Gisela Orozco

2022

Functional genomics in primary T cells and monocytes identifies mechanisms by which genetic susceptibility loci influence systemic sclerosis risk

González-Serna, D., Shi, C., Kerick, M., Hankinson, J., Ding, J., McGovern, A., Tutino, M., Villanueva Martin, G., Ortego-Centeno, N., Callejas, J. L., Martin, J. & Orozco, G., 25 Oct 2022, In: Arthritis & rheumatology (Hoboken, N.J.).

Research output: Contribution to journal › Article › peer-review

Open Access

Germline intergenic duplications at Xq26.1 underlie Bazex-Dupré-Christol basal cell carcinoma susceptibility syndrome

Liu, Y., Banka, S., Huang, Y., Hardman-Smart, J., Pye, D., Torrelo, A., Beaman, G. M., Kazanietz, M. G., Baker, M. J., Ferrazzano, C., Shi, C., Orozco, G., Eyre, S., van Geel, M., Bygum, A., Fischer, J., Miedzybrodzka, Z., Abuzahra, F., Rübben, A., Cuvertino, S., & 12 othersEllingford, J. M., Smith, M. J., Evans, D. G., Weppner-Parren, L. J. M. T., van Steensel, M. A. M., Chaudhary, I. H., Mangham, D. C., Lear, J. T., Paus, R., Frank, J., Newman, W. G. & Zhang, X., 20 Aug 2022, (E-pub ahead of print) In: British Journal of Dermatology.

Research output: Contribution to journal › Article › peer-review

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Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

BioBank Japan Project, 4 Nov 2022, In: Nature Genetics.

Research output: Contribution to journal › Article › peer-review

2021

Chromatin Looping Links Target Genes with Genetic Risk Loci for Dermatological Traits

Shi, C., Ray-Jones, H., Ding, J., Duffus, K., Fu, Y., Gaddi, V. P., Gough, O., Hankinson, J., Martin, P., McGovern, A., Yarwood, A., Gaffney, P., Eyre, S., Rattray, M., Warren, R. B. & Orozco, G., 1 Aug 2021, In: The Journal of Investigative Dermatology. 141, 8, p. 1975-1984 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms

Lopez Isac, E., Smith, S., Marion, M. C., Wood, A., Sudman, M., Yarwood, A., Shi, C., Gaddi, V., Martin, P., Prahalad, S., Eyre, S., Orozco, G., Morris, A., Langefeld, C. D., Thompson, S. D., Thomson, W. & Bowes, J., 11 Feb 2021, In: Annals of the rheumatic diseases. 80, p. 321-328

Research output: Contribution to journal › Article › peer-review

Open Access

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability

Ge, X., Frank-Bertoncelj, M., Klein, K., McGovern, A., Kuret, T., Houtman, M., Burja, B., Micheroli, R., Shi, C., Marks, M., Filer, A., Buckley, C. D., Orozco, G., Distler, O., Morris, A. P., Martin, P., Eyre, S. & Ospelt, C., 25 Aug 2021, In: Genome Biology. 22, 1, p. 247 247.

Research output: Contribution to journal › Article › peer-review

Open Access

Transcriptome-wide study of TNF-inhibitor therapy in rheumatoid arthritis reveals early signature of successful treatment

Oliver, J., Nair, N., Orozco, G., Smith, S., Hyrich, K., Morgan, A. W., Isaacs, J. D., Wilson, A., BRAGGSS., Barton, A. & Plant, D., 10 Mar 2021, In: Arthritis Research & Therapy. 23, 1, 80.

Research output: Contribution to journal › Article › peer-review

Open Access

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2020

Characterisation of CD4+ T-cell subtypes using single cell RNA sequencing and the impact of cell number and sequencing depth

Ding, J., Smith, S., Orozco, G., Barton, A., Eyre, S. & Martin, P., 13 Nov 2020, In: Scientific Reports. 10, 1, 19825.

Research output: Contribution to journal › Article › peer-review

Open Access

Exploring the overlap between rheumatoid arthritis susceptibility loci and long non-coding RNA annotations

Ding, J., Shi, C., Bowes, J., Eyre, S. & Orozco, G., 20 Mar 2020, In: P L o S One. 15, 3, e00223939.

