Personal profile

Biography

1996, Diploma, University of Constance, Germany;

2000, PhD, University of Geneva, Switzerland;

2000-2001, Post doctoral fellow, Technical University of Dresden, Germany;

2001-2004, Postdoctoral fellow, Weizmann Institute of Science, Israel; supported by Feinberg Graduate School and Minerva fellowships;

2004-2007, Wellcome Trust Research Fellow, School of Biological Sciences, University of Manchester

2007-present, Lecturer, Faculty of Life Sciences, Wellcome Trust Centre for Cell-Matrix Research, University of Manchester

Research interests

For migration over external surfaces cells need to form adhesions with the extracellular matrix and to modulate these adhesions in a spatially- and temporally-coordinated manner. Cell adhesion occurs in specialized sites, known as focal adhesions (FA), where transmembrane adhesion receptors (e.g. integrins) link the extracellular environment to the actin skeleton. The intracellular connection between integrins and microfilaments is regulated by a vast number of adaptor and signaling molecules, interconnected via a huge number of possible molecular interactions. It is apparent that these interactions do not all take place simultaneously and that they are tightly regulated. Our aim is to study molecular interactions in live cells to get a better understanding of how and through which pathways adhesion events in cells are regulated. To monitor such events we use FRET and FRAP analysis.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Areas of expertise

  • Q Science (General)
  • Cell Biology
  • Cell Signalling
  • Cell Adhesion
  • Microscopy
  • Extracellular Matrix
  • Podocytes
  • Neurons

Research Beacons, Institutes and Platforms

  • Cancer
  • Digital Futures
  • Christabel Pankhurst Institute

Keywords

  • Cell-Matrix Adhesion
  • Cell-Cell Adhesion
  • Extracellular Matrix
  • Integrins
  • Desmosomes
  • Cytoskeleton
  • Mechanotransduction
  • Matrix Sensing
  • Adhesion signalling
  • Fluorescence Microscopy

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