Personal profile
Biography
Chris Griffiths is Director of the Manchester Centre for Dermatology Research and Head of the Dermatology Theme of the National Institute for Health Research (NIHR) Manchester Biomedical Research Centre.
He gained a 1st Class Hons BSc in Anatomy from St Thomas’ Hospital Medical School, London in 1976 and qualified in Medicine MB BS in 1979. Following junior hospital posts in South London he trained in Dermatology at St Mary’s Hospital, London (1983-87) where he was a Wellcome Trust Clinical Research Training Fellow (1985-87). In 1987 he took up a research fellowship in Dermatology at the University of Michigan, USA, and was appointed to Assistant Professorship on Faculty 1989-93. He was appointed to the Foundation Chair in Dermatology at the University of Manchester in 1994 and is an Honorary Consultant Dermatologist at Salford Royal NHS Foundation Trust. He founded the Manchester Dermatopharmacology Unit and the Manchester Psoriasis Service in 1994. At the University of Manchester he has held several senior posts including Head of School of Translational Medicine, Faculty Research Dean and Director of the Manchester Academic Health Science Centre. He currently leads for precision medicine in the UK Government’s Greater Manchester Devolution initiative. Chris received a lifetime achievement award from the American Skin Association in 2009. In 2015 he received the Sir Archibald Gray Medal for outstanding service to British Dermatology and the Society of Cosmetic Scientists Medal and in 2018 was made a Pro Meritis laureate of the European Dermatology Forum. He is a NIHR Senior Investigator, Fellow of the Academy of Medical Sciences and an elected Member of Academia Europaea. Chris was appointed an Officer of the Order of the British Empire (OBE), for services to dermatology, in the Queen’s 2018 New Year’s Honours.
Professor Griffiths is past-President of the British Association of Dermatologists, European Dermatology Forum, British Society for Investigative Dermatology and International Psoriasis Council (which he co-founded in 2004). He is an Executive Board member of the International League of Dermatological Societies, Chair of the Scientific Programme Committee for the World Congress of Dermatology 2019 and Secretary/Treasurer of the European Society for Dermatological Research. Chris is Director of the UK Medical Research Council funded stratified medicine consortium on psoriasis (Psoriasis Stratification to Optimise Relevant Therapy; PSORT) and Chief Investigator of the British Association of Dermatologists Biologic Interventions Register (BADBIR). He has published 604 Pubmed cited articles in scientific journals (h-index 90), and is Editor-in-Chief of Rook’s Textbook of Dermatology. Chris has long-standing research interests in all aspects of psoriasis and skin ageing. He is credited with helping to develop the concept that psoriasis is an immune-mediated disease which has led to the development of targeted, life-transforming, biologic drugs for the disease. He was part of the team in Michigan that demonstrated that topical retinoids are efficacious in the management of ageing skin and has used this knowledge to found a spinout company “CGSkin”. Chris has a particular interest in the intersection of arts and medicine to which end he founded a visual literacy course for dermatology trainees in 2016.
Research Beacons, Institutes and Platforms
- Digital Futures
- Lydia Becker Institute
- Christabel Pankhurst Institute
- Manchester Institute for Collaborative Research on Ageing
Keywords
- psoriasis
- Ageing
- eczema
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 2 Zero Hunger
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 5 Gender Equality
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Collaborations and top research areas from the last five years
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Adalimumab Monotherapy vs Adalimumab With Methotrexate for Psoriasis
BADBIR Study Group, 4 Jun 2025, (E-pub ahead of print) In: JAMA dermatology. 161, 7, p. 731-738Research output: Contribution to journal › Article › peer-review
Open AccessFile6 Downloads (Pure) -
Age and biologic survival in patients with moderate-to-severe psoriasis: A cohort study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR)
BADBIR Study Group, Alabas, O. A., Mason, K. J., Yiu, Z. Z. N., Smith, C. H., Warren, R. B. & Griffiths, C. E. M., 12 Feb 2025, In: The British journal of dermatology. 10 p., ljaf017.Research output: Contribution to journal › Article › peer-review
