Clare Megarity

2024

Biocatalytic pathways, cascades, cells and systems: general discussion

Abramiuk, M., Acevedo-Rocha, C., Alogaidi, A., Armstrong, F., Bakshi, A., Bornscheuer, U., Campopiano, D. J., Chaiyen, P., Ehinger, F. J., Flitsch, S., Harvey, J. N., Hilvert, D., Jarvis, A., Jones, R. E. H., Jones, R. E. H., Luk, L. Y. P., Lurshay, T. C., Malcomson, T., Marsh, E. N. G. & McFarlane, N. R. & 13 others, McKenzie, A., Megarity, C. F., Moliner, V., Mulholland, A. J., Orton, B., Pelletier, J., Raczyńska, A., Syrén, P.-O., Thompson, S. A., Turner, N., Valetti, F., Wong, L. S. & Zeymer, C., 22 Aug 2024, In: Faraday Discussions. 252, p. 241-261 21 p.

Research output: Contribution to journal › Commentary/debate › peer-review

Cofactor regeneration

Armstrong, F. A. (Inventor), Megarity, C. (Inventor) & Morello, G. (Inventor), 11 Jan 2024, IPC No. G01N 33/573 2006.1, C12Q 1/00 2006.1, C12Q 1/26 2006.1, C12Q 1/48 2006.1, C12Q 1/32 2006.1, World Intellectual Property Organization, Patent No. PCT/GB2023/051749 , 4 Jul 2023, Priority date 4 Jul 2022, Priority No. 2209773.7

Research output: Patent

Electrochemically-driven enzyme cascades: Recent developments in design, control, and modelling

Siritanaratkul, B. & Megarity, C. F., Oct 2024, In: Current Opinion in Electrochemistry. 47

Research output: Contribution to journal › Article › peer-review

Interactive biocatalysis achieved by driving enzyme cascades inside a porous conducting material

Siritanaratkul, B., Megarity, C. F., Herold, R. A. & Armstrong, F. A., 10 Jun 2024, In: Communications Chemistry. 7, 1, 132.

Research output: Contribution to journal › Article › peer-review

Open Access

Retuning the potential of the electrochemical leaf

Dolińska, M. M., Kirwan, A. J. & Megarity, C. F., 7 Jun 2024, (E-pub ahead of print) In: Faraday Discussions.

Research output: Contribution to journal › Article › peer-review

Open Access

Voices: Introducing: Ulrich J. Lorenz, Radoslav I. Enchev, Clare F. Megarity, Helen Ginn, Patrick Rabe, Alice R. Walker, and Kartik Ayyer

Megarity, C., 2 May 2024, In: Structure.

Research output: Contribution to journal › Article › peer-review

2023

Electrodes

Armstrong, F. A. (Inventor), Megarity, C. (Inventor), Roberts, T. (Inventor) & Siritanaratkul, B. (Inventor), 4 Jun 2023, IPC No. C12Q 1/00 2006.1, World Intellectual Property Organization, Patent No. 11694852, 20 Mar 2017, Priority date 20 Mar 2016, Priority No. 1604671.6

Research output: Patent

From Protein Film Electrochemistry to Nanoconfined Enzyme Cascades and the Electrochemical Leaf

Armstrong, F. A., Cheng, B., Herold, R. A., Megarity, C. F. & Siritanaratkul, B., 10 May 2023, In: Chemical Reviews.

Research output: Contribution to journal › Article › peer-review

2022

A Nanoconfined Four-Enzyme Cascade Simultaneously Driven by Electrical and Chemical Energy, with Built-in Rapid, Confocal Recycling of NADP(H) and ATP

Megarity, C. F., Weald, T. R. I., Heath, R. S., Turner, N. J. & Armstrong, F. A., 5 Aug 2022, In: ACS Catalysis. 12, 15, p. 8811–8821

Research output: Contribution to journal › Article › peer-review

Open Access

Deracemisation and stereoinversion by a nanoconfined bidirectional enzyme cascade: dual control by electrochemistry and selective metal ion activation

Cheng, B., Heath, R. S., Turner, N. J., Armstrong, F. A. & Megarity, C. F., 2022, In: Chemical Communications.

