Research output per year
Research output per year
- 20 results
Search results
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2021
Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
PDXNET Consortium, EurOPDX Consortium, Alferez-Castro, D., Spence, K., Clarke, R. & et al., 7 Jan 2021, In: Nature Genetics. 53, 1, p. 86-99 14 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile80 Downloads (Pure) -
2020
Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer
M Simoes, B., Santiago-Gómez, A., Chiodo, C., Moreira, T., Conole, D., Lovell, S., Alferez-Castro, D., Eyre, R., Spence, K., Sarmiento Castro, A., Kohler, B., Morisset, L., Lanzino, M., Ando, S., Marangoni, E., Sims, A. H., Tate, E., Howell, S. & Clarke, R., 18 Jun 2020, In: Oncogene. 39, 25, p. 4896–4908 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts
Lefley, D. V., Howard, F., Arshad, F., Bradbury, S., Brown, H., Tulotta, C., Eyre, R., Alferez-Castro, D., Wilkinson, J. M., Holen, I., Clarke, R. B. & Ottewell, P. D., 29 Nov 2019, In: Breast cancer research : BCR. 21, 1, p. 130 21 p., 1.Research output: Contribution to journal › Article › peer-review
Open Access -
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Eyre, R., Alferez-Castro, D., Santiago-Gómez, A., Spence, K., Mcconnell, J., Hart, C., M Simoes, B., Lefley, D., Tulotta, C., Storer, J., Gurney, A., Clarke, N., Brown, M., Howell, S., Sims, A. H., Farnie, G., Ottewell, P. D. & Clarke, R. B., 1 Nov 2019, In: Nature Communications. 10, 1, p. 5016 15 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells
Alferez-Castro, D., M Simoes, B., Howell, S. & Clarke, R., 2018, In: Current Stem Cell Reports.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Interrogating open issues in cancer precision medicine with patient-derived xenografts
EurOPDX Consortium, Byrne, A. T., Alférez, D. G., Amant, F., Annibali, D., Arribas, J., Biankin, A. V., Bruna, A., Budinská, E., Caldas, C., Chang, D. K., Clarke, R. B., Clevers, H., Coukos, G., Dangles-Marie, V., Eckhardt, S. G., Gonzalez-Suarez, E., Hermans, E., Hidalgo, M. & Jarzabek, M. A. & 23 others, , 2017, In: Nature Reviews. Cancer.Research output: Contribution to journal › Commentary/debate › peer-review
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Targeting IL-1 beta-Wnt signalling to prevent breast cancer colonisation in the bone microenvironment
Eyre, R., Alferez, D., Santiago-Gomez, A., Spence, K., McConnell, J., Simoes, B., Hart, C., Lefley, D., Tulotta, C., Gurney, A., Howell, S., Brown, M., Sims, A., Farnie, G., Ottewell, P. & Clarke, R., Dec 2017, In: Clinical and Experimental Metastasis. 34, 8, p. 493-493Research output: Contribution to journal › Meeting Abstract › peer-review
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2016
Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis
Eyre, R., Alférez, D. G., Spence, K., Kamal, M., Shaw, F. L., Simões, B. M., Santiago-Gómez, A., Sarmiento-Castro, A., Bramley, M., Absar, M., Saad, Z., Chatterjee, S., Kirwan, C., Gandhi, A., Armstrong, A. C., Wardley, A. M., O'Brien, C. S., Farnie, G., Howell, S. J. & Clarke, R. B., 28 Sept 2016, In: Journal of Mammary Gland Biology and Neoplasia.Research output: Contribution to journal › Article › peer-review
Open Access -
Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Dobrolecki, L. E., Airhart, S. D., Alferez, D. G., Aparicio, S., Behbod, F., Bentires-Alj, M., Brisken, C., Bult, C. J., Cai, S., Clarke, R. B., Dowst, H., Ellis, M. J., Gonzalez-Suarez, E., Iggo, R. D., Kabos, P., Li, S., Lindeman, G. J., Marangoni, E., McCoy, A. & Meric-Bernstam, F. & 12 others, , 27 Dec 2016, In: Cancer and Metastasis Reviews. 35, 4, p. 547-573 27 p.Research output: Contribution to journal › Article › peer-review
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2015
Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
