquitylases (DUBs) in DNA repair using a range of biochemical and structural biology approaches. Ben joined the lab in Summer 2023 as a Postdoctoral Research Associate to study the role of intrinsically disordered regions (IDRs) in ubiquitin/ubiquitin-like signalling relevant to genome stability.

Research visitors

Moritz Weiss (since September 2024)

[email protected]

Moritz Weiß obtained his BSc in Biomedical Engineering in 2023 at the University of Technology, Chemnitz, Germany. In his final thesis, at the MAIN Research Centre under supervision of Prof. Oliver G. Schmidt, he developed a microfluidic sperm sorting device that can significantly increase the quality of sperm used for IVF and ICSI. During his master’s degree specialising in microtechnology, he continued his research in the field of engineered sperm robotics and joined the group in 2024 as a research visitor to work on the advanced use of microfluidics and sperm robots in ovarian cancer research.

PhD students

Zijuan Wang (since October 2021)

[email protected]

Zijuan received her Master’s degree in Pharmaceutical Chemistry in 2021 from Zhejiang University, China. There, she focused on the exploration of the structure-activity relationships of influenza endonuclease. In October 2021 she joined the lab as a BBSRC DTP student to work on the mapping of weak and transient UBL receptor interactions using tailored photo-crosslinking chemistry.

Joseph Hallett (since May 2022) 

[email protected]

Joseph Hallett obtained his BSc in Applied Medical Sciences from University College London (UCL) in 2019. Whilst there, he undertook a research placement within the UCL Cancer Institute Translational Radiation Oncology Lab (Professor Ricky Sharma). This involved testing the therapeutic potential of olaparib and SAHA as radio-sensitising drugs in colorectal cancer cell lines. Before starting his PhD, he worked at a Contract Research Organization (CRO) in central London, screening patients for phase 1, 2 and 3 clinical trials of investigational drugs. His current work (primary supervisor: Dr Stefan Meyer) focusses on comparing the DNA damage response to proton beam therapy and x-rays in Fanconi Anaemia cells.

Hazim A. Al Hazmi (since June 2022)

[email protected]

Hazim Al Hazmi obtained his Master's degree in biochemistry at the King Saud University (Riyadh, Saudi Arabia) where he worked as a researcher at the Chair for Biomarkers of Chronic Disease. In his MSc he focussed on studying the methylation status of the core components of the hippo pathway genes in bone cancers. In 2022, he started his PhD in Cancer Sciences in the lab, where, in collaboration with Dr Stefan Meyer, he is investigating posttranslational modifications, such as ubiquitin-like modifiers, on proto-oncogenes in the context of the DNA damage response in different cancer contexts.

Deepak Behera (since September 2022)

[email protected]

Deepak Behera obtained an Integrated Master’s degree in Chemistry from the National Institute of Science Education and Research (NISER), India. There he has completed his master thesis titled “Catalytic Transformations Based on Half-Sandwich Ruthenium Complexes” under supervision of Prof. C. Gunanathan. He has also qualified for a CSIR - Junior Research Fellowship, India. He joined the lab as part of a BBSRC DTP studentship in collaboration with Prof. Igor Larrosa's and Prof. Perdita Barran’s groups at the University of Manchester. His current research focuses on precise mapping of protein-protein interactions in living cells using radical clock molecules.

Yue Wu (since October 2022)

[email protected]

Yue obtained his Master’s degree (MRes) in Cancer Science in 2020 from Imperial College London where he worked on the interaction of epigenetic therapies with PARP inhibitors (Prof. Bob Brown’s lab), and imaging and quantifying tissue growth during Drosophila development (Dr Nic Tapon’s lab). Before starting his PhD in the group (in collaboration with Dr Stefan Meyer), he worked at Wuxi Biologics in Shanghai, conducting immunoassays and cell-based experiments in support of their therapeutic antibody/biotech product portfolio. Now his research focuses on characterising ubiquitin-like proteins in the DNA damage response in relevant cancer contexts.

