David Wedge

David Wedge, BA, PGCE, MSc, PhD

Prof

 https://orcid.org/0000-0002-7572-3196

Search results

  • 2020

    Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

    Rubanova, Y., Shi, R., Harrigan, C. F., Li, R., Wintersinger, J., Sahin, N., Deshwar, A. G., Dentro, S. C., Leshchiner, I., Gerstung, M., Jolly, C., Haase, K., Tarabichi, M., Wintersinger, J., Deshwar, A. G., Yu, K., Gonzalez, S., Rubanova, Y., Macintyre, G. & Adams, D. J. & 58 others, Anur, P., Beroukhim, R., Boutros, P. C., Bowtell, D. D., Campbell, P. J., Cao, S., Christie, E. L., Cmero, M., Cun, Y., Dawson, K. J., Demeulemeester, J., Donmez, N., Drews, R. M., Eils, R., Fan, Y., Fittall, M., Garsed, D. W., Getz, G., Ha, G., Imielinski, M., Jerman, L., Ji, Y., Kleinheinz, K., Lee, J., Lee-Six, H., Livitz, D. G., Malikic, S., Markowetz, F., Martincorena, I., Mitchell, T. J., Mustonen, V., Oesper, L., Peifer, M., Peto, M., Raphael, B. J., Rosebrock, D., Sahinalp, S. C., Salcedo, A., Schlesner, M., Schumacher, S., Sengupta, S., Shi, R., Shin, S. J., Spiro, O., Stein, L. D., Vázquez-García, I., Vembu, S., Wheeler, D. A., Yang, T.-P., Yao, X., Yuan, K., Zhu, H., Wang, W., Morris, Q., Spellman, P. T., Wedge, D. C., Van Loo, P. & Morris, Q., 1 Dec 2020, In: Nature Communications. 11, 1

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Reference bias in the Illumina Isaac aligner

    Cornish, A. J., Chubb, D., Frangou, A., Hoang, P. H., Kaiser, M., Wedge, D. C., Houlston, R. S. & Valencia, A., 21 May 2020, (E-pub ahead of print) In: Bioinformatics. 36, 17, p. 4671-4672

    Research output: Contribution to journal › Letter › peer-review

    Open Access

  • The evolutionary history of 2,658 cancers

    Gerstung, M., Jolly, C., Leshchiner, I., Dentro, S. C., Gonzalez, S., Rosebrock, D., Mitchell, T. J., Rubanova, Y., Anur, P., Yu, K., Tarabichi, M., Deshwar, A. G., Wintersinger, J., Kleinheinz, K., Vázquez-García, I., Haase, K., Jerman, L., Sengupta, S., Macintyre, G. & Malikic, S. & 94 others, Donmez, N., Livitz, D. G., Cmero, M., Demeulemeester, J., Schumacher, S., Fan, Y., Yao, X., Lee, J., Schlesner, M., Boutros, P. C., Bowtell, D. D., Zhu, H., Getz, G., Imielinski, M., Beroukhim, R., Sahinalp, S. C., Ji, Y., Peifer, M., Markowetz, F., Mustonen, V., Yuan, K., Wang, W., Morris, Q. D., Dentro, S. C., Leshchiner, I., Gerstung, M., Jolly, C., Haase, K., Tarabichi, M., Wintersinger, J., Deshwar, A. G., Yu, K., Gonzalez, S., Rubanova, Y., Macintyre, G., Adams, D. J., Anur, P., Beroukhim, R., Boutros, P. C., Bowtell, D. D., Campbell, P. J., Cao, S., Christie, E. L., Cmero, M., Cun, Y., Dawson, K. J., Donmez, N., Drews, R. M., Eils, R., Fan, Y., Fittall, M., Garsed, D. W., Getz, G., Ha, G., Imielinski, M., Jerman, L., Ji, Y., Kleinheinz, K., Lee, J., Lee-Six, H., Livitz, D. G., Malikic, S., Markowetz, F., Martincorena, I., Mitchell, T. J., Mustonen, V., Oesper, L., Peifer, M., Peto, M., Raphael, B. J., Rosebrock, D., Sahinalp, S. C., Salcedo, A., Schlesner, M., Schumacher, S., Sengupta, S., Shi, R., Shin, S. J., Spiro, O., Stein, L. D., Vázquez-García, I., Vembu, S., Wheeler, D. A., Yang, T.-P., Yao, X., Yuan, K., Zhu, H., Wang, W., Morris, Q. D., Spellman, P. T., Wedge, D. C., Van Loo, P., Spellman, P. T. & Wedge, D. C., 6 Feb 2020, In: Nature. 578, 7793, p. 122-128 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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    69 Downloads (Pure)

