Research output per year
Research output per year
Research in my laboratory is focusing on understanding the molecular aspects of cardiac remodelling and heart regeneration. My research is currently supported mainly by programme and project grants from the British Heart Foundation (BHF) as well as research grants from Medical Research Council (MRC) and Heart Research UK (HRUK). Please see Research and Projects for details.
I teach postgraduate (Master) and undergraduate students (MBChB and BSc Biological sciences) and supervise postgraduate research students (PhD). I review manuscripts and grants for international journals and funding bodies, respectively and also an Editorial Board member for several journals.
I graduated from the School of Medicine, Universitas Airlangga, Indonesia in 1996. I then worked as Research Assistant at the Eijkman Institute Indonesia under the supervision of Prof Sangkot Marzuki. I went to the University of Queensland in 1998 and completed my PhD in 2001 under the guidance of Professors Brandon Wainwright and David Hume. I did a short post-doctoral study in the Institute of Molecular Bioscience, Queensland before joining the laboratory of Prof Ludwig Neyses in Manchester in 2002. I have been awarded the British Heart Foundation Intermediate Fellowship in 2009 and was appointed as Senior Lecturer in Cardiovascular Medicine in 2015 before promoted to Reader.
Major Awards and Prizes:
British Heart Foundation Project Grant Committee Panel Member (2015 - 2019)
Editorial Board Member, Nature Scientific Reports
British Society of Cardiovascular Research
Heart Failure Association of the ESC
European Society of Cardiology Working Group of Cellular Biology of the Heart
MD, School of Medicine, University of Airlangga, Indonesia
PGDipSc in Molecular Biology, University of Queensland, Australia
PhD in Molecular Genetics, University of Queensland, Australia
1. MBChB Programme:
- Year 1 MBChB: PBL tutor (semester 1 module)
- Year 1 & 2 MBChB: academic advisor and tutor for professional and personal development (TPPD) and tutor for personal excellence path (PEP).
- Year 3: APEP supervisor
2. BSc in Biomedical Science
- Year 3: tutor for Year 3 final year project
- Year 2 dissertation supervisor
3. MRes in Cardiovascular Sciences
- Tutor for literature review and project proposal writing
- Supervisor for final research project
- Tutorial Course Unit
- Principal of CVHD lecture
4. MSc in Tissue Engineering and Regenerative Medicine
- Tutor for literature review and project proposal writing
- Supervisor for final research project
1) Role of the Hippo signalling pathway in cardiac regeneration and cell reprogramming
My group is interested in investigating novel modulators of the Hippo signalling pathway which are important in cell replication and repair. We modulates Hippo pathway to induce cardiomyocyte regeneration and to improve induced pluripotent stem cells (iPSC)-based cell replacement therapy.
2) The regulatory role of tumour suppressor molecules during cardiac hypertrophy, remodelling and failure
We are also interested in investigating the role of tumour suppressors and oncogenes during cardiac growth. We are focusing on the tumour suppressors and oncogenes related to the Hippo signalling pathway in regulating cardiac hypertrophy.
3 )Local calcium signalling in the heart regulated by sarcolemmal calcium pump
I am also interested in studying how calcium microdomain governs the molecular signaling pathway. We are particularly interested in studying calcium signals regulated by the plasma membrane calcium pump (PMCA)
Research Grants awarded
1) As Principal Investigator:
British Heart Foundation Programme Grant (RG/F/21/11055)(£728K, 2022-2027)
Heart Research UK Translational Research Project Grant (RG2696/21/23)(£151K, 2022 -2024)
British Heart Foundation Project Grant (PG/18/40/33767)(£160K, 2018-2020).
British Heart Foundation Project Grant (PG/17/78/33304)(£221K. 2018-2021).
MRC Research Grant (MR/P015816/1)(£276K. 2017-2020)
British Heart Foundation Project Grant (PG/16/77/32400)(£135K, 2016-2018)
British Heart Foundation Project Grant (PG/13/12/30017)(£202K, 2013-2016)
British Heart Foundation Basic Science Intermediate Fellowship (FS/09/046/28043)
(£546K, 2010-2015)
British Heart Foundation Project Grant (PG/11/23/28801)(£62,200, 2011-2014).
2) As Co-Investigator:
British Heart Foundation Programme Grant (RG/18/2/33392, £1.3M 2018-2023).
BHF Project Grant (PG/14/24/30626)(£22K,2014-2017).
BRC George Lancashire Award (£45,900, 2011-2014).
British Heart Foundation Project Grant (PG/05/082) (£149,408, 2005-2008).
Lab Member:
Collaborators:
Transgenesis and knock out models
In vivo cardiac physiology: echocardiography, invasive haemodynamics
Disease models: transverse aortic constriction, mini pump implantation
Cellular models: primary cardiomyocyte culture, adult cardiomyocyte
Molecular and cellular biology techniques
Adenoviral gene transfer system
Gene silencing using RNAi system
Stem cell technology and cell reprogramming
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Cartwright, E., Abraham, S., Allan, S., Ashton, N., Ballestrem, C., Dibb, K., Dobrzynski, H., Eisner, D., Galli, G., Greenstein, A., Heagerty, A., Hentges, K., Herbert, S., Keavney, B., Kitmitto, A., Liu, W., Oceandy, D., Pinali, C., Pinteaux, E., Saiani, A., Shiels, H., Talavera, D., Tomaszewski, M., Trafford, A., Venetucci, L. & Wang, X.
1/10/19 → 30/09/23
Project: Research
Cartwright, E., Abraham, S., Allan, S., Ballestrem, C., Boyett, M., Canfield, A., Dibb, K., Dobrzynski, H., Eisner, D., Galli, G., Heagerty, A., Hentges, K., Herbert, S., Holt, C., Humphries, M., Keavney, B., Kitmitto, A., Liu, W., Miller, C., Oceandy, D., Parry-Jones, A., Saiani, A., Sherratt, M., Shiels, H., Talavera, D., Tomaszewski, M., Trafford, A., Venetucci, L., Wang, X. & Zhang, Y.
1/10/17 → 30/09/21
Project: Research
Delvac Oceandy (Participant)
Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc
Gindo Tampubolon (Participant) & Delvac Oceandy (Participant)
Impact
Delvac Oceandy (Participant)
Impact: Health and wellbeing