Finlay Martin (since October 2023)

[email protected]

Finlay obtained his BSc (Hons) in Immunology from the University of Glasgow in 2023. There he undertook a Wellcome Trust-funded summer research project in Professor Julia Edgar's lab, visualising CNS myelination by oligodendrocytes during early development. His final year research project compared computational methods of cell-cell interaction analysis using scRNA-seq and spatial transcriptomics data. Finlay joined the Genome Stability Lab in 2023 as an EPSRC DTP PhD student, where he is using photo-crosslinking chemistry to study the interactions and roles of selected ubiquitin-like proteins, particularly in the context of the DNA damage response.

Joanne Oke (since October 2023)

[email protected]

Joanne obtained a BSc in Biomedical Science with Infection and Immunology from St George's University of London in 2021. For her final year project, she worked in Dr Qinxue Hu's lab investigating the early infection mechanism of HSV-2 proteins on the innate immune system. She has completed the preclinical years of her medical degree at the University of Manchester. She joined the lab in 2023 as a MB-PhD student funded by Cancer Research UK focusing on the engineering of cellular microrobots to improve ovarian cancer care.

Prithvi Moharana (since October 2023)

[email protected]

Prithvi completed his Master's degree in Chemistry from Vellore Institute of Technology (VIT), India. There, under the supervision of Dr Priyankar Pairahe, he worked on the development of metal-based complexes and their theranostic applications in cancer, in particular the phototoxicity of rhenium complexes  in triple-negative breast cancer cells. After his Master's, he joined Unilever, India, as an R&D Consultant focussing on Product Development in the Department of Home Care and Hygiene. He joined the genome stability lab as a BBSRC DTP student, in collaboration with Dr Alice Bowen's and Dr Sam Hay's groups, investigating the structure and functionality of the XRCC4-SUMO system using EPR spectroscopy, molecular modelling, biochemistry and cell biology assays.

Aitor Carneiro (since October 2023)

[email protected]

Aitor obtained his Master of Pharmacy in 2020 from the University of Santiago de Compostela, Spain. There, he worked on the synthesis of coumarin derivatives in Prof. Eugenio Uriarte’s group. He then completed a MSc in Medicinal Chemistry at Cardiff University in 2021, focusing on the synthesis of boronic acid complexes as potential chemical probes, supervised by Dr D. Heulyn Jones. In the two years previous to his PhD start, Aitor worked on the synthesis of peptide-drug conjugates as a FCT predoctoral fellow supervised by Dr Maria João Matos and Prof. Fernanda Borges from the University of Porto, and on the synthesis of non-covalent inhibitors of acid ceramidase as a research assistant for the Medicines Discovery Institute of Cardiff University. His current research involves the design and synthesis of small molecules to enable the study of ubiquitin/UBL pathways in collaboration with Prof. Igor Larrosa’s and Dr Sam Butterworth’s groups. 

Master's students

Rebecca Wright (since October 2024), MSc Oncology

Macy Yau (since September 2024)

[email protected]

Macy is a fourth year MSci Biomedical Sciences student at the University of Manchester. She studied BSc Speech and Hearing Sciences at the University of Hong Kong from 2018-2021, and was in the Dean’s Honours List for two consecutive years, before she withdrew from the course as she discovered that her true passion is in the biomedical sciences. During her studies at the University of Manchester, she was selected as a mentee of the Manchester Cancer Research PhD Mentorship scheme, and has fostered an interest in molecular biology and cancer research. In the summer of 2023, she was awarded the Summer Vacation Programming Studentship by the Biochemical Society. She is joining the Genome Stability Lab for her MSci project, which focuses on  finding interactors of selected ubiquitin-like proteins using photo-crosslinking chemistry, to gain insights into their functions, particularly in the context of the DNA damage response. She obtained a Fellowship in Violin Performance from the Trinity College London in 2016.

Final-year project students

Maya Nayyar (since January 2025)

[email protected]

Maya is a fourth-year Biotechnology student at the University of Manchester. She completed her third year of study in Adelaide, Australia, under the supervision of Prof. Janni Petersen at the Flinders Centre for Innovation in Cancer. Her project focused on the DNA repair protein RAD52 and its importance in cancer research, particularly the nutrient-dependent regulation of RAD52 S446 phosphorylation. Upon returning to Manchester, she has joined the laboratory as part of her final-year research project, which investigates the role of ubiquitin-like proteins in the DNA damage response, utilising techniques such as genetic code expansion.

