Elizabeth Cartwright

2024

Empowering artificial intelligence in characterizing the human primary pacemaker of the heart at single cell resolution

Chelu, A., Cartwright, E. J. & Dobrzynski, H., 18 Jun 2024, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca2+ handling

Quinn, C. J., Cartwright, E. J., Trafford, A. W. & Dibb, K. M., 1 May 2024, In: The Journal of physiology. 602, 9, p. 1893-1910

Research output: Contribution to journal › Article › peer-review

Open Access

Treatment with αvβ3-integrin-specific 29P attenuates pressure-overload induced cardiac remodelling after transverse aortic constriction in mice

Njegić, A., Laid, L., Zi, M., Maniati, E., Wang, J., Chelu, A., Wisniewski, L., Hunter, J., Prehar, S., Stafford, N., Gilon, C., Hoffman, A., Weinmüller, M., Kessler, H., Cartwright, E. J. & Hodivala-Dilke, K., 1 Jun 2024, In: Journal of Molecular and Cellular Cardiology Plus. 8, 100069.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Extracellular Histone-Induced Protein Kinase C Alpha Activation and Troponin Phosphorylation Is a Potential Mechanism of Cardiac Contractility Depression in Sepsis

Abrams, S. T., Alhamdi, Y., Zi, M., Guo, F., Du, M., Wang, G., Cartwright, E. J. & Toh, C.-H., 6 Feb 2023, In: International Journal of Molecular Sciences. 24, 4, 3225.

Research output: Contribution to journal › Article › peer-review

Open Access

Restored autophagy is protective against PAK3-induced cardiac dysfunction

Ruiz Velasco Hernandez, A., Raja, R., Chen, X., Ganenthiran, H., Kaur, N., Alatawi, N. H. O., Miller, J. M., Abouleisa, R. R. E., Ou, Q., Zhao, X., Fonseka, O., Wang, X., Hille, S., Frey, N., Wang, T., Mohamed, T., Müller, O. J., Cartwright, E. & Liu, W., 16 Jun 2023, In: iScience. 26, 6, 106970.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Cardiomyocyte-specific loss of plasma membrane calcium ATPase 1 impacts cardiac rhythm and is associated with ventricular repolarisation dysfunction

Wilson, C., Stafford, N., Zi, M., Chelu, A., Niort, B. C., Li, Y., Baudoin, F., Prehar, S., Trafford, A. W. & Cartwright, E. J., 1 Aug 2022, In: Journal of molecular and cellular cardiology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes

Rajab, B., Kassab, S., Mironov, A., Stonall, C., Daghistani, H., Gibbons, S., Mamas, M., Smith, D., Albalawi, Z., Baudoin, F., Zi, M., Prehar, S., Cartwright, E., Zhang, Y. H. & Kitmitto, A., 19 Jan 2022, In: Scientific Reports. 12, 1, 978.

Research output: Contribution to journal › Article › peer-review

Open Access

Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice

Nugroho, A. B., Stafford, N., Zi, M., Prehar, S., Potter, R., Kwon, D., Kohar, Y. S., Triastuti, E., Bui, T. A., Cartwright, E. J. & Oceandy, D., Sept 2022, In: JACC: Basic to Translational Science. 7, 9, p. 859-875 17 p.

Research output: Contribution to journal › Article › peer-review

Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy

Kaur, N., Ruiz-velasco, A., Raja, R., Howell, G., Miller, J. M., Abouleisa, R. R. E., Ou, Q., Mace, K., Hille, S. S., Frey, N., Binder, P., Smith, C. P., Fachim, H., Soran, H., Swanton, E., Mohamed, T. M. A., Müller, O. J., Wang, X., Chernoff, J. & Cartwright, E. J. & 1 others, Liu, W., 23 Feb 2022, In: iScience. 25, 3, p. 103973 103973.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

D’Souza, A., Wang, Y., Anderson, C., Bucchi, A., Baruscotti, M., Olieslagers, S., Mesirca, P., Johnsen, A. B., Mastitskaya, S., Ni, H., Zhang, Y., Black, N., Cox, C., Wegner, S., Bano-Otalora, B., Petit, C., Gill, E., Logantha, S. J. R. J., Dobrzynski, H. & Ashton, N. & 10 others, Hart, G., Zhang, R., Zhang, H., Cartwright, E. J., Wisloff, U., Mangoni, M. E., Martins, P. A. D. C., Piggins, H. D., DiFrancesco, D. & Boyett, M. R., 1 May 2021, In: Heart Rhythm. 18, 5, p. 801-810 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes

