Research output per year
Research output per year
Personal profile
Biography
Costas graduated as pharmacist in 1983, from Aristotle University of Thessaloniki, School of Pharmacy.
He was awarded PhD in 1994, in Molecular Biology and Biochemistry from the National and Kapodistrian University of Athens, School of Biology.
He has acquired experience in a wide spectrum of pharmaceutical sciences working as a community and hospital pharmacist as well as quality control scientist in the pharmaceutical industry.
Research interests
Exploiting endoplasmic reticulum stress and unfolded protein response signaling in the immunotherapy of cancer, neurodegenerative and autoimmune diseases
The role of reactive oxygen species in cancer cells' evasion of immunosurveillance
Mechanisms of cell cycle regulation.
Novel biological networks involving transcriptional co-factors in the regulation of cell cycle and apoptosis.
Regulatory mechanisms controlling the malignant transformation through nuclear and mitochondrial inter-genomic signalling pathways.
My collaborations
- Professor Pa-thai Yenchitsomanus, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok Thailand
- Professor Thawornchai Limjindaporn, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok Thailand
- Dr Sasiprapa Kunchai, Naresuan University, Phitsanulok, Thailand
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Professor Masayuki Fujii, Kindai University, Japan
- Professor Hitoshi Okada, Kindai University, Japan
- Dr Keiko Kawauchi, Konan University, Japan
- Professor Emiko Isogai, Tohoku University, Japan
- Professor Marija Krstic-Demonacos, University of Salford, Manchester, UK
Teaching
Pharmaceutical Immunology
Cancer Biology and Therapy
Development of research skills
Physiology & Pharmacology (cardiovascular & respiratory systems) (Practical lecturer)
Memberships of committees and professional bodies
The European Association for Cancer Research
The Royal Society of Medicine
New York Academy of Sciences
Society for Endocrinology
The Biochemical Society
Marie Curie Fellows Association
Hellenic Biochemical Biophysical Society
Hellenic Association of Pharmaceutical Chemistry
Academic Pharmacy Group, Royal Pharmaceutical Society of Great Britain
Methodological knowledge
Molecular Biology (regulation of gene expression)
Biochemistry (protein-protein interaction)
Molecular Pharmacology (dissection of signaling pathways with therapeutic targeting potential)
Qualifications
B.Sc Pharmacy, Aristotle University of Thessaloniki, Greece
PhD Molecular Biology & Biochemistry, National and Kapodistrian University of Athens, Greece
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Areas of expertise
- RM Therapeutics. Pharmacology
- Molecular Pharmacology
- Q Science (General)
- Molecular Biology
- Cell Signalling
- Cell Death
- Tumour Immunology
- Oxidative Stress
Research Beacons, Institutes and Platforms
- Digital Futures
- Institute for Data Science and AI
Keywords
- Transcription
- DNA damage
- Cellular Energy Metabolism
- Reactive oxygen species
- Immunotherapy
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Elimination of Off-Target Effect by Chemical Modification of 5'-End of siRNA: 5′-modified siRNA
Shiohama, Y., Fujita, R., Sonokawa, M., Hisano, M., Kotake, Y., Krstic-Demonacos, M., Demonacos, C., Kashiwazaki, G. & Fujii, M., 11 Apr 2022, In: Nucleic Acid Therapeutics. 32, 5, p. 438-447 10 p.Research output: Contribution to journal › Article › peer-review
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Protein Disulfide Isomerase A1 (PDIA1)-associated pathways in the development of stratified breast cancer therapies: PDIA1-associated pathways in stratified breast cancer therapies
Bakker, E., Fujii, M., Krstic-Demonacos, M., Demonacos, C. (Corresponding) & Alhammad, R. (Corresponding), 10 Jan 2022, In: International Journal of Oncology. 60, 2, 19 p., 16.Research output: Contribution to journal › Article › peer-review
Open AccessFile124 Downloads (Pure) -
A Novel Mechanism of Ataxia Telangiectasia Mutated Mediated Regulation of Chromatin Remodeling in Hypoxic Conditions
Likhatcheva, M., Gieling, R. G., Brown, J. A. L., Demonacos, C. & Williams, K. J., 21 Sept 2021, In: Frontiers in cell and developmental biology. 9, 11 p., 720194.Research output: Contribution to journal › Article › peer-review
Open Access -
Evaluation of the Role of p53 Tumour Suppressor Posttranslational Modifications and TTC5 Cofactor in Lung Cancer
Alhebshi, H., Tian, K., Patnaik, L., Taylor, R., Bezecny, P., Hall, C., Muller, P., Safari , N., Menendez Creamer , D. P., Demonacos, C., Mutti, L., Bittar, M. N. & Krstic-Demonacos, M., 7 Dec 2021, In: International Journal of Molecular Sciences. 22, 24, 14 p., 13198.Research output: Contribution to journal › Article › peer-review
Open AccessFile94 Downloads (Pure) -
Endoplasmic Reticulum stress, Unfolded Protein Response and autophagy contribute to resistance to glucocorticoid treatment in human Acute Lymphoblastic Leukemia cells
Sudsaward, S., Khunchai, S., Thepmalee, C., Othman, A., Limjindaporn, T., Yenchitsomanus, P.-T., Mutti, L., Krstic-Demonacos, M. & Demonacos, C., 29 May 2020, (Accepted/In press) In: International Journal of Oncology. 244781.Research output: Contribution to journal › Article › peer-review
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Advance HE Connect Network On-Boarding Grant for the Pharmacy Education Network: Lead recipient
Parmar, H. (Recipient), Willis, S. (Recipient), Silkstone, V. (Recipient), Hall, J. (Recipient), Demonacos, C. (Recipient), McCaugue, P. (Recipient), Smith, M. (Recipient), Fleming, G. (Recipient) & Boyd, M. (Recipient)
26 Jul 2019Activity: Internal positions, career professional development, other peer review and other › Other › Research
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World Academy of Sciences Journal (Journal)
Constantinos Demonacos (Member of editorial board)
2019 → …Activity: Publication peer-review and editorial work › Editorial work › Research
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Oncology Reports (Journal)
Constantinos Demonacos (Member of editorial board)
3 Dec 2012 → …Activity: Publication peer-review and editorial work › Editorial work › Research
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World Journal of Medical Genetics (Journal)
Constantinos Demonacos (Member of editorial board)
24 Oct 2011 → …Activity: Publication peer-review and editorial work › Editorial work › Research
Datasets
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miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway
Kuroda, K. (Contributor), Fukuda, T. (Contributor), Krstic-Demonacos, M. (Contributor), Demonacos, C. (Contributor), Okumura, K. (Contributor), Isogai, E. (Contributor), Hayashi, M. (Contributor), Saito, K. (Contributor) & Isogai, E. (Contributor), figshare , 7 Jan 2017
DOI: 10.6084/m9.figshare.c.3660476.v1, https://figshare.com/collections/miR-663a_regulates_growth_of_colon_cancer_cells_after_administration_of_antimicrobial_peptides_by_targeting_CXCR4-p21_pathway/3660476/1
Dataset