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Costas Demonacos

Dr, BPharm

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Personal profile


Costas graduated as pharmacist in 1983, from Aristotle University of Thessaloniki, School of  Pharmacy.
He was awarded PhD in 1994, in Molecular Biology and Biochemistry from the National and Kapodistrian University of Athens, School of Biology.
He has acquired experience in a wide spectrum of pharmaceutical sciences working as a community and hospital pharmacist as well as quality control scientist in the pharmaceutical industry.

Research interests

Exploiting endoplasmic reticulum stress and unfolded protein response signaling in the immunotherapy of cancer, neurodegenerative and autoimmune diseases 

The role of reactive oxygen species in cancer cells' evasion of immunosurveillance

Mechanisms of cell cycle regulation.

Novel biological networks involving transcriptional co-factors in the regulation of cell cycle and apoptosis.

Regulatory mechanisms controlling the malignant transformation through nuclear and mitochondrial inter-genomic signalling pathways.

My collaborations

  • Professor Pa-thai Yenchitsomanus, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok Thailand
  • Professor Thawornchai Limjindaporn, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok Thailand
  • Dr Sasiprapa Kunchai, Naresuan University, Phitsanulok, Thailand
  • Professor Masayuki Fujii, Kindai University, Japan
  • Professor Hitoshi Okada, Kindai University, Japan
  • Dr Keiko Kawauchi, Konan University, Japan
  • Professor Emiko Isogai, Tohoku University, Japan
  • Professor Marija Krstic-Demonacos, University of Salford, Manchester, UK


Pharmaceutical Immunology

Cancer Biology and Therapy

Development of research skills

Physiology & Pharmacology (cardiovascular & respiratory systems) (Practical lecturer)

Memberships of committees and professional bodies

The European Association for Cancer Research

The Royal Society of Medicine 

New York Academy of Sciences   

Society for Endocrinology

The Biochemical Society

Marie Curie Fellows Association

Hellenic Biochemical Biophysical Society

Hellenic Association of Pharmaceutical Chemistry

Academic Pharmacy Group, Royal Pharmaceutical Society of Great Britain 

Methodological knowledge

Molecular Biology (regulation of gene expression)
Biochemistry (protein-protein interaction)
Molecular Pharmacology (dissection of signaling pathways with therapeutic targeting potential)


B.Sc Pharmacy, Aristotle University of Thessaloniki, Greece
PhD Molecular Biology & Biochemistry, National and Kapodistrian University of Athens, Greece

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 7 - Affordable and Clean Energy

Areas of expertise

  • RM Therapeutics. Pharmacology
  • Molecular Pharmacology
  • Q Science (General)
  • Molecular Biology
  • Cell Signalling
  • Cell Death
  • Tumour Immunology
  • Oxidative Stress

Research Beacons, Institutes and Platforms

  • Digital Futures
  • Institute for Data Science and AI


  • Transcription
  • DNA damage
  • Cellular Energy Metabolism
  • Reactive oxygen species
  • Immunotherapy


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Collaborations and top research areas from the last five years

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