Research output per year
Research output per year
- 1 - 50 out of 225 results
Search results
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2019
A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites
Zhang, S., Sakuma, M., Deora, G. S., Levy, C., Klausing, A., Breda, C., Read, K. D., Ross, B. P., Wright Muelas, M., Day, P., O'Hagan, S., Kell, D., Schwarcz, R., Leys, D., Heyes, D., Giorgini, F. & Scrutton, N., 2019, In: Communications Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris
Visser, M. J. E., Kell, D. B. & Pretorius, E., 2019, In: Frontiers in cellular and infection microbiology. 9, 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries
Currin, A., Kwok, J., Sadler, J. C., Bell, E. L., Swainston, N., Ababi, M., Day, P., Turner, N. J. & Kell, D. B., 21 Jun 2019, In: ACS Synthetic Biology. 8, 6, p. 1371-1378Research output: Contribution to journal › Article › peer-review
Open Access -
Involvement of multiple influx and efflux transporters in the accumulation of cationic fluorescent dyes by Escherichia coli
Jindal, S., Yang, L., Day, P. & Kell, D., 22 Aug 2019, In: B M C Microbiology.Research output: Contribution to journal › Article › peer-review
Open Access -
Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation
Page, M. J., Thomson, G. J. A., Nunes, J. M., Engelbrecht, A. M., Nell, T. A., de Villiers, W. J. S., de Beer, M. C., Engelbrecht, L., Kell, D. B. & Pretorius, E., 2019, In: Scientific Reports. 9, 1, 3102.Research output: Contribution to journal › Article › peer-review
Open Access -
The role and robustness of the Gini coefficient as an unbiased tool for the selection of Gini genes for normalising expression profiling data
Wright Muelas, M., Mughal, F., O’Hagan, S., Day, P. J. & Kell, D. B., 29 Nov 2019, In: Scientific Reports. 9, 1, 17960.Research output: Contribution to journal › Article › peer-review
Open AccessFile163 Downloads (Pure) -
Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth
Jindal, S., Thampy, H., Day, P. & Kell, D., 1 Apr 2019, In: Microbiology.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Analysing and navigating natural products space for generating small, diverse, but representative chemical libraries
O'Hagan, S. & Kell, D., 10 Jan 2018, In: Biotechnology Journal (Print). 13, 1Research output: Contribution to journal › Article › peer-review
Open Access -
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P. & Goodacre, R. & 9 others, , 2018, In: Communications Biology. 1, 66.Research output: Contribution to journal › Article › peer-review
Open Access -
Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains
Pretorius, E., Page, M. J., Hendricks, L., Nkosi, N. B., Benson, S. R. & Kell, D., 2018, In: Journal of the Royal Society Interface.Research output: Contribution to journal › Article › peer-review
Open Access -
Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus
de Waal, G. M., Engelbrecht, L., Davis, T., de Villiers, W. J., Kell, D. & Pretorius, E., 2018, In: Scientific Reports. 8Research output: Contribution to journal › Article › peer-review
Open Access -
Energetic evolution of cellular Transportomes
Darbani, B., Kell, D. B. & Borodina, I., 30 May 2018, In: BMC Genomics. 19, 1, 418.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering the ‘Missing Link’ in Biosynthetic (–)-Menthol Production: Bacterial Isopulegone Isomerase
Currin, A., Dunstan, M., Johannissen, L., Hollywood, K., Vinaixa, M., Jervis, A., Swainston, N., Rattray, N., Gardiner, J., Kell, D., Takano, E., Toogood, H. & Scrutton, N., 24 Jan 2018, In: ACS Catalysis. 8, 3, p. 2012-2020 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Fast and Flexible Synthesis of Combinatorial Libraries for Directed Evolution
Sadler, J. C., Green, L., Swainston, N., Kell, D. B. & Currin, A., 2018, In: Methods in Enzymology.Research output: Contribution to journal › Article › peer-review
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GeneGini: Assessment via the Gini Coefficient of Reference ‘‘Housekeeping’’ Genes and Diverse Human Transporter Expression Profiles
O'Hagan, S., Wright Muelas, M., Day, P. & Kell, D., 7 Feb 2018, In: Cell Systems. 6, 2, p. 230-244.e1Research output: Contribution to journal › Article › peer-review
Open Access -
Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father
Kenny, L. C. & Kell, D. B., Jan 2018, In: Frontiers in Medicine. 4, p. 239Research output: Contribution to journal › Article › peer-review
Open Access -
IRON DYSREGULATION AND DORMANT MICROBES AS CAUSATIVE AGENTS FOR IMPAIRED BLOOD RHEOLOGY AND PATHOLOGICAL CLOTTING IN ALZHEIMER’S TYPE DEMENTIA
Pretorius, L., Kell, D. & Pretorius, E., 2018, In: Frontiers in Neuroscience.Research output: Contribution to journal › Article › peer-review
Open Access -
Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson’s disease
Pretorius, E., Page, M. J., Mbotwe, S. & Kell, D. B., 1 Mar 2018, In: PLoS ONE. 13, 3, e0192121.Research output: Contribution to journal › Article › peer-review
