David Eisner

2024

Restoring Atrial T-Tubules Augments Systolic Ca Upon Recovery From Heart Failure

Caldwell, J. L., Clarke, J. D., Smith, C. E. R., Pinali, C., Quinn, C. J., Pearman, C. M., Adomaviciene, A., Radcliffe, E. J., Watkins, A. E., Horn, M. A., Bode, E. F., Madders, G. W. P., Eisner, M., Eisner, D. A., Trafford, A. W. & Dibb, K. M., 13 Sept 2024, In: Circulation research. 135, 7, p. 739-754 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Atrial t-tubules adopt a specialist developmental state while alterations to Ca2+ buffering maintain systolic Ca2+ during postnatal development

Smith, C. E. R., Clarke, J., Quinn, C., Najem, H., Sultan, Z., Denham, N., Hutchings, D., Madders, G., Caldwell, J., Toms, L., Pinali, C., Eisner, D., Trafford, A. & Dibb, K., 2 Oct 2023, Cold Spring Harbor Laboratory Press, (bioRxiv).

Research output: Preprint/Working paper › Preprint

Open Access

Physiology of intracellular calcium buffering

Eisner, D., Neher, E., Taschenberger, H. & Smith, G., 1 Oct 2023, In: Physiological Reviews. 103, 4, p. 2767-2845 79 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

2022

Enhanced calcium release at specialised surface sites compensates for reduced t-tubule density in neonatal sheep atrial myocytes

Smith, C. E. R., Pinali, C., Eisner, D., Trafford, A. & Dibb, K., 26 Aug 2022, In: Journal of molecular and cellular cardiology.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Downloads (Pure)

Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart

Hutchings, D., Madders, G., Niort, B., Bode, E., Waddell, C., Woods, L., Dibb, K., Eisner, D. & Trafford, A., 1 Mar 2022, In: JOURNAL OF PHYSIOLOGY-LONDON. 17332515.

Research output: Contribution to journal › Article › peer-review

Open Access

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35 Downloads (Pure)

2021

Blockade of sodium‑calcium exchanger via ORM-10962 attenuates cardiac alternans

Szlovák, J., Tomek, J., Zhou, X., Tóth, N., Veress, R., Horváth, B., Szentandrássy, N., Levijoki, J., Papp, J. G., Herring, N., Varró, A., Eisner, D. A., Rodriguez, B. & Nagy, N., Apr 2021, In: Journal of molecular and cellular cardiology. 153, p. 111-122 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

84 Downloads (Pure)

Disordered yet functional atrial t-tubules on recovery from heart failure

Caldwell, J. L., Clarke, J. D., Smith, C. E. R., Pinali, C., Quinn, C. J., Pearman, C. M., Adomaviciene, A., Radcliffe, E. J., Watkins, A. E., Horn, M. A., Bode, E. F., Eisner, M., Eisner, D. A., Trafford, A. W. & Dibb, K. M., 28 Oct 2021, bioRxiv, p. 1-3, 3 p. (bioRxiv).

Research output: Preprint/Working paper › Preprint

Edward Carmeliet: his contributions and scientific legacy

Sipido, K. R. & Eisner, D. A., 17 Sept 2021, (E-pub ahead of print) In: The Journal of physiology. 599, 21, p. 4727-4729 3 p.

Research output: Contribution to journal › Commentary/debate › peer-review

Open Access

PDE5 inhibition suppresses ventricular arrhythmias by reducing SR Ca2+ content

Hutchings, D., Pearman, C., Madders, G., Woods, L., Eisner, D., Dibb, K. & Trafford, A., 12 Jul 2021, (E-pub ahead of print) In: Circulation research.

Research output: Contribution to journal › Article › peer-review

Open Access

Pseudoreplication in physiology: More means less

Eisner, D. A., 19 Jan 2021, In: Journal of General Physiology. 153, 2, e202012826.

Research output: Contribution to journal › Review article › peer-review

Open Access

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128 Downloads (Pure)

2020

Calcium Handling Defects and Cardiac Arrhythmia Syndromes

Kistamás, K., Veress, R., Horváth, B., Bányász, T., Nánási, P. P. & Eisner, D. A., 25 Feb 2020, In: Frontiers in Pharmacology. 11, p. 72 72.

