Dan is a Lecturer in Applied Pharmacokinetics and PBPK/IVIVE Lead in the Centre for Applied Pharmacokinetic Research (CAPKR), with expertise in developing, refining, and applying mechanistic approaches to predict drug metabolism and transport in vivo using computational models. His research focuses on the use of physiologically-based pharmacokinetic (PBPK) models for translation of experimental in vitro data to predict clinical outcomes, within in vitro-in vivo extrapolation (IVIVE) framework.

Dan has expertise in the modelling of renal disposition of drugs, having made significant contributions to the understanding of the impact of chronic conditions on drug pharmacokinetics. His interdisciplinary research has included the modelling of endogenous biomarkers and imaging biomarkers for drug transporter activity modulation. He has also has expertise in IVIVE/PBPK for non-CYP enzymes, with recent research establishing a PBPK framework for substrates of aldehyde oxidase. Dan has a track record of successful national and international collaborations, including projects with clinicians and pharmaceutical industry partners (within and outside of CAPKR). He serves on the editorial board member for Drug Metabolism and Disposition.

Dan is Deputy Director of the MSc in Model-Based Drug Development, and he leads two units on PBPK modelling and IVIVE within the MSc.