Mesirca, P., Nakao, S., Nissen, S. D., Forte, G., Anderson, C., Trussell, T., Li, J., Cox, C., Zi, M., Logantha, S. J. R., Yaar, S., Carstensen, H., Bidaud, I., Stuart, L., Soattin, L., Morris, G. M., da Costa Martins, P. A., Cartwright, E. J., Oceandy, D. & Mangoni, M. E. & 5 others, Jespersen, T., Buhl, R., Dobrzynski, H., Boyett, M. R. & D'Souza, A., 14 Apr 2021, In: Circulation research.

Research output: Contribution to journal › Article › peer-review

Substrate for the Myocardial Inflammation-Heart Failure Hypothesis Identified Using Novel USPIO Methodology

Lagan, J., Naish, J., Simpson, K., Zi, M., Cartwright, E., Foden, P., Morris, J., Clark, D., Birchall, L., Caldwell, J., Trafford, A., Fortune, C., Cullen, M. H., Chaudhuri, N., Fildes, J., Sarma, J., Schelbert, E. B., Schmitt, M., Piper Hanley, K. & Miller, C., 1 Feb 2021, In: JACC: Cardiovascular Imaging. 14, 2, p. 365-376 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Adenoviral Mediated Delivery of OSKM Factors Induces Partial Reprogramming of Mouse Cardiac Cells In Vivo

Kisby, T., Lázaro, I., Fisch, S., Cartwright, E. J., Cossu, G. & Kostarelos, K., 27 Oct 2020, (E-pub ahead of print) In: Advanced Therapeutics. p. 2000141

Research output: Contribution to journal › Article › peer-review

Open Access

Cardiac mitochondrial function depends on BUD23 mediated ribosome programming

Baxter, M., Voronkov, M., Poolman, T., Galli, G., Pinali, C., Goosey, L., Knight, A., Krakowiak, K., Maidstone, R., Iqbal, M., Zi, M., Prehar, S., Cartwright, E. J., Gibbs, J., Matthews, L. C., Adamson, A. D., Humphreys, N. E., Rebelo-guiomar, P., Minczuk, M. & Bechtold, D. A. & 2 others, Loudon, A. & Ray, D., 15 Jan 2020, In: eLife. 9, e50705.

Research output: Contribution to journal › Article › peer-review

Open Access

Signaling via the Interleukin-10 Receptor Attenuates Cardiac Hypertrophy in Mice During Pressure Overload, but not Isoproterenol Infusion

Stafford, N., Assrafally, F., Prehar, S., Zi, M., De Morais, A. M., Maqsood, A., Cartwright, E., Mueller, W. & Oceandy, D., 30 Oct 2020, (E-pub ahead of print) In: Frontiers in Pharmacology.

Research output: Contribution to journal › Article › peer-review

Open Access

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

Yanni Gerges, J., D'Souza, A., Wang, Y., Li, N., Hansen, B. J., Zakharkin, S., Smith, M., Hayward, C., Whitson, B. A., Mohler, P. J., Janssen, P. M. L., Zeef, L., Choudhury, M., Zi, M., Cai, X., Logantha, S., Nakao, S., Atkinson, A., Petkova, M. & Doris, U. & 8 others, Ariyaratnam, J., Cartwright, E., Griffiths-Jones, S., Hart, G., Federov, V. V., Oceandy, D., Dobrzynski, H. & Boyett, M., 9 Jul 2020, In: Scientific Reports. 10, 11279.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure: javascript:void(0);

Ruiz-velasco, A., Zi, M., Hille, S. S., Azam, T., Kaur, N., Jiang, J., Nguyen, B., Sekeres, K., Binder, P., Collins, L., Pu, F., Xiao, H., Guan, K., Frey, N., Cartwright, E. J., Müller, O. J., Wang, X. & Liu, W., 30 Mar 2020, (E-pub ahead of print) In: eLife. 9

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Cardiac hypertrophy or failure? - A systematic evaluation of the transverse aortic constriction model in C57BL/6NTac and C57BL/6J substrains

Zi, M., Stafford, N., Prehar, S., Baudoin, F., Oceandy, D., Wang, X., Bui, T., Shaheen, M., Neyses, L. & Cartwright, E., 1 Dec 2019, In: Current Research in Physiology.