Research output: Contribution to journal › Article › peer-review

Open Access

Chronic vagal nerve stimulation has no effect on tachycardia-induced heart failure progression or excitation-contraction coupling

Radcliffe, E., Pearman, C., Watkins, A., Lawless, M., Kirkwood, G., Saxton, S., Eisner, D. & Trafford, A. (Corresponding), 20 Jan 2020, In: Physiological Reports. 8, 2, e14321.

Research output: Contribution to journal › Article › peer-review

Open Access

The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications

Eisner, D., Trafford, A., Caldwell, J. & Hutchings, D., 31 Jan 2020, In: Circulation research. 126, 3

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Calcium buffering in the heart in health and disease

Smith, G. L. & Eisner, D., 14 May 2019, (E-pub ahead of print) In: Circulation.

Research output: Contribution to journal › Article › peer-review

Open Access

Disordered yet functional atrial t-tubules on recovery from heart failure

Caldwell, J., Clarke, J., Pinali, C., Eisner, D., Trafford, A. & Dibb, K., 30 Apr 2019, p. 20. 1 p.

Research output: Contribution to conference › Poster › peer-review

Disruption of Pressure-Induced Ca2+ Spark Vasoregulation of Resistance Arteries, Rather Than Endothelial Dysfunction, Underlies Obesity-Related Hypertension

Greenstein, A. S., Kadir, S. Z. A. S., Csato, V., Sugden, S. A., Baylie, R. A., Eisner, D. A. & Nelson, M. T., 23 Dec 2019, In: Hypertension (Dallas, Tex. : 1979).

Research output: Contribution to journal › Article › peer-review

Open Access

Dual antiarrhythmic properties of phosphodiesterase-5 inhibitors suppress Ca2+ waves in systolic heart failure

Hutchings, D., Madders, G., Waddell, C., Woods, L., Dibb, K., Eisner, D. & Trafford, A., 2019, In: Proceedings of The Physiological Society. 43, C014.

Research output: Contribution to journal › Meeting Abstract › peer-review

Misleading with citation statistics?

Bennet, L., Eisner, D. A. & Gunn, A. J., 15 May 2019, In: Journal of Physiology. 597, 10, p. 2593-2594 2 p.

Research output: Contribution to journal › Editorial › peer-review

Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure.

Lawless, M., Caldwell, J., Radcliffe, E., Smith, C., Madders, G., Hutchings, D., Woods, L., Church, S., Unwin, R., Kirkwood, G., Becker, L., Pearman, C., Taylor, R., Eisner, D., Dibb, K. & Trafford, A., 1 May 2019, In: Scientific Reports. 9, 1, 6801.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Bringing European physiologists together

Eisner, D., 22 Jan 2018, In: Acta Physiologica. p. 1 4 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

File

42 Downloads (Pure)

Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure

Denham, N. C., Pearman, C. M., Caldwell, J. L., Madders, G. W. P., Eisner, D. A., Trafford, A. W. & Dibb, K. M., 4 Oct 2018, In: Frontiers in Physiology. 9, OCT, p. 1380 1380.

Research output: Contribution to journal › Article › peer-review

Open Access

Increased vulnerability to atrial fibrillation is associated with increased susceptibility to alternans in old sheep

Pearman, C. M., Madders, G. W. P., Radcliffe, E. J., Kirkwood, G. J., Lawless, M., Watkins, A., Smith, C. E. R., Trafford, A. W., Eisner, D. A. & Dibb, K. M., 4 Dec 2018, In: Journal of the American Heart Association. 7, 23

Research output: Contribution to journal › Article › peer-review

Open Access

Not all choices are equal

Eisner, D., May 2018, In: Acta Physiologica. 223, 1, 1 p., e13040.

Research output: Contribution to journal › Letter › peer-review

Open Access

Phosphodiesterase-5 inhibition with sildenafil suppresses triggered ventricular arrhythmias and calcium waves via reduced sarcoplasmic reticulum content in the large mammal

Hutchings, D., Madders, G., Pearman, C., Woods, L., Dibb, K., Eisner, D. & Trafford, A., Jul 2018, In: Journal of molecular and cellular cardiology. 120, p. 37 1 p.

