Daniel Scotcher

2024

Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance

Tan, S. P. F., Tillmann, A., Murby, S. J., Rostami-Hodjegan, A., Scotcher, D. & Galetin, A., 2 Sept 2024, In: Molecular Pharmaceutics. 21, 9, p. 4603 - 4617 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Establishing a physiologically-based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates

Izat, N., Bolleddula , J., Carione, P., Huertas Valentin, L., Jones, R. S., Kulkarni, P., Moss, D., Peterkin, V. C., Tian, D.-D., Treyer, A., Venkatakrishnan, K., Zientek, M. A., Barber, J., Houston, J., Galetin, A. & Scotcher, D., 27 Sept 2024, (Accepted/In press) In: CPT: Pharmacometrics and Systems Pharmacology.

Research output: Contribution to journal › Article › peer-review

Facing the facts of altered plasma protein binding: Do current models correctly predict changes in fraction unbound in special populations?

Al Qassabi, J., Tan, P. F. S., Phonboon, P., Galetin, A., Rostami-Hodjegan, A. & Scotcher, D., 26 Feb 2024, (E-pub ahead of print) In: Journal of Pharmaceutical Sciences.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Challenges and opportunities for in vitro-in vivo extrapolation of aldehyde oxidase-mediated clearance: Towards a roadmap for quantitative translation

Izat, N., Bolleddula, J., Abbasi, A., Cheruzel, L., Jones, R., Moss, D., Ortega-Muro, F., Parmentier, Y., Peterkin, V. C., Tian, D.-D., Venkatakrishnan, K., Zientek, M., Barber, J., Houston, J., Galetin, A. & Scotcher, D., 28 Aug 2023, (Accepted/In press) In: Drug Metabolism and Disposition.

Research output: Contribution to journal › Article › peer-review

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Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker- Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease

Tan, S. P. F., Willemin, M., Snoeys, J., Shen, H., Rostami‐hodjegan, A., Scotcher, D. & Galetin, A., 24 Aug 2023, (E-pub ahead of print) In: Clinical Pharmacology & Therapeutics.

Research output: Contribution to journal › Article › peer-review

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Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling

Barber, J., Al-Majdoub, Z. M., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alizai, N., de Wildt, S., Stader, F., Sepp, A., Rostami-Hodjegan, A. & Achour, B., 1 Mar 2023, In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 182, p. 106375

Research output: Contribution to journal › Article › peer-review

Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats

Melillo, N., Scotcher, D., Kenna, J. G., Green, C., Hines, C. D. G., Laitinen, I., Hockings, P. D., Ogungbenro, K., Gunwhy, E. R., Sourbron, S., Waterton, J. C., Schuetz, G. & Galetin, A., 10 Mar 2023, In: Pharmaceutics. 15, 3, 25 p., 896.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Coproporphyrin I as an endogenous biomarker to detect reduced OATP1B activity and shift in elimination route in chronic kidney disease

Takita, H., Scotcher, D., Chu, X., Yee, K. L., Ogungbenro, K. & Galetin, A., 2 Jun 2022, In: Clinical Pharmacology & Therapeutics.

Research output: Contribution to journal › Article › peer-review

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Effect of chronic kidney disease on the renal secretion via organic anion transporters (OAT)1/3: Implications for PBPK modelling and dose adjustment

Tan, S. P. F., Scotcher, D., Rostami‐hodjegan, A. & Galetin, A., 15 May 2022, In: Clinical Pharmacology & Therapeutics.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions

Willemin, M.-E., Van Der Made, T. K., Pijpers, I., Dillen, L., Kunze, A., Jonkers, S., Steemans, K., Tuytelaars, A., Jacobs, F., Monshouwer, M., Scotcher, D., Rostami-hodjegan, A., Galetin, A. & Snoeys, J., 10 Apr 2021, In: Clinical Pharmacokinetics.

