Research output per year
Research output per year
- 1 - 50 out of 126 results
Search results
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2024
Bioproduction of methylated phenylpropenes and isoeugenol in Escherichia coli
Chua, J., Hanko, E. K. R., Yiakoumetti, A., Stoney, R. S., Chromy, J., Valdehuesa, K. N. G., Hollywood, K. A., Yan, C., Takano, E. & Breitling, R., 1 Jun 2024, In: Metabolic Engineering Communications. 18, e00237.Research output: Contribution to journal › Article › peer-review
Open Access -
Synthetic Biology of Natural Products Engineering: Recent Advances Across the Discover−Design−Build−Test−Learn Cycle
Foldi, J., Connolly, J., Takano, E. & Breitling, R., 20 Aug 2024, (E-pub ahead of print) In: ACS Synthetic Biology. 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Biosynthesis of cannabigerol and cannabigerolic acid, the gateways to further cannabinoid production.
Kearsey, L. J., Yan, C., Prandi, N., Toogood, H. S., Takano, E. & Scrutton, N. S., 27 May 2023, In: Synthetic Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Expanding flavone and flavonol production capabilities in Escherichia coli
Yiakoumetti, A., Hanko, E. K. R., Zou, Y., Chua, J., Chromy, J., Stoney, R. A., Valdehuesa, K. N. G., Connolly, J. A., Yan, C., Hollywood, K. A., Takano, E. & Breitling, R., 18 Oct 2023, In: Frontiers in Bioengineering and Biotechnology.Research output: Contribution to journal › Article › peer-review
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Microbial production of the plant flavanone hesperetin from caffeic acid
Hanko, E. K. R., Correia, J., Souza, C. S., Green, A., Chromy, J., Stoney, R., Yan, C., Takano, E., Lousa, D., Soares, C. M. & Breitling, R., 18 Nov 2023, In: BMC Research Notes. 16, 343.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Biotechnological application of Streptomyces for the production of clinical drugs and other bioactive molecules
Carratore, F. D., Hanko, E. K., Breitling, R. & Takano, E., 1 Oct 2022, In: Current Opinion in Biotechnology. 77, 7 p., 102762.Research output: Contribution to journal › Article › peer-review
Open Access -
How a 10-epi-cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity
Whitehead, J. N., Leferink, N. G. H., Komati Reddy, G., Levy, C. W., Hay, S., Takano, E. & Scrutton, N. S., 7 Oct 2022, In: ACS Catalysis. 12, 19, p. 12123–12131Research output: Contribution to journal › Article › peer-review
Open Access -
2021
A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli
Jervis, A., Hanko, E., Dunstan, M., Robinson, C., Takano, E. & Scrutton, N., 12 Mar 2021, In: Microbial Biotechnology.Research output: Contribution to journal › Article › peer-review
Open Access -
Blood, sweat and tears: extraterrestrial regolith biocomposites with in vivo binders
Roberts, A., Whittall, D., Breitling, R., Takano, E., Blaker, J., Hay, S. & Scrutton, N., 3 Sept 2021, (Accepted/In press) In: Materials Today Bio.Research output: Contribution to journal › Article › peer-review
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Harnessing Intercellular Signals to Engineer the Soil Microbiome
Connolly, J., Harcombe, W., Smanski, M. J., Kinkel, L. L., Takano, E. & Breitling, R., 23 Nov 2021, (Accepted/In press) In: Natural Product Reports.Research output: Contribution to journal › Article › peer-review
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Multi-omics study of Planobispora rosea, producer of the thiopeptide antibiotic GE2270A
Del Carratore, F., Iorio, M., Pérez-Bonilla, M., Schmidt, K., Pérez-Redondo, R., Sosio, M., Macdonald, S. J., Gyulev, I. S., Tsigkinopoulou, A., Thomas, G. H., Genilloud, O., Rodríguez-García, A., Donadio, S., Breitling, R. & Takano, E., 3 Jun 2021, (Accepted/In press) In: mSystems.Research output: Contribution to journal › Article › peer-review
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Prototyping of microbial chassis for the biomanufacturing of high-value chemical targets
Robinson, C. J., Tellechea-luzardo, J., Carbonell, P., Jervis, A. J., Yan, C., Hollywood, K. A., Dunstan, M. S., Currin, A., Takano, E. & Scrutton, N. S., 8 Jun 2021, In: Biochemical Society Transactions.Research output: Contribution to journal › Article › peer-review
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Synthetic biology approaches to actinomycete strain improvement
Breitling, R., Avbelj, M., Bilyk, O., Del Carratore, F., Filisetti, A., Hanko, E. K. R., Iorio, M., Redondo, R. P., Reyes, F., Rudden, M., Severi, E., Slemc, L., Schmidt, K., Whittall, D. R., Donadio, S., García, A. R., Genilloud, O., Kosec, G., De Lucrezia, D. & Petković, H. & 2 others, , 31 May 2021, In: FEMS microbiology letters.Research output: Contribution to journal › Article › peer-review
Open Access -
The evolving art of creating genetic diversity: from directed evolution to synthetic biology
Currin, A., Parker, S., Robinson, C., Takano, E., Scrutton, N. & Breitling, R., 26 Apr 2021, (Accepted/In press) In: Biotechnology Advances.Research output: Contribution to journal › Article › peer-review
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2020
Bioengineering horizon scan 2020
Kemp, L., Adam, L., Boehm, C. R., Breitling, R., Casagrande, R., Dando, M., Djikeng, A., Evans, N. G., Hammond, R., Hills, K., Holt, L. A., Kuiken, T., Markotić, A., Millett, P., Napier, J., Nelson, C., Oheigeartaigh, S. S., Osbourn, A., Palmer, M. J. & Patron, N. J. & 16 others, , 29 May 2020, In: eLife. 9:e54489.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol.