  • The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

    Zhu, B., Poeta, M. L., Costantini, M., Zhang, T., Shi, J., Sentinelli, S., Zhao, W., Pompeo, V., Cardelli, M., Alexandrov, B. S., Otlu, B., Hua, X., Jones, K., Brodie, S., Dabrowska, M. E., Toro, J. R., Yeager, M., Wang, M., Hicks, B. & Alexandrov, L. B. & 6 others, Brown, K. M., Wedge, D. C., Chanock, S., Fazio, V. M., Gallucci, M. & Landi, M. T., 18 Jun 2020, (E-pub ahead of print) In: Nature Communications. 11, 1

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2019

    Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis

    Petljak, M., Alexandrov, L. B., Brammeld, J. S., Price, S., Wedge, D. C., Grossmann, S., Dawson, K. J., Ju, Y. S., Iorio, F., Tubio, J. M. C., Koh, C. C., Georgakopoulos-Soares, I., Rodríguez-Martín, B., Otlu, B., O'Meara, S., Butler, A. P., Menzies, A., Bhosle, S. G., Raine, K. & Jones, D. R. & 15 others, Teague, J. W., Beal, K., Latimer, C., O'Neill, L., Zamora, J., Anderson, E., Patel, N., Maddison, M., Ng, B. L., Graham, J., Garnett, M. J., McDermott, U., Nik-Zainal, S., Campbell, P. J. & Stratton, M. R., 7 Mar 2019, In: Cell.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    132 Downloads (Pure)

  • Embryonal precursors of Wilms tumor

    Coorens, T. H. H., Treger, T. D., Al-Saadi, R., Moore, L., Tran, M. G. B., Mitchell, T. J., Tugnait, S., Thevanesan, C., Young, M. D., Oliver, T. R. W., Oostveen, M., Collord, G., Tarpey, P. S., Cagan, A., Hooks, Y., Brougham, M., Reynolds, B. C., Barone, G., Anderson, J. & Jorgensen, M. & 21 others, Burke, G. A. A., Visser, J., Nicholson, J. C., Smeulders, N., Mushtaq, I., Stewart, G. D., Campbell, P. J., Wedge, D. C., Martincorena, I., Rampling, D., Hook, L., Warren, A. Y., Coleman, N., Chowdhury, T., Sebire, N., Drost, J., Saeb-Parsy, K., Stratton, M. R., Straathof, K., Pritchard-Jones, K. & Behjati, S., 6 Dec 2019, In: Science.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genomic landscape and chronological reconstruction of driver events in multiple myeloma

    Maura, F., Bolli, N., Angelopoulos, N., Dawson, K. J., Leongamornlert, D., Martincorena, I., Mitchell, T. J., Fullam, A., Gonzalez, S., Szalat, R., Abascal, F., Rodriguez-Martin, B., Samur, M. K., Glodzik, D., Roncador, M., Fulciniti, M., Tai, Y. T., Minvielle, S., Magrangeas, F. & Moreau, P. & 8 others, Corradini, P., Anderson, K. C., Tubio, J. M. C., Wedge, D. C., Gerstung, M., Avet-Loiseau, H., Munshi, N. & Campbell, P. J., 2019, In: Nature Communications.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
    98 Downloads (Pure)

  • Profiling molecular regulators of recurrence in chemorefractory triple-negative breast cancers

    Hancock, B. A., Chen, Y.-H., Solzak, J. P., Ahmad, M. N., Wedge, D. C., Brinza, D., Scafe, C., Veitch, J., Gottimukkala, R., Short, W., Atale, R. V., Ivan, M., Badve, S. S., Schneider, B. P., Lu, X., Miller, K. D. & Radovich, M., 2019, In: Breast Cancer Research.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2018

    A unified haplotype-based method for accurate and comprehensive variant calling

    Cooke, D. P., Wedge, D. C. & Lunter, G., 29 Oct 2018

    Research output: Other contribution

  • Classification and personalized prognosis in myeloproliferative neoplasms

    Grinfeld, J., Nangalia, J., Baxter, E. J., Wedge, D. C., Angelopoulos, N., Cantrill, R., Godfrey, A. L., Papaemmanuil, E., Gundem, G., MacLean, C., Cook, J., O'Neil, L., O'Meara, S., Teague, J. W., Butler, A. P., Massie, C. E., Williams, N., Nice, F. L., Andersen, C. L. & Hasselbalch, H. C. & 7 others, Guglielmelli, P., McMullin, M. F., Vannucchi, A. M., Harrison, C. N., Gerstung, M., Green, A. R. & Campbell, P. J., 11 Oct 2018, In: New England Journal Of Medicine.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genomic patterns of progression in smoldering multiple myeloma