Research output: Contribution to journal › Article › peer-review

2021

Exploiting Bidirectional Electrocatalysis by a Nanoconfined Enzyme Cascade to Drive and Control Enantioselective Reactions

Wan, L., Heath, R. S., Megarity, C. F., Sills, A. J., Herold, R. A., Turner, N. J. & Armstrong, F. A., 4 Jun 2021, In: ACS Catalysis. 11, 11, p. 6526-6533 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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49 Downloads (Pure)

Exploiting Electrode Nanoconfinement to Investigate the Catalytic Properties of Isocitrate Dehydrogenase (IDH1) and a Cancer-Associated Variant

Herold, R. A., Reinbold, R., Megarity, C. F., Abboud, M. I., Schofield, C. J. & Armstrong, F. A., 8 Jul 2021, In: Journal of Physical Chemistry Letters. 12, p. 6095-6101 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The power of electrified nanoconfinement for energising, controlling and observing long enzyme cascades

Morello, G., Megarity, C. F. & Armstrong, F. A., 1 Dec 2021, In: Nature Communications. 12, p. 340

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Electron flow between the worlds of Marcus and Warburg

Megarity, C. F., Siritanaratkul, B., Herold, R. A., Morello, G. & Armstrong, F. A., 14 Dec 2020, In: The Journal of chemical physics. 153, 22, p. 1-13 13 p., 225101.

Research output: Contribution to journal › Article › peer-review

Nanotechnology for catalysis and solar energy conversion

Banin, U., Waiskopf, N., Hammarström, L., Boschloo, G., Freitag, M., Johansson, E. M. J., Sá, J., Tian, H., Johnston, M. B., Herz, L. M., Milot, R. L., Kanatzidis, M. G., Ke, W., Spanopoulos, I., Kohlstedt, K. L., Schatz, G. C., Lewis, N., Meyer, T., Nozik, A. J. & Beard, M. C. & 5 others, Armstrong, F., Megarity, C. F., Schmuttenmaer, C. A., Batista, V. S. & Brudvig, G. W., 5 Nov 2020, In: Nanotechnology. 32, 4, 042003.

Research output: Contribution to journal › Review article › peer-review

Open Access

2019

Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity

Megarity, C. F. & Timson, D. J., 6 Sept 2019, In: Bioscience reports. 39, 9, 10 p., BSR20191874.

Research output: Contribution to journal › Article › peer-review

Efficient Electrocatalytic CO₂ Fixation by Nanoconfined Enzymes via a C3-to-C4 Reaction That Is Favored over H₂ Production

Morello, G., Siritanaratkul, B., Megarity, C. F. & Armstrong, F. A., 11 Nov 2019, In: ACS Catalysis. 9, 12, p. 11255-11262 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Electrified Nanoconfined Biocatalysis with Rapid Cofactor Recycling

Megarity, C. F., Siritanaratkul, B., Cheng, B., Morello, G., Wan, L., Sills, A. J., Heath, R. S., Turner, N. J. & Armstrong, F. A., 5 Dec 2019, In: ChemCatChem. 11, 23, p. 5662-5670 9 p.

Research output: Contribution to journal › Article › peer-review

Electrocatalytic Volleyball: Rapid Nanoconfined Nicotinamide Cycling for Organic Synthesis in Electrode Pores

Megarity, C. F., Siritanaratkul, B., Heath, R. S., Wan, L., Morello, G., FitzPatrick, S. R., Booth, R. L., Sills, A. J., Robertson, A. W., Warner, J. H., Turner, N. J. & Armstrong, F. A., 1 Apr 2019, In: Angewandte Chemie. 131, 15, p. 5002-5006 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineering enzyme catalysis: an inverse approach

Megarity, C., 12 Feb 2019, In: Bioscience reports. 39, 2, 4 p., BSR20181107.

Research output: Contribution to journal › Article › peer-review

Enzyme-catalysed enantioselective oxidation of alcohols by air exploiting fast electrochemical nicotinamide cycling in electrode nanopores

Wan, L., Heath, R. S., Siritanaratkul, B., Megarity, C. F., Sills, A. J., Thompson, M. P., Turner, N. J. & Armstrong, F. A., 30 Aug 2019, In: Green Chemistry. 21, 18, p. 4958–4963 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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68 Downloads (Pure)

Escherichia coli Modulator of Drug Activity B (MdaB) Has Different Enzymological Properties to Eukaryote Quinone Oxidoreductases

Megarity, C. F. & Timson, D. J., Aug 2019, In: Helvetica Chimica Acta. 102, 8, p. 1-9 9 p., e1900135.

