Research output per year
Research output per year
Personal profile
Overview
The NLRP3 inflammasome drives inflammatory responses and contributes to numerous diseases. My research is addressing the cellular mechanisms of NLRP3 regulation, aiming to promote the therapeutic targeting of NLRP3.
Education/Academic qualification
Bachelor of Science, Neuroscience with Industrial Experience, The University of Manchester
2012 → 2016
Award Date: 12 Jul 2016
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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Dive into the research topics where Christopher Hoyle is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Research output
- 13 Article
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Inflammatory responses following CRISPR modification of the nuclear localisation sequence in endogenous interleukin-1alpha
Hoyle, C., Diaz Pino, R., Lai, S. M., Green, J., Adamson, A., Coutts, G., Lawrence, C., Travis, M., Brough, D. & Lopez-Castejon, G., 4 Mar 2026, In: DMM Disease Models and Mechanisms.Research output: Contribution to journal › Article › peer-review
Open Access -
The role of 25-hydroxycholesterol in the pathophysiology of brain vessel dysfunction associated with infection and cholesterol dysregulation
Tapia, V. S., Withers, S. E., Zhou, R., Bennington, A., Hoyle, C., Hedley, F., Khouja, A. E., Luka, N., Massimo, M., Crilly, S., Long, K. R., Lawrence, C. B. & Kasher, P. R., 1 Sept 2025, In: Disease Models & Mechanisms. 18, 9Research output: Contribution to journal › Article › peer-review
Open Access -
Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome
Mcmahon, E., El Sayed, S., Green, J., Hoyle, C., Fitzpatrick, L., Jones, E., Corrie, E., Kelly, R., Challinor, M., Freeman, S., Bryce, R., Lawrence, C. B., Brough, D. & Kasher, P., 16 Feb 2024, In: iScience. 27, 2, 108968.Research output: Contribution to journal › Article
Open Access -
C9orf72 dipeptides activate the NLRP3 inflammasome
Rivers-Auty, J., Hoyle, C., Pointer, A., Lawrence, C., Pickering-Brown, S., Brough, D. & Ryan, S., 20 Aug 2024, In: Brain Communications. fcae282.Research output: Contribution to journal › Article › peer-review
Open Access -
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions
Wellens, R., Tapia , V., Seoane Denicola, P., Bennett, H., Adamson, A., Coutts, G., Rivers-Auty, J., Lowe, M., Green, J., Lopez-Castejon, G., Brough, D. & Hoyle, C., 8 Aug 2024, In: Nature Communications. 15, 6750.Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
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Finding new ways to investigate inflammation in the brain
29/06/20
1 Media contribution
Press/Media: Blogs and social media
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Interviews with Scientists: Chris Hoyle
26/11/18
1 Media contribution
Press/Media: Blogs and social media
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Thesis
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Understanding mechanisms of NLRP3 inflammasome regulation
Hoyle, C. (Author), Brough, D. (Main Supervisor), Kostarelos, K. (Co Supervisor) & Allan, S. (Co Supervisor), 15 May 2020Student thesis: Phd
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