    Bolli, N., Maura, F., Minvielle, S., Gloznik, D., Szalat, R., Fullam, A., Martincorena, I., Dawson, K. J., Samur, M. K., Zamora, J., Tarpey, P., Davies, H., Fulciniti, M., Shammas, M. A., Tai, Y. T., Magrangeas, F., Moreau, P., Corradini, P., Anderson, K. & Alexandrov, L. & 4 others, Wedge, D. C., Avet-Loiseau, H., Campbell, P. & Munshi, N., 22 Aug 2018, In: Nature Communications.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Neutral tumor evolution?

    Tarabichi, M., Martincorena, I., Gerstung, M., Leroi, A. M., Markowetz, F., Spellman, P. T., Morris, Q. D., Lingjærde, O. C., Wedge, D. C. & Loo, P. V., 29 Dec 2018, In: Nature Genetics.

    Research output: Contribution to journal › Letter › peer-review

  • Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics

    Li, X., Francies, H. E., Secrier, M., Perner, J., Miremadi, A., Galeano-Dalmau, N., Barendt, W. J., Letchford, L., Leyden, G. M., Goffin, E. K., Barthorpe, A., Lightfoot, H., Chen, E., Gilbert, J., Noorani, A., Devonshire, G., Bower, L., Grantham, A., MacRae, S. & Grehan, N. & 3 others, Wedge, D. C., Fitzgerald, R. C. & Garnett, M. J., 2018, In: Nature Communications.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

    Wedge, D. C., Gundem, G., Mitchell, T., Woodcock, D. J., Martincorena, I., Ghori, M., Zamora, J., Butler, A., Whitaker, H., Kote-Jarai, Z., Alexandrov, L. B., Loo, P. V., Massie, C. E., Dentro, S., Warren, A. Y., Verrill, C., Berney, D. M., Dennis, N., Merson, S. & Hawkins, S. & 66 others, Howat, W., Lu, Y.-J., Lambert, A., Kay, J., Kremeyer, B., Karaszi, K., Luxton, H., Camacho, N., Marsden, L., Edwards, S., Matthews, L., Bo, V., Leongamornlert, D., McLaren, S., Ng, A., Yu, Y., Zhang, H., Dadaev, T., Thomas, S., Easton, D. F., Ahmed, M., Bancroft, E., Fisher, C., Livni, N., Nicol, D., Tavaré, S., Gill, P., Greenman, C., Khoo, V., As, N. V., Kumar, P., Ogden, C., Cahill, D., Thompson, A., Mayer, E., Rowe, E., Dudderidge, T., Gnanapragasam, V., Shah, N. C., Raine, K., Jones, D., Menzies, A., Stebbings, L., Teague, J., Hazell, S., Corbishley, C., Bono, J. D., Attard, G., Isaacs, W., Visakorpi, T., Fraser, M., Boutros, P. C., Bristow, R. G., Workman, P., Sander, C., Hamdy, F. C., Futreal, A., McDermott, U., Al-Lazikani, B., Lynch, A. G., Bova, G. S., Foster, C. S., Brewer, D. S., Neal, D. E., Cooper, C. S. & Eeles, R. A., May 2018, In: Nature Genetics. 50, 5, p. 682-692 11 p.

    Research output: Contribution to journal › Article › peer-review

  • The evolutionary landscape of colorectal tumorigenesis

    Cross, W., Kovac, M., Mustonen, V., Temko, D., Davis, H., Baker, A.-M., Biswas, S., Arnold, R., Chegwidden, L., Gatenbee, C., Anderson, A. R., Koelzer, V. H., Martinez, P., Jiang, X., Domingo, E., Woodcock, D. J., Feng, Y., Kovacova, M., Maughan, T. & Adams, R. & 51 others, Bach, S., Beggs, A., Brown, L., Buffa, F., Cazier, J.-B., Domingo, E., Blake, A., Wu, C.-H., Chatzpili, E., Richman, S., Dunne, P., Harkin, P., Higgins, G., Hill, J., Holmes, C., Horgan, D., Kaplan, R., Kennedy, R., Lawler, M., Leedham, S., Maughan, T., McDermott, U., McKenna, G., Middleton, G., Morton, D., Murray, G., Quirke, P., Salto-Tellez, M., Samuel, L., Schuh, A., Sebag-Montefiore, D., Seymour, M., Sharma, R., Sullivan, R., Tomlinson, I., West, N., Wilson, R., Jansen, M., Rodriguez-Justo, M., Ashraf, S., Guy, R., Cunningham, C., East, J. E., Wedge, D. C., Wang, L. M., Palles, C., Heinimann, K., Sottoriva, A., Leedham, S., Graham, T. A. & Tomlinson, I. P. M., 2018, In: Nature Ecology and Evolution.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Time series analysis of neoadjuvant chemotherapy and bevacizumab-treated breast carcinomas reveals a systemic shift in genomic aberrations

