David Wedge

2014

Fast randomization of large genomic datasets while preserving alteration counts

Gobbi, A., Iorio, F., Dawson, K. J., Wedge, D. C., Tamborero, D., Alexandrov, L. B., Lopez-Bigas, N., Garnett, M. J., Jurman, G. & Saez-Rodriguez, J., 1 Sept 2014, In: Bioinformatics. 30, 17, p. i617-i623 7 p.

Research output: Contribution to journal › Conference article › peer-review

Genome sequencing of normal cells reveals developmental lineages and mutational processes

Behjati, S., Huch, M., Van Boxtel, R., Karthaus, W., Wedge, D. C., Tamuri, A. U., Martincorena, I., Petljak, M., Alexandrov, L. B., Gundem, G., Tarpey, P. S., Roerink, S., Blokker, J., Maddison, M., Mudie, L., Robinson, B., Nik-Zainal, S., Campbell, P., Goldman, N. & Van De Wetering, M. & 3 others, Cuppen, E., Clevers, H. & Stratton, M. R., 29 Jun 2014, In: Nature. 513, p. 422-425 4 p.

Research output: Contribution to journal › Article › peer-review

Heterogeneity of genomic evolution and mutational profiles in multiple myeloma

Bolli, N., Avet-Loiseau, H., Wedge, D. C., Van Loo, P., Alexandrov, L. B., Martincorena, I., Dawson, K. J., Iorio, F., Nik-Zainal, S., Bignell, G. R., Hinton, J. W., Li, Y., Tubio, J. M. C., McLaren, S., O'Meara, S., Butler, A. P., Teague, J. W., Mudie, L., Anderson, E. & Rashid, N. & 15 others, Tai, Y.-T., Shammas, M. A., Sperling, A. S., Fulciniti, M., Richardson, P. G., Parmigiani, G., Magrangeas, F., Minvielle, S., Moreau, P., Attal, M., Facon, T., Futreal, P. A., Anderson, K. C., Campbell, P. J. & Munshi, N. C., 16 Jan 2014, In: Nature Communications. 5, 2997.

Research output: Contribution to journal › Article › peer-review

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

Zhang, J., Fujimoto, J., Zhang, J., Wedge, D. C., Song, X., Zhang, J., Seth, S., Chow, C.-W., Cao, Y., Gumbs, C., Gold, K. A., Kalhor, N., Little, L., Mahadeshwar, H., Moran, C., Protopopov, A., Sun, H., Tang, J., Wu, X. & Ye, Y. & 7 others, William, W. N., Lee, J. J., Heymach, J. V., Hong, W. K., Swisher, S., Wistuba, I. I. & Futreal, P. A., 10 Oct 2014, In: Science. 346, 6206, p. 256-259 4 p.

Research output: Contribution to journal › Article › peer-review

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

Woll, P. S., Kjällquist, U., Chowdhury, O., Doolittle, H., Wedge, D. C., Thongjuea, S., Erlandsson, R., Ngara, M., Anderson, K., Deng, Q., Mead, A. J., Stenson, L., Giustacchini, A., Duarte, S., Giannoulatou, E., Taylor, S., Karimi, M., Scharenberg, C., Mortera-Blanco, T. & Macaulay, I. C. & 28 others, Clark, S.-A., Dybedal, I., Josefsen, D., Fenaux, P., Hokland, P., Holm, M. S., Cazzola, M., Malcovati, L., Tauro, S., Bowen, D., Boultwood, J., Pellagatti, A., Pimanda, J. E., Unnikrishnan, A., Vyas, P., Göhring, G., Schlegelberger, B., Tobiasson, M., Kvalheim, G., Constantinescu, S. N., Nerlov, C., Nilsson, L., Campbell, P. J., Sandberg, R., Papaemmanuil, E., Hellström-Lindberg, E., Linnarsson, S. & Jacobsen, S. E. W., 16 Jun 2014, In: Cancer Cell. 25, 6, p. 794-808 15 p.