Open Access -
No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases
Kell, D. & Pretorius, E., 2018, In: Biological Reviews.Research output: Contribution to journal › Article › peer-review
Open Access -
PartsGenie: an integrated tool for optimizing and sharing synthetic biology parts
Swainston, N., Dunstan, M., Jervis, A. J., Robinson, C. J., Carbonell, P., Williams, A. R., Faulon, J.-L., Scrutton, N. S. & Kell, D. B., 1 Jul 2018, In: Bioinformatics. 34, 12Research output: Contribution to journal › Article › peer-review
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Selenzyme: Enzyme selection tool for pathway design
Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., Kell, D., Breitling, R. & Faulon, J.-L., 15 Jun 2018, In: Bioinformatics. 34, 12Research output: Contribution to journal › Article › peer-review
Open Access -
The potential of LPS-binding protein to reverse amyloid formation in plasma fibrin of individuals with Alzheimer-type dementia
Pretorius, E., Page, M. J., Bester, J. & Kell, D., 2018, In: Frontiers in aging neuroscience. 10, 257Research output: Contribution to journal › Article › peer-review
Open Access -
Ultra-high throughput functional enrichment of large monoamine oxidase (MAO-N) libraries by fluorescence activated cell sorting
Sadler, J., Currin, A. & Kell, D., 7 Oct 2018, In: Analyst. 143, 19, p. 4747-4755 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Analysis of drug-endogenous human metabolite similarities in terms of their maximum common substructures
O’Hagan, S. & Kell, D., 2017, In: Journal of Cheminformatics. 9, 18, 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
biochem4j: integrated and extensible biochemical knowledge through graph databases
Swainston, N., Batista-Navarro, R. T., Carbonell, P., Dobson, P., Dunstan, M., Jervis, A., Vinaixa, M., Williams, A., Ananiadou, S., Faulon, J.-L., Pedrosa Mendes, P., Kell, D., Scrutton, N. & Breitling, R., 2017, In: PLoS ONE. 12, 7, e0179130.Research output: Contribution to journal › Article › peer-review
Open Access -
CodonGenie: Optimised ambiguous codon design tools
Swainston, N., Currin, A., Green, L., Breitling, R., Day, P. J. & Kell, D. B., 10 Jul 2017, In: PeerJ Computer Science. 2017, 7, e120.Research output: Contribution to journal › Article › peer-review
Open Access -
Commentary on "rapid identification of streptococcus and enterococcus species using diffuse reflectance-absorbance fourier transform infrared spectroscopy and artificial neural networks"
Goodacre, R. & Kell, D., 1 May 2017, In: FEMS microbiology letters. 364, 10, p. 1-4 4 p., fnx018.Research output: Contribution to journal › Article › peer-review
Open Access -
Computing exponentially faster: Implementing a non-deterministic universal Turing machine using DNA
Currin, A., Korovin, K., Ababi, M., Roper, K., Kell, D. B., Day, P. J. & King, R. D., 1 Mar 2017, In: Journal of the Royal Society Interface. 14, 128, 20160990.Research output: Contribution to journal › Article › peer-review
Open Access -
Consensus rank orderings of molecular fingerprints illustrate the ‘most genuine’ similarities between marketed drugs and small endogenous human metabolites, but highlight exogenous natural products as the most important ‘natural’ drug transporter substrates
Kell, D. & O'Hagan, S., 2017, In: ADMET and DMPK. 5, 2, p. 85-125 41 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhancing drug efficacy and therapeutic index through cheminformatics-based selection of small molecule binary weapons that improve transportermediated targeting: a cytotoxicity system based on gemcitabine.
Grixti, J., O’Hagan, S., Day, P. & Kell, D., 27 Mar 2017, In: Frontiers in Pharmacology.Research output: Contribution to journal › Article › peer-review
Open Access -
Evolutionary Algorithms and Synthetic Biology for directed evolution: Commentary on “On the Mapping of Genotype to Phenotype in Evolutionary Algorithms” by Peter A. Whigham, Grant Dick, and James Maclaurin
Kell, D., 2017, In: Genetic Programming and Evolvable Machines. 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities
Pretorius, E., Mbotwe, S. & Kell, D. B., 2017, In: Scientific Reports. 7, 1, 9680.Research output: Contribution to journal › Article › peer-review
Open Access -
Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability
Pretorius, E., Akeredolu, O.-O., Soma, P. & Kell, D., 2017, In: Experimental Biology and Medicine. 242, 4Research output: Contribution to journal › Article › peer-review
Open Access -
Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model
Esteve, C., Jones, E. A., Kell, D. B., Boutin, H. & McDonnell, L. A., 2017, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 7, p. 747-754Research output: Contribution to journal › Article › peer-review
Open AccessFile118 Downloads (Pure) -
Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting1.
