Elise Kleyn MBChB, FRCP, MMedSci, PhD

Search results

• 2023

  Fertility Trends and Adverse Pregnancy Outcomes in Female Patients With Psoriasis in the UK

  Chen, T.-C. (Corresponding), Iskandar, I., Parisi, R., Pierce, M., Tower, C., Kleyn MBChB, FRCP, MMedSci, PhD, E., Griffiths, C. E. M. & Ashcroft, D., 7 Jun 2023, In: JAMA dermatology. 159, 7, p. 736-744 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Psoriasis 100%
  • Cohort Study 100%
  • Sample Size 50%
  • Cohort Analysis 11%
  • General Medicine 11%
• 2022

  Brain structure and connectivity in psoriasis and associations with depression and inflammation; findings from the UK Biobank

  Lada, G., Talbot, P. S., Chinoy, H., Warren, R., Mcfarquhar, M. & Kleyn MBChB, FRCP, MMedSci, PhD, E., 1 Dec 2022, In: Brain, Behavior, & Immunity - Health. 26

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain Imaging 100%
  • Precuneus 100%
  • Magnetic Resonance Imaging 50%
  • C-Reactive Protein 50%
  • Depression Co Morbidities 50%

• Impact of the COVID-19 Pandemic on the Mental Health and Quality of Life of Patients with Psoriasis in Tertiary Care; A One-year Follow-up

  Lada, G., Chinoy, H., Talbot, P. S., Warren, R. B. & Kleyn, C. E., 14 Nov 2022, In: Acta Dermato-Venereologica. 102, p. adv00814

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  Risks of basal cell and squamous cell carcinoma in psoriasis patients after treatment with biologic vs non‐biologic systemic therapies

  Mason, K. J., Burden, A. D., Barker, J. N. W. N., Lunt, M., Ali, H., Kleyn, C. E., McElhone, K., Soliman, M. M., Green, A. C., Griffiths, C. E. M., Reynolds, N. J., Ormerod, A. D., Benham, M., Browne, F., Evans, I., Hussain, S., Kirby, B., Lawson, L., Laws, P. & Mackenzie, T. & 7 others, McPherson, T., Murphy, R., Owen, C., Pearson, E., Richards, J., Smith, C. & Warren, R., 1 Aug 2021, In: Journal of the European Academy of Dermatology and Venereology. 35, 8, p. e496-e498

  Research output: Contribution to journal › Article › peer-review
• 2020

  Psoriasis and Mental Health Workshop Report: Exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk

  Kleyn, C. E., Talbot, P., Mehta, N. N., Sampogna, F., Bundy, C., Ashcroft, D., Kimball, A. B., van de Kerkhof, P., Griffiths, C., Valenzuela, F., van der Walt, J. M., Aberra, T. & Puig , L., 2020, In: Acta Dermato-Venereologica. 100, 1, p. 1-8 8 p., adv00020.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Mental Health 100%
  • Comorbidity 100%
  • Innate Immune System 33%
  • Inflammatory Disorder 33%
  • Adaptive Immune System 33%
• 2019

  Clinical Goals and Barriers to Effective Psoriasis Care

  Strober, B. E., van der Walt, J. M., Armstrong, A. W., Bourcier, M., Carvalho, A. V. E., Chouela, E., Cohen, A. D., de la Cruz, C., Ellis, C. N., Finlay, A. Y., Gottlieb, A. B., Gudjonsson, J. E., Iversen, L., Kleyn, C. E., Leonardi, C. L., Lynde, C. W., Ryan, C., Theng, C. T., Valenzuela, F. & Vender, R. & 3 others, Wu, J. J., Young, H. S. & Kimball, A. B., Mar 2019, In: Dermatology and Therapy. 9, 1, p. 5-18 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Psoriasis 100%
  • Disease 16%
  • Combination Therapy 16%
  • Autoimmune Disease 16%
  • Clinical Science 16%

• Persistence and Effectiveness of Non-Biologic Systemic Therapies for Moderate-Severe Psoriasis in Adults: a Systematic Review

  Mason, K., Williams, S., Yiu, Z., McElhone, K., Ashcroft, D., Kleyn, C., Jabbar-Lopez, Z. K., Owen, C. M., Reynolds, N. J., Smith, C. H., Wilson, N., Warren, R. & Griffiths, C., 2019, In: Br J Dermatol. 181, 2, p. 256-264