    Höglander, E. K., Nord, S., Wedge, D. C., Lingjærde, O. C., Silwal-Pandit, L., Gythfeldt, H. V., Vollan, H. K. M., Fleischer, T., Krohn, M., Schlitchting, E., Borgen, E., Garred, Ø., Holmen, M. M., Wist, E., Naume, B., Van Loo, P., Børresen-Dale, A.-L., Engebraaten, O. & Kristensen, V., 2018, In: Genome Medicine.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal

    Mitchell, T. J., Turajlic, S., Rowan, A., Nicol, D., Farmery, J. H. R., O'Brien, T., Martincorena, I., Tarpey, P., Angelopoulos, N., Yates, L. R., Butler, A., Raine, K., Stewart, G., Challacombe, B., Fernando, A., Lopez, J., Hazell, S., Chandra, A., Chowdhury, S. & Rudman, S. & 27 others, Soultati, A., Stamp, G., Fotiadis, N., Pickering, L., Au, L., Spain, L., Lynch, J., Stares, M., Teague, J., Maura, F., Wedge, D. C., Horswell, S., Chambers, T., Litchfield, K., Xu, H., Elaidi, R., Stewart, A., Oudard, S., McGranahan, N., Csabai, I., Gore, M., Futreal, P. A., Larkin, J., Lynch, A., Szallasi, Z., Swanton, C. & Campbell, P., 2018, In: Cell.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2017

    Appraising the relevance of DNA copy number loss and gain in prostate cancer using whole genome DNA sequence data

    Camacho, N., Van Loo, P., Edwards, S., Kay, J. D., Matthews, L., Haase, K., Clark, J., Dennis, N., Thomas, S., Kremeyer, B., Zamora, J., Butler, A. P., Gundem, G., Merson, S., Luxton, H., Hawkins, S., Ghori, M., Marsden, L., Lambert, A. & Karaszi, K. & 36 others, Pelvender, G., Massie, C. E., Kote-Jarai, Z. S., Raine, K., Jones, D., Howat, W. J., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Nicol, D., Mayer, E., Dudderidge, T., Yu, Y., Zhang, H., Shah, N. C., Gnanapragasam, V. J., Isaacs, W., Visakorpi, T., Hamdy, F., Berney, D., Verrill, C., Warren, A. Y., Wedge, D. C., Lynch, A. G., Foster, C. S., Lu, Y. J., Bova, G. S., Whitaker, H. C., McDermott, U., Neal, D. E., Eeles, R., Cooper, C. S. & Brewer, D. S., 2017, In: PLoS Genetics.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Genomic Evolution of Breast Cancer Metastasis and Relapse

    Yates, L. R., Knappskog, S., Wedge, D., Farmery, J. H. R., Gonzalez, S., Martincorena, I., Alexandrov, L. B., Van Loo, P., Haugland, H. K., Lilleng, P. K., Gundem, G., Gerstung, M., Pappaemmanuil, E., Gazinska, P., Bhosle, S. G., Jones, D., Raine, K., Mudie, L., Latimer, C. & Sawyer, E. & 10 others, Desmedt, C., Sotiriou, C., Stratton, M. R., Sieuwerts, A. M., Lynch, A. G., Martens, J. W., Richardson, A. L., Tutt, A., Lønning, P. E. & Campbell, P. J., 2017, In: Cancer Cell.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • How subclonal modeling is changing the metastatic paradigm

    Macintyre, G., Van Loo, P., Corcoran, N. M., Wedge, D. C., Markowetz, F. & Hovens, C. M., 2017, In: Clinical Cancer Research.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

    Cheng, J., Demeulemeester, J., Wedge, D. C., Vollan, H. K. M., Pitt, J. J., Russnes, H. G., Pandey, B. P., Nilsen, G., Nord, S., Bignell, G. R., White, K. P., Børresen-Dale, A.-L., Campbell, P. J., Kristensen, V. N., Stratton, M. R., Lingjærde, O. C., Moreau, Y. & Van Loo, P., 2017, In: Nature Communications.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Principles of Reconstructing the Subclonal Architecture of Cancers

