Research output per year
Research output per year
Personal profile
Biography
Dan is based in the Centre for Applied Pharmacokinetic Research (CAPKR), with research interests in quantitative translation of in vitro data to predict in vivo pharmacokinetic endpoints. Dr Scotcher has particular expertise in the use of physiologically-based pharmacokinetic (PBPK) modelling to mechanistically describe and predict drug disposition in health and disease.
After a brief time working in the pharmaceutical industry, Dan completed his PhD at the University of Manchester in 2016, and then visited the US Food and Drug Administration as an ORISE research fellow. He returned to Manchester as a Research Associate working on an Innovative Medicines Initiative project on Translational Imaging in Drug Safety Assessment, and was subsequently appointed as Lecturer in 2019.
Dan is Deputy Director of the MSc in Model-Based Drug Development, and also contributes to the teaching of the MPharm Pharmacy course.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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Collaborations and top research areas from the last five years
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Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance
Tan, S. P. F., Tillmann, A., Murby, S. J., Rostami-Hodjegan, A., Scotcher, D. & Galetin, A., 2 Sept 2024, In: Molecular Pharmaceutics. 21, 9, p. 4603 - 4617 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Facing the facts of altered plasma protein binding: Do current models correctly predict changes in fraction unbound in special populations?
Al Qassabi, J., Tan, P. F. S., Phonboon, P., Galetin, A., Rostami-Hodjegan, A. & Scotcher, D., 26 Feb 2024, (E-pub ahead of print) In: Journal of Pharmaceutical Sciences.Research output: Contribution to journal › Article › peer-review
Open Access -
Challenges and opportunities for in vitro-in vivo extrapolation of aldehyde oxidase-mediated clearance: Towards a roadmap for quantitative translation
Izat, N., Bolleddula, J., Abbasi, A., Cheruzel, L., Jones, R., Moss, D., Ortega-Muro, F., Parmentier, Y., Peterkin, V. C., Tian, D.-D., Venkatakrishnan, K., Zientek, M., Barber, J., Houston, J., Galetin, A. & Scotcher, D., 28 Aug 2023, (Accepted/In press) In: Drug Metabolism and Disposition.Research output: Contribution to journal › Article › peer-review
Open AccessFile3 Downloads (Pure) -
Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker- Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease
Tan, S. P. F., Willemin, M., Snoeys, J., Shen, H., Rostami‐hodjegan, A., Scotcher, D. & Galetin, A., 24 Aug 2023, (E-pub ahead of print) In: Clinical Pharmacology & Therapeutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile40 Downloads (Pure) -
Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling
Barber, J., Al-Majdoub, Z. M., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alizai, N., de Wildt, S., Stader, F., Sepp, A., Rostami-Hodjegan, A. & Achour, B., 1 Mar 2023, In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 182, p. 106375Research output: Contribution to journal › Article › peer-review
Thesis
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PHYSIOLOGICAL SCALING FACTORS AND MECHANISTIC MODELS FOR PREDICTION OF RENAL CLEARANCE FROM IN VITRO DATA
Scotcher, D. (Author), Rostami-Hochaghan, A. (Supervisor) & Galetin, A. (Supervisor), 1 Aug 2016Student thesis: Phd
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