Dunstan, M., Robinson, C., Jervis, A., Yan, C., Carbonell, P., Hollywood, K., Currin, A., Swainston, N., Le Feuvre, R., Micklefield, J., Faulon, J.-L., Breitling, R., Turner, N., Takano, E. & Scrutton, N., 6 Aug 2020, In: Synthetic Biology . 5, 1, ysaa012.Research output: Contribution to journal › Article › peer-review
Open Access -
Exploring Novel Bacterial Terpene Synthases
Komati Reddy, G., Leferink, N., Umemura, M., Ahmed, S., Breitling, R., Scrutton, N. & Takano, E., 10 Apr 2020, (Accepted/In press) In: P L o S One.Research output: Contribution to journal › Article › peer-review
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Fine-tuning the regulation of Cas9 expression levels for efficient CRISPR-Cas9 mediated recombination in Streptomyces
Ye Huang, S., Enghiad, B., Zhao, H. & Takano, E., 20 Apr 2020, (Accepted/In press) In: Journal of Industrial Microbiology & Biotechnology.Research output: Contribution to journal › Article › peer-review
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Host systems for the production of recombinant spider silk
Whittall, D., Baker, K., Breitling, R. & Takano, E., 18 Sept 2020, (Accepted/In press) In: Trends in Biotechnology.Research output: Contribution to journal › Article › peer-review
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In silico design and automated learning to boost next-generation smart biomanufacturing
Carbonell, P., Le Feuvre, R., Takano, E. & Scrutton, N., 17 Oct 2020, (E-pub ahead of print) In: Synthetic Biology . 5, 1Research output: Contribution to journal › Article › peer-review
Open Access -
Multi-Omics Analysis of the Effect of cAMP on Actinorhodin Production in Streptomyces coelicolor
Nitta, K., Carratore, F. D., Breitling, R., Takano, E., Putri, S. P. & Fukusaki, E., 5 Nov 2020, (E-pub ahead of print) In: Frontiers in Bioengineering and Biotechnology. 8Research output: Contribution to journal › Article › peer-review
Open Access -
Non-covalent protein-based adhesives for transparent substrates – bovine serum albumin vs. recombinant spider silk
Roberts, A., Finnigan, W., Kelly, P., Faulkner, M., Breitling, R., Takano, E., Scrutton, N., Blaker, J. & Hay, S., 10 Jul 2020, In: Materials Today Bio. 7, p. 100068Research output: Contribution to journal › Article › peer-review
Open Access -
Production of the Fragrance Geraniol in Peroxisomes of a Product-Tolerant Baker’s Yeast
Gerke, J., Frauendorf, H., Schneider, D., Wintergoller, M., Hofmeister, T., Poehlein, A., Zebec, Z., Takano, E., Scrutton, N. S. & Braus, G. H., 23 Sept 2020, In: Frontiers in Bioengineering and Biotechnology. 8, p. 1097Research output: Contribution to journal › Article › peer-review
Open Access -
Rapid prototyping of microbial production strains for the biomanufacture of potential material monomers
Robinson, C., Carbonell, P., Jervis, A., Yan, C., Hollywood, K., Currin, A., Swainston, N., Speiss, R., Taylor, S., Mulherin, P., Parker, S., Rowe, W., Matthews, N., Malone, K., Le Feuvre, R., Shapira, P., Barran, P., Turner, N., Micklefield, J. & Breitling, R. & 2 others, , 1 Jul 2020, In: Metabolic Engineering.Research output: Contribution to journal › Article › peer-review
Open AccessFile223 Downloads (Pure) -
Structure and function of a novel elongation factor P subfamily in Actinobacteria
Pinheiro, B., Scheidler, C., Kielkowski, P., Schmid, M., Forne, I., Ye Huang, S., Reiling, N., Takano, E., Imhof, A., Sieber, S., Schneider, S. & Jung, K., 31 Mar 2020, In: Cell Reports.Research output: Contribution to journal › Article › peer-review
Open AccessFile70 Downloads (Pure) -
Switchable foldamer ion channels with antibacterial activity
Peters, A. D., Borsley, S., Della Sala, F., Cairns-gibson, D. F., Leonidou, M., Clayden, J., Whitehead, G. F. S., Vitorica-yrzebal, I., Takano, E., Burthem, J., Cockroft, S. L. & Webb, S., 4 Jun 2020, (E-pub ahead of print) In: Chemical Science.Research output: Contribution to journal › Article › peer-review
