David Eisner

2011

Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure

Briston, S. J., Caldwell, J. L., Horn, M. A., Clarke, J. D., Richards, M. A., Greensmith, D. J., Graham, H. K., Hall, M. C. S., Eisner, D. A., Dibb, K. M. & Trafford, A. W., Mar 2011, In: Journal of Physiology. 589, 6, p. 1367-1382 15 p.

Research output: Contribution to journal › Article › peer-review

2010

Calcium signaling in cardiac muscle

Dibb, K. M., Trafford, A. W. & Eisner, D. A., 1 Dec 2010, Handbook of Cell Signaling. Bradshaw, R. A. & Dennis, E. A. (eds.). 2 ed. Elsevier BV, Vol. 2. p. 1027-1030 4 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

How does CaMKIIδ phosphorylation of the cardiac ryanodine receptor contribute to inotropy?

Eisner, D. A., George, C. H., Smith, G. L., Trafford, A. W. & Venetucci, L. A., 3 Aug 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 31, p. E123 1 p.

Research output: Contribution to journal › Letter › peer-review

Open Access

In the RyR2R4496C mouse model of CPVT, β-adrenergic stimulation induces ca waves by increasing SR Ca content and not by decreasing the threshold for Ca Waves

Kashimura, T., Briston, S. J., Trafford, A. W., Napolitano, C., Priori, S. G., Eisner, D. A. & Venetucci, L. A., 10 Dec 2010, In: Circulation research. 107, 12, p. 1483-1489 6 p.

Research output: Contribution to journal › Article › peer-review

Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes

Stokke, M. K., Hougen, K., Sjaastad, I., Louch, W. E., Briston, S. J., Enger, U. H., Andersson, K. B., Christensen, G., Eisner, D. A., Sejersted, O. M. & Trafford, A. W., Apr 2010, In: Cardiovascular research. 86, 1, p. 63-71 8 p.

Research output: Contribution to journal › Article › peer-review

The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte

Nirmalan, M., Greensmith, D. J., Eisner, D. A. & Nirmalan, M., Dec 2010, In: Cell calcium. 48, 6, p. 341-351 10 p.

Research output: Contribution to journal › Article › peer-review

2009

Beating to time: Calcium clocks, voltage clocks, and cardiac pacemaker activity

Eisner, D., Eisner, D. A. & Cerbai, E., Mar 2009, In: American Journal of Physiology: Heart and Circulatory Physiology. 296, 3, p. H561-H562

Research output: Contribution to journal › Article › peer-review

Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure

Dibb, K. M., Clarke, J. D., Horn, M. A., Richards, M. A., Graham, H. K., Eisner, D. A. & Trafford, A. W., Sept 2009, In: Circulation: Heart Failure. 2, 5, p. 482-489 7 p.

Research output: Contribution to journal › Article › peer-review

From the ryanodine receptor to cardiac arrhythmias

Eisner, D. A., Kashimura, T., Venetucci, L. A. & Trafford, A. W., Sept 2009, In: Circulation Journal. 73, 9, p. 1561-1567 6 p.

Research output: Contribution to journal › Article › peer-review

How structure, ca signals, and cellular communications underlie function in precapillary arterioles

Borisova, L., Wray, S., Eisner, D. A. & Burdyga, T., Oct 2009, In: Circulation research. 105, 8, p. 803-810 7 p.

Research output: Contribution to journal › Article › peer-review

Regulation of Intracellular and Mitochondrial Sodium in Health and Disease

Murphy, E. & Eisner, D. A., 13 Feb 2009, In: Circulation research. 104, 3, p. 292-303 11 p.

Research output: Contribution to journal › Article › peer-review

The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate

Eisner, D. A., Dibb, K. M. & Trafford, A. W., May 2009, In: Experimental Physiology. 94, 5, p. 520-528 8 p.

Research output: Contribution to journal › Article › peer-review

What is the purpose of the large sarcolemmal calcium flux on each heartbeat?

Eisner, D. A. & Trafford, A. W., Aug 2009, In: American Journal of Physiology: Heart and Circulatory Physiology. 297, 2, p. H493-H494

Research output: Contribution to journal › Article › peer-review

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?

Eisner, D. A., Kashimura, T., O'Neill, S. C., Venetucci, L. A. & Trafford, A. W., Apr 2009, In: Journal of molecular and cellular cardiology. 46, 4, p. 474-481 7 p.

Research output: Contribution to journal › Article › peer-review

2008

Sarcoplasmic reticulum and mitochondria in cardiac pathophysiology

Garcia-Dorado, D., Piper, H. M. & Eisner, D. A., Jan 2008, In: Cardiovascular research. 77, 2, p. 231-233 2 p.

Research output: Contribution to journal › Article › peer-review

2007

Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart

Dibb, K. M., Graham, H. K., Venetucci, L. A., Eisner, D. A. & Trafford, A. W., Oct 2007, In: Cell calcium. 42, 4-5, p. 503-512 9 p.

Research output: Contribution to journal › Article › peer-review

Does the adenosine A2A receptor stimulate the ryanodine receptor?

