Eriko Takano

2024

Bioproduction of methylated phenylpropenes and isoeugenol in Escherichia coli

Chua, J., Hanko, E. K. R., Yiakoumetti, A., Stoney, R. S., Chromy, J., Valdehuesa, K. N. G., Hollywood, K. A., Yan, C., Takano, E. & Breitling, R., 1 Jun 2024, In: Metabolic Engineering Communications. 18, e00237.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthetic Biology of Natural Products Engineering: Recent Advances Across the Discover−Design−Build−Test−Learn Cycle

Foldi, J., Connolly, J., Takano, E. & Breitling, R., 20 Aug 2024, (E-pub ahead of print) In: ACS Synthetic Biology. 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Biosynthesis of cannabigerol and cannabigerolic acid, the gateways to further cannabinoid production.

Kearsey, L. J., Yan, C., Prandi, N., Toogood, H. S., Takano, E. & Scrutton, N. S., 27 May 2023, In: Synthetic Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

Expanding flavone and flavonol production capabilities in Escherichia coli

Yiakoumetti, A., Hanko, E. K. R., Zou, Y., Chua, J., Chromy, J., Stoney, R. A., Valdehuesa, K. N. G., Connolly, J. A., Yan, C., Hollywood, K. A., Takano, E. & Breitling, R., 18 Oct 2023, In: Frontiers in Bioengineering and Biotechnology.

Research output: Contribution to journal › Article › peer-review

Microbial production of the plant flavanone hesperetin from caffeic acid

Hanko, E. K. R., Correia, J., Souza, C. S., Green, A., Chromy, J., Stoney, R., Yan, C., Takano, E., Lousa, D., Soares, C. M. & Breitling, R., 18 Nov 2023, In: BMC Research Notes. 16, 343.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

Biotechnological application of Streptomyces for the production of clinical drugs and other bioactive molecules

Carratore, F. D., Hanko, E. K., Breitling, R. & Takano, E., 1 Oct 2022, In: Current Opinion in Biotechnology. 77, 7 p., 102762.

Research output: Contribution to journal › Article › peer-review

Open Access

How a 10-epi-cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity

Whitehead, J. N., Leferink, N. G. H., Komati Reddy, G., Levy, C. W., Hay, S., Takano, E. & Scrutton, N. S., 7 Oct 2022, In: ACS Catalysis. 12, 19, p. 12123–12131

Research output: Contribution to journal › Article › peer-review

Open Access

2021

A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli

Jervis, A., Hanko, E., Dunstan, M., Robinson, C., Takano, E. & Scrutton, N., 12 Mar 2021, In: Microbial Biotechnology.

Research output: Contribution to journal › Article › peer-review

Open Access

Blood, sweat and tears: extraterrestrial regolith biocomposites with in vivo binders

Roberts, A., Whittall, D., Breitling, R., Takano, E., Blaker, J., Hay, S. & Scrutton, N., 3 Sept 2021, (Accepted/In press) In: Materials Today Bio.

Research output: Contribution to journal › Article › peer-review

Harnessing Intercellular Signals to Engineer the Soil Microbiome

Connolly, J., Harcombe, W., Smanski, M. J., Kinkel, L. L., Takano, E. & Breitling, R., 23 Nov 2021, (Accepted/In press) In: Natural Product Reports.

Research output: Contribution to journal › Article › peer-review

Multi-omics study of Planobispora rosea, producer of the thiopeptide antibiotic GE2270A

Del Carratore, F., Iorio, M., Pérez-Bonilla, M., Schmidt, K., Pérez-Redondo, R., Sosio, M., Macdonald, S. J., Gyulev, I. S., Tsigkinopoulou, A., Thomas, G. H., Genilloud, O., Rodríguez-García, A., Donadio, S., Breitling, R. & Takano, E., 3 Jun 2021, (Accepted/In press) In: mSystems.

Research output: Contribution to journal › Article › peer-review

Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets

Robinson, C. J., Tellechea-luzardo, J., Carbonell, P., Jervis, A. J., Yan, C., Hollywood, K. A., Dunstan, M. S., Currin, A., Takano, E. & Scrutton, N. S., 8 Jun 2021, In: Biochemical Society Transactions.

Research output: Contribution to journal › Article › peer-review

Synthetic biology approaches to actinomycete strain improvement

Breitling, R., Avbelj, M., Bilyk, O., Del Carratore, F., Filisetti, A., Hanko, E. K. R., Iorio, M., Redondo, R. P., Reyes, F., Rudden, M., Severi, E., Slemc, L., Schmidt, K., Whittall, D. R., Donadio, S., García, A. R., Genilloud, O., Kosec, G., De Lucrezia, D. & Petković, H. & 2 others, Thomas, G. & Takano, E., 31 May 2021, In: FEMS microbiology letters.