Research output: Contribution to journal › Article › peer-review

Open Access

Functional genomics in autoimmune diseases

Ding, J., Frantzeskos, A. & Orozco, G., 18 May 2020, In: Human Molecular Genetics. 29, R1, p. R59-R65

Research output: Contribution to journal › Article › peer-review

Open Access

HiChIP-Peaks: A HiChIP peak calling algorithm

Shi, C., Rattray, M. & Orozco, G., 24 Mar 2020, In: Bioinformatics (Oxford, England). 36, 12, p. 3625-3631

Research output: Contribution to journal › Article › peer-review

Open Access

Mapping DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31

Ray-Jones, H., Duffus, K., Mcgovern, A., Martin, P., Shi, C., Hankinson, J., Gough, O., Yarwood, A., Morris, A., Adamson, A., Taylor, C., Ding, J., Gaddi, V., Fu, Y., Gaffney, P., Orozco, G., Warren, R. & Eyre, S., 4 May 2020, In: BMC Biology. 18, 1, 47.

Research output: Contribution to journal › Article › peer-review

Open Access

Using functional genomics to advance the understanding of psoriatic arthritis

Shi, C., Rattray, M., Barton, A., Bowes, J. & Orozco, G., 2020, In: Rheumatology (Oxford). 59, 11, p. 3137-3146

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Chromatin-based techniques map DNA interaction landscapes in psoriasis susceptibility loci and highlight KLF4 as a target gene in 9q31

Orozco, G., 30 Oct 2019, In: bioRxiv.

Research output: Contribution to journal › Article

Chromatin interactions reveal novel gene targets for drug repositioning in rheumatic diseases

Martin, P., Ding, J., Duffus, K., Gaddi, V., Mcgovern, A., Ray-Jones, H., Yarwood, A., Worthington, J., Barton, A. & Orozco, G., 15 May 2019, In: Annals Of Rheumatic Diseases. 78, p. 1127-1134

Research output: Contribution to journal › Article › peer-review

Open Access

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

Orozco, G. & Worthington, J., 31 Oct 2019, In: Nature Communications. 10, 4955.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Analysis of SNP-SNP interactions and bone quantitative ultrasound parameter in early adulthood

Correa-Rodríguez, M., Viatte, S., Massey, J., Schmidt-RioValle, J., Rueda-Medina, B. & Orozco, G., 2017, In: BMC Medical Genetics. 18, 1, 107.

Research output: Contribution to journal › Article › peer-review

Open Access

The genetics revolution in rheumatology: large scale genomic arrays and genetic mapping

Eyre, S., Orozco, G. & Worthington, J., 2017, In: Nature Reviews Rheumatology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Capture Hi-C identifies a novel causal gene, IL20RA, in the pan-autoimmune genetic susceptibility region 6q23

Mcgovern, A., Schoenfelder, S., Martin, P., Massey, J., Duffus, K., Plant, D., Yarwood, A., Pratt, A., Anderson, A., Isaacs, J. D., Diboll, J., Thalayasingam, N., Ospelt, C., Barton, A., Worthington, J., Fraser, P., Eyre, S. & Orozco, G., 1 Nov 2016, In: Genome biology. 17, 1, 212.

Research output: Contribution to journal › Article › peer-review

Open Access

Identifying Causal Genes at the Multiple Sclerosis Associated Region 6q23 Using Capture Hi-C

Martin, P., Mcgovern, A., Massey, J., Schoenfelder, S., Duffus, K., Yarwood, A., Barton, A., Worthington, J., Fraser, P., Eyre, S. & Orozco, G., 18 Nov 2016, In: PLoS ONE. 11, 11, e0166923.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Downloads (Pure)

2015

Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci.

Martin, P., Mcgovern, A., Orozco, G., Duffus, K., Yarwood, A., Schoenfelder, S., Cooper, N., Barton, A., Wallace, C., Fraser, P., Worthington, J. & Eyre, S., 30 Nov 2015, In: Nature Communications. 6, 10069.

Research output: Contribution to journal › Article › peer-review

2014

Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study

Orozco, G., Viatte, S., Bowes, J., Martin, P., Wilson, A. G., Morgan, A. W., Steer, S., Wordsworth, P., Hocking, L. J., Barton, A., Worthington, J. & Eyre, S., 2014, In: Arthritis and Rheumatology. 66, 1, p. 24-30 6 p.