Research output: Contribution to journal › Article › peer-review

Open Access

Cardiomyocyte damage control in heart failure and the role of the sarcolemma

Kitmitto, A., Baudoin, F. & Cartwright, E. J., 13 Sept 2019, In: Journal of Muscle Research and Cell Motility .

Research output: Contribution to journal › Article › peer-review

Open Access

Pak2 as a Novel Therapeutic Target for Cardioprotective Endoplasmic Reticulum Stress Response

Binder, P., Wang, S., Radu, M., Zi, M., Collins, L., Khan, S., Li, Y., Sekeres, K., Humphreys, N. E., Swanton, E., Reid, A., Pu, F., Oceandy, D., Guan, K., Hille, S., Frey, N., Müller, O. J., Cartwright, E. J., Chernoff, J. & Liu, W. & 1 others, Wang, X., 8 Jan 2019, In: Circulation research. 124, 5, p. 696-711 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Pharmacological Inhibition of Hippo Pathway using XMU‐MP‐1 Protects The Heart Against Adverse Effects during Pressure Overload

Triastuti, E., Nugroho, A. B., Zi, M., Prehar, S., Kohar, Y. S., Bui, T. A., Stafford, N., Cartwright, E. J., Abraham, S. & Oceandy, D., 2019, In: British Journal of Pharmacology.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Acute inhibition of PMCA4, but not global ablation, reduces blood pressure and arterial contractility via a nNOS-dependent mechanism

Lewis, S., Little, R., Baudoin, F., Prehar, S., Neyses, L., Cartwright, E. & Austin, C., 2017, In: Journal of cellular and molecular medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

Advanced glycation end products reduce the calcium transient in cardiomyocytes by increasing production of reactive oxygen species and nitric oxide

Hegab, Z., Mohamed, T. M. A., Stafford, N., Mamas, M., Cartwright, E. J. & Oceandy, D., Nov 2017, In: FEBS open bio. 7, 11, p. 1672-1685 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival

Robertson, A., Mohamed, T., El Maadawi, Z., Stafford, N., Bui, T., Lim, D. S., Cartwright, E. & Oceandy, D., 1 Apr 2017, In: Stem Cell Research. 20, p. 42-49 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signalling

Liu, W., Ruiz Velasco Hernandez, A., Wang, S., Khan, S., Zi, M., Jungmann, A., Camacho-Munoz, M. D., Guo, J., Du, G., Xie, L., Oceandy, D., Nicolaou, A., Galli, G., Müller, O. J., Cartwright, E., Ji, Y. & Wang, X., 8 Sept 2017, In: Nature Communications. 8, 494.

Research output: Contribution to journal › Article › peer-review

Open Access

Plasma membrane Ca2+ ATPase 1 is required for maintaining atrial Ca2+ homeostasis and electrophysiological stability in the mouse

Wang, Y., Wilson, C., Cartwright, E. & Lei, M., 2017, In: The Journal of Physiology.

Research output: Contribution to journal › Article › peer-review

Open Access

Reduced Expression of PMCA1 is Associated with Increased Blood Pressure with Age Which is Preceded by Remodeling of Resistance Arteries

Little, R., Zi, M., Hammad, S. K., Nguyen, L., Njegic, A., Kurusamy, S., Prehar, S., Armesilla, A. L., Neyses, L., Austin, C. & Cartwright, E., 2017, In: Aging cell. 16, 5

Research output: Contribution to journal › Article › peer-review

Open Access

Selective inhibition of plasma membrane calcium ATPase 4 improves angiogenesis and vascular reperfusion

Kurusamy, S., López-Maderuelo, D., Little, R., Cadagan, D., Savage, A. M., Ihugba, J. C., Baggott, R. R., Rowther, F. B., Martínez-Martínez, S., Arco, P. G. D., Murcott, C., Wang, W., Francisco Nistal, J., Oceandy, D., Neyses, L., Wilkinson, R. N., Cartwright, E. J., Redondo, J. M. & Armesilla, A. L., Aug 2017, In: Journal of molecular and cellular cardiology. 109, p. 38-47 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Stress-Activated Kinase MKK7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention

