If you made any changes in Pure these will be visible here soon.

Personal profile


Understanding the mechanisms of microbial ecology and evolution

I want to understand how complex behaviour of populations is determined by interactions between individuals. My research combines various experimental and modelling approaches to investigate how mobile genetic elements, like plasmids and bacteriophages, spread through a bacterial population. By first learning about the interaction mechanisms between mobile genetic elements and bacterial cells, I aim to improve our ability to predict long-term population behaviour.

The current focus of my work lies on the intracellular interactions between phages and their bacterial host cells. Phages rely on bacterial functions to produce proteins and to replicate themselves. Particularly, most phages need to produce lysis proteins to break open bacterial cells and release new phages. I am exploring how lysis efficiency is affected by genetic and environmental factors. Understanding phage lysis of bacterial cells is not only important for predicting bacteria-phage ecology and evolution but is also crucial for using phages as therapeutics against antibiotic-resistant bacteria.


I come from a theoretical background in Mathematics (BSc) and Biomedical Engineering (MSc) but I felt that true understanding of any system requires a combination of mathematical analysis and experimental verification. Therefore, I did an empirically driven PhD on the evolution of gene regulation in microbes at IST Austria with Calin Guet and Jon Bollback. During my postdoc at ETH Zurich with Roland Regoes and Sebastian Bonhoeffer, I combined experimental and mathematical approaches to investigate bacterial resistance evolution and the spread of mobile genetic elements. I am currently a Wellcome Trust ECA Fellow at the University of Manchester, deepening my work on the interactions and dynamics of mobile genetic elements with their bacterial hosts.   


If you are curious about the lives of bacteria or viruses and want to work in an interdisciplinary environment, please contact me under claudia.igler@manchester.ac.uk . I am happy to explore possibilities for doing an internship, a thesis project, a PhD or a Postdoc with me.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Doctor of Philosophy, The biophysics of transcription factor binding, IST Austria

1 Sept 20139 May 2019

Award Date: 9 May 2019

Master of Science, Biomedical Engineering, Vienna University of Technology

1 Sept 201012 Mar 2013

Award Date: 12 Mar 2013

Bachelor of Science, Mathematics in Science and Technology, Vienna University of Technology

1 Sept 200731 Aug 2010

Award Date: 31 Aug 2010

Areas of expertise

  • QH301 Biology
  • gene regulation
  • infectious disease dynamics
  • mobile genetic elements
  • resistance
  • microbiology
  • phages


Dive into the research topics where Claudia Igler is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or