Research output: Contribution to journal › Meeting Abstract › peer-review

2017

Calcium and Excitation-Contraction Coupling in the Heart

Eisner, D., Caldwell, J., Kistamas, K. & Trafford, A., 6 Jul 2017, In: Circulation research.

Research output: Contribution to journal › Article › peer-review

Open Access

Effects of phosphodiesterase-5 inhibition with sildenafil on calcium waves in cardiac myocytes

Hutchings, D., Dibb, K., Eisner, D. & Trafford, A., 23 Feb 2017, In: The Lancet. 389, Special issue S50, 1 p.

Research output: Contribution to journal › Meeting Abstract

Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes

Clarke, J., Caldwell, J., Pearman, C., Eisner, D., Trafford, A. & Dibb, K., 2017, In: The Journal of Physiology. TJP12537.

Research output: Contribution to journal › Article › peer-review

Open Access

Phosphodiesterase-5 inhibition with sildenafil suppresses calcium waves by reducing sarcoplasmic reticulum content

Hutchings, D., Dibb, K., Pearman, C., Madders, G., Woods, L., Eisner, D. & Trafford, A., 1 Jun 2017, In: Heart. 103, 5, 1 p., 179.

Research output: Contribution to journal › Meeting Abstract

Reproducibility of Science: Fraud, Impact Factors and Carelessness

Eisner, D., 2017, In: Journal of molecular and cellular cardiology. JMCC11148R1 .

Research output: Contribution to journal › Article › peer-review

Open Access

Systolic [Ca²⁺]_i regulates diastolic levels in rat ventricular myocytes.

Sankaranarayanan, R., Kistamas, K., Greensmith, D., Venetucci, L. & Eisner, D., 14 Aug 2017, In: The Journal of Physiology. 595, 16, p. 5545-5555 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Ups and downs of calcium in the heart

Eisner, D., 2017, In: The Journal of Physiology. JP-PL-2017-275130R1 .

Research output: Contribution to journal › Article › peer-review

Open Access

File

108 Downloads (Pure)

2015

A model model: a commentary on DiFrancesco and Noble (1985) 'A model of cardiac electrical activity incorporating ionic pumps and concentration changes'.

Dibb, K., Trafford, A., Zhang, H. & Eisner, D., 19 Apr 2015, In: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370, 1666

Research output: Contribution to journal › Article › peer-review

Biphasic decay of the Ca transient results from increased sarcoplasmic reticulum Ca leak.

Sankaranarayanan, R., Li, Y., Greensmith, D. J., Eisner, D. A. & Venetucci, L., 5 Nov 2015, (E-pub ahead of print) In: The Journal of Physiology. 594, 3, p. 611-623 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Perturbed atrial calcium handling in an ovine model of heart failure: Potential roles for reductions in the L-type calcium current.

Clarke, J. D., Caldwell, J. L., Horn, M. A., Bode, E. F., Richards, M. A., Hall, M. C. S., Graham, H., Briston, S. J., Greensmith, D. J., Eisner, D. A., Dibb, K. M. & Trafford, A. W., Feb 2015, In: Journal of molecular and cellular cardiology. 79, p. 169-179 10 p.

Research output: Contribution to journal › Article › peer-review

The effect of 2,5-di-(tert-butyl)-1,4-benzohydroquinone (TBQ) on intracellular Ca2+ handling in rat ventricular myocytes.

Miller, L., Greensmith, D., Sankaranarayanan, R., O'Neill, S. & Eisner, D., Aug 2015, In: Cell calcium. 58, 2, p. 208-214 7 p.

Research output: Contribution to journal › Article › peer-review

2014

Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes

Briston, S., Dibb, K. M., Solaro, R. J., Eisner, D. A. & Trafford, A., 1 Nov 2014, In: Cardiovascular research. 104, 2, p. 347-354 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Calcium in the heart: from physiology to disease.

Eisner, D., 1 Oct 2014, In: Experimental Physiology. 99, 10

Research output: Contribution to journal › Article › peer-review

Dependence of Cardiac Transverse Tubules on the BAR Domain Protein Amphiphysin II (BIN-1)

Caldwell, J. L., Smith, C. E. R., Taylor, R. F., Kitmitto, A., Eisner, D. A., Dibb, K. M. & Trafford, A. W., 2014, In: Circulation research. 115, 12, p. 986-996 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Direct measurements of SR free Ca reveal the mechanism underlying the transient effects of RyR potentiation under physiological conditions

Greensmith, D. J., Galli, G. L. J., Trafford, A. W. & Eisner, D. A., 2014, In: Cardiovascular research. 103, 4, p. 554-563 9 p.