    Dentro, S. C., Wedge, D. C. & Van Loo, P., 7 Mar 2017, In: Cold Spring Harbor Perspectives in Medicine.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

    Behjati, S., Tarpey, P. S., Haase, K., Ye, H., Young, M. D., Alexandrov, L. B., Farndon, S. J., Collord, G., Wedge, D. C., Martincorena, I., Cooke, S. L., Davies, H., Mifsud, W., Lidgren, M., Martin, S., Latimer, C., Maddison, M., Butler, A. P., Teague, J. W. & Pillay, N. & 13 others, Shlien, A., McDermott, U., Futreal, P. A., Baumhoer, D., Zaikova, O., Bjerkehagen, B., Myklebost, O., Amary, M. F., Tirabosco, R., Loo, P. V., Stratton, M. R., Flanagan, A. M. & Campbell, P. J., 23 Jun 2017, In: Nature Communications.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

    Ju, Y. S., Martincorena, I., Gerstung, M., Petljak, M., Alexandrov, L. B., Rahbari, R., Wedge, D. C., Davies, H. R., Ramakrishna, M., Fullam, A., Martin, S., Alder, C., Patel, N., Gamble, S., O'Meara, S., Giri, D. D., Sauer, T., Pinder, S. E., Purdie, C. A. & Borg, Å. & 21 others, Stunnenberg, H., Van De Vijver, M., Tan, B. K. T., Caldas, C., Tutt, A., Ueno, N. T., Van 'T Veer, L. J., Martens, J. W. M., Sotiriou, C., Knappskog, S., Span, P. N., Lakhani, S. R., Eyfjörd, J. E., Børresen-Dale, A.-L., Richardson, A., Thompson, A. M., Viari, A., Hurles, M. E., Nik-Zainal, S., Campbell, P. J. & Stratton, M. R., 2017, In: Nature.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2016

    ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.

    Raine, K., Van, L. P., Wedge, D., Jones, D., Menzies, A., Butler, A., Teague, J., Tarpey, P., Nik-Zainal, S. & Campbell, P., 8 Dec 2016, In: Current Protocols in Bioinformatics.

    Research output: Contribution to journal › Article › peer-review

  • Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.

    Shlien, A., Raine, K., Fuligni, F., Arnold, R., Nik-Zainal, S., Dronov, S., Mamanova, L., Rosic, A., Ju, Y., Cooke, S., Ramakrishna, M., Papaemmanuil, E., Davies, H., Tarpey, P., Van, L. P., Wedge, D., Jones, D., Martin, S., Marshall, J. & Anderson, E., 4 Aug 2016, In: Cell Reports.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Landscape of somatic mutations in 560 breast cancer whole-genome sequences

    Nik-Zainal, S., Davies, H., Staaf, J., Ramakrishna, M., Glodzik, D., Zou, X., Martincorena, I., Alexandrov, L. B., Martin, S., Wedge, D. C., Van Loo, P., Ju, Y. S., Smid, M., Brinkman, A. B., Morganella, S., Aure, M. R., Lingjærde, O. C., Langerød, A., Ringnér, M. & Ahn, S.-M. & 68 others, Boyault, S., Brock, J. E., Broeks, A., Butler, A., Desmedt, C., Dirix, L., Dronov, S., Fatima, A., Foekens, J. A., Gerstung, M., Hooijer, G. K. J., Jang, S. J., Jones, D. R., Kim, H.-Y., King, T. A., Krishnamurthy, S., Lee, H. J., Lee, J.-Y., Li, Y., McLaren, S., Menzies, A., Mustonen, V., O'Meara, S., Pauporté, I., Pivot, X., Purdie, C. A., Raine, K., Ramakrishnan, K., Rodríguez-González, F. G., Romieu, G., Sieuwerts, A. M., Simpson, P. T., Shepherd, R., Stebbings, L., Stefansson, O. A., Teague, J., Tommasi, S., Treilleux, I., Van Den Eynden, G. G., Vermeulen, P., Vincent-Salomon, A., Yates, L., Caldas, C., Veer, L. V., Tutt, A., Knappskog, S., Tan, B. K. T., Jonkers, J., Borg, Å., Ueno, N. T., Sotiriou, C., Viari, A., Futreal, P. A., Campbell, P. J., Span, P. N., Van Laere, S., Lakhani, S. R., Eyfjord, J. E., Thompson, A. M., Birney, E., Stunnenberg, H. G., Van De Vijver, M. J., Martens, J. W. M., Børresen-Dale, A.-L., Richardson, A. L., Kong, G., Thomas, G. & Stratton, M. R., 2 May 2016, In: Nature.