Research output: Contribution to journal › Article › peer-review

2013

Brief report: Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data

McAllister, K., Yarwood, A., Bowes, J., Orozco, G., Viatte, S., Diogo, D., Hocking, L. J., Steer, S., Wordsworth, P., Wilson, A. G., Morgan, A. W., UK Rheumatoid Arthritis Genetics Consortium, Rheumatoid Arthritis Consortium International, Kremer, J. M., Pappas, D., Gregersen, P., Klareskog, L., Plenge, R., Barton, A., Greenberg, J., & 2 othersWorthington, J. & Eyre, S., Dec 2013, In: Arthritis Care & Research. 65, 12, p. 3058-3062 4 p.

Research output: Contribution to journal › Article › peer-review

2012

Common genetic variants associated with disease from genome-wide association studies are mutually exclusive in prostate cancer and rheumatoid arthritis

Orozco, G., Goh, C. L., Al Olama, A. A., Benlloch-Garcia, S., Govindasami, K., Guy, M., Muir, K. R., Giles, G. G., Severi, G., Neal, D. E., Hamdy, F. C., Donovan, J. L., Kote-Jarai, Z., Easton, D. F., Eyre, S. & Eeles, R. A., 2012, In: BJU Int. 111, 7, p. 1148-1155 7 p.

Research output: Contribution to journal › Article › peer-review

Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA

Maxwell, J. R., Marinou, I., Kuet, K. P., Orozco, G., Moore, D. J., Barton, A., Worthington, J. & Wilson, A. G., Sep 2012, In: Journal of Rheumatology. 39, 9, p. 1781-1785 4 p.

Research output: Contribution to journal › Article › peer-review

Sex-specific differences in effect size estimates at established complex trait loci

Orozco, G., Ioannidis, J. P. A., Morris, A. & Zeggini, E., Oct 2012, In: International Journal of Epidemiology. 41, 5, p. 1376-1382 6 p., dys104.

Research output: Contribution to journal › Article › peer-review

2011

Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis

Bowes, J., Orozco, G., Flynn, E., Ho, P., Brier, R., Marzo-Ortega, H., Coates, L., McManus, R., Ryan, A. W., Kane, D., Korendowych, E., McHugh, N., FitzGerald, O., Packham, J., Morgan, A. W., Bruce, I. N. & Barton, A., Sep 2011, In: Annals of the rheumatic diseases. 70, 9, p. 1641-1644 3 p.

Research output: Contribution to journal › Article › peer-review

Genetics of rheumatoid arthritis: GWAS and beyond

Duffus, K., McAllister, K., Eyre, S. & Orozco, G., 2011, In: Open Access Rheumatology: Research and Reviews. 3, p. 31-46 15 p., 5.

Research output: Contribution to journal › Article › peer-review

Open Access

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HLA-DPB1-COL11A2 and three additional xMHC loci are independently associated with RA in a UK cohort

Orozco, G., Barton, A., Eyre, S., Ding, B., Worthington, J., Ke, X. & Thomson, W., Apr 2011, In: Genes and Immunity. 12, 3, p. 169-175 6 p.

Research output: Contribution to journal › Article › peer-review

Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus

Orozco, G., Eyre, S., Hinks, A., Bowes, J., Morgan, A. W., Wilson, A. G., Wordsworth, P., Steer, S., Hocking, L., Thomson, W., Worthington, J., Barton, A., Gibbons, L. J., Flynn, E., Martin, P., Ke, X., Donn, R., Martin, S., Robinson, J. I., Emery, P., & 2 othersReid, D. M. & Harrison, P., Mar 2011, In: Annals of the rheumatic diseases. 70, 3, p. 463-468 5 p.

Research output: Contribution to journal › Article › peer-review

2010

Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study

Orozco, G., Eyre, S., Hinks, A., Ke, X., Wilson, A. G., Bax, D. E., Morgan, A. W., Emery, P., Steer, S., Hocking, L., Reid, D. M., Wordsworth, P., Harrison, P., Thomson, W., Barton, A. & Worthington, J., May 2010, In: Annals of the rheumatic diseases. 69, 5, p. 813-816 3 p.

Research output: Contribution to journal › Article › peer-review

Functional evaluation of TNFAIP3 (A20) in rheumatoid arthritis

Elsby, L. M., Orozco, G., Denton, J., Worthington, J., Ray, D. W. & Donn, R. P., 2010, In: Clinical and Experimental Rheumatology. 28, 5, p. 708-714 6 p.