Chowdhury, S. K., Liu, W., Zi, M., Li, Y., Wang, S., Tsui, H., Prehar, S., Castro, S., Zhang, H., Ji, Y., Zhang, X., Xiao, R., Zhang, R., Lei, M., Cyganek, L., Guan, K., Millar, C. B., Liao, X., Jain, M. K. & Boyett, M. R. & 3 others, Cartwright, E. J., Shiels, H. A. & Wang, X., 2017, In: Circulation. 135, 7, p. 683-699 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia

D'Souza, A., Pearman, C. M., Wang, Y., Nakao, S., Logantha, S. J. R. J., Cox, C., Bennett, H., Zhang, Y., Johnsen, A. B., Linscheid, N., Poulsen, P. C., Elliott, J., Coulson, J., McPhee, J., Robertson, A., Da Costa Martins, P. A., Kitmitto, A., Wisløff, U., Cartwright, E. J. & Monfredi, O. & 5 others, Lundby, A., Dobrzynski, H., Oceandy, D., Morris, G. M. & Boyett, M. R., 13 Oct 2017, In: Circulation research. 121, 9, p. 1058-1068 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The plasma membrane calcium ATPases and their role as major new players in human disease.

Stafford, N., Wilson, C., Oceandy, D., Neyses, L. & Cartwright, E. (Corresponding), 2017, In: Physiological Reviews. 97, 3, p. 1089-1125 37 p.

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Open Access

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2016

Atrioventricular node dysfunction and ion channel transcriptome in pulmonary hypertension

Temple, I., Logantha, S., Absi, M., Zhang, Y., Pervolaraki, E., Yanni Gerges, J., Atkinson, A., Petkova, M., Quigley, G., Castro, S., Drinkhill, M. J., Schneider, H., Monfredi, O., Cartwright, E., Yamanushi, T. T., Mahadevan, V. S., Gurney, A., White, E., Zhang, H. & Hart, G. & 2 others, Boyett, M. & Dobrzynski, H., 15 Dec 2016, In: Circulation: Arrhythmia and Electrophysiology. 9, e003432.

Research output: Contribution to journal › Article › peer-review

Open Access

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Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?

van Loon, E. P. M., Little, R., Prehar, S., Bindels, R. J. M., Cartwright, E. J. & Hoenderop, J. G. J., 21 Apr 2016, In: PLoS ONE. 11, 4, e0153483.

Research output: Contribution to journal › Article › peer-review

Open Access

Circulating histone concentrations differentially affect the predominance of left or right ventricular dysfunction in critical illness.

Alhamdi, Y., Zi, M., Abrams, S. T., Liu, T., Su, D., Welters, I., Dutt, T., Cartwright, E. J., Wang, G. & Toh, C.-H., 1 May 2016, In: Critical Care Medicine. 44, 5, p. e278-e288

Research output: Contribution to journal › Article › peer-review

The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice

Omede, A., Zi, M., Prehar, S., Maqsood, A., Stafford, N., Mamas, M., Cartwright, E. & Oceandy, D., 2016, In: Biochemical and Biophysical Research Communications. 479, 4, p. 708-714 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The Plasma Membrane Calcium ATPase 4 Signalling in Cardiac Fibroblasts Mediates Cardiomyocyte Hypertrophy

Mohamed, T. M. A., Abou-Leisa, R., Stafford, N., Maqsood, A., Zi, M., Prehar, S., Baudoin, F., Wang, X., Neyses, L., Cartwright, E. & Oceandy, D., 29 Mar 2016, In: Nature Communications. 7:1107, 11074.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired eesponsiveness to 1, 25-Dihydroxyvitamin D3.

Ryan, Z. C., Craig, T. A., Filoteo, A. G., Westendorf, J. J., Cartwright, E. J., Neyses, L., Strehler, E. E. & Kumar, R., 2015, In: Biochemical and biophysical research communications. 467, 1, p. 152–156

Research output: Contribution to journal › Article › peer-review

Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32.

Tsui, H., Zi, M., Wang, S., Chowdhury, S. K., Prehar, S., Liang, Q., Cartwright, E. J., Lei, M., Liu, W. & Wang, X., Dec 2015, In: Hypertension. 66, 6, p. 1176-1183 8 p.

