Research output per year
Research output per year
Personal profile
Overview
The NLRP3 inflammasome drives inflammatory responses and contributes to numerous diseases. My research is addressing the cellular mechanisms of NLRP3 regulation, aiming to promote the therapeutic targeting of NLRP3.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Bachelor of Science, Neuroscience with Industrial Experience, The University of Manchester
2012 → 2016
Award Date: 12 Jul 2016
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Research output
- 8 Article
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Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Lee, B., Hoyle, C., Wellens, R., Green, J. P., Martin-Sanchez, F., Williams, D. M., Matchett, B. J., Seoane, P. I., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M. & Brough, D., 21 Feb 2023, In: Science Signaling. 16, 773Research output: Contribution to journal › Article › peer-review
Open AccessFile60 Downloads (Pure) -
Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages
Hoyle, C., Green, J., Allan, S. & Brough, D., 1 Apr 2022, In: Immunology. 165, 4Research output: Contribution to journal › Article › peer-review
Open Access -
NLRP3 activation in response to disrupted endocytic traffic
Lee, B., Hoyle, C., Green, J., Wellens, R., Martín-Sánchez, F., Williams, D., Seoane Denicola, P., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M. & Brough, D., 16 Sep 2021, In: bioRxiv.Research output: Contribution to journal › Article
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Hallmarks of NLRP3 inflammasome activation are observed in organotypic hippocampal slice culture
Hoyle, C., Redondo Castro, E., Cook, J., Tzeng, T-C., Allan, S., Brough, D. & Lemarchand, E., 23 May 2020, In: Immunology. 161, 1, p. 39-52Research output: Contribution to journal › Article › peer-review
Open Access -
The NLRP3 inflammasome as a sensor of organelle dysfunction
Seoane Denicola, P., Lee, B., Hoyle, C., Yu Shi, A., Lopez-Castejon, G., Lowe, M. & Brough, D., 18 Sep 2020, (Accepted/In press) In: Journal of Cell Biology.Research output: Contribution to journal › Article › peer-review
Press/Media
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Finding new ways to investigate inflammation in the brain
29/06/20
1 Media contribution
Press/Media: Blogs and social media
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Interviews with Scientists: Chris Hoyle
26/11/18
1 Media contribution
Press/Media: Blogs and social media
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Thesis
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Understanding mechanisms of NLRP3 inflammasome regulation
Author: Hoyle, C., 1 Aug 2020Supervisor: Allan, S. (Supervisor), Brough, D. (Supervisor) & Kostarelos, K. (Supervisor)
Student thesis: Phd
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