Research output: Contribution to journal › Article › peer-review

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Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation (IVIVE) of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis

Vasilogianni, A.-M., Achour, B., Scotcher, D., Peters, S. A., Al-Majdoub, Z. M., Barber, J. & Rostami-Hodjegan, A., 12 May 2021, In: Drug Metabolism and Disposition.

Research output: Contribution to journal › Article › peer-review

PBPK simulation-based evaluation of ganciclovir crystalluria risk factors: effect of renal impairment, old age and low fluid intake

Scotcher, D. & Galetin, A., 2021, In: AAPS Journal.

Research output: Contribution to journal › Article › peer-review

Physiologically-based pharmacokinetic modelling of transporter-mediated hepatic disposition of 1 imaging biomarker gadoxetate in rats

Scotcher, D., Melillo, N., Tadimalla, S., Darwich, A., Ziemian, S., Ogungbenro, K., Schütz, G., Sourbron, S. P. & Galetin, A., 2021, In: Molecular Pharmaceutics.

Research output: Contribution to journal › Article › peer-review

Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics

Al-Majdoub, Z., Scotcher, D., Achour, B., Barber, J., Galetin, A. & Rostami-Hodjegan, A., 1 Nov 2021, In: Clinical Pharmacology & Therapeutics. 110, 5, p. 1389-1400 12 p.

Research output: Contribution to journal › Article › peer-review

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2020

A novel physiologically based model of creatinine renal disposition to integrate current knowledge of systems parameters and clinical observations

Scotcher, D., Arya, V., Yang, X., Zhao, P., Zhang, L., Huang, S.-M., Rostami-Hodjegan, A. & Galetin, A., 22 May 2020, In: CPT: Pharmacometrics and Systems Pharmacology.

Research output: Contribution to journal › Article › peer-review

Open Access

Mass Spectrometry‐Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin

Al-Majdoub, Z., Achour, B., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alrubia, S., Elkhateeb, E., Vasilogianni, A. M., Alohali, N., Neuhoff, S., Schmidt, L., Rostami-Hodjegan, A. & Barber, J., 31 Oct 2020, In: FEBS Letters.

Research output: Contribution to journal › Article › peer-review

Open Access

Mechanistic models as framework for understanding biomarker disposition: Prediction of creatinine-drug interactions

Scotcher, D., Arya, V., Yang, X., Zhao, P., Zhang, L., Huang, S.-M., Rostami-Hodjegan, A. & Galetin, A., 14 May 2020, In: CPT: Pharmacometrics and Systems Pharmacology. 9, 5, p. 282-293 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Physiologically-based Pharmacokinetic Modelling of Creatinine-drug Interactions in the Chronic Kidney Disease Population

Takita, H., Scotcher, D., Chinnadurai, R., Kalra, P. & Galetin, A., 13 Oct 2020, In: CPT: Pharmacometrics and Systems Pharmacology. 9, 12, p. 695-706 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Scaling Factors for Clearance in Adult Liver Cirrhosis

Elkhateeb, E., Achour, B., Scotcher, D., Al-Majdoub, Z., Athwal, V., Barber, J. & Rostami-Hodjegan, A., 25 Sept 2020, (E-pub ahead of print) In: Drug Metabolism and Disposition.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease

Van Der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-hodjegan, A., Sastre Torano, J., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R. & Galetin, A., 16 Sept 2019, In: Molecular Pharmaceutics. 16, 11, p. 4551–4562

Research output: Contribution to journal › Article › peer-review

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2018

Noninvasive preclinical and clinical imaging of liver transporter function relevant to drug-induced liver injury

Kenna, J. G., Waterton, J. C., Baudy, A., Galetin, A., Hines, C. D. G., Hockings, P., Patel, M., Scotcher, D., Sourbron, S., Ziemian, S. & Schuetz, G., 21 Mar 2018, Drug-Induced Liver Toxicity. New York, NY: Humana Press, Inc, p. 627-651 25 p. (Methods in Pharmacology and Toxicology; no. 9781493976768).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Open Access