Research output: Contribution to journal › Article › peer-review

Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor

Balsa, A., Cabezón, A., Orozco, G., Cobo, T., Miranda-Carus, E., López-Nevot, M. Á., Vicario, J. L., Martín-Mola, E., Martín, J. & Pascual-Salcedo, D., 6 Apr 2010, In: Arthritis Research and Therapy. 12, 2, 62.

Research output: Contribution to journal › Article › peer-review

Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis

Hinks, A., Martin, P., Flynn, E., Packham, J., Barton, A., Baildam, E., Brown, L., Buckley, J., Chieng, A., Davidson, J., Eltringham, M., Friswell, M., Gardner-Medwin, J., Gilbert, P., Hyrich, K., Jones, J., Lal, S., Lay, M., Lydon, C., Meijer, A., & 42 othersPrice, V., Sim, J., Todd, M., Ward, P., Wedderburn, L., Eyre, S., Bowes, J., Orozco, G., Thomson, W., Worthington, J., Martin, S., Robinson, J. I., Morgan, A. W., Emery, P., Wilson, A. G., Steer, S., Hocking, L., Reid, D. M., Harrison, P., Wordsworth, P., Abinum, M., Becker, M., Bell, A., Craft, A., Crawley, E., David, J., Foster, H., Gardener-Medwin, J., Griffin, J., Hall, A., Hall, M., Herrick, A., Hollingworth, P., Holt, L., Jones, S., Pountain, G., Ryder, C., Southwood, T., Stewart, I., Venning, H., Woo, P. & Wyatt, S., Dec 2010, In: Annals of the rheumatic diseases. 69, 12, p. 2169-2172 3 p.

Research output: Contribution to journal › Article › peer-review

Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis

Bowes, J., Lawrence, R., Eyre, S., Panoutsopoulou, K., Orozco, G., Elliott, K. S., Ke, X., Thomson, W., Worthington, J., Barton, A., Zeggini, E. & Morris, A., Dec 2010, In: Human Genetics. 128, 6, p. 627-633 6 p.

Research output: Contribution to journal › Article › peer-review

Synthetic associations in the context of genome-wide association scan signals

Orozco, G., Barrett, J. C. & Zeggini, E., 15 Oct 2010, In: Human Molecular Genetics. 19, 2, p. R137-R144

Research output: Contribution to journal › Article › peer-review

Update on the genetic risk factors for rheumatoid arthritis

Orozco, G. & Barton, A., 2010, In: Expert review of clinical immunology. 6, 1, p. 61-75 14 p.

Research output: Contribution to journal › Article › peer-review

2009

Study of functional variants of the BANK1 gene in rheumatoid arthritis

Orozco, G., Abelson, A. K., González-Gay, M. A., Balsa, A., Pascual-Salcedo, D., García, A., Fernández-Gutierrez, B., Petersson, I., Pons-Estel, B., Eimon, A., Paira, S., Scherbarth, H. R., Alarcón-Riquelme, M. & Martín, J., Feb 2009, In: Arthritis Care & Research. 60, 2, p. 372-379 7 p.

Research output: Contribution to journal › Article › peer-review

2008

Association of STAT4 with rheumatoid arthritis: A replication study in three European populations

Orozco, G., Alizadeh, B. Z., Delgado-Vega, A. M., González-Gay, M. Á., Balsa, A., Pascual-Salcedo, D., Fernández-Gutierrez, B., González-Escribano, M. F., Petersson, I. F., Van Riel, P. L. C. M., Barrera, P., Coenen, M. J. H., Radstake, T. R. D. J., Van Leeuwen, M. A., Wijmenga, C., Koeleman, B. P. C., Alarcón-Riquelme, M. & Martín, J., Jul 2008, In: Arthritis Care & Research. 58, 7, p. 1974-1980 6 p.

Research output: Contribution to journal › Article › peer-review

Auto-antibodies, HLA and PTPN22: Susceptibility markers for rheumatoid arthritis

Orozco, G., Pascual-Salcedo, D., López-Nevot, M. A., Cobo, T., Cabezón, A., Martín-Mola, E., Balsa, A. & Martín, J., 2008, In: Rheumatology. 47, 2, p. 138-141 3 p.