Alumni

Zac Sandy (October 2019 - March 2024)

Zac Sandy obtained his Master’s degree (MRes) in Cancer Science in 2019 from the University of Birmingham. There he worked in Dr Clare Davies’ lab investigating the roles of arginine modifications in the DNA damage response. In October 2019 he joined the lab as part of a BBSRC CTP studentship in collaboration with Dr Josep Forment’s group at AstraZeneca. His research focussed on exploring the roles of selected ubiquitin-like modifiers in the DNA damage response. After completing his PhD, Zac accepted a position as a Research Technician in Dr Alexandra Davies' lab, UoM, using spatial proteomics to investigate protein trafficking in neurodegradation.

Melanie Seaton (October 2019 - September 2023)

Melanie joined the lab in 2019 as a PhD student to work on the development of cellular micromotors for improved management of ovarian cancer. Part of her work was published in Nanoscale in 2020, and she also presented her findings at the European Association for Cancer Research's 2023 conference in Turin, as well as GSK's Opportunities in Ovarian Cancer 2023 Meeting in Edinburgh. Having developed a passion for scientific writing and communications during her PhD, winning Molecular Oncology's scientific writing competition and The University of Manchester's Three Minute Thesis competition, Melanie entered a full-time medical communications role as an Analyst at Costello Medical upon completion of her PhD studies.

Isabelle Cristine Da Costa (October 2018 - October 2023)

Isabelle Cristine has a conjoined BSc in Biotechnology from the Federal University of Goias (Brazil) and Michigan State University (USA) and an industrial internship on lung cancer at Abbot/AbbVie Laboratories (USA). She obtained her Master's degree in Biological Sciences in 2018 from the University of Manchester where she worked with haematopoietic stem cells (Dr Valerie Kouskoff's lab) and creation of yeast hybrids with biotechnological applications (Prof. Daniela Delneri's lab). Her research in the lab focused on understanding the function and molecular pathways of selected ubiquitin-like modifiers in the DNA damage response. 

Anita Safina (June 2023 - September 2023)

Anita is a BSc Biochemistry graduate from Lancaster University currently studying for her MSc Clinical Biochemistry at The University of Manchester. She joined the group in June 2023 for her dissertation research project focussing on applying genetic code expansion to uncover non-covalent interactions of UBLs in mammalian cells using photocrosslinking chemistry.

Alice Cross (January 2023 - July 2023)

Alice was a Master's student in Biochemistry at the University of Manchester, and worked in the lab for her MSc research project. The project focused on identifying novel receptors of ubiquitin-like proteins using a photocrosslinking chemistry approach. After her MSc Alice went on to join Igor Vivanco’s group at King’s College London as a PhD student.

Anthony Wilby (September 2022 - May 2023)

Anthony joined the group as an integrated Master’s student in Medical Biochemistry, working in the lab for his final year project. The project focussed on protein interactions between the DNA damage response protein XRCC4 and SUMOylated proteins.

María José Cabello (August 2017 - March 2023)

María José received her PhD in 2016 at the Andalusian Centre of Molecular Biology and Regenerative Biomedice (Seville, Spain). She joined the lab in August 2017 as a postdoctoral researcher to work on the role of SUMO in the DNA damage response.

Hugh Osborne (October 2018 - October 2022)

Hugh Osborne obtained a Master’s degree in Pharmacy (MPharm) in 2016 from the University of East Anglia (UEA), later qualifying as a pharmacist in August 2017. He joined the lab in collaboration with Prof. Igor Larrosa's group in September 2018 as a PhD student to work on the development of small molecule inhibitors of DNA double-strand break repair. Following his departure from the group, Hugh began work in Medical Consultancy with Costello Medical in Cambridge.

Konstancja Urbaniak (September 2018 - November 2022)

Konstancja Urbaniak obtained her Master’s by Research (MRes) in Molecular and Cellular Medicine in 2017 from the University of Bristol where she worked on the correlation between posttranslational modifications and dynamics of microtubules and DNA damage response signalling. In September 2018, she started an A*STAR PhD programme in the group in collaboration with Dr Jim Warwicker’s and Prof. Frank Eisenhaber’s labs. Her research focused on the systematic identification of SUMO-binding proteins within and beyond the DNA damage response. After her PhD she went on to do a postdoc in Sergio Branciamore's group in the US.