Venetucci, L., O'Neill, S. C. & Eisner, D. A., 1 Jan 2007, In: Cardiovascular research. 73, 1, p. 247-248 1 p.

Research output: Contribution to journal › Article › peer-review

Evolution of calcium homeostasis: From birth of the first cell to an omnipresent signalling system

Case, R. M., Eisner, D., Gurney, A., Jones, O., Muallem, S. & Verkhratsky, A., Oct 2007, In: Cell calcium. 42, 4-5, p. 345-350 5 p.

Research output: Contribution to journal › Article › peer-review

Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves: Threshold sarcoplasmic reticulum calcium content is required

Eisner, D., Venetucci, L. A., Trafford, A. W. & Eisner, D. A., Jan 2007, In: Circulation research. 100, 1, p. 105-111 6 p.

Research output: Contribution to journal › Article › peer-review

Na/Ca exchange: Regulator of intracellular calcium and source of arrhythmias in the heart

Eisner, D., Venetucci, L. A., Trafford, A. W., O'Neill, S. C. & Eisner, D. A., Mar 2007, In: Annals of the New York Academy of Sciences. 1099, p. 315-325 10 p.

Research output: Contribution to journal › Article › peer-review

Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+, L-type Ca2+ current and diastolic [Ca2+]i

Dibb, K. M., Eisner, D. A. & Trafford, A. W., 1 Dec 2007, In: Journal of Physiology. 585, 2, p. 579-592 13 p.

Research output: Contribution to journal › Article › peer-review

2006

Alternans of intracellular calcium: Mechanism and significance

Eisner, D. A., Li, Y. & O'Neill, S. C., Jun 2006, In: Heart rhythm : the official journal of the Heart Rhythm Society. 3, 6, p. 743-745 2 p.

Research output: Contribution to journal › Article › peer-review

A mechanism distinct from the L-type Ca current or Na-Ca exchange contributes to Ca entry in rat ventricular myocytes

Kupittayanant, P., Trafford, A. W., Díaz, M. E. & Eisner, D. A., May 2006, In: Cell calcium. 39, 5, p. 417-423 6 p.

Research output: Contribution to journal › Article › peer-review

How does endothelin-1 cause a sustained increase in intracellular sodium and calcium which lead to hypertrophy?

Eisner, D., Murphy, E. & Eisner, D. A., Nov 2006, In: Journal of molecular and cellular cardiology. 41, 5, p. 782-784 2 p.

Research output: Contribution to journal › Article › peer-review

Sodium calcium exchange as a target for antiarrhythmic therapy

Sipido, K. R., Varro, A. & Eisner, D., 2006, In: Handbook of Experimental Pharmacology. 171, p. 159-199 40 p.

Research output: Contribution to journal › Article › peer-review

2005

Stability and instability of regulation of intracellular calcium

Eisner, D. A., Diaz, M. E., Li, Y., O'Neill, S. C. & Trafford, A. W., Jan 2005, In: Experimental Physiology. 90, 1, p. 3-12 9 p.

Research output: Contribution to journal › Article › peer-review

The control of sarcoplasmic reticulum Ca content in cardiac muscle

Díaz, M. E., Graham, H. K., O'Neill, S. C., Trafford, A. W. & Eisner, D. A., Sept 2005, In: Cell calcium. 38, 3-4, p. 391-396 5 p.

Research output: Contribution to journal › Article › peer-review

2004

Interplay between SERCA and sarcolemmal Ca2+ efflux pathways controls spontaneous release of Ca2+ from the sarcoplasmic reticulum in rat ventricular myocytes

O'Neill, S. C., Miller, L., Hinch, R. & Eisner, D. A., 15 Aug 2004, In: Journal of Physiology. 559, 1, p. 121-128 7 p.

Research output: Contribution to journal › Article › peer-review

Mechanisms underlying enhanced cardiac excitation contraction coupling observed in the senescent sheep myocardium

Dibb, K. M., Rueckschloss, U., Eisner, D. A., Isenberg, G. & Trafford, A. W., Dec 2004, In: Journal of molecular and cellular cardiology. 37, 6, p. 1171-1181 10 p.

Research output: Contribution to journal › Article › peer-review

Physiological and pathological modulation of ryanodinereceptor function in cardiac muscle.

Eisner, D., Diaz, M., O'Neill, S. & Trafford, A., Jun 2004, In: Cell calcium. 35( 6)

Research output: Contribution to journal › Article › peer-review

Sarcoplasmic Reticulum Calcium Content Fluctuation Is the Key to Cardiac Alternans

Eisner, D., Díaz, M. E., O'Neill, S. C. & Eisner, D. A., 19 Mar 2004, In: Circulation research. 94, 5, p. 650-656 6 p.

Research output: Contribution to journal › Article › peer-review

Sodium calcium exchange in the heart: necessity or luxury?

Eisner, D. & Sipido, K., 17 Sept 2004, In: Circ. Res.. 95( 6)

Research output: Contribution to journal › Article › peer-review

Two centuries of excitation-contraction coupling

Wray, S., Ravens, U., Verkhratsky, A. & Eisner, D., Jun 2004, In: Cell calcium. 35, 6, p. 485-489 4 p.

