Personal profile
Overview
Director, Manchester Clinical Trials Unit
Honorary Consultant Paediatric Oncologist, Royal Manchester Children's Hospital
Training Programme Director Paediatrics ST4-8, North Western Deanery
Director MRes Oncology
Research interests
- Investigating hypoxia-induced drug resistance in childhood cancer
- Evaluating mechanism based therapeutics in childhood cancer
- Evaluation of whether an interactive child-centred workshop reduces treatment-related distress and improve quality of life in children with leukaemia
- A pilot study of circulating biomarkers in childhood cancer
- Cellular therapy for high risk neuroblastoma
- Clinical trial development and methodology
Teaching
PBL tutor for year 4 Families and Children module
Yr4 Clinical Firm Lead
Yr1 PEP supervisor
Yr3 PEP supervisor
Yr4 Project option supervisor
Families and Children OSCE examiner
Academic Advisor
My collaborations
Professor Gareth Veal, University of Newcastle-upon-Tyne
Professor Rob Falconer, Institute for Cancer Therapeutics, University of Bradford
Professor Deb Tweddle, University of Newcastle-upon-Tyne
Professor Muhammad Zaman, Department of Biomedical Engineering, Boston University
Dr Richard Rowe, Department of Psychology, University of Sheffield
Professor Barry Pizer, Alder Hey Children's Hospital
Professor Darren Hargrave, Great Ormond Street Hospital
Memberships of committees and professional bodies
National Institute for Health and Care Excellence, Technology Appraisal Committee D.
National Cancer Research Institute Children's Cancer and Leukaemia (NCRI CCL) neuroblastoma subgroup
NCRI CCL new agents group
Qualifications
BA Cambridge 1988
BM BCh Oxford 1991
PhD Manchester 2000
MRCP (UK) 1994
FRCPCH 2001
External positions
Lead, Paediatric Network Experimental Cancer Medicine Centre
Areas of expertise
- RJ101 Child Health. Child health services
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Research Beacons, Institutes and Platforms
- Cancer
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Whole Genome Sequencing to Identify Novel Germline Fumarate Hydratase Mutation in Child With Bilateral Renal Cell Carcinoma.
Kershaw, C., Demain, L., Baker, E., Burghel, G., Durkie, M., Forde, C., Makin, G., Cheesman, E., Warren, A., Gokhale, D., Schlecht, H., Maher, E., Oliveira, P. & Woodward, E., Feb 2025, In: Clinical Genetics.Research output: Contribution to journal › Article › peer-review
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Bevacizumab, Irinotecan, or Topotecan Added to Temozolomide for Children With Relapsed and Refractory Neuroblastoma: Results of the ITCC-SIOPEN BEACON-Neuroblastoma Trial
Innovative Therapies for Children with Cancer (ITCC) and European Association for Neuroblastoma Research (SIOPEN), 1 Apr 2024, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 42, 10, p. 1135-1145 11 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Downloads (Pure) -
Parc: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults
Fenwick, N., Weston, R., Wheatley, K., Hodgson, J., Marshall, L., Elliott, M., Makin, G., Ng, A., Brennan, B., Lowis, S., Adamski, J., Kilday, J. P., Cox, R., Gattens, M., Moore, A., Trahair, T., Ronghe, M., Campbell, M., Campbell, H. & Williams, M. W. & 10 others, , 31 Jan 2024, In: Frontiers in Oncology. 14, 1296576.Research output: Contribution to journal › Article › peer-review
Open Access -
Afatinib in paediatric patients with recurrent/refractory ErbB-dysregulated tumours: Results of a phase I/expansion trial
Geoerger, B., Marshall, L. V., Nysom, K., Makin, G., Bouffet, E., Defachelles, A.-S., Amoroso, L., Aerts, I., Leblond, P., Barahona, P., Van-Vlerken, K., Fu, E., Solca, F., Lorence, R. M. & Ziegler, D. S., 1 Jul 2023, In: European Journal of Cancer. 188, p. 8-19Research output: Contribution to journal › Article › peer-review
Open Access -
Generation of evidence-based carboplatin dosing guidelines for neonates and infants
Barnett, S., Makin, G., Tweddle, D., Osborne, C. & Veal, G. J., 23 Nov 2023, In: BJC. 129, 11, p. 1773-1779 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Downloads (Pure)
Projects
- 1 Active
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BART II: Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): A randomised controlled trial to investigate the efficacy of a treatment approach targeted at key appraisal change (BART II)
Sutton, C. (PI), Shields, G. (CoI), Peters, S. (CoI) & Makin, G. (CoI)
1/04/22 → 31/03/27
Project: Research
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The National Institute for Health & Care Excellence (External organisation)
Makin, G. (Academic expert member)
1 Sept 2018 → …Activity: Membership › Membership of committee › Research
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UK Childhood Cancer Conference
Makin, G. (Discussant)
22 Jun 2018Activity: Talk or presentation › Invited talk › Research
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The paediatric ECMC network
Makin, G. (Discussant)
9 May 2018Activity: Talk or presentation › Invited talk › Research
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The future for the paediatric ECMC network
Makin, G. (Discussant)
14 Nov 2017Activity: Talk or presentation › Invited talk › Research
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HR-NBL-01 and VERITAS
Makin, G. (Discussant)
4 Dec 2016Activity: Talk or presentation › Invited talk › Research