Research output per year
Research output per year
- 26 results
Search results
-
2024
Albumin-Mediated Drug Uptake by Organic Anion Transporter 1/3 Is Real: Implications for the Prediction of Active Renal Secretion Clearance
Tan, S. P. F., Tillmann, A., Murby, S. J., Rostami-Hodjegan, A., Scotcher, D. & Galetin, A., 2 Sept 2024, In: Molecular Pharmaceutics. 21, 9, p. 4603 - 4617 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Establishing a physiologically-based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase-CYP substrates
Izat, N., Bolleddula , J., Carione, P., Huertas Valentin, L., Jones, R. S., Kulkarni, P., Moss, D., Peterkin, V. C., Tian, D.-D., Treyer, A., Venkatakrishnan, K., Zientek, M. A., Barber, J., Houston, J., Galetin, A. & Scotcher, D., 27 Sept 2024, (Accepted/In press) In: CPT: Pharmacometrics and Systems Pharmacology.Research output: Contribution to journal › Article › peer-review
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Facing the facts of altered plasma protein binding: Do current models correctly predict changes in fraction unbound in special populations?
Al Qassabi, J., Tan, P. F. S., Phonboon, P., Galetin, A., Rostami-Hodjegan, A. & Scotcher, D., 26 Feb 2024, (E-pub ahead of print) In: Journal of Pharmaceutical Sciences.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Challenges and opportunities for in vitro-in vivo extrapolation of aldehyde oxidase-mediated clearance: Towards a roadmap for quantitative translation
Izat, N., Bolleddula, J., Abbasi, A., Cheruzel, L., Jones, R., Moss, D., Ortega-Muro, F., Parmentier, Y., Peterkin, V. C., Tian, D.-D., Venkatakrishnan, K., Zientek, M., Barber, J., Houston, J., Galetin, A. & Scotcher, D., 28 Aug 2023, (Accepted/In press) In: Drug Metabolism and Disposition.Research output: Contribution to journal › Article › peer-review
Open AccessFile4 Downloads (Pure) -
Development of 4-Pyridoxic Acid PBPK Model to Support Biomarker- Informed Evaluation of OAT1/3 Inhibition and Effect of Chronic Kidney Disease
Tan, S. P. F., Willemin, M., Snoeys, J., Shen, H., Rostami‐hodjegan, A., Scotcher, D. & Galetin, A., 24 Aug 2023, (E-pub ahead of print) In: Clinical Pharmacology & Therapeutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile43 Downloads (Pure) -
Toward systems-informed models for biologics disposition: covariates of the abundance of the neonatal Fc Receptor (FcRn) in human tissues and implications for pharmacokinetic modelling
Barber, J., Al-Majdoub, Z. M., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alizai, N., de Wildt, S., Stader, F., Sepp, A., Rostami-Hodjegan, A. & Achour, B., 1 Mar 2023, In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 182, p. 106375Research output: Contribution to journal › Article › peer-review
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Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats
Melillo, N., Scotcher, D., Kenna, J. G., Green, C., Hines, C. D. G., Laitinen, I., Hockings, P. D., Ogungbenro, K., Gunwhy, E. R., Sourbron, S., Waterton, J. C., Schuetz, G. & Galetin, A., 10 Mar 2023, In: Pharmaceutics. 15, 3, 25 p., 896.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Coproporphyrin I as an endogenous biomarker to detect reduced OATP1B activity and shift in elimination route in chronic kidney disease
Takita, H., Scotcher, D., Chu, X., Yee, K. L., Ogungbenro, K. & Galetin, A., 2 Jun 2022, In: Clinical Pharmacology & Therapeutics.Research output: Contribution to journal › Article › peer-review
Open AccessFile37 Downloads (Pure) -
Effect of chronic kidney disease on the renal secretion via organic anion transporters (OAT)1/3: Implications for PBPK modelling and dose adjustment
Tan, S. P. F., Scotcher, D., Rostami‐hodjegan, A. & Galetin, A., 15 May 2022, In: Clinical Pharmacology & Therapeutics.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions
Willemin, M.-E., Van Der Made, T. K., Pijpers, I., Dillen, L., Kunze, A., Jonkers, S., Steemans, K., Tuytelaars, A., Jacobs, F., Monshouwer, M., Scotcher, D., Rostami-hodjegan, A., Galetin, A. & Snoeys, J., 10 Apr 2021, In: Clinical Pharmacokinetics.Research output: Contribution to journal › Article › peer-review
Open AccessFile249 Downloads (Pure) -
Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation (IVIVE) of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis
Vasilogianni, A.-M., Achour, B., Scotcher, D., Peters, S. A., Al-Majdoub, Z. M., Barber, J. & Rostami-Hodjegan, A., 12 May 2021, In: Drug Metabolism and Disposition.Research output: Contribution to journal › Article › peer-review
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PBPK simulation-based evaluation of ganciclovir crystalluria risk factors: effect of renal impairment, old age and low fluid intake
Scotcher, D. & Galetin, A., 2021, In: AAPS Journal.Research output: Contribution to journal › Article › peer-review