Research output: Contribution to journal › Article › peer-review

Genetic association of vasoactive intestinal peptide receptor with rheumatoid arthritis: Altered expression and signal in immune cells

Delgado, M., Robledo, G., Rueda, B., Varela, N., O'Valle, F., Hernandez-Cortes, P., Caro, M., Orozco, G., Gonzalez-Rey, E. & Martin, J., Apr 2008, In: Arthritis Care & Research. 58, 4, p. 1010-1019 9 p.

Research output: Contribution to journal › Article › peer-review

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis

Rueda, B., Orozco, G., Raya, E., Fernandez-Sueiro, J. L., Mulero, J., Blanco, F. J., Vilches, C., Gonzalez-Gay, M. A. & Martin, J., Oct 2008, In: Annals of the rheumatic diseases. 67, 10, p. 1451-1454 3 p.

Research output: Contribution to journal › Article › peer-review

2007

Asporin repeat polymorphism in rheumatoid arthritis

Torres, B., Orozco, G., García-Lozano, J. R., Oliver, J., Fernández, O., Gonzalez-Gay, M. A., Balsa, A., García, A., Pascual-Salcedo, D., López-Nevot, M. A., Núñez-Roldán, A., Martín, J. & González-Escribano, M. F., Jan 2007, In: Annals of the rheumatic diseases. 66, 1, p. 118-120 2 p.

Research output: Contribution to journal › Article › peer-review

Caspase 7 influences susceptibility to rheumatoid arthritis

García-Lozano, J. R., Torres, B., Fernández, O., Orozco, G., Álvarez-Márquez, A., González-Gay, M. A., García, A., Núñez-Roldán, A., Martín, J. & González-Escribano, M. F., Aug 2007, In: Rheumatology. 46, 8, p. 1243-1247 4 p.

Research output: Contribution to journal › Article › peer-review

Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort

Orozco, G., Rueda, B., Robledo, G., García, A. & Martín, J., Aug 2007, In: Human immunology. 68, 8, p. 681-684 3 p.

Research output: Contribution to journal › Article › peer-review

Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to Henoch-Schölein purpura

Orozco, G., Miranda-Filloy, J. A., Martin, J. & Gonzalez-Gay, M. A., Sep 2007, In: Clinical and Experimental Rheumatology. 25, 5, p. 750-753 3 p.

Research output: Contribution to journal › Article › peer-review

Macrophage migration inhibitory factor gene: Influence on rheumatoid arthritis susceptibility

Martínez, A., Orozco, G., Varadé, J., Sánchez López, M., Pascual, D., Balsa, A., García, A., de la Concha, E. G., Fernández-Gutiérrez, B., Martín, J. & Urcelay, E., Sep 2007, In: Human immunology. 68, 9, p. 744-747 3 p.

Research output: Contribution to journal › Article › peer-review

2006

Epistatic interaction between FCRL3 and NFκB1 genes in Spanish patients with rheumatoid arthritis

Martínez, A., Sánchez, E., Valdivia, A., Orozco, G., López-Nevot, M. A., Pascual-Salcedo, D., Balsa, A., Fernández-Gutiérrez, B., De La Concha, E. G., García-Sánchez, A., Koeleman, B. P. C., Urcelay, E. & Martín, J., Sep 2006, In: Annals of the rheumatic diseases. 65, 9, p. 1188-1191 3 p.

Research output: Contribution to journal › Article › peer-review

Genetic basis of rheumatoid arthritis

Orozco, G., Rueda, B. & Martin, J., Dec 2006, In: Biomedicine and Pharmacotherapy. 60, 10, p. 656-662 6 p.

Research output: Contribution to journal › Article › peer-review

SLC22A4, RUNX1, and SUMO4 polymorphisms are not associated with rheumatoid arthritis: A case-control study in a Spanish population

Orozco, G., Sänchez, E., González-Gay, M. A., López-Nevot, M. A., Torres, B., Pascual-Salcedo, D., Balsa, A., Pablos, J. L., García, A., González-Escribano, M. F. & Martín, J., Jul 2006, In: Journal of Rheumatology. 33, 7, p. 1235-1239 4 p.

Research output: Contribution to journal › Article › peer-review

Gisela Orozco, PhD

Research output

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