Research output: Contribution to journal › Article › peer-review

2013

A functional role for transverse (t-) tubules in the atria.

Dibb, K. M., Clarke, J. D., Eisner, D. A., Richards, M. A. & Trafford, A. W., May 2013, In: Journal of molecular and cellular cardiology. 58, 1, p. 84-91 7 p.

Research output: Contribution to journal › Article › peer-review

Calcium flux balance in the heart

Eisner, D., Bode, E., Venetucci, L. & Trafford, A., May 2013, In: Journal of molecular and cellular cardiology. 58, 1, p. 110-117 7 p.

Research output: Contribution to journal › Article › peer-review

Calcium signalling microdomains and the t-tubular system in atrial mycoytes: potential roles in cardiac disease and arrhythmias.

Trafford, A. W., Clarke, J. D., Richards, M. A., Eisner, D. A. & Dibb, K. M., 1 May 2013, In: Cardiovascular research. 98, 2, p. 192-203 11 p.

Research output: Contribution to journal › Article › peer-review

Diastolic spontaneous calcium release from the sarcoplasmic reticulum increases beat-to-beat variability of repolarization in canine ventricular myocytes after β-adrenergic stimulation

Johnson, D. M., Heijman, J., Bode, E. F., Greensmith, D. J., Van Der Linde, H., Abi-Gerges, N., Eisner, D. A., Trafford, A. W. & Volders, P. G. A., 18 Jan 2013, In: Circulation research. 112, 2, p. 246-256 10 p.

Research output: Contribution to journal › Article › peer-review

Effects of phosphodiesterase type 5 inhibition on intracellular calcium handling and its implications for cardioprotection and antiarrhythmogenesis

Hutchings, D., Lawless, M., Eisner, D. & Trafford, A., 27 Feb 2013, In: The Lancet. 381, Special issue S53, 1 p.

Research output: Contribution to journal › Meeting Abstract

How calcium signals in myocytes and pericytes are integrated across in situ microvascular networks and control microvascular tone

Borysova, L., Wray, S., Eisner, D. A. & Burdyga, T., Sept 2013, In: Cell calcium. 54, 3, p. 163-174 11 p.

Research output: Contribution to journal › Article › peer-review

Sarcoplasmic reticulum Ca-ATPase and heart failure 20 years later

Eisner, D., Caldwell, J. & Trafford, A., 27 Sept 2013, In: Circulation research. 113, 8, p. 958-961 3 p.

Research output: Contribution to journal › Article › peer-review

2012

Do calcium waves propagate between cells and synchronize alternating calcium release in rat ventricular myocytes?

Li, Y., Eisner, D. A. & O'Neill, S. C., Dec 2012, In: Journal of Physiology. 590, 24, p. 6353-6361 8 p.

Research output: Contribution to journal › Article › peer-review

Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation study.

Li, Q., O'Neill, S. C., Tao, T., Li, Y., Eisner, D. & Zhang, H., 4 Apr 2012, In: BIOPHYSICAL JOURNAL. 102, 7, p. 1471-1482 11 p.

Research output: Contribution to journal › Article › peer-review

2011

Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content

Stokke, M. K., Briston, S. J., Jølle, G. F., Manzoor, I., Louch, W. E., Øyehaug, L., Christensen, G., Eisner, D. A., Trafford, A. W., Sejersted, O. M. & Sjaastad, I., 1 Jun 2011, In: Cardiovascular research. 90, 3, p. 503-512 9 p.

Research output: Contribution to journal › Article › peer-review

Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca 2+ content in rat ventricular myocytes

Bode, E. F., Briston, S. J., Overend, C. L., O'Neill, S. C., Trafford, A. W. & Eisner, D. A., Oct 2011, In: Journal of Physiology. 589, 19, p. 4723-4729 6 p.

Research output: Contribution to journal › Article › peer-review

David Eisner, M.A. D.Phil, Dr (h.c.), FRCP (Hon), FMedSci

Research output

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