Personal profile
Research interests
David graduated in Medicine from London University (St. Bartholomew’s) in 1976 and moved to Manchester to study Psychiatry in 1979. After completing his training in general psychiatry , he arranged a temporary secondment to Clinical Genetics in 1986 to pursue an interest in the genetic aspects of psychiatric disorders, and ended up 'going native'. He is now a senior lecturer and honorary consultant in neuropsychiatric genetics.
His research interests are concerned mainly with the neuropsychiatric aspects of Huntington's disease (HD), and with the psychological and social impact of predictive DNA testing for late-onset genetic disorders. He set up the UK’s first multidisciplinary management clinic for HD, currently the largest contributing site to the European HD Network (EHDN) case registry, and is actively involved in a number of European and World-wide research projects and clinical trials. He is a member of the Scientific Review Committee of the EHDN, leads the EHDN Behavioural Phenotype Working Group and is a former Secretary-General of the World Federation of Neurology Research Group on HD. He is co-Director of the MSc programme and teaches on the Clinical Genetics and Advanced Genetic Counselling modules.
Research Beacons, Institutes and Platforms
- Digital Futures
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 5 Gender Equality
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“It’s being part of the big picture, even though you’re a tiny jigsaw piece”—motivations and expectations of individuals participating in the Enroll-HD observational study
Davies, E., Craufurd, D. & Macleod, R., 10 Mar 2020, In: Journal of community genetics.Research output: Contribution to journal › Article › peer-review
Open Access -
PILOT OBSERVATIONS FROM A MULTIMODAL IMAGING STUDY OF DYSPHAGIC PATIENTS IN EARLY STAGE HUNTINGTON'S DISEASE
Michou, E., Trender-Gerhard, I., Gerhard, A., Craufurd, D., Herholz, K. & Hamdy, S., Apr 2017, In: Gastroenterology. 152, 5, p. S928-S928Research output: Contribution to journal › Meeting Abstract › peer-review
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Dysphagia in early stage Huntington’s disease (HD) – Pilot observations from a multimodal imaging study
Trender-Gerhard, I., Michou, E., Gerhard, A., Craufurd, D., Handy, S. & Herholz, K., 1 Jun 2016, In: Gastroenterology. 31, 2, p. http://www.mdsabstracts.org/abstract/dysphagia-in-Research output: Contribution to journal › Meeting Abstract › peer-review
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An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease.
Süssmuth, S. D., Haider, S., Landwehrmeyer, G. B., Farmer, R., Frost, C., Tripepi, G., Andersen, C. A., Di Bacco, M., Lamanna, C., Diodato, E., Massai, L., Diamanti, D., Mori, E., Magnoni, L., Dreyhaupt, J., Schiefele, K., Craufurd, D., Saft, C., Rudzinska, M. & Ryglewicz, D. & 8 others, , Mar 2015, In: British Journal of Clinical Pharmacology. 79, 3Research output: Contribution to journal › Article › peer-review
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Characterization of Gastric Mucosa Biopsies Reveals Alterations in Huntington's Disease.
McCourt, A. C., O'Donovan, K. L., Ekblad, E., Sand, E., Craufurd, D., Rosser, A., Sanders, D., Stoy, N., Rickards, H., Wierup, N., Bates, G. P., Björkqvist, M. & Quarrell, O., 2015, In: PL o S currents. 7Research output: Contribution to journal › Article › peer-review