M Simoes, B., O'Brien, C., Eyre, R., Silva, A., Yu, L., Sarmiento Castro, A., Alferez-Castro, D., Spence, K., Santiago-Gomez, A., Chemi, F., Acar, A., Gandhi, A., Howell, A., Brennan, K., Rydén, L., Catalano, S., Andó, S., Gee, J., Ucar, A. & Sims, A. H. & 5 others, , 29 Sept 2015, In: Cell Reports. 12, 12, p. 1968-1977 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile142 Downloads (Pure) -
2012
Enhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055)
Holt, S. V., Logie, A., Davies, B. R., Alferez, D., Runswick, S., Fenton, S., Chresta, C. M., Gu, Y., Zhang, J., Wu, Y.-L., Wilkinson, R. W., Guichard, S. M. & Smith, P. D., 1 Apr 2012, In: Cancer Research. 72, 7, p. 1804-13 10 p.Research output: Contribution to journal › Article › peer-review
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Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia
Alferez, D. G., Goodlad, R. A., Odedra, R., Sini, P., Crafter, C., Ryan, A. J., Wedge, S. R., Wright, N. A., Anderson, E. & Wilkinson, R. W., Oct 2012, In: International Journal of Oncology. 41, 4, p. 1475-85 11 p.Research output: Contribution to journal › Article › peer-review
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Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
Schlicker, A., Beran, G., Chresta, C. M., McWalter, G., Pritchard, A., Weston, S., Runswick, S., Davenport, S., Heathcote, K., Alferez, D., Orphanides, G., French, T. & Wessels, L. F. A., 2012, In: BMC Medical Genomics. 5, p. 66Research output: Contribution to journal › Article › peer-review
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The MEK1/2 inhibitor, selumetinib (AZD6244; ARRY-142886), enhances anti-tumour efficacy when combined with conventional chemotherapeutic agents in human tumour xenograft models
Holt, S. V., Logié, A., Odedra, R., Heier, A., Heaton, S. P., Alferez, D., Davies, B. R., Wilkinson, R. W. & Smith, P. D., 28 Feb 2012, In: British Journal of Cancer. 106, 5, p. 858-66 9 p.Research output: Contribution to journal › Article › peer-review
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2010
Effects of vandetanib on adenoma formation in a dextran sodium sulphate enhanced Apc(MIN/+) mouse model
Alferez, D. G., Ryan, A. J., Goodlad, R. A., Wright, N. A. & Wilkinson, R. W., Oct 2010, In: International Journal of Oncology. 37, 4, p. 767-72 6 p.Research output: Contribution to journal › Article › peer-review
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2009
Detection of metabolic alterations in non-tumor gastrointestinal tissue of the Apc(Min/+) mouse by (1)H MAS NMR spectroscopy
Backshall, A., Alferez, D., Teichert, F., Wilson, I. D., Wilkinson, R. W., Goodlad, R. A. & Keun, H. C., Mar 2009, In: Journal of Proteome Research. 8, 3, p. 1423-30 8 p.Research output: Contribution to journal › Article › peer-review
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2008
Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice
Alferez, D., Wilkinson, R. W., Watkins, J., Poulsom, R., Mandir, N., Wedge, S. R., Jackson, L., Pyrah, I. T., Smith, N. R., Ryan, A. J. & Goodlad, R. A., Mar 2008, In: Molecular Cancer Therapeutics. 7, 3, p. 590-8 9 p.Research output: Contribution to journal › Article › peer-review
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2007
To best measure cell proliferation in samples from the intestine
Alferez, D. & Goodlad, R. A., Apr 2007, In: Cell Proliferation. 40, 2, p. 231-40 10 p.Research output: Contribution to journal › Article › peer-review
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2006
Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer
Goodlad, R. A., Ryan, A. J., Wedge, S. R., Pyrah, I. T., Alferez, D., Poulsom, R., Smith, N. R., Mandir, N., Watkins, A. J. & Wilkinson, R. W., Oct 2006, In: Carcinogenesis. 27, 10, p. 2133-9 7 p.Research output: Contribution to journal › Article › peer-review
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2004
Effects of gravity, hypergravity and microgravity on vestibular neurones of the crab
Fraser, P. J., Araujo, R., Alferez, D., Carneiro, M. J. & Pollard, M., Jul 2004, In: Journal of Gravitational Physiology . 11, 2, p. P1-4Research output: Contribution to journal › Article › peer-review