Research output per year
Research output per year
Personal profile
Overview
The NLRP3 inflammasome drives inflammatory responses and contributes to numerous diseases. My research is addressing the cellular mechanisms of NLRP3 regulation, aiming to promote the therapeutic targeting of NLRP3.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Bachelor of Science, Neuroscience with Industrial Experience, The University of Manchester
2012 → 2016
Award Date: 12 Jul 2016
Fingerprint
Dive into the research topics where Christopher Hoyle is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
- 11 Article
-
Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome
Mcmahon, E., El Sayed, S., Green, J., Hoyle, C., Fitzpatrick, L., Jones, E., Corrie, E., Kelly, R., Challinor, M., Freeman, S., Bryce, R., Lawrence, C. B., Brough, D. & Kasher, P., 30 Oct 2023, In: bioRxiv.Research output: Contribution to journal › Article
-
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
Lee, B., Hoyle, C., Wellens, R., Green, J. P., Martin-Sanchez, F., Williams, D. M., Matchett, B. J., Seoane, P. I., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M. & Brough, D., 21 Feb 2023, In: Science Signaling. 16, 773Research output: Contribution to journal › Article › peer-review
Open AccessFile142 Downloads (Pure) -
The comparable tumour microenvironment in sporadic and NF2-related schwannomatosis vestibular schwannoma.
Gregory, G. E., Jones, A. P., Haley, M. J., Hoyle, C., Zeef, L. A. H., Lin, I-H., Coope, D. J., King, A. T., Evans, D. G., Paszek, P., Couper, K. N., Brough, D. & Pathmanaban, O. N., 2023, In: Brain Communications. 5, 4, p. fcad197Research output: Contribution to journal › Article › peer-review
-
The comparable tumour microenvironment in sporadic and NF2-schwannomatosis vestibular schwannoma
Gregory, G., Jones, A. P., Haley, M., Hoyle, C., Zeef, L., Lin, I-H., Coope, D., King, A., Evans, D. G., Paszek, P., Couper, K., Brough, D. & Pathmanaban, O., 13 Jun 2023, (Accepted/In press) In: Brain Communications. 64 p.Research output: Contribution to journal › Article › peer-review
-
Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages
Hoyle, C., Green, J., Allan, S. & Brough, D., 1 Apr 2022, In: Immunology. 165, 4Research output: Contribution to journal › Article › peer-review
Open Access
Press/Media
-
Finding new ways to investigate inflammation in the brain
29/06/20
1 Media contribution
Press/Media: Blogs and social media
-
Interviews with Scientists: Chris Hoyle
26/11/18
1 Media contribution
Press/Media: Blogs and social media
-
Thesis
-
Understanding mechanisms of NLRP3 inflammasome regulation
Author: Hoyle, C., 1 Aug 2020Supervisor: Allan, S. (Supervisor), Brough, D. (Supervisor) & Kostarelos, K. (Supervisor)
Student thesis: Phd
File