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psoriasis 100%
  • Systemic Therapy 100%
  • Methotrexate 100%
  • Fumaric Acid 71%
  • Cyclosporine 57%
  89 Downloads (Pure)

• Psychiatric morbidity and suicidal behaviour in psoriasis: a primary care cohort study

  Parisi, R., Webb, R. T., Kleyn, C. E., Carr, M. J., Kapur, N., Griffiths, C. E. M. & Ashcroft, D. M., 1 Jan 2019, In: The British journal of dermatology. 180, 1, p. 108-115 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psoriasis 100%
  • Hazard Ratio 38%
  • Comorbidity 7%
  • Mental Illness 7%
  • Bipolar Disorder 7%
  387 Downloads (Pure)
• 2018

  Risk of Cancer in Patients with Psoriasis on Biological Therapies: A Systematic Review

  Peleva, E., Exton, L., Kelley, K., Kleyn, C., Mason, K. & Smith, C. H., Jan 2018, In: British Journal of Dermatology. 178, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Psoriasis 100%
  • Malignant Neoplasm 100%
  • Biological Therapy 100%
  • Non Melanoma Skin Cancer 66%
  • TNF Inhibitor 50%
  717 Downloads (Pure)
• 2017

  Alcohol-related mortality in patients with psoriasis: A Population-Based Cohort Study

  Parisi, R., Webb, R. T., Carr, M. J., Moriarty, K. J., Kleyn, C. E., Griffiths, C. E. M. & Ashcroft, D. M., 1 Dec 2017, In: JAMA dermatology. 153, 12, p. 1256-1262 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cohort Study 100%
  • Ethanol 100%
  • Psoriasis 100%
  • Premature Mortality 100%
  • Cohort Analysis 100%
  68 Downloads (Pure)

• Functional magnetic resonance imaging in dermatology: The skin, the brain and the invisible

  Mueller, S. M., Hogg, S., Mueller, J., McKie, S., Itin, P., Reinhardt, J., Griffiths, C. E. M. & Kleyn, C. E., 2017, In: Experimental Dermatology.

  Research output: Contribution to journal › Article › peer-review

  • Experimental Pruritus 100%

• Topical treatment of psoriasis: questionnaire results on topical therapy accessibility and influence of body surface area on usage

  Kleyn, C., Jul 2017, In: European Academy of Dermatology and Venereology. Journal . 31, 7, p. 1188-1195

  Research output: Contribution to journal › Article › peer-review

  • Psoriasis 100%
  • Topical Agent 25%
  • Combination Therapy 25%
  • Adverse Event 25%
  • Disease Severity 25%
• 2016

  Brain inflammation and psoriasis: a [11C]-(R)-PK11195 positron emission tomography study

  Hunter, H. J., Hinz, R., Gerhard, A., Talbot, P., Su, Z., Holland, G., Hopkins, S. J., Griffiths, C. & Kleyn, C., Nov 2016, In: British Journal of Dermatology. 175, 5, p. 1082-1084 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Arthritis 100%
  • Positron Emission Tomography 100%
  • Dermatitis 100%
  • Comorbidity 100%

• Identification of key research needs for topical therapy treatment of psoriasis - a consensus paper by the International Psoriasis Council

  Wu, J. J., Lynde, C. W., Kleyn, C., Iversen, L., Van der Walt, J. M., Carvalho, A., Kirby, B. & Bissonnette, R., Jul 2016, In: Journal of the European Academy of Dermatology and Venereology. 30, 7, p. 1115-1119

  Research output: Contribution to journal › Article › peer-review

  • Psoriasis 100%
  • Topical Treatment 100%
  • Topical Agent 16%
  • Phototherapy 16%
• 2015

  The Impact of psychosocial stress on healthy skin

  Hunter, H. J., Momen, S. E. & Kleyn, C. E., 25 Mar 2015, In: Clinical and Experimental Dermatology. p. 540-546 6 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  A temporal analysis of the central neural processing of itch

  Kleyn, C. E., McKie, S., Ross, A., Elliott, R. & Griffiths, C. E. M., May 2012, In: British Journal of Dermatology. 166, 5, p. 994-1001 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Blood-Oxygen-Level Dependent 100%
  • Histamine 66%
  • Anterior Cingulate Cortex 66%
  • Functional Magnetic Resonance Imaging 66%
  • Ventral Striatum 50%

• The British Association of Dermatologists' Biologic Interventions Register (BADBIR): Design, methodology and objectives

  Burden, A. D., Warren, R. B., Kleyn, C. E., McElhone, K., Smith, C. H., Reynolds, N. J., Ormerod, A. D. & Griffiths, C. E. M., Mar 2012, In: British Journal of Dermatology. 166, 3, p. 545-554 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Biological Product 100%
  • Psoriasis 80%
  • Adverse Event 40%
  • Disease Activity 20%
  • Infection 20%
• 2011

  Cumulative life course impairment in psoriasis: patient perception of disease-related impairment throughout the life course.

