Research output per year
Research output per year
Prof
Principal Investigator, Manchester Fungal infection Group
Managing Editor, The Aspergillus Website
Chief Executive, Global Action Fund for Fungal infections (GAFFI)
Over 300 million people worldwide suffer from serious fungal infections. Aspergillus causes 100,000s of life-threatening infections worldwide and millions of allergic and chronic infections, with much morbidity. Over the past few decades, the incidence of invasive aspergillosis has risen steadily. It is now the most common invasive mould infection worldwide. Mortality is almost 100% if the disease is left untreated and high (40 to 90%) with therapy. Invasive aspergillosis occurs in 5 to 25% of all leukemia patients and is the leading infectious cause of death in many transplant centres. Over 4.8 million are estimated to suffer from allergic aspergillosis complicating asthma. Aspergillus fumigatus is the most common responsible species, causing approximately 90% of human Aspergillus infections.
As well as the clinical aspects of medical mycology including diagnostics and the role of filamentous fungi in various forms of severe allergy, research carried out in the Manchester Fungal Infection Group group ranges from genomics through to diagnostics and studies of new antifungal drugs. Current collaboration with the JC Venter [genomics] Institute involve the sequencing and comparative analysis of multiple isolates of A. fumigatus.
Projects in the laboratory include studies of the frequency and mechanisms of azole drug resistance, human genetic variants underlying the different aspergillus diseases, the role of Aspergillus pathogenicity factors in infection using knockout mutants, and identification of novel drug targets. A substantial effort goes into evaluation of new antifungal drugs and diagnostics clinically and in the clinical laborarory. The Aspergillus Website has been developed to enable the dissemination of medical and scientific information about Aspergillus and aspergillosis
Work is or has been supported by the Wellcome Trust, National Institute of Allergy and Infectious Diseases (USA), the EU, the Moulton Trust, the Medical Research Council, the Fungal Research Trust, National Institute for Health Research and the Chronic Granulomatous Disease Research Trust.
The impact of completed research is summarised here: http://www.aspergillus.org.uk/content/diagnostics-and-novel-life-saving-therapies-aspergillosis-prof-david-denning
Our work also contributed to the SDG3 goal for the University's return on social responsibility here: https://www.manchester.ac.uk/research/impact/sdgs/health/fungal-disease-sdg-3/
Most teaching involves project options students and postgaduate research students.
Externally, expertise on chronic and allergic aspergillosis and the treatment of fungal disease is shared with doctors all over the world.
Leading International Fungal Infection is one of many online resources available worldwide.
Principal investigators in the Manchester Fungal Infection Group include:
MB BS FRCP FRCPath DCH FIDSA FMedSci FECMM FAAM
Leading International Fungal Education (LIFE) at www.fungaleducation.org
Global Action For Fungal Infections at www.GAFFI.org
Main research interests are:
Burden of fungal diseases
Antifungal drug resistance
Phenotypes and genotypes of chronic and allergic pulmonary aspergillosis
Improving and evaluating fngal disease diagnostics.
Gary M. Megson, MSc 1993: The application of gas-liquid chromatography for the detection of fungal polyols in serum (with Dr Drucker & Dr L Ganguli).
Michael Birch, MSc 1994 : DNA typing of A.fumigatus.
Emma Prebble, 1994 (Transferred to PhD from MSc): Hydrogen ion concentration of growing hyphae measured by fluorescence microscopy (with W. Robertson and G.D. Robson).
Seoughun Nho, PhD 1997 : Molecular taxonomy of C.inconspicua.
Karen Oakley, MSc 1997 : In vitro/in vivo correlation of susceptibility testing of Aspergillus fumigatus.
G.Guy Baily, MD, 1997 : Fluconazole resistant Candida
Lucy Ochola, MSc, 1999 : Antifungal activity from Kenyan plants (with R Brown).
Jeanette Bond, External MSc, University of Belfast, 1999: Cost implications of azole resistant thrush (dissertation).
Steven Hood, MD 2000 : Azole resistant Candida.
Michael Birch, PhD 2001 : Phospholipase activity in Aspergillus.
John W. Slaven, PhD 2001 : Multidrug resistance in Aspergillus (with I.S. Roberts).
A. Hassan Kazemi, PhD 2002: Phospholipases of Aspergillus fumigatus (with G. Robson)
Juan Mosquero, PhD 2002 : Resistance in Aspergillus flavus.
Peter Warn, PhD 2003 : Pathogenicity and virulence in Candida tropicalis.
Caroline Moore, PhD 2003 : Susceptibility testing of Candida.
Andrew Dodgson, PhD 2005: Molecular epidemiology of Candida glabrata.
William Hope, PhD 2006: Pathogenesis and diagnosis of invasive fungal infection
Ahmed Al-Barrag, PhD 2008: Aspects of growth and resistance in Aspergillus.