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Physiologically-based pharmacokinetic modelling of transporter-mediated hepatic disposition of 1 imaging biomarker gadoxetate in rats
Scotcher, D., Melillo, N., Tadimalla, S., Darwich, A., Ziemian, S., Ogungbenro, K., Schütz, G., Sourbron, S. P. & Galetin, A., 2021, In: Molecular Pharmaceutics.Research output: Contribution to journal › Article › peer-review
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Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics
Al-Majdoub, Z., Scotcher, D., Achour, B., Barber, J., Galetin, A. & Rostami-Hodjegan, A., 1 Nov 2021, In: Clinical Pharmacology & Therapeutics. 110, 5, p. 1389-1400 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile206 Downloads (Pure) -
2020
A novel physiologically based model of creatinine renal disposition to integrate current knowledge of systems parameters and clinical observations
Scotcher, D., Arya, V., Yang, X., Zhao, P., Zhang, L., Huang, S.-M., Rostami-Hodjegan, A. & Galetin, A., 22 May 2020, In: CPT: Pharmacometrics and Systems Pharmacology.Research output: Contribution to journal › Article › peer-review
Open Access -
Mass Spectrometry‐Based Abundance Atlas of ABC Transporters in Human Liver, Gut, Kidney, Brain, and Skin
Al-Majdoub, Z., Achour, B., Couto, N., Howard, M., Elmorsi, Y., Scotcher, D., Alrubia, S., Elkhateeb, E., Vasilogianni, A. M., Alohali, N., Neuhoff, S., Schmidt, L., Rostami-Hodjegan, A. & Barber, J., 31 Oct 2020, In: FEBS Letters.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanistic models as framework for understanding biomarker disposition: Prediction of creatinine-drug interactions
Scotcher, D., Arya, V., Yang, X., Zhao, P., Zhang, L., Huang, S.-M., Rostami-Hodjegan, A. & Galetin, A., 14 May 2020, In: CPT: Pharmacometrics and Systems Pharmacology. 9, 5, p. 282-293 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Physiologically-based Pharmacokinetic Modelling of Creatinine-drug Interactions in the Chronic Kidney Disease Population
Takita, H., Scotcher, D., Chinnadurai, R., Kalra, P. & Galetin, A., 13 Oct 2020, In: CPT: Pharmacometrics and Systems Pharmacology. 9, 12, p. 695-706 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Scaling Factors for Clearance in Adult Liver Cirrhosis
Elkhateeb, E., Achour, B., Scotcher, D., Al-Majdoub, Z., Athwal, V., Barber, J. & Rostami-Hodjegan, A., 25 Sept 2020, (E-pub ahead of print) In: Drug Metabolism and Disposition.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease
Van Der Made, T. K., Fedecostante, M., Scotcher, D., Rostami-hodjegan, A., Sastre Torano, J., Middel, I., Koster, A. S., Gerritsen, K. G., Jankowski, V., Jankowski, J., Hoenderop, J. G. J., Masereeuw, R. & Galetin, A., 16 Sept 2019, In: Molecular Pharmaceutics. 16, 11, p. 4551–4562Research output: Contribution to journal › Article › peer-review
Open AccessFile219 Downloads (Pure) -
2018
Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance
Matsuzaki, T., Scotcher, D., Darwich, A., Galetin, A. & Rostami-hodjegan, A., 2018, In: Journal of Pharmacology and Experimental Therapeutics.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Delineating the role of various factors in renal disposition of digoxin through application of physiologically-based kidney model to renal impairment populations
Scotcher, D., Jones, C., Galetin, A. & Rostami-Hochaghan, A., Mar 2017, In: Journal of Pharmacology and Experimental Therapeutics. 360, 3, p. 484-495 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Microsomal and cytosolic scaling factors in dog and human kidney cortex and application for in vitro-in vivo extrapolation of renal metabolic clearance
Scotcher, D., Billington, S., Brown, J., Jones, C. R., Brown, C. D. A., Rostami-Hochaghan, A. & Galetin, A., May 2017, In: Drug Metabolism and Disposition. 45, 5, p. 556-568 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
Key to opening kidney for in vitro-in vivo extrapolation entrance in health and disease: Part II Mechanistic models and in vitro-in vivo extrapolation
Scotcher, D., Jones, C., Posada, M., Galetin, A. & Rostami, A., Sept 2016, In: AAPS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
Key to opening kidney for in vitro-in vivo extrapolation entrance in health and disease: Part I: In vitro systems and physiological data
Scotcher, D., Jones, C., Posada, M., Rostami-Hodjegan, A. & Galetin, A., Sept 2016, In: The A A P S Journal. 18, 5Research output: Contribution to journal › Article › peer-review
Open Access -
Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance
Scotcher, D., Jones, C., Rostami-Hodjegan, A. & Galetin, A., 2016, In: European Journal of Pharmaceutical Sciences.Research output: Contribution to journal › Article › peer-review
Open AccessFile223 Downloads (Pure)