David Eisner (B.A. Cambridge, Natural Sciences, 1976; D.Phil Oxford, Physiology, 1979).

Lecturer and Wellcome Trust Senior Lecturer,  Department of Physiology, University College London (1980-1990).

Professor of Veterinary Biology, University of Liverpool (1990-1999)

David Eisner is the British Heart Foundation Professor of Cardiac Physiology at the University of Manchester. 

He received his B.A. (Natural Sciences) from Cambridge and D. Phil (Physiology) from Oxford.  His early research focused on the regulation of intracellular sodium in cardiac muscle and the effects on contraction. He then investigated the control of intracellular calcium concentration and its role in the production of arrhythmias. He has worked extensively on the factors that regulate the calcium content of the sarcoplasmic reticulum and how this is altered in disease.  His most recent work has been concerned with the regulation of diastolic calcium concentration.

He has served as Editor-in-Chief of The Journal of Molecular and Cellular Cardiology  and The Journal of  Physiology.  He has served on grants panels for The British Heart Foundation, MRC and Wellcome Trust.  He was a member of panels for RAE 2001 & 2008 as well as REF2014. 

 

Cardiovascular disease is the major cause of death in the developed world. David Eisner’s research group is trying to understand the mechanisms that regulate the contraction of the heart under both normal and diseased conditions. The heart is composed of billions of cells (myocytes) and, in order for it to pump blood these cells must contract synchronously. Contraction is initiated by an increase of the amount of calcium in the cell. Most of this calcium is released from an intracellular store. This group has defined the mechanisms that control the amount of calcium in the store and thence the amount that can be released to activate contraction. Current work is focused on changes in the store content of calcium in disease conditions.

Fellow Academy of Medical Sciences (1999)

Member Academia Europaeae (2007)

Honorary Fellowship, Royal College of Physicians (2010)

Doctor honoris causa, University of Debrecen (2018)

Doctor honoris causa, University of Szeged (2021)

 

 

Pfizer Prize for Biology (1985)

Wellcome Physiology Prize (1988)

QR Murphy lecture, University of Wisconsin (1992)

Reimer Lecture, International Society for Heart Research (2008)

Hon Dorothy Wedgwood Lecture for Young People (2008)

Peter Baker Memorial Lecture, Kings College London (2010)

Carmeliet-Coraboeuf-Weidmann Lecture, European Working Group on Cardiac Cellular Electrophysiology (2013)  

 GL Brown Lecture of the Physiological Society (2014) The Bohuslav Ostadal Lecture of The International Academy of Cardiovascular Sciences (2016)

Peter Harris Distinguished Scientist Award, International Society for Heart Research (2017)

Annual Review Prize Lecture, The Physiological Society (2017)

Naranjan Dhalla Lecture of The International Academy of Cardiovascular Sciences (2017)

Distinguished Leader Award, International Society for Heart Research (2019)

Fabio Ruzzier Lecture of the Italian Physiological Society (2019) 

Chairman, Editorial Board, The Journal of Physiology (1997-2000)

International Secretary, The Physiological Society (2003-2007)

Editor-in-Chief, Journal of Molecular and Cellular Cardiology (2007-2016)

Chair, British Society for Cardiovascular Research (2006-2008)

Chair, European Working Group of Cellular Cardiac Electrophysiology (2008-2010)

President, European Federation of Physiological Societies (2011-2015)

President, International Society for Heart Research, European Section (2014-2016)

President, The Physiological Society (2016-2018)

 

Member of panels for Research Assessment Exercise (RAE) 2001 and 2008

Member of panel for Research Excellence Framework (REF) 2014