Research output: Contribution to journal › Article › peer-review

Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649)

Knappskog, S., Gansmo, L. B., Dibirova, K., Metspalu, A., Cybulski, C., Peterlongo, P., Aaltonen, L., Vatten, L., Romundstad, P., Hveem, K., Devilee, P., Evans, G. D., Lin, D., Van Camp, G. V., Manolopoulos, V. G., Osorio, A., Milani, L., Ozcelik, T., Zalloua, P. & Mouzaya, F. & 17 others, Bliznetz, E., Balanovska, E., Pocheshkova, E., Kucinskas, V., Atramentova, L., Nymadawa, P., Titov, K., Lavryashina, M., Yusupov, Y., Bogdanova, N., Koshel, S., Zamora, J., Wedge, D. C., Charlesworth, D., Dörk, T., Balanovsky, O. & Lønning, P. E., Sept 2014, In: Oncotarget. 5, 18, p. 8223-8234 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

Papaemmanuil, E., Rapado, I., Li, Y., Potter, N. E., Wedge, D. C., Tubio, J., Alexandrov, L. B., Van Loo, P., Cooke, S. L., Marshall, J., Martincorena, I., Hinton, J., Gundem, G., Van Delft, F. W., Nik-Zainal, S., Jones, D. R., Ramakrishna, M., Titley, I., Stebbings, L. & Leroy, C. & 17 others, Menzies, A., Gamble, J., Robinson, B., Mudie, L., Raine, K., O'meara, S., Teague, J. W., Butler, A. P., Cazzaniga, G., Biondi, A., Zuna, J., Kempski, H., Muschen, M., Ford, A. M., Stratton, M. R., Greaves, M. & Campbell, P. J., 12 Jan 2014, In: Nature Genetics. 46, p. 116-125 10 p.

Research output: Contribution to journal › Article › peer-review

Recurrent PTPRB and PLCG1 mutations in angiosarcoma

Behjati, S., Tarpey, P. S., Sheldon, H., Martincorena, I., Van Loo, P., Gundem, G., Wedge, D. C., Ramakrishna, M., Cooke, S. L., Pillay, N., Vollan, H. K. M., Papaemmanuil, E., Koss, H., Bunney, T. D., Hardy, C., Joseph, O. R., Martin, S., Mudie, L., Butler, A. & Teague, J. W. & 30 others, Patil, M., Steers, G., Cao, Y., Gumbs, C., Ingram, D., Lazar, A. J., Little, L., Mahadeshwar, H., Protopopov, A., Al Sannaa, G. A., Seth, S., Song, X., Tang, J., Zhang, J., Ravi, V., Torres, K. E., Khatri, B., Halai, D., Roxanis, I., Baumhoer, D., Tirabosco, R., Amary, M. F., Boshoff, C., McDermott, U., Katan, M., Stratton, M. R., Futreal, P. A., Flanagan, A. M., Harris, A. & Campbell, P. J., 16 Mar 2014, In: Nature Genetics. 46, 4, p. 376-379 4 p.

Research output: Contribution to journal › Article › peer-review

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

de Bruin, E. C., McGranahan, N., Mitter, R., Salm, M., Wedge, D. C., Yates, L., Jamal-Hanjani, M., Shafi, S., Murugaesu, N., Rowan, A. J., Grönroos, E., Muhammad, M. A., Horswell, S., Gerlinger, M., Varela, I., Jones, D., Marshall, J., Voet, T., Van Loo, P. & Rassl, D. M. & 23 others, Rintoul, R. C., Janes, S. M., Lee, S.-M., Forster, M., Ahmad, T., Lawrence, D., Falzon, M., Capitanio, A., Harkins, T. T., Lee, C. C., Tom, W., Teefe, E., Chen, S.-C., Begum, S., Rabinowitz, A., Phillimore, B., Spencer-Dene, B., Stamp, G., Szallasi, Z., Matthews, N., Stewart, A., Campbell, P. & Swanton, C., 10 Oct 2014, In: Science. 346, 6206, p. 251-256 6 p.

Research output: Contribution to journal › Article › peer-review

Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage

Murchison, E. P., Wedge, D. C., Alexandrov, L. B., Fu, B., Martincorena, I., Ning, Z., Tubio, J. M. C., Werner, E. I., Allen, J., De Nardi, A. B., Donelan, E. M., Marino, G., Fassati, A., Campbell, P. J., Yang, F., Burt, A., Weiss, R. A. & Stratton, M. R., 24 Jan 2014, In: Science. 343, 6169, p. 437-440 4 p.