Open Access -
Blood Single-Cell Transcriptomic and Proteomic Signatures of Paradoxical Eczema in Patients with Psoriasis Treated with Biologics
Al-Janabi, A., Martin, P., Simpson, C., Rhys, H., Khan, A. R., Eyre, S., Christofi, M., Foulkes, A. C., Skelton, A., Viatte, S., Barton, A., Morris, A. P., Smith, C. H., Griffiths, C. E. M. & Warren, R. B., 27 Mar 2025, (E-pub ahead of print) In: Journal of Investigative Dermatology.Research output: Contribution to journal › Article › peer-review
Open Access -
Circulating CD8 T cells from patients with mild-to-moderate psoriasis are functionally impaired
Chen, Y., Tontini, C., Tosi, I., Barker, J. N., Di Meglio, P., Griffiths, C. E. M., Bahri, R. & Bulfone-Paus, S., 5 May 2025, In: Frontiers in Immunology. 16, 1585378.Research output: Contribution to journal › Article › peer-review
Open Access -
Drug survival of IL-23 and IL-17 inhibitors versus other biologics for psoriasis: A British Association of Dermatologists Biologics and Immunomodulators Register cohort study
BADBIR Study Group, 29 May 2025, (E-pub ahead of print) In: Journal of the European Academy of Dermatology and Venereology : JEADV.Research output: Contribution to journal › Article › peer-review
Open Access
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NIHR Manchester Biomedical Research Centre
Bruce, I. (PI), Lord, G. (CoI), Lennon, R. (CoI), Black, G. (CoI), Wedge, D. (CoI), Morris, A. (CoI), Hussell, T. (CoI), Sharrocks, A. (CoI), Stivaros, S. (CoI), Buch, M. (CoI), Gough, J. (CoI), Kostarelos, K. (CoI), Thistlethwaite, F. (CoI), Kadler, K. (CoI), Barton, A. (CoI), Hyrich, K. (CoI), Mcbeth, J. (CoI), O'Neill, T. (CoI), Vestbo, J. (CoI), Simpson, A. (CoI), Singh, S. (CoI), Smith, J. (CoI), Felton, T. (CoI), Murray, C. (CoI), Griffiths, C. (CoI), Cullum, N. (CoI), Rhodes, L. (CoI), Warren, R. (CoI), Paus, R. (CoI), Dumville, J. (CoI), Viros Usandizaga, A. (CoI), Keavney, B. (CoI), Tomaszewski, M. (CoI), Allan, S. (CoI), Body, R. (CoI), Cartwright, E. (CoI), Heagerty, A. (CoI), Kalra, P. (CoI), Miller, C. (CoI), Rutter, M. (CoI), Smith, C. (CoI), Trafford, A. (CoI), Evans, D. (CoI), Davidson, E. (CoI), Crosbie, P. (CoI), Harvie, M. (CoI), Howell, S. (CoI), Renehan, A. (CoI), Dive, C. (CoI), Blackhall, F. (CoI), Landers, D. (CoI), Krebs, M. (CoI), Cook, N. (CoI), Clarke, R. (CoI), Taylor, S. (CoI), Jorgensen, C. (CoI), Lorigan, P. (CoI), Jayson, G. (CoI), Valle, J. (CoI), Mccabe, M. (CoI), Armstrong, A. (CoI), Freitas, A. (CoI), Illidge, T. (CoI), Choudhury, A. (CoI), Hoskin, P. (CoI), West, C. (CoI), Van Herk, M. (CoI), Faivre-Finn, C. (CoI), Bristow, R. (CoI), Kirkby, K. (CoI), Birtle, A. (CoI), Mackay, R. (CoI), Radford, J. (CoI), Linton, K. (CoI), Higham, C. (CoI), Munro, K. (CoI), Plack, C. (CoI), Arden Armitage, C. (CoI), Bruce, I. (CoI), Moore, D. (CoI), Saunders, G. (CoI), Stone, M. (CoI), Haddock, G. (CoI), Lewis, S. (CoI), Elliott, R. (CoI), Green, J. (CoI), Lovell, K. (CoI), Morrison, A. (CoI), Shaw, J. (CoI), Bucci, S. (CoI), Ainsworth, J. (CoI), Webb, R. (CoI), Newman, W. (CoI), Banka, S. (CoI), Clayton-Smith, J. (CoI), Payne, K. (CoI), Moldovan, R. (CoI), Wynn, R. (CoI) & Jones, S. (CoI)
1/12/22 → 30/11/27
Project: Research
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NIHR BioResource for Translational Research - Immune-Mediated Inflammatory Disease (IMID).
Bruce, I. (PI), Barton, A. (CoI), Griffiths, C. (CoI) & Mcbeth, J. (CoI)
1/04/19 → 30/11/22
Project: Research
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International Project on the Global Epidemiology of Psoriasis: Development of the Global Psoriasis Atlas.
Griffiths, C. (PI) & Ashcroft, D. (CoI)
1/04/17 → 31/03/21
Project: Research
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Manchester Molecular Pathology Innovation Centre (MMPathIC): Bridging the Gap Between Biomarker Discovery and Health and Wealth.
Freemont, A. (PI), Ananiadou, S. (CoI), Barton, A. (CoI), Black, G. (CoI), Bruce, I. (CoI), Buchan, I. (CoI), Byers, R. (CoI), Dive, C. (CoI), Goodacre, R. (CoI), Griffiths, C. (CoI), Hoyland, J. (CoI), Payne, K. (CoI), Radford, J. (CoI) & Whetton, A. (CoI)
1/10/15 → 31/03/21
Project: Research
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Risk and Predictors of Infections in Psoriasis Patients Exposed to Biologic Therapy: A Prospective Observational Cohort Study in the British Association of Dermatologists' Biologic Interventions Register (BADBIR).
