Personal profile
Overview
Eriko Takano is Professor of Synthetic Biology in the Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, at the University of Manchester. She is one of three directors for the EPSRC/BBSRC-funded Manchester Synthetic Biology Research Centre, SYNBIOCHEM. Since 2017, she is the Section Head of Chemical Biology and Biological Chemistry and in 2018 to present, she is the Deputy Head of the Chemistry Department.
Eriko is internationally recognized as a pioneer in the synthetic biology of microbes for antibiotic production. She has been working in both industrial and academic Streptomyces research for 26 years. She studied pharmacy at Kitasato University, School of Pharmacy, Tokyo, Japan. After working as a researcher at the Department of Genetics of Meiji Seika Kaisha, Yokohama, Japan, for four years, she moved to the John Innes Center, Norwich, UK, where she obtained her PhD from the University of East Anglia in 1994 and worked as a postdoc in the Molecular Microbiology department until 2002. After three years as Assistant Professor in the Department of Microbiology / Biotechnology, University of Tübingen, Germany, she was appointed as a Rosalind Franklin Fellow in Microbial Physiology at the Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, The Netherlands in 2006 and as an Associate Professor in Synthetic Microbiology at 2010. Since September 2012 she is Professor of Synthetic Biology at the Manchester Institute of Biotechnology and from 2014 the Biotechnology and Synthetic Biology Research Theme Director in Faculty of Life Sciences.
Areas of expertise of the Takano group include the synthetic biology of antibiotic production: bioinformatics software development (e.g. antiSMASH, MultiGeneBlast); untargeted metabolomics for chassis engineering in Streptomyces; regulatory circuits engineering through signalling molecules; translational control using noncoding RNAs; biosynthetic pathway assembly and engineering; systems biology of the metabolic switch from primary to secondary metabolism; regulation of antibiotic production through signalling molecules and noncoding RNAs in Streptomyces coelicolor, the model organism of the most important group of industrial antibiotics producers.
Present and past funding include UKRI, NERC EPSRC, BBSRC, H2020, DSTL, ERA-IB Terpenosome, STW (the Dutch Research Agency, Technology Foundation), NWO (The Netherlands Organisation for Scientific Research), BE-Basic, EraSysBio SysMO-STREAM, EUFP6 ActinoGEN, DFG.
She has been awarded the Rosalind Franklin Fellowship from the University of Groningen (2006), Naito Kinen Kaigai Ryigaku Jyoseikin from the Naito Foundation Japan (1994), Lepetit Award from Lepetit and the Italian Society for General Microbiology and Microbial Biotechnology (1993).
Eriko is a Fellow of the Royal Society of Biology and Royal Society of Chemistry. She has served as an expert advisor for the European Commission Scientific Committee on Emerging and Newly Identified Health Risks of synthetic biology, where she contributed to a series of three official Opinions with major impact on the development of the field.
Biography
2020 – 2022 Visiting Professor World Research Hub Initiative (WRHI) at School of Life Science and Technology, Tokyo Technology Institute, Tokyo, Japan
2018 – 2020 Visiting Professor at Laboratory of Bio-resource Engineering, Department of Advanced Science and Biotechnology, Graduate School of Engineering, University of Osaka, Japan collaborating together with Prof. E. Fukusaki on microbial metabolomics
2018 – present Faculty of Science and Engineering, Deputy Head of School of Chemistry
2017 – present Faculty of Science and Engineering, School of Chemistry, Chemical Biology and Biological Chemistry Section Head
2017-2021 Coordinator of H2020 TOPCAPI: Thoroughly Optimised Production Chassis for Advanced Pharmaceutical Ingredients project
2014-present BBSRC, EPSRC funded Manchester Synthetic Biology Research Centre, SYNBIOCHEM, Director
2014-2016 Biotechnology and Synthetic Biology Research Theme Director, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, UK
2011-present Professor of Synthetic Biology, Manchester Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, UK
2010–2011 Associate Professor (permanent) in Synthetic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, The Netherlands
2006–2010 Assistant Professor (tenure track), Rosalind Franklin Fellow, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen, The Netherlands