Research output: Contribution to journal › Article › peer-review

2013

A comparison of Raman and FT-IR spectroscopy for the prediction of meat spoilage

Argyri, A. A., Jarvis, R. M., Wedge, D., Xu, Y., Panagou, E. Z., Goodacre, R. & Nychas, G. J. E., Feb 2013, In: Food Control. 29, 2, p. 461-470 10 p.

Research output: Contribution to journal › Article › peer-review

Clinical and biological implications of driver mutations in myelodysplastic syndromes

Papaemmanuil, E., Gerstung, M., Malcovati, L., Tauro, S., Gundem, G., Van Loo, P., Yoon, C. J., Ellis, P., Wedge, D. C., Pellagatti, A., Shlien, A., Groves, M. J., Forbes, S. A., Raine, K., Hinton, J., Mudie, L. J., McLaren, S., Hardy, C., Latimer, C. & Della Porta, M. G. & 18 others, O'Meara, S., Ambaglio, I., Galli, A., Butler, A. P., Walldin, G., Teague, J. W., Quek, L., Sternberg, A., Gambacorti-Passerini, C., Cross, N. C. P., Green, A. R., Boultwood, J., Vyas, P., Hellstrom-Lindberg, E., Bowen, D., Cazzola, M., Stratton, M. R. & Campbell, P. J., 21 Nov 2013, In: Blood. 122, 22, p. 3616-3627 12 p.

Research output: Contribution to journal › Article › peer-review

Deciphering Signatures of Mutational Processes Operative in Human Cancer

Alexandrov, L., Nik-Zainal, S., Wedge, D., Campbell, P. & Stratton, M. R., 10 Jan 2013, In: Cell Reports. 3, 1, p. 246-259 14 p.

Research output: Contribution to journal › Article › peer-review

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

Behjati, S., Tarpey, P. S., Presneau, N., Scheipl, S., Pillay, N., Van Loo, P., Wedge, D. C., Cooke, S. L., Gundem, G., Davies, H., Nik-Zainal, S., Martin, S., McLaren, S., Goodie, V., Robinson, B., Butler, A., Teague, J. W., Halai, D., Khatri, B. & Myklebost, O. & 9 others, Baumhoer, D., Jundt, G., Hamoudi, R., Tirabosco, R., Amary, M. F., Futreal, P. A., Stratton, M. R., Campbell, P. J. & Flanagan, A. M., 27 Oct 2013, In: Nature Genetics. 45, 12, p. 1479-1482 4 p.

Research output: Contribution to journal › Article › peer-review

Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma

Tarpey, P. S., Behjati, S., Cooke, S. L., Van Loo, P., Wedge, D. C., Pillay, N., Marshall, J., Meara, S. O., Davies, H., Zainal, S. N., Beare, D., Butler, A., Gamble, J., Hardy, C., Hinton, J., Jia, M. M., Jayakumar, A., Jones, D., Latimer, C. & Maddison, M. & 14 others, Martin, S., McLaren, S., Menzies, A., Mudie, L., Raine, K., Teague, J. W., Tubio, J. M. C., Halai, D., Tirabosco, R., Amary, F., Campbell, P. J., Stratton, M. R., Flanagan, A. M. & Futreal, P. A., 16 Jun 2013, In: Nature Genetics. 45, p. 923-926 4 p.

Research output: Contribution to journal › Article › peer-review

Signatures of mutational processes in human cancer

ICGC Consortium, 14 Aug 2013, In: Nature. 500, 7463, p. 415-421 7 p.

Research output: Contribution to journal › Article › peer-review

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2

Nangalia, J., Massie, C. E., Baxter, E. J., Nice, F. L., Gundem, G., Wedge, D. C., Avezov, E., Li, J., Kollmann, K., Kent, D. G., Aziz, A., Godfrey, A. L., Hinton, J., Martincorena, I., Van Loo, P., Jones, A. V., Guglielmelli, P., Tarpey, P., Harding, H. P. & Fitzpatrick, J. D. & 32 others, Goudie, C. T., Ortmann, C. A., Loughran, S. J., Raine, K., Jones, D. R., Butler, A. P., Teague, J. W., O'Meara, S., McLaren, S., Bianchi, M., Silber, Y., Dimitropoulou, D., Bloxham, D., Mudie, L., Maddison, M., Robinson, B., Keohane, C., Maclean, C., Hill, K., Orchard, K., Tauro, S., Du, M.-Q., Greaves, M., Bowen, D., Huntly, B. J. P., Harrison, C. N., Cross, N. C. P., Ron, D., Vannucchi, A. M., Papaemmanuil, E., Campbell, P. J. & Green, A. R., 19 Dec 2013, In: New England Journal Of Medicine. 369, 25, p. 2391-2405 15 p.

