Research output per year
Research output per year
Personal profile
Memberships of committees and professional bodies
Registered Scientist (MIScT RSci) - Institute of Science and Technology
Fellow of Royal Astronomical Society (FRAS)
Member of European Astronomical Society
Member of British Astronomical Association
Biography
In my current position I am a Senior Scientific Officer (main technical lead) in the research arm of the translationally orientated Genito Urinary Cancer Research group led by Professor Noel Clarke and Dr Mick Brown. The main research focus of the group is on prostate cancer, in particular the mechanisms of prostate cancer metastasis to the bone; the role of lipids in prostate cancer progression; the development / study of novel agents and molecular markers in prostate cancer. A secondary research aim of the group, through the use of tissue banking and Tissue MicroArrays (TMA) is to study novel markers/pathways and the stem like phenotype of tumour initiating cells in other urological cancers (Kidney, Bladder, Testes).
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Master of Philosophy, A study of the enzymes involved in the invasion of bone marrow stroma by prostatic epithelial cells, The University of Manchester
1 Oct 1998 → 31 Jul 2000
Award Date: 1 Sept 2000
Bachelor of Science, Biology, The University of Manchester
20 Sept 1991 → 26 Jun 1994
Award Date: 31 Jul 1994
Research Beacons, Institutes and Platforms
- Cancer
Keywords
- Prostate Cancer
- Biomarker Research
- Cell Biology
- Imaging
- TMA
- Urological Cancer
- Tissue Culture
- Immunohistochemistry
- Immunofluorescence
- Metastasis
- Human Bone Marrow
- Haemopoiesis
- Invasion
- Lipids
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue
Sachdeva, A., Hart, C. A., Carey, C. D., Vincent, A. E., Greaves, L. C., Heer, R., Oliveira, P., Brown, M. D., Clarke, N. W. & Turnbull, D. M., 22 Apr 2022, In: Scientific Reports. 12, 1, 6660.Research output: Contribution to journal › Article › peer-review
Open Access -
IRF7 impacts on prostate cancer cell survival in response to radiation
Pickard, A., Amoroso, F., McCulloch, K., Erickson, A., Sachdeva, A., Steele, R., Mukherjee, D., Dellett, M., McComb, J., McCaffery, L., Hart, C. A., Brown, M. D., McDade, S., Waugh, D., Clarke, N., Butterworth, K., Illidge, T., Mirtti, T., Overton, I. M. & Mills, I. G., 23 Sept 2022, In: bioRxiv.Research output: Contribution to journal › Article
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Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer
Sachdeva, A., Hart, C. A., Kim, K., Tawadros, T., Oliveira, P., Shanks, J., Brown, M. & Clarke, N., 22 Jul 2022, In: British Journal of Cancer.Research output: Contribution to journal › Article › peer-review
Open Access -
Acceleration of Coronal Mass Ejection Plasma in the Low Corona as Measured by the Citizen CATE Experiment
Hart, C. A., Jan 2020, In: Publications of the Astronomical Society of the Pacific. 132:014201, 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In: Nature Communications. 10, 1, p. 5016 15 p.Research output: Contribution to journal › Article › peer-review
Open Access