    Research output: Contribution to journal › Article › peer-review

  • Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

    Strakova, A., Leathlobhair, M. N., Wang, G.-D., Yin, T.-T., Airikkala-Otter, I., Allen, J. L., Allum, K. M., Bansse-Issa, L., Bisson, J. L., Domracheva, A. C., De Castro, K. F., Corrigan, A. M., Cran, H. R., Crawford, J. T., Cutter, S. M., Keenan, L. D., Donelan, E. M., Faramade, I. A., Reynoso, E. F. & Fotopoulou, E. & 41 others, Fruean, S. N., Gallardo-Arrieta, F., Glebova, O., Häfelin Manrique, R. F., Henriques, J. J. G. P., Ignatenko, N., Koenig, D., Lanza-Perea, M., Lobetti, R., Lopezquintana, A. M., Losfelt, T., Marino, G., Martincorena, I., Castañeda, S. M., Martínez-López, M. F., Meyer, M., Nakanwagi, B., De Nardi, A. B., Neunzig, W., Nixon, S. J., Onsare, M. M., Ortega-Pacheco, A., Peleteiro, M. C., Pye, R. J., Reece, J. F., Gutierrez, J. R., Sadia, H., Schmeling, S. K., Shamanova, O., Ssuna, R. K., Steenland-Smitsvitich, A. E., Ngoka, I. T., Vitǎlaru, B. A., De Vos, A. P., De Vos, J. P., Walkinton, O., Wedge, D. C., Wehrle-Martinez, A. S., Van Der Wel, M. G., Widdowson, S. A. & Murchison, E. P., 17 May 2016, In: eLife. 5

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Mutational signatures of ionizing radiation in second malignancies.

    Behjati, S., Gundem, G., Wedge, D., Roberts, N., Tarpey, P., Cooke, S., Van, L. P., Alexandrov, L., Ramakrishna, M., Davies, H., Nik-Zainal, S., Hardy, C., Latimer, C., Raine, K., Stebbings, L., Menzies, A., Jones, D., Shepherd, R., Butler, A. & Teague, J., 12 Sept 2016, In: Nature Communications. 7

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Perturbed hematopoietic stem and progenitor cell hierarchy in myelodysplastic syndromes patients with monosomy 7 as the sole cytogenetic abnormality.

    Dimitriou, M., Woll, P., Mortera-Blanco, T., Karimi, M., Wedge, D., Doolittle, H., Douagi, I., Papaemmanuil, E., Jacobsen, S. & Hellström-Lindberg, E., Nov 2016, In: Oncotarget.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution.

    Grove, C., Bolli, N., Manes, N., Varela, I., Van't, V. M., Bench, A., Eldaly, H., Wedge, D., Van, L. P. & Vassiliou, G., 7 Apr 2016, In: British Journal of Haematology.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • The Genomic Landscape of Pancreatic and Periampullary Adenocarcinoma.

    Sandhu, V., Wedge, D., Bowitz, L. I., Labori, K., Dentro, S., Buanes, T., Skrede, M., Dalsgaard, A., Munthe, E., Myklebost, O., Lingjærde, O. C., Børresen-Dale, A., Ikdahl, T., Van, L. P., Nord, S. & Kure, E., Sept 2016, In: Cancer Research.

    Research output: Contribution to journal › Article › peer-review

  • Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing.

    Demeulemeester, J., Kumar, P., Møller, E., Nord, S., Wedge, D., Peterson, A., Mathiesen, R., Fjelldal, R., Zamani, E. M., Theunis, K., Fernandez, G. E., Grundstad, A., Borgen, E., Baumbusch, L., Børresen-Dale, A., White, K., Kristensen, V., Van, L. P., Voet, T. & Naume, B., 9 Dec 2016, In: Genome biology.

    Research output: Contribution to journal › Article › peer-review

    Open Access
  • 2015

    Clock-like mutational processes in human somatic cells

    Alexandrov, L. B., Jones, P. H., Wedge, D. C., Sale, J. E., Campbell, P. J., Nik-Zainal, S. & Stratton, M. R., Nov 2015, In: Nature Genetics. 47, p. 1402-1407 6 p.

    Research output: Contribution to journal › Article › peer-review

  • Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

    Biallelic Mismatch Repair Deficiency Consortium, Mar 2015, In: Nature Genetics. 47, 3, p. 257-262 6 p.