Research output: Contribution to journal › Article › peer-review

Open Access

The evolving art of creating genetic diversity: from directed evolution to synthetic biology

Currin, A., Parker, S., Robinson, C., Takano, E., Scrutton, N. & Breitling, R., 26 Apr 2021, (Accepted/In press) In: Biotechnology Advances.

Research output: Contribution to journal › Article › peer-review

2020

Bioengineering horizon scan 2020

Kemp, L., Adam, L., Boehm, C. R., Breitling, R., Casagrande, R., Dando, M., Djikeng, A., Evans, N. G., Hammond, R., Hills, K., Holt, L. A., Kuiken, T., Markotić, A., Millett, P., Napier, J., Nelson, C., Oheigeartaigh, S. S., Osbourn, A., Palmer, M. J. & Patron, N. J. & 16 others, Perello, E., Piyawattanametha, W., Restrepo-Schild, V., Rios-Rojas, C., Rhodes, C., Roessing, A., Scott, D. J., Simuntala, C., Shapira, P., Smith, R. D. J., Sundaram, L. S., Takano, E., Uttmark, G., Wintle, B. C., Zahra, N. B. & Sutherland, W. J., 29 May 2020, In: eLife. 9:e54489.

Research output: Contribution to journal › Article › peer-review

Open Access

Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol.

Dunstan, M., Robinson, C., Jervis, A., Yan, C., Carbonell, P., Hollywood, K., Currin, A., Swainston, N., Le Feuvre, R., Micklefield, J., Faulon, J.-L., Breitling, R., Turner, N., Takano, E. & Scrutton, N., 6 Aug 2020, In: Synthetic Biology . 5, 1, ysaa012.

Research output: Contribution to journal › Article › peer-review

Open Access

Exploring Novel Bacterial Terpene Synthases

Komati Reddy, G., Leferink, N., Umemura, M., Ahmed, S., Breitling, R., Scrutton, N. & Takano, E., 10 Apr 2020, (Accepted/In press) In: P L o S One.

Research output: Contribution to journal › Article › peer-review

Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces

Ye Huang, S., Enghiad, B., Zhao, H. & Takano, E., 20 Apr 2020, (Accepted/In press) In: Journal of Industrial Microbiology & Biotechnology.

Research output: Contribution to journal › Article › peer-review

Host systems for the production of recombinant spider silk

Whittall, D., Baker, K., Breitling, R. & Takano, E., 18 Sept 2020, (Accepted/In press) In: Trends in Biotechnology.

Research output: Contribution to journal › Article › peer-review

In silico design and automated learning to boost next-generation smart biomanufacturing

Carbonell, P., Le Feuvre, R., Takano, E. & Scrutton, N., 17 Oct 2020, (E-pub ahead of print) In: Synthetic Biology . 5, 1

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor

Nitta, K., Carratore, F. D., Breitling, R., Takano, E., Putri, S. P. & Fukusaki, E., 5 Nov 2020, (E-pub ahead of print) In: Frontiers in Bioengineering and Biotechnology. 8

Research output: Contribution to journal › Article › peer-review

Open Access

Non-covalent protein-based adhesives for transparent substrates – bovine serum albumin vs. recombinant spider silk

Roberts, A., Finnigan, W., Kelly, P., Faulkner, M., Breitling, R., Takano, E., Scrutton, N., Blaker, J. & Hay, S., 10 Jul 2020, In: Materials Today Bio. 7, p. 100068

Research output: Contribution to journal › Article › peer-review

Open Access

Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker’s Yeast

Gerke, J., Frauendorf, H., Schneider, D., Wintergoller, M., Hofmeister, T., Poehlein, A., Zebec, Z., Takano, E., Scrutton, N. S. & Braus, G. H., 23 Sept 2020, In: Frontiers in Bioengineering and Biotechnology. 8, p. 1097

Research output: Contribution to journal › Article › peer-review

Open Access

Rapid prototyping of microbial production strains for the biomanufacture of potential material monomers

Robinson, C., Carbonell, P., Jervis, A., Yan, C., Hollywood, K., Currin, A., Swainston, N., Speiss, R., Taylor, S., Mulherin, P., Parker, S., Rowe, W., Matthews, N., Malone, K., Le Feuvre, R., Shapira, P., Barran, P., Turner, N., Micklefield, J. & Breitling, R. & 2 others, Takano, E. & Scrutton, N., 1 Jul 2020, In: Metabolic Engineering.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structure and function of a novel elongation factor P subfamily in Actinobacteria