Research output: Contribution to journal › Article › peer-review

The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models

Yen, J., White, R. M., Wedge, D. C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I. R., Wu, C.-J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P. & Shlien, A. & 20 others, Whitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O'Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D. J., Zon, L. I., Patton, E. E., Stemple, D. L. & Futreal, P. A., 10 Dec 2013, In: Genome biology. 14, 10, R113.

Research output: Contribution to journal › Article › peer-review

Whole exome sequencing of adenoid cystic carcinoma

Stephens, P. J., Davies, H. R., Mitani, Y., Van Loo, P., Shlien, A., Tarpey, P. S., Papaemmanuil, E., Cheverton, A., Bignell, G. R., Butler, A. P., Gamble, J., Gamble, S., Hardy, C., Hinton, J., Jia, M., Jayakumar, A., Jones, D., Latimer, C., McLaren, S. & McBride, D. J. & 16 others, Menzies, A., Mudie, L., Maddison, M., Raine, K., Nik-Zainal, S., O'Meara, S., Teague, J. W., Varela, I., Wedge, D. C., Whitmore, I., Lippman, S. M., McDermott, U., Stratton, M. R., Campbell, P. J., El-Naggar, A. K. & Futreal, P. A., Jul 2013, In: Journal of Clinical Investigation. 123, 7, p. 2965-2968 4 p.

Research output: Contribution to journal › Article › peer-review

2012

Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer

Murchison, E. P., Schulz-Trieglaff, O. B., Ning, Z., Alexandrov, L. B., Bauer, M. J., Fu, B., Hims, M., Ding, Z., Ivakhno, S., Stewart, C., Ng, B. L., Wong, W., Aken, B., White, S., Alsop, A., Becq, J., Bignell, G. R., Cheetham, R. K., Cheng, W. & Connor, T. R. & 36 others, Cox, A. J., Feng, Z.-P., Gu, Y., Grocock, R. J., Harris, S. R., Khrebtukova, I., Kingsbury, Z., Kowarsky, M., Kreiss, A., Luo, S., Marshall, J., McBride, D. J., Murray, L., Pearse, A.-M., Raine, K., Rasolonjatovo, I., Shaw, R., Tedder, P., Tregidgo, C., Vilella, A. J., Wedge, D. C., Woods, G. M., Gormley, N., Humphray, S., Schroth, G., Smith, G., Hall, K., Searle, S. M. J., Carter, N. P., Papenfuss, A. T., Futreal, P. A., Campbell, P. J., Yang, F., Bentley, D. R., Evers, D. J. & Stratton, M. R., 17 Feb 2012, In: Cell. 148, 4, p. 780-791 12 p.

Research output: Contribution to journal › Article › peer-review

Liquid chromatography-mass spectrometry calibration transfer and metabolomics data fusion

Vaughan, A. A., Dunn, W. B., Allwood, J. W., Wedge, D., Blackhall, F. H., Whetton, A. D., Dive, C. & Goodacre, R., 20 Nov 2012, In: Analytical Chemistry. 84, 22, p. 9848-9857 9 p.

Research output: Contribution to journal › Article › peer-review

Mutational processes molding the genomes of 21 breast cancers

Breast Cancer Working Group of the International Cancer Genome Consortium, 25 May 2012, In: Cell. 149, 5, p. 979-993 15 p.

Research output: Contribution to journal › Article › peer-review

Tandem duplication of chromosomal segments is common in ovarian and breast cancer genomes

McBride, D. J., Etemadmoghadam, D., Cooke, S. L., Alsop, K., George, J., Butler, A., Cho, J., Galappaththige, D., Greenman, C., Howarth, K. D., Lau, K. W., Ng, C. K., Raine, K., Teague, J., Wedge, D. C., Cancer Study Group, A. O., Caubit, X., Stratton, M. R., Brenton, J. D. & Campbell, P. J. & 2 others, Futreal, P. A. & Bowtell, D. D. L., 12 Jun 2012, In: Journal of Pathology. 227, 4, p. 446-455 10 p.