2002–2005 Assistant Professor (C1), Department of Microbiology / Biotechnology, University of Tübingen, Biological Institute, Germany
1994–2002 Postdoctoral fellow, John Innes Centre, Norwich, UK
1989–1990 Assistant scientific officer, John Innes Centre, Norwich, UK
1985–1989 Research assistant at Meiji Seika Kaisha Ltd, Central Reserach Center, Department of Genetics, Yokohama, Japan
Education/Academic qualification
Doctor of Philosophy, ppGpp and antibiotic production in Streptomyces coelicolor A3(2), University of East Anglia
1990 → 1994
Bachelor of Pharmacy, Kitasato University, School of Pharmacy
1981 → 1985
Areas of expertise
- Q Science (General)
- Microbiology
- Synthetic Biology
- Antimicrobial discovery
- Streptomyces
- fine and speciality chemicals
Research Beacons, Institutes and Platforms
- Biotechnology
- Sustainable Futures
- Christabel Pankhurst Institute
- Manchester Institute of Biotechnology
Keywords
- Synthetic Biology
- Antibiotics
- Streptomyces
- Fine and Speciality Chemicals
- Antimicrobial discovery
- Secondary metabolite biosynthesis pathways
- Untargeted metabolonics
- Signalling molecules
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 7 Affordable and Clean Energy
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 12 Responsible Consumption and Production
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SDG 13 Climate Action
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SDG 15 Life on Land
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Collaborations and top research areas from the last five years
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Beyond nature: in vivo production of natural product analogues through programmed biosynthetic pathways
Lipinski, C., Tanifuji, R., Connolly, J., Breitling, R., Oguri, H. & Takano, E., 1 Apr 2026, In: Current Opinion in Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploring the biotechnological potential of terrestrial hot spring microbiomes for CO2 utilisation
Stead, C., Walker, L., Greco, C., Greco, C., Cousins, C., Nagel, F., Breitling, R., Takano, E., Björnsdóttir, S. H. & Nixon, S., 11 Mar 2026, In: Environmental Microbiome.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering Streptomyces coelicolor for heterologous expression of the thiopeptide GE2270A – a cautionary tale
Del Carratore, F., Hanko, E., Schmidt, K., Bilyk, O., Ye Huang, S., Kirkwood, T., Whittall, D., Manousaki, A., Breitling, R., Takano, E. & al, E., 11 Jun 2025, (Accepted/In press) In: Journal of Industrial Microbiology & Biotechnology.Research output: Contribution to journal › Article › peer-review
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Exploring the versatility of fatty acid biosynthesis in Escherichia coli: Production of random methyl branched fatty acids.
Takano, E., Jul 2025, In: Metabolic Engineering. 90, p. 78-91Research output: Contribution to journal › Article › peer-review
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Synteny plot quality control with SyntenyQC
Kirkwood, T., Connolly, J., Ang, E. L., Zhao, H., Takano, E. & Breitling, R., 28 Oct 2025, (Accepted/In press) In: Bioinformatics Advances.Research output: Contribution to journal › Article › peer-review
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Rules of life in CO2-driven microbial communities: Microbiome engineering for a Net Zero future
Nixon, S. (PI), Breitling, R. (CoI), Brockhurst, M. (CoI), Cameron, D. (CoI), Coyte, K. (CoI), Cuellar Franca, R. (CoI), Hollywood, K. (CoI), Johnson, D. (CoI), Pitt, A. (CoI), Quince, C. (CoI), Takano, E. (CoI) & Dixon, N. (PI)
1/01/25 → 31/12/29
Project: Research
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SPINS: Synthetic biology Pipeline for the Investigation of Novel Spidroins (SPINS)
Takano, E. (PI) & Blaker, J. (CoI)
1/09/23 → 31/08/26
Project: Research
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High Resolution Metabolomics – generating a step change in metabolomics at Manchester with the Orbitrap IQ-X
Hollywood, K. (PI), Barran, P. (CoI), Breitling, R. (CoI), Brockhurst, M. (CoI), Buckley, M. (CoI), Cameron, D. (CoI), Delneri, D. (CoI), Dickson, A. (CoI), Dixon, N. (CoI), Field, R. (CoI), Flitsch, S. (CoI), Green, A. (CoI), Henderson, A. (CoI), Lovelock, S. (CoI), Micklefield, J. (CoI), Nixon, S. (CoI), Pitt, A. (CoI), Scrutton, N. (CoI), Takano, E. (CoI), Trivedi, D. (CoI), Turner, N. (CoI) & Wong, L. S. (CoI)
1/08/23 → 31/07/24
Project: Research