Kell, D. & Pretorius, E., Jan 2017, In: Progress in biophysics and molecular biology. 123, p. 16-41 26 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation
Glymenaki, M., Barnes, A., O'Hagan, S., Warhurst, G., Mcbain, A., Wilson, I. D., Kell, D., Else, K. & Cruickshank, S., 2017, In: Scientific Reports. 7Research output: Contribution to journal › Article › peer-review
Open Access -
Substantial fibrin amyloidogenesis in type 2 diabetes assessed using amyloid-selective fluorescent stains
Pretorius, E., Page, M. J., Engelbrecht, L., Ellis, G. C. & Kell, D. B., 2 Nov 2017, In: Cardiovascular Diabetology. 16, 1, 141.Research output: Contribution to journal › Article › peer-review
Open Access -
To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?
Kell, D. B. & Pretorius, E., 2017, In: Seminars in Thrombosis and Hemostasis.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease
Pretorius, E., Bester, J. & Kell, D., 8 Aug 2016, In: Journal of Alzheimer's Disease. 53, 4, p. 1237-1256 20 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide
Pretorius, E., Mbotwe , S., Bester , J., Robinson, C. & Kell, D., 7 Sept 2016, In: Journal of the Royal Society Interface. 13, 122, 20160539.Research output: Contribution to journal › Article › peer-review
Open Access -
A dormant microbial component in the development of pre-eclampsia
Kell, D. & Kenny, L. C., 2016, In: Frontiers in Medicine. 3, 60Research output: Contribution to journal › Article › peer-review
Open Access -
MetMaxStruct: A Tversky-similarity-based strategy for analysing the (sub)structural similarities of drugs and endogenous metabolites
O'Hagan, S. & Kell, D. B., 22 Aug 2016, In: Frontiers in Pharmacology. 7, AUG, 266.Research output: Contribution to journal › Article › peer-review
Open Access -
Microbes and Alzheimer’s Disease
Itzhaki, R., Lathe, R., Balin, B. J., Ball, M. J., Bearer, E. L., Braak, H., Bullido, M. J., Carter, C., Clerici, M., Cosby , S. L., Del Tredici, K., Field, H., Fulop, T., Grassi, C., Griffin, W. S. T., Haas, J., Hudson, A. P., Kamer, A. R., Kell, D. & Licastro, F. & 13 others, , 12 Apr 2016, In: Journal of Alzheimer's Disease. 51, 4, p. 979 984 p.Research output: Contribution to journal › Article › peer-review
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Recon 2.2: from reconstruction to model of human metabolism
Swainston, N., Smallbone, K., Hefzi, H., Dobson, P. D., Brewer, J., Hanscho, M., Zielinski, D. C., Ang, K. S., Gardiner, N., Gutierrez, J. M., Kyriakopoulos, S., Lakshmanan, M., Li, S., Liu, J. K., Martínez, V. S., Orellana, C. A., Quek, L.-E., Thomas, A., Zanghellini, J. & Borth, N. & 5 others, , 1 Jul 2016, In: Metabolomics : Official journal of the Metabolomic Society. 12, p. 109Research output: Contribution to journal › Article › peer-review
Open Access -
SYNBIOCHEM - A SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals.
Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N. J. W., Robinson, C. J., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G.G.-Q., Faulon, J.-L., Goble, C., Goodacre, R., Kell, D. B., Feuvre, R. L. & Micklefield, J. & 4 others, , 15 Jun 2016, In: Biochemical Society Transactions. 44, 3, p. 675-7Research output: Contribution to journal › Article › peer-review
Open Access -
SYNBIOCHEM Synthetic Biology Research Centre, Manchester - A UK foundry for fine and speciality chemicals production
Le, F. R., Carbonell, P., Currin, A., Dunstan, M., Fellows, D., Jervis, A., Rattray, N., Robinson, C., Swainston, N., Vinaixa, M., Williams, A., Yan, C., Barran, P., Breitling, R., Chen, G., Faulon, J., Goble, C., Goodacre, R., Kell, D. & Micklefield, J. & 4 others, , 2016, In: Synthetic and Systems Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
2015
Alignment by numbers: sequence assembly using compressed numerical representations
Tapinos, A., Constantinides, B., Kell, D. & Robertson, D., 27 Jan 2015, In: bioRxiv.Research output: Contribution to journal › Article › peer-review
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A 'rule of 0.5' for the metabolite-likeness of approved pharmaceutical drugs
O'Hagan, S., Swainston, N., Handl, J. & Kell, D. B., Apr 2015, In: Metabolomics. 11, 2, p. 323-339 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Event-based text mining for biology and functional genomics
Ananiadou, S., Thompson, P., Nawaz, R., McNaught, J. & Kell, D., May 2015, In: Briefings in functional genomics. 14, 3, p. 213-30 17 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Fitting transporter activities to cellular drug concentrations and fluxes: why the bumblebee can fly
Mendes, P., Oliver, S. G. & Kell, D. B., Nov 2015, In: Trends in pharmacological sciences. 36, 11, p. 710-723 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile194 Downloads (Pure)