    Research output: Contribution to journal › Article › peer-review

  • Concomitant inactivation of the p53- and pRB- functional pathways predicts resistance to DNA damaging drugs in breast cancer in vivo

    Knappskog, S., Berge, E. O., Chrisanthar, R., Geisler, S., Staalesen, V., Leirvaag, B., Yndestad, S., de Faveri, E., Karlsen, B. O., Wedge, D. C., Akslen, L. A., Lilleng, P. K., Løkkevik, E., Lundgren, S., Østenstad, B., Risberg, T., Mjaaland, I., Aas, T. & Lønning, P. E., Oct 2015, In: Molecular Oncology. 9, 8, p. 1553-1564 12 p.

    Research output: Contribution to journal › Article › peer-review

  • Corrigendum: Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue (Nature Genetics (2015) 47 (367-372))

    Cooper, C. S., Eeles, R., Wedge, D. C., Van Loo, P., Gundem, G., Alexandrov, L. B., Kremeyer, B., Butler, A., Lynch, A. G., Camacho, N., Massie, C. E., Kay, J., Luxton, H. J., Edwards, S., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D., Zamora, J. & Corbishley, C. & 52 others, Thomas, S., Nik-Zainal, S., Ramakrishna, M., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen, R., Bristow, R. G., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., McLaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C., Nicol, D., Mayer, E., Dudderidge, T., Shah, N. C., Gnanapragasam, V., Voet, T., Campbell, P., Futreal, A., Easton, D., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., McDermott, U., Brewer, D. S. & Neal, D. E., 27 May 2015, In: Nature Genetics. 47, 6, p. 689 1 p.

    Research output: Contribution to journal › Commentary/debate

  • Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast-rich mimics.

    Presneau, N., Baumhoer, D., Behjati, S., Pillay, N., Tarpey, P., Campbell, P., Jundt, G., Hamoudi, R., Wedge, D., Loo, P., Hassan, A., Khatri, B., Ye, H., Tirabosco, R., Amary, M. & Flanagan, A., Apr 2015, In: The Journal of Pathology: Clinical Research. 1, p. 113-123

    Research output: Contribution to journal › Article › peer-review

  • DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype

    Nangalia, J., Nice, F. L., Wedge, D. C., Godfrey, A. L., Grinfeld, J., Thakker, C., Massie, C. E., Baxter, J., Sewell, D., Silber, Y., Campbell, P. J. & Green, A. R., Nov 2015, In: Haematologica. 100, 11, p. 438-442 5 p.

    Research output: Contribution to journal › Article › peer-review

  • Effect of mutation order on myeloproliferative neoplasms

    Ortmann, C. A., Kent, D. G., Nangalia, J., Silber, Y., Wedge, D. C., Grinfeld, J., Baxter, E. J., Massie, C. E., Papaemmanuil, E., Menon, S., Godfrey, A. L., Dimitropoulou, D., Guglielmelli, P., Bellosillo, B., Besses, C., Döhner, K., Harrison, C. N., Vassiliou, G. S., Vannucchi, A. & Campbell, P. J. & 1 others, Green, A. R., 12 Feb 2015, In: New England Journal Of Medicine. 372, 7, p. 601-612 12 p.

    Research output: Contribution to journal › Article › peer-review

  • Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

    Ju, Y., Tubio, J., Mifsud, W., Fu, B., Davies, H., Ramakrishna, M., Li, Y., Yates, L., Gundem, G., Tarpey, P., Behjati, S., Papaemmanuil, E., Martin, S., Fullam, A., Gerstung, M., Group, I. P. C. W., Group, I. B. C. W., Group, I. B. C. W., Nangalia, J. & Green, A. & 1 others, Wedge, D., May 2015, In: Genome research. 25, p. 814-824

    Research output: Contribution to journal › Article › peer-review

  • High burden and pervasive positive selection of somatic mutations in normal human skin

    Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., Stebbings, L., Menzies, A., Widaa, S., Stratton, M. R., Jones, P. H. & Campbell, P. J., 22 May 2015, In: Science. 348, 6237, p. 880-886 7 p.