Open Access -
The effect of terminal globular domains on the response of recombinant mini-spidroins to fiber spinning triggers
Finnigan, W., Roberts, A., Ligorio, C., Scrutton, N., Breitling, R., Blaker, J. & Takano, E., 30 Jun 2020, In: Scientific Reports. 10671.Research output: Contribution to journal › Article › peer-review
Open Access -
Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling
Tsigkinopoulou, A., Takano, E. & Breitling, R., 1 Jul 2020, (Accepted/In press) In: PL o S Computational Biology.Research output: Contribution to journal › Article › peer-review
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2019
Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli
Cummings, M., Peters, A., Whitehead, G., Menon, B., Micklefield, J., Webb, S. & Takano, E., 2019, In: PL o S Biology.Research output: Contribution to journal › Article › peer-review
Open Access -
Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters
Del Carratore, F., Zych, K., Cummings, M., Takano, E., Medema, M. H. & Breitling, R., 28 Feb 2019, In: Communications Biology. 2, 1, 83.Research output: Contribution to journal › Article › peer-review
Open Access -
Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries
Currin, A., Swainston, N., Dunstan, M., Jervis, A., Mulherin, P., Robinson, C., Taylor, S., Carbonell, P., Hollywood, K., Yan, C., Takano, E., Scrutton, N. & Breitling, R., 29 Oct 2019, In: Synthetic Biology .Research output: Contribution to journal › Article › peer-review
Open Access -
Integrated Probabilistic Annotation (IPA): A Bayesian-based annotation method for metabolomic profiles integrating biochemical connections, isotope patterns and adduct relationships
Del Carratore, F., Schmidt, K., Vinaixa, M., Hollywood, K., Greenland-Bews, C., Takano, E., Rogers, S. & Breitling, R., 19 Oct 2019, In: Analytical Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile101 Downloads (Pure) -
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli
Jervis, A. J., Carbonell, P., Vinaixa, M., Dunstan, M. S., Hollywood, K. A., Robinson, C. J., Rattray, N. J. W., Yan, C., Swainston, N., Currin, A., Sung, R., Toogood, H., Taylor, S., Faulon, J.-L., Breitling, R., Takano, E. & Scrutton, N. S., 18 Jan 2019, In: ACS Synthetic Biology. 8, 1, p. 127-136 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli
Jervis, A. J., Carbonell, P., Taylor, S., Sung, R., Dunstan, M. S., Robinson, C. J., Breitling, R., Takano, E. & Scrutton, N. S., 2019, In: ACS Synthetic Biology.Research output: Contribution to journal › Article › peer-review
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Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases
Kearsey, L. J., Prandi, N., Karuppiah, V., Yan, C., Leys, D., Toogood, H., Takano, E. & Scrutton, N. S., 2019, In: FEBS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace
Roberts, A., Finnigan, W., Wolde-Michael, E., Kelly, P., Blaker, J., Hay, S., Breitling, R., Takano, E. & Scrutton, N., 2019, In: MRS Communications.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P. & Goodacre, R. & 9 others, , 2018, In: Communications Biology. 1, 66.Research output: Contribution to journal › Article › peer-review
Open Access -
A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes
Hernandez Ortega, A., Vinaixa, M., Zebec, Z., Takano, E. & Scrutton, N., 2018, In: Scientific Reports. 8, p. 14396 8 p., 14396.Research output: Contribution to journal › Article › peer-review
Open Access -
Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase
Sabatini, M., Comba, S., Altabe, S., Recio-Balsells, A. I., Labadie, G. R., Takano, E., Gramajo, H. & Arabolaza, A., 2018, In: FEBS Journal.Research output: Contribution to journal › Article › peer-review
