Research output per year
Research output per year
Personal profile
Overview
I am a Lecturer in Genetics/Genomics at the Division of Cardiovascular Sciences since November 2015. Having come from a background in yeast genetics, I have committed my future career to the identification and study of genes linked to diseases, especially in the cardiovascular system, recognising the potential for patient benefit that may result from novel computational approaches.
Research interests
My main research interest is in understanding why some variation (either quantitative or qualitative) is tolerated whereas other variation is deleterious.
Identification and interpretation of genetic variants linked to cardiovascular diseases
The use of high-throughput methodologies and large cohorts has permitted the identification of many genes and genetic variants associated to congenital diseases. Nevertheless, we have not seen the expected breakthrough: causative genes only explain a small proportion of cases, and most identified variants are of unknown significance. Therefore, we need to develop novel bioinforamtics approaches for interrogating the vast amount of available genetic variation data.
Functional genomics of cardiovascular development and disease
Cardiovascular diseases encompass many diverse conditions with very dissimilar origins; e.g., congenital, environmental, or as a complication of diseases such as kidney failure or diabetes mellitus. Therefore the comprehension of the pathophysiology of diseases not only relies on the identification of the genetic causes and the influence of external factors, but also on the understanding of the molecular consequences caused by any anomaly. This highlights the necessity for approaches that permit modelling the systemic changes (from transcriptional variation to protein degradation) undergoing within the cell.
Transcriptional and translational response to stress
Yeast is a very useful model organism for studying basic global processes such as translational control and stress response. We have been collaborating extensively with the Pavitt, Grant, O'Keefe, Ashe, and Hubbard labs in the study of some of these processes.
Teaching
Co-Director of the MSc Bioinformatics and Systems Biology programme
Unit coordinator and lecturer on BIOL60791 Introduction to Bioinformatics
Lecturer on BIOL33011 MSci Bioinfromatics Tools and Resources
Lecturer on MRes Cardiovascular Health and Disease
Various roles on the MBChB programme
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research Beacons, Institutes and Platforms
- Digital Futures
- Christabel Pankhurst Institute
Fingerprint
Dive into the research topics where David Talavera is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Joint analysis of functionally related genes yields further candidates associated with Tetralogy of Fallot
Chelu, A., Williams, S., Keavney, B. D. & Talavera, D., 20 Jun 2022, In: Journal of Human Genetics.Research output: Contribution to journal › Article › peer-review
Open Access -
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
Eales, J., Jiang, X., Xu, X., Saluja, S., Akbarov, A., Cano-Gomez, E., McNulty, M. T., Finan, C., Guo, H., Wystrychowski, W., Szulinska, M., Thomas, H., Pramanik, S., Chopade, S., Prestes, P. R., Wise, I., Evangelou, E., Salehi, M., Shakanti, Y., Ekholm, M., & 30 others, 6 May 2021, In: Nature Genetics. 53, 5, p. 630–637 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile50 Downloads (Pure) -
Archetypal transcriptional blocks underpin yeast gene regulation in response to changes in growth conditions
Talavera, D., Kershaw, C., Costello, J. L., Castelli, L. M., Rowe, W., Sims, P. F. G., Ashe, M., Grant, C., Pavitt, G. D. & Hubbard, S., 2018, In: Scientific Reports. 8, 7949.Research output: Contribution to journal › Article › peer-review
Open Access -
Molecular insights into genome-wide association studies of chronic kidney disease-defining traits
Xu, X., Eales, J., Akbarov, A., Guo, H., Becker, L., Talavera, D., Ashraf, F., Nawaz, J., Pramanik, S., Bowes, J., Jiang, X., Dormer, J., Denniff, M., Antczak, A., Sszulinska, M., Wise, I., Prestes, P. R., Glyda, M., Bogdanski, P., Zukowska-Szczechowska, E., & 5 others, 22 Nov 2018, In: Nature Communications. 9, 1, 4800.Research output: Contribution to journal › Article › peer-review
Open Access -
Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses
Costello, J. L., Kershaw, C., Castelli, L. M., Talavera, D., Rowe, W., Sims, P. F. G., Ashe, M., Grant, C., Hubbard, S. & Pavitt, G. D., 27 Oct 2017, In: Genome biology. 18, 1, 201.Research output: Contribution to journal › Article › peer-review
Open Access
-
Modelling Human Genomic Variation Using Markov Random Fields: A Feasibility Study
1/11/22 → 30/06/23
Project: Research
-
BHF 4-Year PhD Studentship - University of Manchester (3rd Intake 2019 of 4th Scheme).
Cartwright, E., Abraham, S., Allan, S., Ashton, N., Ballestrem, C., Dibb, K., Dobrzynski, H., Eisner, D., Galli, G., Greenstein, A., Heagerty, A., Hentges, K., Herbert, S., Keavney, B., Kitmitto, A., Liu, W., Oceandy, D., Pinali, C., Pinteaux, E., Saiani, A., Shiels, H., Talavera, D., Tomaszewski, M., Trafford, A., Venetucci, L. & Wang, X.
1/10/19 → 30/09/23
Project: Research
-
BHF 4-Year PhD Studentship Award - University of Manchester (1st Intake 2017 of 4th Scheme).
Cartwright, E., Abraham, S., Allan, S., Ballestrem, C., Boyett, M., Canfield, A., Dibb, K., Dobrzynski, H., Eisner, D., Galli, G., Heagerty, A., Hentges, K., Herbert, S., Holt, C., Humphries, M., Keavney, B., Kitmitto, A., Liu, W., Miller, C., Oceandy, D., Parry-Jones, A., Saiani, A., Sherratt, M., Shiels, H., Talavera, D., Tomaszewski, M., Trafford, A., Venetucci, L., Wang, X. & Zhang, Y.
1/10/17 → 30/09/21
Project: Research
Datasets
-
Binding interface change and cryptic variation in the evolution of protein-protein interactions
Ames, R. (Contributor), Talavera, D. (Contributor), Williams, S. (Contributor), Robertson, D. (Contributor) & Lovell, S. (Contributor), figshare , 18 Feb 2016
DOI: 10.6084/m9.figshare.c.3618035.v1, https://figshare.com/collections/Binding_interface_change_and_cryptic_variation_in_the_evolution_of_protein-protein_interactions/3618035/1
Dataset
-
Dynamic changes in eIF4F-mRNA interactions revealed by global analyses of environmental stress responses
Costello, J. L. (Contributor), Kershaw, C. (Contributor), Castelli, L. M. (Contributor), Talavera, D. (Contributor), Rowe, W. (Contributor), Sims, P. F. G. (Contributor), Ashe, M. (Contributor), Grant, C. (Contributor), Hubbard, S. (Contributor) & Pavitt, G. (Contributor), figshare , 27 Oct 2017
DOI: 10.6084/m9.figshare.c.3915958.v1, https://figshare.com/collections/Dynamic_changes_in_eIF4F-mRNA_interactions_revealed_by_global_analyses_of_environmental_stress_responses/3915958/1
Dataset