Brett Weller (October 2021 - August 2022)

Brett gained his Bachelor’s degree in Biochemistry from the University of Bedfordshire in 2021. He joined the lab for his research project as part of his MRes Biochemistry Master’s degree, focusing on ubiquitin receptors in genome stability.

Jennifer Chandler (September 2021 - April 2022)

As part of an integrated MSci degree in Biomedical Sciences at the University of Manchester, Jenny joined the lab for her final year research project looking into the binding characteristics and functions of SUMO chains in non-homologous end-joining. She then went on for a PhD at the University of Leeds with Dr Joan Boyes, looking at the repair of aberrant cut-and-run DNA breaks in V(D)J recombination.

Elsa Irving (February 2019 - December 2021)

Elsa received her PhD from the UCL Great Ormond Street Institute of Child Health in 2019. She then completed a postdoctoral fellowship in collaboration with Dr Josep Forment at AstraZeneca based in the DNA damage response group within oncology. Her work focussed on understanding the contribution of BRCA1 hypomorph expression to PARP inhibitor resistance. Elsa then went on to work as a senior research scientist at AstraZeneca investigating tumour drivers and resistance.

Caitlin Kyle (June - September 2021)

Caitlin gained her Bachelor’s degree in Biochemistry at the University of Manchester in 2020. She joined the lab for her research project on defining novel ubiquitin receptors as part of her Clinical Biochemistry Master’s degree. After this, she joined the NHS Scientist Training Programme in Manchester where she is specialising in Clinical Biochemistry and gaining another Master’s degree in Clinical Science.

Stephenie Purvis (October 2018 - July 2019)

Stephenie gained her Bachelor's degree in Biomedical Science from the University of Kent in 2018. She joined the lab for her research project as part of her MRes Oncology Master's degree. Since leaving, she has been accepted onto the highly competitive NHS Scientific Training Programme in Cambridge where she will not only be specialising in Cancer Genomics but also gaining another Master's degree in Clinicial Science.

Mariam Nasr (September 2017 - May 2018)

Mariam joined the lab and Richard Edmondson's group as an undergraduate student in her final year of her MSci Genetics degree, looking into defects in homologous recombination in ovarian cancer cells.

Selected external collaborations

• Prof. Jeremy Stark (City of Hope, USA)
• Prof. Oliver G. Schmidt (Institute for Integrative Nanosciences, IFW, Dresden, Germany)
• Dr Josep Forment (Director at AstraZeneca Oncology R&D, Cambridge, UK)
• Prof. Henning Mootz (University of Muenster, Germany)
• Dr Matthew Jenner (University of Warwick, UK)
• Dr Petra Beli (Institute of Molecular Biology, Mainz, Germany)
• Dr Christian Loch (CEO of AVMBiomed, Pottstown, USA)
• Prof. Stephen P. Jackson (The Gurdon Institute, University of Cambridge, UK)

Please directly contact Christine Schmidt if you are interested in joining the group.

Publications & preprints

Sandy Z, Wang Z, Behera D, Foster BM, Martin FA, Brüninghoff K, Cain KM, Dörner W, Cabello-Lobato MJ, Forment JV, Cliff MJ, Larrosa I, Barran P, Smith DL, Mootz HD, Schmidt CK. Site-selective photo-crosslinking for the characterisation of transient ubiquitin-like protein-protein interactions. PLoS ONE (2025). 20(1), e0316321. https://doi.org/10.1371/journal.pone.0316321

Osborne HC, Foster BM, Al-Hazmi H, Meyer S, Larrosa I, Schmidt CK. Small-molecule inhibition of CBX4/7 hypersensitises homologous recombination-impaired cancer to radiation by compromising CtIP-mediated DNA end resection. Cancers (2024). 16 (11), 2155.

Foster BM, Wang Z, Schmidt CK. DoUBLing up: ubiquitin and ubiquitin-like proteases in genome stability. Biochemical Journal (2024). 481 (7), 515.