Yiu, Z. (PI), Ashcroft, D. (CoI), Griffiths, C. (CoI) & Warren, R. (CoI)
1/10/15 → 30/09/18
Project: Research
Impacts
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Biologics registers for immune-mediated inflammatory diseases: enhancing access to novel therapies and balancing drug safety concerns versus effectiveness
Hyrich, K. (Participant), Bruce, I. (Participant), Griffiths, C. (Participant), Warren, R. (Participant), Symmons, D. (Participant), Ashcroft, D. (Participant), Dixon, W. (Participant), Lunt, M. (Participant), Yiu, Z. (Participant) & Mercer, L. (Participant)
Impact: Health and wellbeing
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Fibrillin-rich microfibrils and efficacy of anti-ageing cosmetics
Griffiths, C. (Participant), Watson, R. (Participant), Kielty, C. (Participant) & Shuttleworth, A. (Participant)
Impact: Health impacts
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The Manchester Patch Test Assay: providing a scientific test for the efficacy of anti-ageing products
Kielty, C. (Participant), Shuttleworth, A. (Participant), Griffiths, C. (Participant), Watson, R. (Participant) & Sherratt, M. (Participant)
Impact: Health impacts, Economic impacts
Datasets
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Tissue Microfibril Comparison
Eckersley, A. (Owner), Mellody, K. T. (Contributor), Pilkington, S. (Contributor), Griffiths, C. (Contributor), Watson, R. (Supervisor), O’Cualain, R. (Data Collector), Baldock, C. (Contributor), Knight, D. (Data Collector) & Sherratt, M. (Supervisor), ProteomeXchange, 16 Feb 2018
DOI: 10.6019/PXD008450, https://www.ebi.ac.uk/pride/archive/projects/PXD008450 and one more link, https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD008450 (show fewer)
Dataset
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Bimekizumab for patients with moderate-to-severe plaque psoriasis: 60-week results from BE ABLE 2, a randomized, double-blinded, placebo-controlled phase 2b extension study (supplemental materials)
Blauvelt, A. (Contributor), Papp, K. A. (Contributor), Merola, J. F. (Contributor), Gottlieb, A. B. (Contributor), Cross, N. (Contributor), Madden, C. (Contributor), Wang, M. (Contributor), Cioffi, C. (Contributor) & Griffiths, C. E. M. (Contributor), Mendeley Data, 8 Jun 2020
DOI: 10.17632/5ry2hmc2wm.1, https://data.mendeley.com/datasets/5ry2hmc2wm
Dataset
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Erratum: Skin and Nail Responses after 1 Year of Infliximab Therapy in Patients with Moderate-to-Severe Psoriasis: A Retrospective Analysis of the EXPRESS Trial
Reich, K. (Contributor), Ortonne, J. P. (Contributor), Kerkmann, U. (Contributor), Wang, Y. (Contributor), Saurat, J. H. (Contributor), Papp, K. (Contributor), Langley, R. G. (Contributor) & Griffiths, C. (Contributor), figshare , 25 Jul 2017
DOI: 10.6084/m9.figshare.5241232.v1, https://figshare.com/articles/Erratum_Skin_and_Nail_Responses_after_1_Year_of_Infliximab_Therapy_in_Patients_with_Moderate-to-Severe_Psoriasis_A_Retrospective_Analysis_of_the_EXPRESS_Trial/5241232/1 and one more link, https://ndownloader.figshare.com/files/8955829 (show fewer)
Dataset
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Supplemental tables: Risk of serious infection and infection mortality in patients with psoriasis: a nationwide cohort study using the Taiwan National Health Insurance claims database
Chen, T.-C. (Creator), Wang , T.-C. (Contributor), Yiu, Z. (Contributor), Lee, M.-S. (Contributor), Chen, L.-C. (Contributor), Chan, K. A. (Contributor), Griffiths, C. (Contributor) & Ashcroft, D. (Contributor), Mendeley Data, 6 Dec 2022
DOI: 10.17632/y33j4dpyyc.1, https://data.mendeley.com/datasets/y33j4dpyyc
Dataset
Press/Media
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The Skin Diary's Night Therapy Repair cream featured in the Times Magazine best luxury buys
25/01/25
1 item of Media coverage
Press/Media: Research
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The Skin Diary's Night Therapy Repair cream featured on ITV's This Morning programme
9/01/25
1 item of Media coverage
Press/Media: Research
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The Skin Diary acquires CGSkin in mission to shake up skincare space
25/09/24 → 27/09/24
2 items of Media coverage
Press/Media: Research
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BBC NEWS ONLINE: University of Manchester creates global psoriasis database
5/11/19
1 item of Media coverage
Press/Media: Research
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THE TIMES: She knows why you really have that spot
7/02/19
1 Media contribution
Press/Media: Expert comment