Research output: Contribution to journal › Article › peer-review

The landscape of cancer genes and mutational processes in breast cancer

Oslo Breast Cancer Consortium (OSBREAC), 16 May 2012, In: Nature. 486, 7403, p. 400-404 5 p.

Research output: Contribution to journal › Article › peer-review

The life history of 21 breast cancers

Nik-Zainal, S., Van Loo, P., Wedge, D. C., Alexandrov, L. B., Greenman, C. D., Lau, K. W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M., Shlien, A., Cooke, S. L., Hinton, J., Menzies, A., Stebbings, L. A., Leroy, C., Jia, M., Rance, R., Mudie, L. J. & Gamble, S. J. & 29 others, Stephens, P. J., McLaren, S., Tarpey, P. S., Papaemmanuil, E., Davies, H. R., Varela, I., McBride, D. J., Bignell, G. R., Leung, K., Butler, A. P., Teague, J. W., Martin, S., Jönsson, G., Mariani, O., Boyault, S., Miron, P., Fatima, A., Langerod, A., Aparicio, S. A. J. R., Tutt, A., Sieuwerts, A. M., Borg, Å., Thomas, G., Salomon, A. V., Richardson, A. L., Borresen-Dale, A.-L., Futreal, P. A., Stratton, M. R. & Campbell, P. J., 25 May 2012, In: Cell. 149, 5, p. 994-1007 14 p.

Research output: Contribution to journal › Article › peer-review

2011

Automated workflows for accurate mass-based putative metabolite identification in LC/MS-derived metabolomic datasets

Brown, M., Wedge, D. C., Goodacre, R., Kell, D. B., Baker, P. N., Kenny, L. C., Mamas, M. A., Neyses, L. & Dunn, W. B., Apr 2011, In: Bioinformatics. 27, 8, p. 1108-1112 5 p., btr079.

Research output: Contribution to journal › Article › peer-review

Open Access

CONSeQuence: Prediction of reference peptides for absolute quantitative proteomics using consensus machine learning approaches

Eyers, C. E., Lawless, C., Wedge, D. C., Lau, K. W., Gaskell, S. J. & Hubbard, S. J., Nov 2011, In: Molecular and Cellular Proteomics. 10, 11, M110.003384.

Research output: Contribution to journal › Article › peer-review

FDRAnalysis: A tool for the integrated analysis of tandem mass spectrometry identification results from multiple search engines

Wedge, D. C., Krishna, R., Blackhurst, P., Siepen, J. A., Jones, A. R. & Hubbard, S. J., 1 Apr 2011, In: Journal of Proteome Research. 10, 4, p. 2088-2094 6 p.

Research output: Contribution to journal › Article › peer-review

Is serum or plasma more appropriate for intersubject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer

Wedge, D. C., Allwood, J. W., Dunn, W., Vaughan, A. A., Simpson, K., Brown, M., Priest, L., Blackhall, F. H., Whetton, A. D., Dive, C. & Goodacre, R., 1 Sept 2011, In: Analytical Chemistry. 83, 17, p. 6689-6697 8 p.

Research output: Contribution to journal › Article › peer-review

2010

Analysis of a complete DNA - protein affinity landscape

Rowe, W., Platt, M., Wedge, D. C., Day, P. J., Kell, D. B. & Knowles, J., 6 Mar 2010, In: Journal of the Royal Society Interface. 7, 44, p. 397-408 11 p.

Research output: Contribution to journal › Article › peer-review

Convergent evolution to an aptamer observed in small populations on DNA microarrays

Rowe, W., Platt, M., Wedge, D. C., Day, P. J. R., Kell, D. B. & Knowles, J. D., Sept 2010, In: Physical Biology. 7, 3, 036007.

Research output: Contribution to journal › Article › peer-review

Fabrication of planar organic nanotransistors using low temperature thermal nanoimprint lithography for chemical sensor applications

Kettle, J., Whitelegg, S., Song, A. M., Wedge, D. C., Kotacka, L., Kolarik, V., Madec, M. B., Yeates, S. G. & Turner, M. L., 2010, In: Nanotechnology. 21, 7, 075301.