Pinheiro, B., Scheidler, C., Kielkowski, P., Schmid, M., Forne, I., Ye Huang, S., Reiling, N., Takano, E., Imhof, A., Sieber, S., Schneider, S. & Jung, K., 31 Mar 2020, In: Cell Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

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68 Downloads (Pure)

Switchable foldamer ion channels with antibacterial activity

Peters, A. D., Borsley, S., Della Sala, F., Cairns-gibson, D. F., Leonidou, M., Clayden, J., Whitehead, G. F. S., Vitorica-yrzebal, I., Takano, E., Burthem, J., Cockroft, S. L. & Webb, S., 4 Jun 2020, (E-pub ahead of print) In: Chemical Science.

Research output: Contribution to journal › Article › peer-review

Open Access

The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers

Finnigan, W., Roberts, A., Ligorio, C., Scrutton, N., Breitling, R., Blaker, J. & Takano, E., 30 Jun 2020, In: Scientific Reports. 10671.

Research output: Contribution to journal › Article › peer-review

Open Access

Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling

Tsigkinopoulou, A., Takano, E. & Breitling, R., 1 Jul 2020, (Accepted/In press) In: PL o S Computational Biology.

Research output: Contribution to journal › Article › peer-review

2019

Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli

Cummings, M., Peters, A., Whitehead, G., Menon, B., Micklefield, J., Webb, S. & Takano, E., 2019, In: PL o S Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters

Del Carratore, F., Zych, K., Cummings, M., Takano, E., Medema, M. H. & Breitling, R., 28 Feb 2019, In: Communications Biology. 2, 1, 83.

Research output: Contribution to journal › Article › peer-review

Open Access

Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries

Currin, A., Swainston, N., Dunstan, M., Jervis, A., Mulherin, P., Robinson, C., Taylor, S., Carbonell, P., Hollywood, K., Yan, C., Takano, E., Scrutton, N. & Breitling, R., 29 Oct 2019, In: Synthetic Biology .

Research output: Contribution to journal › Article › peer-review

Open Access

Integrated Probabilistic Annotation (IPA): A Bayesian-based annotation method for metabolomic proﬁles integrating biochemical connections, isotope patterns and adduct relationships

Del Carratore, F., Schmidt, K., Vinaixa, M., Hollywood, K., Greenland-Bews, C., Takano, E., Rogers, S. & Breitling, R., 19 Oct 2019, In: Analytical Chemistry.

Research output: Contribution to journal › Article › peer-review

Open Access

File

100 Downloads (Pure)

Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli

Jervis, A. J., Carbonell, P., Vinaixa, M., Dunstan, M. S., Hollywood, K. A., Robinson, C. J., Rattray, N. J. W., Yan, C., Swainston, N., Currin, A., Sung, R., Toogood, H., Taylor, S., Faulon, J.-L., Breitling, R., Takano, E. & Scrutton, N. S., 18 Jan 2019, In: ACS Synthetic Biology. 8, 1, p. 127-136 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli

Jervis, A. J., Carbonell, P., Taylor, S., Sung, R., Dunstan, M. S., Robinson, C. J., Breitling, R., Takano, E. & Scrutton, N. S., 2019, In: ACS Synthetic Biology.

Research output: Contribution to journal › Article › peer-review

Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases

Kearsey, L. J., Prandi, N., Karuppiah, V., Yan, C., Leys, D., Toogood, H., Takano, E. & Scrutton, N. S., 2019, In: FEBS Journal.

Research output: Contribution to journal › Article › peer-review

Open Access

Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace

Roberts, A., Finnigan, W., Wolde-Michael, E., Kelly, P., Blaker, J., Hay, S., Breitling, R., Takano, E. & Scrutton, N., 2019, In: MRS Communications.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P. & Goodacre, R. & 9 others, Turner, N., Goble, C., Guoqiang Chen, G., Kell, D., Micklefield, J., Breitling, R., Takano, E., Faulon, J.-L. & Scrutton, N., 2018, In: Communications Biology. 1, 66.

Research output: Contribution to journal › Article › peer-review

Open Access

A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes

Hernandez Ortega, A., Vinaixa, M., Zebec, Z., Takano, E. & Scrutton, N., 2018, In: Scientific Reports. 8, p. 14396 8 p., 14396.

