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Personal profile

Overview

QBI Laboratory

I head the Quantitative Biomedical Imaging Lab (QBI Lab). QBI Lab focuses on magnetic resonance imaging (MRI) and other modalities with state-of-the-art analysis techniques to provide quantitative information about the structure and function of both normal and diseased tissues. Our research is a mix of methodological innovation and collaborative research projects with clinicians and industry. We currently enjoy funding from industry, the Engineering and Physical Sciences Research Council (EPSRC), Cancer Research UK, and the Medical research Council (MRC), with on-going research projects in:

  • Quantitative DCE-MRI in oncology, inflammatory lung disease and dementia
  • Tracer kinetic modeling methods
  • Image registration
  • Tumour growth patterns
  • Tumour oxygenation
  • Proton MRI functional lung imaging
  • Tissue microstructure measurements using diffusion MRI and other methods in neuroscience and cancer

QBI Lab has also participated in a number of phase I clinical trials of anti- angiogeneic and antivascular agents using DCE-MRI in the quantification of tumour microvascular function.

Bioxydyn Limited

I am Founder of a University of Manchester spin out company, Bioxydyn Limited. The company provides an advanced imaging biomarkers contract research service to both the pharmaceutical industry and academia. 

Research interests

I have a general interest in quantitative magnetic resonance imaging (MRI), with particular interests in dynamic contrast-enahnced MRI (DCE-MRI) for characterising the functional status of tissue microvasculature and in diffusion MRI for determining cerebral anatomical connections and for quantifying tissue microstructure non-invasively. I also have a strong interest in imaging of tissue oxygenation in the brain, in cancer and in the lung, particularly by oxygen-enhanced MRI (OE-MRI). 

Teaching

I lead the Physics of Medical Imaging module run in the School of Physics. I also teach on MSc and other postgraduate courses.

My collaborations

  • Professor Alan Jackson
  • Professor Gordon Jayson
  • Professor Matthew Lambon Ralph
  • Professor Daniela Montaldi
  • Dr Jo Naish
  • Dr Laura Parkes
  • Professor James O'Connor
  • Professor Steve Williams
  • Dr Fenglei Zhou
  • Dr Penny Hubbard Cristinacce
  • Dr Ben Dickie
  • Dr Hamied Haroon
  • Dr Ross Little
  • Professor Julie Gough
  • Dr Nils Mulhert
  • Dr Mike Berks
  • Dr Damien McHugh

Memberships of committees and professional bodies

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

External positions

Founder and Director, BiOxyDyn Ltd

1 May 2009 → …

Research Beacons, Institutes and Platforms

  • Cancer
  • Institute for Data Science and AI
  • Dementia@Manchester
  • Digital Futures
  • Christabel Pankhurst Institute
  • Manchester Institute for Collaborative Research on Ageing

Keywords

  • MRI
  • imaging biomarkers
  • cancer
  • neuroscience
  • lung
  • phantoms

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