Research output: Contribution to journal › Article › peer-review

Predictive models for population performance on real biological fitness landscapes

Rowe, W., Wedge, D. C., Platt, M., Kell, D. B. & Knowles, J., 17 Jul 2010, In: Bioinformatics. 26, 17, p. 2145-2152 7 p., btq353.

Research output: Contribution to journal › Article › peer-review

2009

Aptamer evolution for array-based diagnostics

Platt, M., Rowe, W., Wedge, D. C., Kell, D. B., Knowles, J. & Day, P. J. R., 15 Jul 2009, In: Analytical Biochemistry. 390, 2, p. 203-205 2 p.

Research output: Contribution to journal › Article › peer-review

Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscape

Knight, C. G., Platt, M., Rowe, W., Wedge, D. C., Khan, F., Day, P. J. R., Mcshea, A., Knowles, J. & Kell, D. B., 2009, In: Nucleic acids research.. 37, 1, e6.

Research output: Contribution to journal › Article › peer-review

In silico modelling of directed evolution: Implications for experimental design and stepwise evolution

Wedge, D. C., Rowe, W., Kell, D. B. & Knowles, J., 7 Mar 2009, In: Journal of Theoretical Biology. 257, 1, p. 131-141 10 p.

Research output: Contribution to journal › Article › peer-review

Low cost, portable, fast multiparameter data acquisition system for organic transistor odour sensors

Das, A., Dost, R., Richardson, T. H., Grell, M., Wedge, D. C., Kell, D. B., Morrison, J. J. & Turner, M. L., 2 Apr 2009, In: Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers. 137, 2, p. 586-591 5 p.

Research output: Contribution to journal › Article › peer-review

pKa prediction from "quantum chemical topology" descriptors

Popelier, P. L. A., Harding, A. P. & Wedge, D. C., 24 Aug 2009, In: Journal of Chemical Information and Modeling. 49, 8, p. 1914-1924 10 p.

Research output: Contribution to journal › Article › peer-review

Real-time vapour sensing using an OFET-based electronic nose and genetic programming

Wedge, D. C., Das, A., Dost, R., Kettle, J., Madec, M. B., Morrison, J. J., Grell, M., Kell, D. B., Richardson, T. H., Yeates, S. & Turner, M. L., 4 Dec 2009, In: Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers. 143, 1, p. 365-372 7 p.

Research output: Contribution to journal › Article › peer-review

2008

Rapid prediction of optimum population size in genetic programming using a novel genotype - Fitness correlation

Wedge, D. C. & Kell, D. B., 2008, GECCO'08: Proceedings of the 10th Annual Conference on Genetic and Evolutionary Computation 2008|GECCO: Genet. Evolut. Comput. Conf. - Proc. Annu. Conf. Genet. Evolut. Comput.. New York: Association for Computing Machinery, p. 1315-1322 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2007

Peptide detectability following ESI mass spectrometry: Prediction using genetic programming.

Wedge, D. C., Gaskell, S. J., Hubbard, S. J., Kell, D. B., Lau, K. W. & Eyers, C., 2007, Proceedings of GECCO 2007: Genetic and Evolutionary Computation Conference|Proc. Gen. Evol. Comput. Conf.. New York: Association for Computing Machinery, p. 2219-2225 6 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2006

On global-local artificial neural networks for function approximation

Wedge, D., Ingram, D., McLean, D., Mingham, C. & Bandar, Z., Jul 2006, In: IEEE Transactions on Neural Networks. 17, 4, p. 942-952 10 p.

Research output: Contribution to journal › Article › peer-review

Wave Overtopping Prediction Using Global-Local Artificial Neural Networks

Wedge, D. C., Mar 2006, Manchester Metropolitan University.

Research output: Thesis › Doctoral Thesis

2005

A Global-Local Artificial Neural Network with application to wave overtopping prediction

Wedge, D., Ingram, D., McLean, D., Mingham, C. & Bandar, Z., 2005, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)|Lect. Notes Comput. Sci.. Springer Nature, Vol. 3697. p. 109-114 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Neural network architectures and overtopping predictions

Wedge, D. C., Ingram, D. M., Mingham, C. G., McLean, D. A. & Bandar, Z. A., Sept 2005, In: Proceedings of the Institution of Civil Engineers: Maritime Engineering. 158, 3, p. 123-133 10 p.

Research output: Contribution to journal › Article › peer-review

David Wedge, BA, PGCE, MSc, PhD

Research output

Search results