Research output: Contribution to journal › Article › peer-review

2003

A new technique for simultaneous and in situ measurements of Ca2+ signals in arteriolar smooth muscle and endothelial cells

Burdyga, T., Shmygol, A., Eisner, D. A. & Wray, S., 1 Jul 2003, In: Cell calcium. 34, 1, p. 27-33 6 p.

Research output: Contribution to journal › Article › peer-review

Illuminating sarcoplasmic reticulum calcium

Venetucci, L., Trafford, A. W. & Eisner, D. A., 11 Jul 2003, In: Circulation research. 93, 1, p. 4-5 1 p.

Research output: Contribution to journal › Article › peer-review

No role for a voltage sensitive release mechanism in cardiac muscle

Trafford, A. W. & Eisner, D. A., 1 Feb 2003, In: Journal of molecular and cellular cardiology. 35, 2, p. 145-151 6 p.

Research output: Contribution to journal › Article › peer-review

Sarcoplasmic reticulum Ca2+ and heart failure roles of diastolic leak and Ca2+ transport

Bers, D. M., Eisner, D. A. & Valdivia, H. H., 19 Sept 2003, In: Circulation research. 93, 6, p. 487-490 3 p.

Research output: Contribution to journal › Article › peer-review

2002

Depressed ryanodine receptor activity increases variability and duration of the systolic Ca2+ transient in rat ventricular myocytes

O'Neill, S., Díaz, M. E., Eisner, D. A. & O'Neill, S. C., 4 Oct 2002, In: Circulation research. 91, 7, p. 585-593 8 p.

Research output: Contribution to journal › Article › peer-review

Heart failure and the ryanodine receptor: does Occam's razor rule?

Eisner, D. & Trafford, A., 2002, In: Circulation research. 91

Research output: Contribution to journal › Article › peer-review

pH-induced changes in calcium: Functional consequences and mechanisms of action in guinea pig portal vein

Smith, R. D., Eisner, D. A. & Wray, S., 1 Dec 2002, In: American Journal of Physiology: Heart and Circulatory Physiology. 283, 6, p. H2518-H2526

Research output: Contribution to journal › Article › peer-review

2001

Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition

O'Neill, S., Overend, C. L., Eisner, D. A. & O'Neill, S. C., 2 Feb 2001, In: Circulation research. 88, 2, p. 181-187 6 p.

Research output: Contribution to journal › Article › peer-review

Coordinated control of cell Ca loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca current.

Trafford, A., Diaz, M. & Eisner, D., 2 Feb 2001, In: Circulation research. 88, p. 195-201

Research output: Contribution to journal › Article › peer-review

Low sodium inotropy is accompanied by diastolic Ca2+ gain and systolic loss in isolated guinea-pig ventricular myocytes

Même, W., O'Neill, S. C. & Eisner, D. A., 1 Feb 2001, In: Journal of Physiology. 530, 3, p. 487-495 8 p.

Research output: Contribution to journal › Article › peer-review

Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic [Ca 2+] in rat uterine smooth muscle cells

Shmigol, A. V., Eisner, D. A. & Wray, S., 15 Mar 2001, In: Journal of Physiology. 531, 3, p. 707-713 6 p.

Research output: Contribution to journal › Article › peer-review

The effects of exogenous Ca buffers on the systolic Ca transient in rat ventricular myocytes.

Diaz, M., Trafford, A. & Eisner, D., Apr 2001, In: Biophysical Journal. 80, p. 1915-1925

Research output: Contribution to journal › Article › peer-review

The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes

Díaz, M. E., Trafford, A. W. & Eisner, D. A., 2001, In: Pflügers Archiv European Journal of Physiology. 442, 1, p. 96-100 4 p.

Research output: Contribution to journal › Article › peer-review

2000

Can changes of ryanodine receptor expression affect cardiac contractility? [2] (multiple letters)

Diaz, M. E., Trafford, A. W., O'Neill, S. C., Eisner, D. A., Yano, M. & Yamamoto, T., 2000, In: Cardiovascular research. 45, 4, p. 1068-1071 3 p.

Research output: Contribution to journal › Article › peer-review

Integrative analysis of calcium cycling in cardiac muscle

Eisner, D., Choi, H. S., Díaz, M. E., O'Neill, S. & Trafford, A. W., 8 Dec 2000, In: Circulation research. 87, 12, p. 1087-1094 7 p.

Research output: Contribution to journal › Article › peer-review

Measurement of calcium entry and exit in quiescent rat ventricular myocytes

Choi, H. S., Trafford, A. W. & Eisner, D. A., 2000, In: Pflügers Archiv European Journal of Physiology. 440, 4, p. 600-608 8 p.

Research output: Contribution to journal › Article › peer-review

Modulation of Ca-induced Ca release has not maintained effect on systolic Ca: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca fluxes in rat ventricular myocytes.

Trafford, A., Eisner, D., Diaz, M. & Sibbring, G. C., 2000, In: Journal of Physiology. 522

Research output: Contribution to journal › Article › peer-review

David Eisner, M.A. D.Phil, Dr (h.c.), FRCP (Hon), FMedSci

Research output

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