Cabello-Lobato MJ, Jenner M, Cisneros-Aguirre M, Brüninghoff K, Sandy Z, da Costa IC, Jowitt TA, Loch CM, Jackson SP, Wu Q, Mootz HD, Stark JM, Cliff MJ, Schmidt CK. Microarray screening reveals two non-conventional SUMO-binding modules linked to DNA repair by non-homologous end-joining. Nucl. Acids Res. (2022). 50(8), 4732.

Heaven CJ, Wanstall HC, Henthorn NT, Warmenhoven J-W, Ingram SP, Chadwick AL, Santina E, Honeychurch J, Schmidt CK, Kirkby KJ, Kirkby NF, Burnet NG, Merchant MJ. The suitability of micronuclei as markers of relative biological effect. Mutagenesis (2022). https://doi.org/10.1093/mutage/geac001

Osborne HC, Larrosa I*, Schmidt CK*. Sesquiterpene lactones potentiate olaparib-induced DNA damage in p53 wildtype cancer cells. IJMS (2022). 23(3), 1116; https://doi.org/10.3390/ijms23031116

Cabello-Lobato MJ, Schmidt CK*, Cliff MJ*. ¹H, ¹³C, ¹⁵N backbone resonance assignment for the 1-164 construct of human XRCC4. Biomolecular NMR Assignments (2021). 15, 389–395. http://link.springer.com/article/10.1007/s12104-021-10035-6

Osborne HC, Irving E, Forment JV, Schmidt CK. E2 enzymes in genome stability: pulling the strings behind the scenes. Trends in Cell Biology (2021). https://doi.org/10.1016/j.tcb.2021.01.009

Cabello-Lobato MJ, Jenner M, Loch CM, Jackson SP, Wu Q, Cliff MJ, Schmidt CK. Microarray screening reveals a non-conventional SUMO-binding mode linked to DNA repair by non-homologous end-joining. bioRxiv (2021). DOI: 10.1101/2021.01.20.427433

Sandy Z, da Costa IC, Schmidt CK. More than meets the ISG15: emerging roles in the DNA damage response and beyond. Biomolecules (2020). DOI: 10.3390/biom10111557

Schmidt CK*, Medina-Sánchez M*, Edmondson RJ, Schmidt OG*. Engineering microrobots for targeted cancer therapies from a medical perspective. Nature Communications (2020). DOI: 10.1038/s41467-020-19322-7. *Co-corresponding authors

Xu H, Medina-Sánchez M*, Zhang W, Seaton M, Brison DR, Edmondson RJ, Taylor SS, Nelson L, Zeng K, Bagley S, Ribeiro C, Restrepo LP, Lucena E, Schmidt CK*, Schmidt OG*. Human spermbots for patient-representative 3D ovarian cancer cell treatment. Nanoscale (2020). DOI: 10.1039/D0NR04488A. *Co-corresponding authors

Osborne HC, Irving E, Schmidt CK. The ubiquitin/UBL drug target repertoire. Trends in Molecular Medicine (2020). DOI: 10.1016/j.molmed.2020.08.009

Osborne HC, Durie A, Schmidt CK, Larrosa I. C-H borylation: no need to stop for directions. Trends in Chemistry (2020). DOI: 10.1016/j.trechm.2020.07.009

Da Costa IC & Schmidt CK. Ubiquitin-like proteins in the DNA damage response: the next generation. Essays Biochem. (2020) 1–16.

van den Tempel N, Zelensky AN, Odijk H, Laffeber C, Schmidt CK, Brandsma I, Demmers J, Krawczyk PM, Kanaar R. On the mechanism of hyperthermia-induced BRCA2 protein degradation. Cancers (2019) 11: 97.

Cabello-Lobato MJ, Wang S, Schmidt CK. SAMHD1 sheds moonlight on DNA double-strand break repair. Trends in Genetics (2017) 12: 895-897.

Xi W*, Schmidt CK*, Sanchez S, Gracias DH, Carazo-Salas RE, Butler R, Lawrence N, Jackson SP, and Schmidt OG. Molecular Insights into Division of Single Human Cancer Cells in On-Chip Transparent Microtubes. ACS Nano (2016) 10: 5835–5846. *Co-corresponding authors; highlighted in acs.org (ACS, June 2016) and sciencenews.org (Sciencenews, June 2016).