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Genome synthesis of a universal synthetic host for antimicrobial drug production - the first deep-engineering of an actinobacterial genome
Takano, E. (PI)
1/06/23 → 31/05/25
Project: Research
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Integrated bioreactor platform for rapid scale-up and translation
Winterburn, J. (PI), Bigger, B. (CoI), Breitling, R. (CoI), Delneri, D. (CoI), Dickson, A. (CoI), Dixon, N. (CoI), Green, A. (CoI), Lovelock, S. (CoI), Martin, P. (CoI), Scrutton, N. (CoI), Takano, E. (CoI) & Theodoropoulos, C. (CoI)
15/02/23 → 14/02/24
Project: Research
Activities
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Plenary talk the BIOPROSP_25, Tromsø, Norway
Takano, E. (Speaker)
Jun 2025Activity: Talk or presentation › Invited talk › Research
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promotion of basic research division Panel member
Takano, E. (Academic founder)
May 2025 → May 2026Activity: Consultancy, spin-outs, CPD & licensing › Consultancy & Services › Teaching and Research
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Appointments Panel Chair
Takano, E. (Academic founder)
Apr 2025 → 2027Activity: Consultancy, spin-outs, CPD & licensing › Consultancy & Services › Research
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Council member
Takano, E. (Academic founder)
Oct 2024 → Oct 2027Activity: Consultancy, spin-outs, CPD & licensing › Consultancy & Services › Teaching and Research
Impacts
Datasets
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SYNBIOCHEM Design-Build-Test-Learn pipeline
Carbonell, P. (Creator), Jervis, A. J. (Contributor), Robinson, C. J. (Contributor), Yan, C. (Contributor), Dunstan, M. (Contributor), Swainston, N. (Contributor), Vinaixa, M. (Contributor), Hollywood, K. A. (Contributor), Currin, A. (Contributor), Rattray, N. J. W. (Contributor), Taylor, S. (Contributor), Spiess, R. (Contributor), Sung, R. (Contributor), Williams, A. R. (Contributor), Fellows, D. (Contributor), Stanford, N. J. (Contributor), Mulherin, P. (Contributor), Le Feuvre, R. (Contributor), Barran, P. (Contributor), Goodacre, R. (Contributor), Turner, N. J. (Contributor), Goble, C. (Contributor), Chen, G. G. (Contributor), Kell, D. B. (Contributor), Micklefield, J. (Contributor), Breitling, R. (Contributor), Takano, E. (Contributor), Faulon, J.-L. (Contributor) & Scrutton, N. S. (Contributor), Mendeley Data, 2 May 2018
DOI: 10.17632/8g4wfwtd43.1, https://data.mendeley.com/datasets/8g4wfwtd43
Dataset
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SYNBIOCHEM - Combinatorial plasmid libraries for material monomer production in Escherichia coli.
Barran, P. (Contributor), Breitling, R. (Contributor), Carbonell, P. (Creator), Currin, A. (Contributor), Dunstan, M. S. (Contributor), Hollywood, K. A. (Contributor), Jervis, A. J. (Contributor), Le Feuvre, R. (Contributor), Malone, K. J. (Contributor), Matthews, N. E. (Contributor), Micklefield, J. (Contributor), Mulherin, P. (Contributor), Robinson, C. J. (Contributor), Scrutton, N. S. (Contributor), Shapira, P. (Contributor), Spiess, R. (Contributor), Swainston, N. (Contributor), Takano, E. (Contributor), Taylor, S. (Contributor), Turner, N. J. (Contributor) & Yan, C. (Contributor), Mendeley Data, 21 Jan 2020
DOI: 10.17632/t4jtcf9dr2.2, https://data.mendeley.com/datasets/t4jtcf9dr2
Dataset
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Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism
Amara, A. (Contributor), Takano, E. (Contributor) & Breitling, R. (Contributor), figshare , 4 Jul 2018
DOI: 10.6084/m9.figshare.c.4154201.v1, https://figshare.com/collections/Development_and_validation_of_an_updated_computational_model_of_Streptomyces_coelicolor_primary_and_secondary_metabolism/4154201/1
Dataset
Press/Media
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THE OBSERVER: The 10 biggest science stories of 2022 – chosen by scientists
18/12/22
1 Media contribution
Press/Media: Expert comment
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Press release for the publication: "Blood, sweat, and tears: extraterrestrial regolith biocomposites with in vivo binders"
Roberts, A., Whittall, D., Breitling, R., Takano, E., Blaker, J., Hay, S. & Scrutton, N.
13/09/21 → 14/09/21
16 items of Media coverage
Press/Media: Research
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MANCHESTER EVENING NEWS: Could Mancunian robots save humanity from superbugs?
14/11/17
1 item of Media coverage
Press/Media: Research