Personal profile

Biography

After graduating in Medicine from Cambridge University, I trained in respiratory medicine and clinical pharmacology. This included an industrial placement for phase 1 experience. I completed an MD at the University of Manchester, and then was appointed as senior lecturer in respiratory pharmacology based in the University Hospital of South Manchester in 2003. My research interests are the pharmacotherapy of Asthma and COPD with studies spanning from basic pharmacology investigations of anti-inflammatory drug action to clinical trials. I am medical director of the Medicines Evaluation Unit performing proof of concept studies in obstructive lung diseases.

Memberships of committees and professional bodies

Member of:-

  • University Of Manchester representative on CHOP (Committee of Heads and Professors of Clinical Pharmacology and Therapeutics)
  • British Pharmacology Society
  • British Association of Lung Research
  • British Thoracic Society
  • Royal College of Physicians
  • American Thoracic Society
  • European Respiratory Society
  • British Society of Immunology 

Qualifications

BA (Hons) Medical Sciences 2:1 (1989) Cambridge University
MB, B.Chir. (1991) Cambridge University
MA (Hon) (1992) Cambridge University
MRCP (1996)
MD (2002)

Overview

  • Head of airway pharmacology group, using human lung tissue models to study inflammation in asthma and COPD
  • Medical Directorfor early phase clinical trials in the Medicines evaluation unit (MEU)

Teaching

  • Undergraduate training – I have supervised 5 medical student 10 week research project options.
  • I contribute every year to undergraduate examinations, and medical student teaching.
  • I have acted as Mres tutor for year 4 medical students for the last 3 years, delivering seminars on asthma

Research interests

I lead a translational airway pharmacology group investigating inflammation in asthma and COPD. My interests span from basic pharmacological studies using primary cells concerning corticosteroid insensitivity and novel molecular targets, through to early phase proof of concept clinical trials. The close links between my laboratory and clinical research enable proper translational studies to be performed. 

My collaborations

Current Research Staff
6 post-docs
1 research assistant

2 research technicians
3 clinical fellows (PhD registered)
3 non-clinical PhD students

INTERNATIONAL COLLABORATIONS

  • EvA – FP7 COPD consortium investigating genetics and gene expression in emphysema vs airway disease
  • ECLIPSE – GSK funded, largest ever COPD longitudinal cohort study.  

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

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