Corinne Faivre-Finn

Corinne Faivre-Finn, FRCR, MD, PhD

Prof

  • The Christie NHS Foundation Trust, Wilmslow Road, Withington

    M20 4BX Manchester

    United Kingdom

Personal profile

Overview

Professor Corinne Faivre-Finn holds a joint appointment between University of Manchester (Professor of Thoracic Radiation Oncology) and The Christie NHS Foundation Trust (Honorary Consultant Clinical Oncologist). She trained in Paris and moved to the UK in 1998. She has numerous professional roles including Radiotherapy Research Lead for Manchester Cancer Research Centre & the CRUK Lung Cancer Centre, Chair of the ESTRO Lung Focus Group and of the Early NSCLC EORTC Lung Group. She is on the editorial board of Lung Cancer.

She has led numerous trials studying radiotherapy in lung cancer and an author of guidelines on the management of patients with lung cancer (ESMO, BTS, EORTC, ERS, ASTRO). She has authored >300 papers including 7 practice changing studies.

In recent years she has developed expertise in electronic patient reported outcomes and real-world evidence. She is particularly interested in novel trial methodologies allowing more inclusive and efficient research, such as platform and pragmatic trials.

Prof Faivre-Finn received a prestigious NIHR Senior Investigator award in 2023.

Research interests

Professor Faivre-Finn has extensive experience in clinical trials, ranging from phase I studies combining novel drugs and radiotherapy to practice changing phase 3 trials investigating radiotherapy with or without systemic treatments. Examples include the CONVERT, LungART, PIT, CREST, PRIMAlung and PACIFIC trials.

She co-leads the CONCORDE trial, an early-phase platform trial combining DNA damage repair inhibitors with radiotherapy in lung cancer. This multi-arm and randomised study uses an innovative Bayesian adaptive design, with potential to improve efficiency of drug-radiotherapy combination trials.

In the last 10 years, she has developed a research programme harnessing digital health for those patients who are typically underrepresented in clinical trials.  Real-world data is used to remove the barriers that result from age, comorbidities, socio-economic background to improve health and cancer care for everyone. She co-leads the ‘RAPID-RT’ NIHR programme, aiming to demonstrate the impact of sparing the base of the heart in  patients with lung cancer. The programme also has an important methodological aim to embed the Learning Healthcare System concept in routine radiotherapy practice to establish a ‘rapid-learning’ methodology for the timely, safe and evidence-based evaluation of changes.

Teaching

  • Supervision for 4th year option projects, University of Manchester Medical Students
  • Supervision of MRes students
  • Supervision of MD and PhD fellows
  • Advisor to PhD students
  • ESMO masterclasses
  • External MD/PhD examiner

My collaborations

  • Christie Medical Oncology (Prof Blackhall, Prof Califano, Dr Colin Lindsay, Dr Fabio Gomes)
  • Cancer Research UK Manchester Institute (Prof Caroline Dive, Prof Fiona Blackhall, Dr Dominic Rothwell).
  • University of Manchester - Radiotherapy Related Research Group (Prof Marcel VanHerk, Prof Marianne Aznar, Dr Gareth Price, Dr Alan McWilliam)
  • University of Manchester School of Pharmacy and Pharmaceutical Sciences (Kaye Williams)
  • University of Manchester - Health Data Science and Health Informatics (Dr Sabine van der Veer and Dr Matt Sperrin)
  • Christie Medical Physics and Engineering (Ran Mackay)
  • External Collaborators nationally: Dr Fiona McDonald (Royal Marsden, London), Prof Anthony Chalmers (University of  Glasgow), Prof Alastair Greystoke (Newcastle),  Dr Kevin Franks (Leeds), Dr Stephen Harrow (Edinburgh), Dr Paul Shaw (Cardiff), Dr Crispin Hiley (UCL, London), Prof Matthew Hatton (Sheffield)
  • External Collaborators internationally : Prof. Dirk de Ruysscher (Maastricht, Netherlands), Dr Cecile le Pechoux and Dr Antonin Levy (Institute Gustave Roussy, Paris), Prof. Ursula Nestle (Mönchengladbach, Germany), Prof Gerry Hanna (Dublin, Ireland)
  • Leeds CTRU
  • EORTC Lung and Radiotherapy groups