    Research output: Contribution to journal › Article › peer-review

  • Subclonal diversification of primary breast cancer revealed by multiregion sequencing

    Yates, L. R., Gerstung, M., Knappskog, S., Desmedt, C., Gundem, G., Van Loo, P., Aas, T., Alexandrov, L. B., Larsimont, D., Davies, H., Li, Y., Ju, Y. S., Ramakrishna, M., Haugland, H. K., Lilleng, P. K., Nik-Zainal, S., McLaren, S., Butler, A., Martin, S. & Glodzik, D. & 18 others, Menzies, A., Raine, K., Hinton, J., Jones, D., Mudie, L. J., Jiang, B., Vincent, D., Greene-Colozzi, A., Adnet, P.-Y., Fatima, A., Maetens, M., Ignatiadis, M., Stratton, M. R., Sotiriou, C., Richardson, A. L., Lønning, P. E., Wedge, D. C. & Campbell, P. J., 9 Jul 2015, In: Nature Medicine. 21, 7, p. 751-759 9 p.

    Research output: Contribution to journal › Article › peer-review

  • The evolutionary history of lethal metastatic prostate cancer

    Gundem, G., Van Loo, P., Kremeyer, B., Alexandrov, L. B., Tubio, J. M. C., Papaemmanuil, E., Brewer, D. S., Kallio, H. M. L., Högnäs, G., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O'Meara, S., Dawson, K. J., Isaacs, W., Emmert-Buck, M. R., Nykter, M., Foster, C. & Kote-Jarai, Z. & 10 others, Easton, D., Whitaker, H. C., Neal, D. E., Cooper, C. S., Eeles, R. A., Visakorpi, T., Campbell, P. J., McDermott, U., Wedge, D. C. & Bova, G. S., 1 Apr 2015, In: Nature. 520, 7547, p. 353-357 5 p.

    Research output: Contribution to journal › Article › peer-review

  • Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer

    Hong, M. K. H., Macintyre, G., Wedge, D. C., Van Loo, P., Patel, K., Lunke, S., Alexandrov, L. B., Sloggett, C., Cmero, M., Marass, F., Tsui, D., Mangiola, S., Lonie, A., Naeem, H., Sapre, N., Phal, P. M., Kurganovs, N., Chin, X., Kerger, M. & Warren, A. Y. & 9 others, Neal, D., Gnanapragasam, V., Rosenfeld, N., Pedersen, J. S., Ryan, A., Haviv, I., Costello, A. J., Corcoran, N. M. & Hovens, C. M., 1 Apr 2015, In: Nature Communications. 6, 6605.

    Research output: Contribution to journal › Article › peer-review

  • Untargeted metabolic profiling identifies altered serum metabolites of type 2 diabetes mellitus in a prospective, nested case control study

    Drogan, D., Dunn, W. B., Lin, W., Buijsse, B., Schulze, M. B., Langenberg, C., Brown, M., Floegel, A., Dietrich, S., Rolandsson, O., Wedge, D. C., Goodacre, R., Forouhi, N. G., Sharp, S. J., Spranger, J., Wareham, N. J. & Boeing, H., 1 Mar 2015, In: Clinical Chemistry. 61, 3, p. 487-497 11 p.

    Research output: Contribution to journal › Article › peer-review

  • 2014

    A comparison of different chemometrics approaches for the robust classification of electronic nose data.

    Gromski, P. S., Correa, E., Vaughan, A. A., Wedge, D. C., Turner, M. L. & Goodacre, R., 2014, In: Analytical and bioanalytical chemistry. 406, 29, p. 7581-7590 10 p.

    Research output: Contribution to journal › Article › peer-review

  • Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer

    Nik-Zainal, S., Wedge, D. C., Alexandrov, L. B., Petljak, M., Butler, A. P., Bolli, N., Davies, H. R., Knappskog, S., Martin, S., Papaemmanuil, E., Ramakrishna, M., Shlien, A., Simonic, I., Xue, Y., Tyler-Smith, C., Campbell, P. J. & Stratton, M. R., 13 Apr 2014, In: Nature Genetics. 46, p. 487-491 5 p.

    Research output: Contribution to journal › Article › peer-review

  • Differential and limited expression of mutant alleles in multiple myeloma

    Rashid, N. U., Sperling, A. S., Bolli, N., Wedge, D. C., Van Loo, P., Tai, Y.-T., Shammas, M. A., Fulciniti, M., Samur, M. K., Richardson, P. G., Magrangeas, F., Minvielle, S., Futreal, P. A., Anderson, K. C., Avet-Loiseau, H., Campbell, P. J., Parmigiani, G. & Munshi, N. C., Nov 2014, In: Blood. 124, 20, p. 3110-3117 8 p.

    Research output: Contribution to journal › Article › peer-review

  • Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

    ICGC Breast Cancer Group, 1 Aug 2014, In: Science. 345, 6196, 1251343.

    Research output: Contribution to journal › Article › peer-review