Susan Howard, PhD 2009 Azole Resistance in Aspergillus Species
Joanne Slater, PhD 2010. Early events in Aspergillus germination (with P. Warn).
Marcin Fraczek, PhD 2010. Cloning Aspergillus allergens (with P. Bowyer).
Vincent Nowaseb, MSc 2011. Evolution of Pneumocystis Pneumonia diagnosis.
Nicola Smith, PhD 2012 Genetics of aspergillosis (with A. Simpson, John Curtin and Paul Bowyer).
Ahmed Buied, PhD 2012. Azole resistance in A. fumigatus (with Paul Bowyer).
Caroline Baxter, PhD 2013. Aspergillus in cystic fibrosis (with Andrew Jones).
Adam Jeans, MD 2013. Diagnostics and aspergillosis (with Malcolm Richardson).
Livingstone Chishimba, PhD 2015. Fungal allergy in asthma (with Rob Niven).
Gemma Hayes, PhD 2017. Interaction of Aspergillus and the lung.
Michael J Clarke, MPhil 2017. An online microscopy and histology course.
Uju (Joy) Icheoku, PhD 2018. Molecular basis of invasive growth during mould infection of the lung.
Rita Oladele, PhD 2018, Fungal Infections in Nigeria.
Abigail Cowley, PhD 2019. Mucins in cystic fibrosis sputum and Aspergillus.
Nagwa Ben Ghazzi, PhD 2020 The mechanistic basis of hemibiotrophy during infection of epithelial cells by Aspergillus fumigatus.
Findra Setianingrum, PhD 2020, Pulmonary fungal infections in Indonesia.
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Bachelor of Medicine and Bachelor of Surgery, The University of London
Award Date: 27 Jun 1980
Chief Executive, Global Action Fund for Fungal Infections (GAFFI)
31 Jul 2001 → …
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Review article › peer-review
Bromley, M., Bertuzzi, M., Gago, S., Denning, D., Kosmidis, C., Bowyer, P., Amich Elias, J., Richardson, M. & Richardson, R.
15/08/13 → …
Project: Research
Van Tongeren, M., Wei, H., Denning, D., Hall, I., Han, Y., Regan, C., Verma, A., Whitfield, C. & Daniels, S.
27/04/20 → 26/04/21
Project: Research
Kosmidis, C., Bowyer, P., Denning, D. & Fowler, S.
1/04/19 → 31/03/21
Project: Research
Denning, David (Recipient), 8 Oct 2017
Prize: Prize (including medals and awards)
David Denning (Participant), Peter Warn (Participant), Michael Bromley (Participant), Paul Bowyer (Participant) & Caroline Moore (Participant)
Impact: Health and wellbeing, Policy, Economic
David Denning (Participant), Michael J. Anderson (Participant), Caroline Moore (Participant), Peter Warn (Participant), Paul Bowyer (Participant), Michael Bromley (Participant), Nicola Smith (Participant), Susan Howard (Participant) & Robert Niven (Participant)
Impact: Health impacts
David Denning (Participant), Malcolm Richardson (Participant) & Sara Gago (Participant)
Impact: Health and wellbeing
David Denning (Participant), Robert Niven (Participant) & Timothy Felton (Participant)
Impact: Health and wellbeing, Economic
Kwizera, R. (Contributor), Rosalind, P. (Contributor), Page, I. (Contributor), Christine, S. (Contributor), Joseph, M. (Contributor), Fehr, J. (Contributor), Castelnuovo, B. (Contributor), Kambugu, A. (Contributor) & Denning, D. (Contributor), figshare , 21 Nov 2017
DOI: 10.6084/m9.figshare.c.3936805.v1, https://figshare.com/collections/Elevated_Aspergillus-specific_antibody_levels_among_HIV_infected_Ugandans_with_pulmonary_tuberculosis/3936805/1
Dataset
Overton, N. (Contributor), Denning, D. (Contributor), Bowyer, P. (Contributor) & Simpson, A. (Contributor), figshare , 27 Sept 2016
DOI: 10.6084/m9.figshare.c.3627629.v1, https://figshare.com/collections/Genetic_susceptibility_to_allergic_bronchopulmonary_aspergillosis_in_asthma_a_genetic_association_study/3627629/1
Dataset
Denning, D. (Contributor), figshare , 7 Oct 2016
DOI: 10.6084/m9.figshare.c.3493059.v2, https://figshare.com/collections/Supplementary_material_from_Minimizing_fungal_disease_deaths_will_allow_the_UNAIDS_target_of_reducing_annual_AIDS_deaths_below_500_000_by_2020_to_be_realized_/3493059/2
Dataset
4/01/23
1 item of Media coverage
Press/Media: Expert comment
9/02/22
1 Media contribution
Press/Media: Expert comment
David Denning & Elaine Bignell
4/06/20
1 Media contribution
Press/Media: Expert comment