Research output per year
Research output per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
MRCP, Royal College of Physicians
FRCPath, The Royal College of Pathologists
Doctor of Philosophy, The University of Manchester
Bachelor of Medicine and Bachelor of Surgery, The University of Manchester
Master of Arts, University of Keele
External positions
Consultant Haematologist- Early Phase Trials, The Christie Hospital NHS Foundation Trust
1 Aug 2020 → …
Member, Royal College of Physicians
Fellow, The Royal College of Pathologists
Research Beacons, Institutes and Platforms
- Manchester Cancer Research Centre
Fingerprint
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- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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An ongoing first-in-human phase 1 trial of NX-5948, an oral Bruton's tyrosine kinase (BTK) degrader, in patients with relapsed/refractory B cell malignancies, including chronic lymphocytic leukemia (CLL)
Forconi, F., Collins, G., Searle, E., El-Sharkawi, D., Lewis, D., Gleeson, M., Riches, J., Mckay, P., Doorduijn, J., Mous, R., Stevens, W., Injac, S. & Linton, K., 2023, In: Leukemia & lymphoma. 64, p. S53-S54 2 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Elranatamab in relapsed or refractory multiple myeloma: phase 2 MagnetisMM-3 trial results
Lesokhin, A. M., Tomasson, M. H., Arnulf, B., Bahlis, N. J., Miles Prince, H., Niesvizky, R., Rodrίguez-Otero, P., Martinez-Lopez, J., Koehne, G., Touzeau, C., Jethava, Y., Quach, H., Depaus, J., Yokoyama, H., Gabayan, A. E., Stevens, D. A., Nooka, A. K., Manier, S., Raje, N. & Iida, S. & 9 others, , 2023, In: Nature Medicine. 29, 9, p. 2259-2267 9 p.Research output: Contribution to journal › Article › peer-review
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Initial Findings from a First-in-Human Phase 1a/b Trial of NX-5948, a Selective Bruton's Tyrosine Kinase (BTK) Degrader, in Patients with Relapsed/Refractory B Cell Malignancies
Searle, E., Forconi, F., Linton, K., Danilov, A., Mckay, P., Lewis, D., El-Sharkawi, D., Gleeson, M., Riches, J., Injac, S. G., Shih, T., Nandakumar, S., Tan, M., Cherala, G., Meredith, E. & Collins, G. P., 2 Nov 2023, In: Blood. 142, 5 p.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access -
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
Nicosia, L., Spencer, G. J., Brooks, N., Amaral, F. M. R., Basma, N. J., Chadwick, J. A., Revell, B., Wingelhofer, B., Maiques-Diaz, A., Sinclair, O., Camera, F., Ciceri, F., Wiseman, D. H., Pegg, N., West, W., Knurowski, T., Frese, K., Clegg, K., Campbell, V. L. & Cavet, J. & 3 others, , 11 Dec 2023, In: Cancer Cell. 41, 12, p. 2136-2153.e13Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting hypoxia in solid and haematological malignancies
Harris, B., Saleem, S., Cook, N. & Searle, E., Dec 2022, In: Journal of Experimental and Clinical Cancer Research. 41, 1, 318.Research output: Contribution to journal › Review article › peer-review
Open Access
Projects
- 1 Finished
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Targeting the Akt Pathway with AZD5363 in Combination with Radiotherapy to Improve Tumour Control in Head and Neck Cancer.
Searle, E. (PI), Illidge, T. (CoI), Metcalf, R. (CoI) & Williams, K. (CoI)
1/09/17 → 28/02/21
Project: Research
Prizes
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ARR/IRRS Meeting Best Poster
Searle, E. (Recipient), 27 Jun 2018
Prize: Prize (including medals and awards)
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National Cancer Research Institute (NCRI) (External organisation)
Searle, E. (Academic expert member)
2018Activity: Membership › Membership of committee › Research
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The Royal College of Pathologists (External organisation)
Searle, E. (Fellow)
2017Activity: Membership › Membership of professional association › Research
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The Royal College of Physicians Edinburgh (External organisation)
Searle, E. (Member)
2006Activity: Membership › Membership of committee › Research
Press/Media
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New breakthrough drug for leukaemia trialled at The Christie
24/04/24
1 item of Media coverage
Press/Media: Research