Memberships of committees and professional bodies

She is involved in several national and international research committees including:

National Committees

  • Radiotherapy research lead for the CRUK lung cancer centre of excellence, 2014-date
  • Scientific Advisor to the Leeds CTRU. 2018-date
  • Member of NHS England and the Royal College of Radiologists taskforce ‘Metrics for assessing the quality of Lung Radiotherapy in England’. 2021-date
  • Member of the NHSE Radiotherapy Lung Plan Quality Indicator Task and Finish Group (Radiotherapy Learning Healthcare System – Sub-Specialty Metric Groups). 2022-date
  • Member of the RCR dose fractionation oligometastases working group. 2022-23
  • Members of the DECIDE-AI expert group. 2021-22
  • Member of the NCRN limited stage small cell lung cancer and stage I-III non-small-cell lung cancer subgroup (LORD subgroup), 2005-2022
  • Member of Workstream 3 (phase III clinical trials) of the NCRI Clinical & Translational Radiotherapy Research Working Group (CTRad), 2009-2023
  • Member of the British Thoracic Oncology Group Steering Committee, 2010-2017
  • National Cancer Trials Translational Accelerator (NCITA) Imaging Trials Unit Board. 2019-2023
  • CRUK Clinical Expert Review Panel, 2015-2018
  • Member of the British Thoracic Society Guidelines Committee on Mesothelioma, 2014-2016
  • SABR consortium guidelines-author of the section on central lung tumours, 2018
  • RCR Consensus Statements for Lung Cancer-author, 2019-2017

International committees

  • Chair of the ESTRO Lung Focus Group, 2023-date
  • Chair Early disease EORTC Lung Group, 2015-date
  • Chair Radiotherapy EORTC Lung Group, 2008-2014
  • Chair of the Advanced Radiation Technology (ART) Committee – International Association for the Study of Lung Cancer (IASLC), 2019-2022
  • ESTRO clinical committee, 2015-date
  • Member of the EORTC Radiation Oncology Scientific Council (ROSC), 2020-date
  • Fellow of the European Academy of Cancer Sciences, 2015-date
  • Member of ERS, ESTRO, ESTS and ELF Taskforce on the management of positive findings in low-dose CT screening for lung cancer- 2022-date
  • Member of the ERS/ESTS Guidelines for fitness for therapy in patients with lung cancer, 2021-date

Methodological knowledge

  • Clinical trials
  • External MD/PhD reviewer
  • External MD examiner
  • ESMO masterclasses

Qualifications

  • PhD - ‘Improvement of Care Practices and Prognosis of Colorectal Cancer. Population Studies’
  • Masters Degree in Epidemiology and Clinical Research
  • MSc Epidemiology and Medical Statistics
  • MSc Cancer Chemotherapy and Pharmacology
  • MSc Pharmacology

Prizes

  • Christie International researcher of the year-2016
  • IASLC Jim Cox Lectureship Award-September 2019
  • ESTRO Honorary physicist Award – April 2022
  • Greater Manchester Cancer Awards - Innovation Award 2022 for My christie-MyHealth - The Christie electronic patient reported outcomes project
  • NIHR Senior Investigator Award-March 2023

Social responsibility

  • CRUK fundraising
  • Extensive PPIE work including 2 Citizens Jury

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 2 - Zero Hunger
  • SDG 3 - Good Health and Well-being
  • SDG 5 - Gender Equality
  • SDG 10 - Reduced Inequalities
  • SDG 11 - Sustainable Cities and Communities
  • SDG 16 - Peace, Justice and Strong Institutions

External positions

Chair early disease Lung Cancer Group, EORTC (European Organisation for Research & Treatment of Cancer)

1 Jul 2015 → …

Research Beacons, Institutes and Platforms

  • Cancer
  • Manchester Cancer Research Centre

Keywords

  • Lung cancer
  • radiotherapy

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