Research output per year
Research output per year
Personal profile
Overview
The NLRP3 inflammasome drives inflammatory responses and contributes to numerous diseases. My research is addressing the cellular mechanisms of NLRP3 regulation, aiming to promote the therapeutic targeting of NLRP3.
Education/Academic qualification
Bachelor of Science, Neuroscience with Industrial Experience, The University of Manchester
2012 → 2016
Award Date: 12 Jul 2016
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Collaborations and top research areas from the last five years
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Research output
- 12 Article
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Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome
Mcmahon, E., El Sayed, S., Green, J., Hoyle, C., Fitzpatrick, L., Jones, E., Corrie, E., Kelly, R., Challinor, M., Freeman, S., Bryce, R., Lawrence, C. B., Brough, D. & Kasher, P., 1 Feb 2024, In: iScience. 27, 2, 108968.Research output: Contribution to journal › Article
Open Access -
C9orf72 dipeptides activate the NLRP3 inflammasome
Rivers-Auty, J., Hoyle, C., Pointer, A., Lawrence, C., Pickering-Brown, S., Brough, D. & Ryan, S., 20 Aug 2024, In: Brain Communications. fcae282.Research output: Contribution to journal › Article › peer-review
Open Access -
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions
Wellens, R., Tapia , V., Seoane Denicola, P., Bennett, H., Adamson, A., Coutts, G., Rivers-Auty, J., Lowe, M., Green, J., Lopez-Castejon, G., Brough, D. & Hoyle, C., 8 Aug 2024, In: Nature Communications. 15, 6750.Research output: Contribution to journal › Article › peer-review
Open Access -
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Lee, B., Hoyle, C., Wellens, R., Green, J. P., Martin-Sanchez, F., Williams, D. M., Matchett, B. J., Seoane, P. I., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M. & Brough, D., 21 Feb 2023, In: Science Signaling. 16, 773Research output: Contribution to journal › Article › peer-review
Open AccessFile319 Downloads (Pure) -
The comparable tumour microenvironment in sporadic and NF2-related schwannomatosis vestibular schwannoma
Gregory, G., Jones, A. P., Haley, M., Hoyle, C., Zeef, L., Lin, I.-H., Coope, D., King, A., Evans, D. G., Paszek, P., Couper, K., Brough, D. & Pathmanaban, O., 21 Jul 2023, In: Brain Communications. 5, 4, 64 p., fcad197.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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Finding new ways to investigate inflammation in the brain
29/06/20
1 Media contribution
Press/Media: Blogs and social media
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Interviews with Scientists: Chris Hoyle
26/11/18
1 Media contribution
Press/Media: Blogs and social media
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Thesis
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Understanding mechanisms of NLRP3 inflammasome regulation
Hoyle, C. (Author), Allan, S. (Supervisor), Brough, D. (Supervisor) & Kostarelos, K. (Supervisor), 1 Aug 2020Student thesis: Phd
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