Schmidt CK^$, Galanty Y^$, Sczaniecka-Clift M, Coates J, Jhujh S, Demir M, Jackson SP. Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair. Nature Cell Biology (2015) 17: 1458-1470. ^$Co-first authors

Aymard F, Bugler B, Schmidt CK, Guillou E, Caron P, Briois S, Iacovoni JS, Daburon V, Miller KM, Jackson SP et al. Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. Nat Struct Mol Biol (2014) 21: 366–374.

Knobel PA, Belotserkovskaya R, Galanty Y, Schmidt CK, Jackson SP, Stracker TH. USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol (2014) 34: 2062–2074.

Xi W, Schmidt CK*, Sanchez S*, Gracias DH, Carazo-Salas RE, Jackson SP, Schmidt OG. Rolled-up Functionalized Nanomembranes as Three-Dimensional Cavities for Single Cell Studies. Nano Letters (2014) 14: 4197–4204. *Co-corresponding authors (Impact Factor: 13; Top 4 Nanoscience & Nanotechnology Journal by Impact Factor); featured as front cover image (Cover Art).

Koch B, Sanchez S*, Schmidt CK*, Swiersy A, Jackson SP, Schmidt OG. Confinement and Deformation of Single Cells and Their Nuclei Inside Size-Adapted Microtubes. Adv Healthc Mater (2014) 3: 1753–1758. *Co-corresponding authors; featured as back cover image.

Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T. Spatial dynamics of chromosome translocations in living cells. Science (2013) 341: 660–664.

Schmidt CK and Jackson SP. On your MARK, get SET(D2), go! H3K36me3 primes DNA mismatch repair. Cell (2013) 153: 513-515.

Smith EJ, Xi W, Makarov D, Monch I, Harazim S, Quinones VAB, Schmidt CK, Mei YF, Sanchez S, Schmidt OG. Lab-in-a-tube: ultracompact components for on-chip capture and detection of individual micro-/nanoorganisms. Lab Chip (2012) 12: 1917-1931.

Harazim SM, Xi W, Schmidt CK, Sanchez S, Schmidt OG. Fabrication and applications of large arrays of multifunctional rolled-up SiO/SiO2 microtubes. J Mater Chem (2012) 22: 2878-2884.

Schneede A, Schmidt CK, Holtta-Vuori M, Heeren J, Willenborg M, Blanz J, Domanskyy M, Breiden B, Brodesser S, Landgrebe J et al. Role for LAMP-2 in endosomal cholesterol transport. J Cell Mol Med (2011) 15: 280-295.

Roukos V, Misteli T, Schmidt CK. Descriptive no more: the dawn of high-throughput microscopy. Trends in Cell Biology (2010) 20: 503-506.

Schulze S, Huang GS, Krause M, Aubyn D, Quinones VAB, Schmidt CK*, Mei YF*, Schmidt OG. Morphological Differentiation of Neurons on Microtopographic Substrates Fabricated by Rolled-Up Nanotechnology. Adv Eng Mater (2010) 12: B558-B564. *Co-corresponding authors

Schmidt CK, Brookes N, Uhlmann F. Conserved features of cohesin binding along fission yeast chromosomes. Genome Biol (2009) 10: R52.

Bernard P^$, Schmidt CK^$, Vaur S^$, Dheur S, Drogat J, Genier S, Ekwall K, Uhlmann F, Javerzat JP. Cell-cycle regulation of cohesin stability along fission yeast chromosomes. Embo J (2008) 27: 111-121 ^$Co-first authors

D'Ambrosio C, Schmidt CK, Katou Y, Kelly G, Itoh T, Shirahige K, Uhlmann F. Identification of cis-acting sites for condensin loading onto budding yeast chromosomes. Genes Dev (2008) 22: 2215-2227.

Willenborg M, Schmidt CK, Braun P, Landgrebe J, von Figura K, Saftig P, Eskelinen, E-L. Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation. J Lipid Res (2005) 46: 2559–2569.

Eskelinen E^$, Schmidt CK^$, Neu S, Willenborg M, Fuertes G, Salvador N, Tanaka Y, Lüllmann-Rauch R, Hartmann D, Heeren J et al. Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts. Mol Biol Cell (2004) 15: 3132–3145. ^$Co-first authors