Research output: Contribution to journal › Article › peer-review

NAD(P)H quinone oxidoreductase (NQO1): An enzyme which needs just enough mobility, in just the right places

Pey, A. L., Megarity, C. F. & Timson, D. J., 3 Jan 2019, In: Bioscience reports. 39, 1

Research output: Contribution to journal › Review article › peer-review

Open Access

Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1)

Megarity, C. F., Abdel-Aal Bettley, H., Caraher, M. C., Scott, K. A., Whitehead, R. C., Jowitt, T. A., Gutierrez, A., Bryce, R. A., Nolan, K. A., Stratford, I. J. & Timson, D. J., 18 Nov 2019, In: CHEMBIOCHEM. 20, 22, p. 2841-2849 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

115 Downloads (Pure)

The final steps of [FeFe]-hydrogenase maturation

Lampret, O., Esselborn, J., Haas, R., Rutz, A., Booth, R. L., Kertess, L., Wittkamp, F., Megarity, C. F., Armstrong, F. A., Winkler, M. & Happe, T., 6 Aug 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 32, p. 15802-15810 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The value of enzymes in solar fuels research – efficient electrocatalysts through evolution

Evans, R. M., Siritanaratkul, B., Megarity, C. F., Pandey, K., Esterle, T. F., Badiani, S. & Armstrong, F. A., 7 Apr 2019, In: Chemical Society Reviews. 48, 7, p. 2039-2052 14 p.

Research output: Contribution to journal › Article › peer-review

2018

A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring

Wan, L., Megarity, C., Siritanaratkul, B. & Armstrong, F., 2018, In: Chem. Commun.. 54, 8, p. 972-975 4 p.

Research output: Contribution to journal › Article › peer-review

Assessment of Electrochemically-based Strategies to Protect [FeFe]-hydrogenases from Oxygen

Rogers, E., Megarity, C. F., Esselborn, J., Winkler, M., Happe, T. & Armstrong, F. A., 27 Mar 2018, Microalgal Hydrogen Production: Achievements and Perspectives. Cambridge: Royal Society of Chemistry, p. 139-154 15 p. (Comprehensive Series in Photochemical & Photobiological Sciences).

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Protein Film Electrochemistry of Iron–Sulfur Enzymes

Armstrong, F., Evans, R. & Megarity, C., 20 Jan 2018, Methods in Methods in Enzymology: Fe-S Cluster Enzymes Part B. David, S. S. (ed.). First ed. Cambridge, MA, Vol. 599. p. 387-407 21 p. (Methods in Enzymology; vol. 599).

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

2017

Transfer of photosynthetic NADP+/NADPH recycling activity to a porous metal oxide for highly specific, electrochemically-driven organic synthesis

Siritanaratkul, B., Megarity, C., Roberts, T. G., Samuels, T. O. M., Winkler, M., Warner, J. H., Happe, T. & Armstrong, F. A., 5 May 2017, In: Chemical Science. 8, 6, p. 4579-4586 8 p.

Research output: Contribution to journal › Article › peer-review

2016

Electrochemical Investigations of the Mechanism of Assembly of the Active-Site H-Cluster of [FeFe]-Hydrogenases

Megarity, C., Esselborn, J., Hexter, S., Wittkamp, F., Apfel, U.-P., Happe, T. & Armstrong, F., 24 Oct 2016, In: Journal of the American Chemical Society. 138, 46, p. 15227-15233 7 p.

Research output: Contribution to journal › Article › peer-review

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms.

Pey, A. L., Megarity, C., Medina-Carmona, E. & Timson, D. J., Oct 2016, In: Current Drug Targets. 17, 13, p. 1506-1514 9 p.

Research output: Contribution to journal › Article › peer-review

2014

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1

Megarity, C., Pey, A. & Timson, D., 29 Aug 2014, In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1842, 11, p. 2163-2173 11 p.

Research output: Contribution to journal › Article › peer-review

The Saccharomyces cerevisiae quinone oxidoreductase Lot6p: Stability, inhibition and cooperativity

Megarity, C. F., Looi, H. K. & Timson, D. J., Aug 2014, In: FEMS Yeast Research. 14, 5, p. 797-807 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

Megarity, C. F., Gill, J. R. E., Clare Caraher, M., Stratford, I. J., Nolan, K. A. & Timson, D. J., 2 May 2014, In: FEBS Letters. 588, 9, p. 1666-1672 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2011

The role of the active site residues in human galactokinase: Implications for the mechanisms of GHMP kinases

Megarity, C., Huang, M., Warnock, C. & Timson, D., Jun 2011, In: Bioorganic Chemistry. 39, 3, p. 120-126 7 p.

Research output: Contribution to journal › Article › peer-review

Clare Megarity

Research output

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