David Talavera


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Personal profile


I am a Senior Lecturer in Genetics/Genomics at the Division of Cardiovascular Sciences. With a background in Biological Sciences, I have been doing Bioinformatics research since 2002. I focus on the identification and study of genes linked to diseases, especially in the cardiovascular system, recognising the potential for patient benefit that may result from novel computational approaches.

Research interests

My main research interest are 1) in understanding why some variation (either quantitative or qualitative) is tolerated whereas other variation is deleterious, and 2) in understanding the effects of combinations of variants.

Identification and interpretation of genetic variants linked to cardiovascular diseases

The use of high-throughput methodologies and large cohorts has permitted the identification of many genes and genetic variants associated to congenital diseases. Nevertheless, we have not seen the expected breakthrough: causative genes only explain a small proportion of cases, and most identified variants are of unknown significance. Therefore, we need to develop novel bioinformatics approaches for interrogating the vast amount of available genetic variation data.
Functional genomics of cardiovascular development and disease

Cardiovascular diseases encompass many diverse conditions with very dissimilar origins; e.g., congenital, environmental, or as a complication of diseases such as kidney failure or diabetes mellitus. Therefore the comprehension of the pathophysiology of diseases not only relies on the identification of the genetic causes and the influence of external factors, but also on the understanding of the molecular consequences caused by any anomaly. This highlights the necessity for approaches that permit modelling the systemic changes (from transcriptional variation to protein degradation) undergoing within the cell.

Transcriptional and translational response to stress

Yeast is a very useful model organism for studying basic global processes such as translational control and stress response. We have been collaborating extensively with the Pavitt, Grant, Ashe, and Hubbard labs in the study of some of these processes.


Co-Director of the MSc Bioinformatics and Systems Biology programme

Unit coordinator and lecturer on BIOL60791 Bioinformatics

Lecturer on BIOL33011 MSci Bioinfromatics Tools and Resources

Lecturer on MSc Cardiovascular Health and Disease (Research)

Tutor on BSc Biomedical Sciences

UG/PG project supervision

Various roles on the MBChB programme

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

UKRI Talent Peer Review College, UK Research and Innovation

1 Mar 2023 → …

Research Beacons, Institutes and Platforms

  • Digital Futures
  • Christabel Pankhurst Institute


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Collaborations and top research areas from the last five years

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