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Open Access

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2014

Ablation of the Hypertension Candidate Gene ATP2B1 Results in Increased Blood Pressure and Cardiac Hypertrophic Remodeling. American Heart Association Scientific Sessions 2014-Abstract 13798

Hammad, S. K., Zi, M., Prehar, S., Little, R., Neyses, L. & Cartwright, E., 2014, In: Circulation. 130, Suppl 2

Research output: Contribution to journal › Article › peer-review

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

D'souza, A., Bucchi, A., Johnsen, A. B., Logantha, S. J. R. J., Monfredi, O., Yanni, J., Prehar, S., Hart, G., Cartwright, E., Wisloff, U., Dobrzynski, H., Difrancesco, D., Morris, G. M. & Boyett, M. R., 13 May 2014, In: Nature Communications. 5, 3775.

Research output: Contribution to journal › Article › peer-review

Open Access

Global PMCA1 deletion leads to increased blood pressure and left ventricular hypertrophy. The Heart Failure Congress 2014-Rapid Fire-Basic Science 1-Abstract 520

Hammad, S., Zi, M., Prehar, S., Neyses, L. & Cartwright, E., 2014, In: European Journal of Heart failure. 16, s2, p. 108-112 5 p.

Research output: Contribution to journal › Article › peer-review

Macitentan treatment retards the progression of established pulmonary arterial hypertension in an animal model

Temple, I. P., Monfredi, O., Quigley, G., Schneider, H., Zi, M., Cartwright, E. J., Boyett, M. R., Mahadevan, V. S. & Hart, G., 15 Dec 2014, In: International Journal of Cardiology. 177, 2, p. 423-8 6 p.

Research output: Contribution to journal › Article › peer-review

Mkk4 Is a Negative Regulator of the Transforming Growth Factor Beta 1 Signaling Associated With Atrial Remodeling and Arrhythmogenesis With Age

Davies, L., Jin, J., Shen, W., Tsui, H., Shi, Y., Wang, Y., Zhang, Y., Hao, G., Wu, J., Chen, S., Fraser, J., Dong, N., Christoffels, V., Ravens, U., Huang, C., Zhang, H., Cartwright, E., Wang, X. & Lei, M., 10 Apr 2014, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, 24 p., e000340.

Research output: Contribution to journal › Article › peer-review

Open Access

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Pak1 Is Required to Maintain Ventricular Ca²⁺ Homeostasis and Electrophysiological Stability through SERCA2a Regulation in Mice

Wang, Y., Tsui, H., Ke, Y., Shi, Y., Li, Y., Davies, L., Cartwright, E., Venetucci, L., Zhang, H., Terrar, D. A., Huang, C.L.-H., Solaro, R. J., Wang, X. & Lei, M., Oct 2014, In: Circulation. Arrhythmia and Electrophysiology (Print). 7, 5, p. 938-948 10 p.

Research output: Contribution to journal › Article › peer-review

Plasma membrane calcium atpase isoform 4 inhibits vascular endothelial growth factor-mediated angiogenesis through interaction with calcineurin

Baggott, R. R., Alfranca, A., López-Maderuelo, D., Mohamed, T. M. A., Escolano, A., Oller, J., Ornes, B. C., Kurusamy, S., Rowther, F. B., Brown, J. E., Oceandy, D., Cartwright, E. J., Wang, W., Gómez-del Arco, P., Martínez-Martínez, S., Neyses, L., Redondo, J. M. & Armesilla, A. L., 21 Aug 2014, In: Arteriosclerosis, Thrombosis, and Vascular Biology.

Research output: Contribution to journal › Article › peer-review

Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction

Ulm, S., Liu, W., Zi, M., Tsui, H., Chowdhury, S. K., Endo, S., Satoh, Y., Prehar, S., Wang, R., Cartwright, E. J. & Wang, X., 13 Mar 2014, In: Journal of molecular and cellular cardiology. 72, p. 104-116 12 p.

Research output: Contribution to journal › Article › peer-review

Targeted deletion of the Extracellular Signal-Regulated Protein Kinase 2 (ERK2) attenuates hypertrophic response in the heart

Ulm, S., Zi, M., Liu, W., Tsui, H., Chowdhury, S. K., Jin, J., Prehar, S., Neyses, L., Lei, M., Cartwright, E. & Wang, X., Jul 2014, In: Journal of molecular and cellular cardiology. 72, p. 104-116 12 p.

Research output: Contribution to journal › Article › peer-review

Elizabeth Cartwright

Research output

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