Research output: Contribution to journal › Article › peer-review

Open Access

Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase

Sabatini, M., Comba, S., Altabe, S., Recio-Balsells, A. I., Labadie, G. R., Takano, E., Gramajo, H. & Arabolaza, A., 2018, In: FEBS Journal.

Research output: Contribution to journal › Article › peer-review

Open Access

Detection and Quantification of Butyrolactones from Streptomyces

Biarnes Carrera, M., Breitling, R. & Takano, E., 2018, Quorum Sensing . Leoni, L. & Rampioni, G. (eds.). 1 ed. Springer Nature, Vol. 1673. p. 117-128 10. (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism

Amara, A., Takano, E. & Breitling, R., 2018, In: BMC Genomics. 19

Research output: Contribution to journal › Article › peer-review

Open Access

Engineering the ‘Missing Link’ in Biosynthetic (–)-Menthol Production: Bacterial Isopulegone Isomerase

Currin, A., Dunstan, M., Johannissen, L., Hollywood, K., Vinaixa, M., Jervis, A., Swainston, N., Rattray, N., Gardiner, J., Kell, D., Takano, E., Toogood, H. & Scrutton, N., 24 Jan 2018, In: ACS Catalysis. 8, 3, p. 2012-2020 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Metabolomics tools for the synthetic biology of natural products

Hollywood, K., Schmidt, K., Takano, E. & Breitling, R., Dec 2018, In: Current Opinion in Biotechnology. 54, p. 114-120 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Multifragment DNA Assembly of Biochemical Pathways via Automated Ligase Cycling Reaction

Robinson, C. J., Dunstan, M. S., Swainston, N., Titchmarsh, J., Takano, E., Scrutton, N. S. & Jervis, A. J., 1 Jan 2018, Methods in Enzymology. Scrutton, N. (ed.). Kluwer Academic/Human Sciences Press Inc., p. 369-392 24 p. (Methods in Enzymology; vol. 608).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Multi-fragment DNA assembly of biochemical pathways via automated Ligase Cycling Reaction

Robinson, C., Dunstan, M., Swainston, N., Scrutton, N., Titchmarsh, J., Takano, E. & Jervis, A., 11 Apr 2018, (Accepted/In press) Methods in Enzymology. (Methods in Enzymology).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Orthogonal Regulatory Circuits for Escherichia coli Based on the gamma-Butyrolactone System of Streptomyces coelicolor

Biarnes-Carrera, M., Lee, C. K., Nihira, T., Breitling, R. & Takano, E., 20 Apr 2018, In: ACS Synthetic Biology. 7, 4, p. 1043-1055 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

378 Downloads (Pure)

Selenzyme: Enzyme selection tool for pathway design

Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., Kell, D., Breitling, R. & Faulon, J.-L., 15 Jun 2018, In: Bioinformatics. 34, 12

Research output: Contribution to journal › Article › peer-review

Open Access

The "Three C's" of Novel Antibiotic Discovery and Production through Synthetic Biology: biosynthetic gene Clusters, heterologous Chassis, and synthetic microbial Consortia

Baker, K., Takano, E. & Breitling, R., 28 May 2018, (Accepted/In press) In: Advanced Biosystems.

Research output: Contribution to journal › Article › peer-review

2017

antiSMASH 4.0––improvements in chemistry prediction and gene cluster boundary identification

Blin, K., Wolf, T., Chevrette, M. G., Lu, X., Schwalen, C. G., Kautsar, S. A., Suarez Duran, H. G., de los Santos, E. L. C., Uk Kim, H., Nave, M., Dickschat, J. S., Mitchell, D. A., Shelest, E., Breitling, R., Takano, E., Lee, S. Y., Weber, T. & Medema, M. H., 2017, In: Nucleic acids research.

Research output: Contribution to journal › Article › peer-review

Open Access

A transatlantic perspective on 20 emerging issues in biological engineering

Wintle, B. C., Boehm, C., Rhodes, C., Molloy, J., Millett, P., Adam, L., Breitling, R., Carlson, R., Casagrande, R., Dando, M., Doubleday, R., Drexler, E., Edwards, B., Ellis, T., Evans, N. G., Hammond, R., Haseloff, J., Kahl, L., Kuiken, T. & Lichman, B. R. & 9 others, Matthewman, C. A., Napier, J., Oheigeartaigh, S. S., Patron, N. J., Perello, E., Shapira, P., Tait, J., Takano, E. & Sutherland, W. J., 14 Nov 2017, In: eLife.

Research output: Contribution to journal › Article › peer-review

Open Access

Eriko Takano, PhD

Research output

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