  Warren, R. B., Kleyn, C. E. & Gulliver, W. P., May 2011, In: The British journal of dermatology. 164 Suppl 1, 1, p. 1-14 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Stigmatization 100%
  • Sectional Data 100%
  • Psoriasis 100%
  • Comorbidity 12%
  • Coping Strategies 12%
• 2010

  Langerhans cell mobilization distinguishes between early-onset and late-onset psoriasis

  Shaw, F. L., Cumberbatch, M., Kleyn, C. E., Begum, R., Dearman, R. J., Kimber, I. & Griffiths, C. E. M., Jul 2010, In: Journal of Investigative Dermatology. 130, 7, p. 1940-1942 2 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Diminished neural and cognitive responses to facial expressions of disgust in patients with psoriasis: A functional magnetic resonance imaging study

  Kleyn, C. E., McKie, S., Ross, A. R., Montaldi, D., Gregory, L. J., Elliott, R., Isaacs, C. L., Anderson, I. M., Richards, H. L., Deakin, J. F. W., Fortune, D. G. & Griffiths, C. E. M., Nov 2009, In: Journal of Investigative Dermatology. 129, 11, p. 2613-2619 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Psoriasis 100%
  • Functional Magnetic Resonance Imaging 100%
  • Facial Expression 100%
  • Disgust 100%
  • Face Perception 40%
• 2008

  Neural correlates for itch processing: a functional magnetic resonance imaging study

  Kleyn, C., Mckie, S., Ross, A., Marsland, A. & Griffiths, C., Apr 2008, In: Journal of Investigative Dermatology. 128, p. S73-S73 438.

  Research output: Contribution to journal › Article › peer-review

• The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

  Skvara, H., Dawid, M., Kleyn, E., Wolff, B., Meingassner, J. G., Knight, H., Dumortier, T., Kopp, T., Fallahi, N., Stary, G., Burkhart, C., Grenet, O., Wagner, J., Hijazi, Y., Morris, R. E., McGeown, C., Rordorf, C., Griffiths, C. E. M., Stingl, G. & Jung, T., 2 Sept 2008, In: Journal of Clinical Investigation. 118, 9, p. 3151-3159 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Psoriasis 100%
  • Sotrastaurin 100%
  • Single Drug Dose 50%
  • Normal Human 28%
  • Cytokine 14%
• 2007

  A spectrum of lupus erythematosus from verrucous to systemic, coexisting with two types of porphyria [25]

  Bharati, A., Kleyn, E., Wong, G. A. E., Leonard, N. & King, C. M., Aug 2007, In: Journal of the European Academy of Dermatology and Venereology. 21, 7, p. 1009-1010 1 p.

  Research output: Contribution to journal › Article › peer-review
• 2006

  Chromate allergy from leather shoes and sofas.

  Patel, T., Kleyn, C., King, C. & Wilson, N., 2006, In: Contact dermatitis. 54, p. 171-172

  Research output: Contribution to journal › Article › peer-review

• Cutaneous Manifestations of Malignancy: Diagnosis and Management.

  Kleyn, C., Lai-Cheong, J. & Bell, H., 2006, In: Am J Clin Dermatol. 7, p. 71-84

  Research output: Contribution to journal › Article › peer-review

• Infliximab for the treatment of psoriasis

  Kleyn, C. E. & Griffiths, C. E. M., Aug 2006, In: Expert opinion on biological therapy. 6, 8, p. 797-805 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Psoriasis 100%
  • Infliximab 100%
  • Tumor Necrosis 40%
  • Tumor Necrosis Factor 40%
  • Infection 20%

• The role of neuropeptides in psoriasis

  Saraceno, R., Kleyn, C. E., Terenghi, G. & Griffiths, C. E. M., Nov 2006, In: British Journal of Dermatology. 155, 5, p. 876-882 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuropeptide 100%
  • Neurogenic Inflammation 100%
  • Nerve Growth Factor 100%
  • Vasoactive Intestinal Peptide 33%
  • Cutaneous Nerve 33%