Open Access -
Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism
Amara, A., Takano, E. & Breitling, R., 2018, In: BMC Genomics. 19Research output: Contribution to journal › Article › peer-review
Open Access -
Engineering the ‘Missing Link’ in Biosynthetic (–)-Menthol Production: Bacterial Isopulegone Isomerase
Currin, A., Dunstan, M., Johannissen, L., Hollywood, K., Vinaixa, M., Jervis, A., Swainston, N., Rattray, N., Gardiner, J., Kell, D., Takano, E., Toogood, H. & Scrutton, N., 24 Jan 2018, In: ACS Catalysis. 8, 3, p. 2012-2020 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Metabolomics tools for the synthetic biology of natural products
Hollywood, K., Schmidt, K., Takano, E. & Breitling, R., Dec 2018, In: Current Opinion in Biotechnology. 54, p. 114-120 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile437 Downloads (Pure) -
Orthogonal Regulatory Circuits for Escherichia coli Based on the gamma-Butyrolactone System of Streptomyces coelicolor
Biarnes-Carrera, M., Lee, C. K., Nihira, T., Breitling, R. & Takano, E., 20 Apr 2018, In: ACS Synthetic Biology. 7, 4, p. 1043-1055 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile379 Downloads (Pure) -
Selenzyme: Enzyme selection tool for pathway design
Carbonell, P., Wong, J., Swainston, N., Takano, E., Turner, N., Scrutton, N., Kell, D., Breitling, R. & Faulon, J.-L., 15 Jun 2018, In: Bioinformatics. 34, 12Research output: Contribution to journal › Article › peer-review
Open Access -
The "Three C's" of Novel Antibiotic Discovery and Production through Synthetic Biology: biosynthetic gene Clusters, heterologous Chassis, and synthetic microbial Consortia
Baker, K., Takano, E. & Breitling, R., 28 May 2018, (Accepted/In press) In: Advanced Biosystems.Research output: Contribution to journal › Article › peer-review
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2017
antiSMASH 4.0––improvements in chemistry prediction and gene cluster boundary identification
Blin, K., Wolf, T., Chevrette, M. G., Lu, X., Schwalen, C. G., Kautsar, S. A., Suarez Duran, H. G., de los Santos, E. L. C., Uk Kim, H., Nave, M., Dickschat, J. S., Mitchell, D. A., Shelest, E., Breitling, R., Takano, E., Lee, S. Y., Weber, T. & Medema, M. H., 2017, In: Nucleic acids research.Research output: Contribution to journal › Article › peer-review
Open Access -
A transatlantic perspective on 20 emerging issues in biological engineering
Wintle, B. C., Boehm, C., Rhodes, C., Molloy, J., Millett, P., Adam, L., Breitling, R., Carlson, R., Casagrande, R., Dando, M., Doubleday, R., Drexler, E., Edwards, B., Ellis, T., Evans, N. G., Hammond, R., Haseloff, J., Kahl, L., Kuiken, T. & Lichman, B. R. & 9 others, , 14 Nov 2017, In: eLife.Research output: Contribution to journal › Article › peer-review
Open Access -
Output Ordering and Prioritisation System (OOPS): ranking biosynthetic gene clusters to enhance bioactive metabolite discovery
Pena, A., Del Carratore, F., Cummings, M., Takano, E. & Breitling, R., 2017, In: Journal of Industrial Microbiology and Biotechnology. p. 1-5 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1,8-cineole synthase
Karuppiah, V., Ranaghan, K. E., Leferink, N., Johannissen, L., Shanmugam, M., Ni Cheallaigh, A., Bennett, N. J., Takano, E., Gardiner, J., van der Kamp, M. W., Hay, S., Mulholland, A. J., Leys, D. & Scrutton, N., 2017, In: ACS Catalysis.Research output: Contribution to journal › Article › peer-review
Open Access -
2016
A 'Plug and Play' Platform for the Production of Diverse Monoterpene Hydrocarbon Scaffolds in Escherichia coli
Leferink, N., Jervis, A., Zebec, Z., Toogood, H., Hay, S., Takano, E. & Scrutton, N., Jun 2016, In: ChemistrySelect . 1, 9, p. 1893-1896 4 p.Research output: Contribution to journal › Article › peer-review
Open Access