Halina Dobrzynski

2024

Empowering artificial intelligence in characterizing the human primary pacemaker of the heart at single cell resolution

Chelu, A., Cartwright, E. J. & Dobrzynski, H., 18 Jun 2024, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

Inherent Atrial Fibrillation Vulnerability in the Appendages Exacerbated in Heart Failure

Agrawal, S., Ashby, J., Bai, J., Feng, F., Cai, X. J., Yanni, J., Jones, C. B., Logantha, S. J. R. J., Vohra, A., Hutcheon, R. C., Corno, A. F., Dobrzynski, H., Stephenson, R. S., Boyett, M., Hart, G., Jarvis, J., Smaill, B. & Zhao, J., 2 Feb 2024, (E-pub ahead of print) Statistical Atlases and Computational Models of the Heart. Regular and CMRxRecon Challenge Papers - 14th International Workshop, STACOM 2023, Held in Conjunction with MICCAI 2023, Revised Selected Papers. Camara, O., Puyol-Antón, E., Suinesiaputra, A., Young, A., Sermesant, M., Tao, Q. & Wang, C. (eds.). Springer Nature, p. 220-229 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 14507 LNCS).

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Profiling Reduced Expression of Contractile and Mitochondrial mRNAs in the Human Sinoatrial Node vs. Right Atrium and Predicting Their Suppressed Expression by Transcription Factors and/or microRNAs

Chen, W., Aminu, A., Yin, Z., Karaesmen, I., Atkinson, A., Kuniewicz, M., Holda, M., Walocha, J., Perde, F., Molenaar, P. & Dobrzynski, H., 27 Sept 2024, In: International Journal of Molecular Sciences. 25, 19, 10402.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Atrioventricular node dysfunction in pressure overload-induced heart failure—Involvement of the immune system and transcriptomic remodelling

Wilson, C., Zi, M., Smith, M., Hussain, M., D’Souza, A., Dobrzynski, H. & Boyett, M. R., 4 Apr 2023, In: Frontiers in Pharmacology. 14

Research output: Contribution to journal › Article › peer-review

Open Access

File

73 Downloads (Pure)

MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment

Asjad , E. & Dobrzynski, H., 11 Nov 2023, In: International Journal of Molecular Sciences. 24, 22, 16207.

Research output: Contribution to journal › Review article › peer-review

Open Access

2022

Inflammatory degranulation of the cardiac resident mast cells suppresses the pacemaking and affects activation pattern in the sinoatrial node

Kuzmin, V., Malykhina, I. A., Pustovit, K. B., Ivanova, A. D., Kuniewicz, M., Walocha, J., Atkinson, A., Dobrzynski, H. & Aminu, A., 1 Mar 2022, (Accepted/In press) In: Translational Research in Anatomy.

Research output: Contribution to journal › Special issue › peer-review

Novel Micro-Computed Tomography Contrast Agents to Visualise The Human Cardiac Conduction System and Surrounding Structures in Hearts From Normal, Aged, and Obese Individuals

Aminu, A., Chen, W., Yin, Z., Kuniewicz, M., Walocha, J., Perde, F., Molenaar, P., Iaizzo, P. A., Dobrzynski, H. & Atkinson, A., 2022, (Accepted/In press) In: Translational Research in Anatomy.

Research output: Contribution to journal › Special issue › peer-review

2021

A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

D’Souza, A., Wang, Y., Anderson, C., Bucchi, A., Baruscotti, M., Olieslagers, S., Mesirca, P., Johnsen, A. B., Mastitskaya, S., Ni, H., Zhang, Y., Black, N., Cox, C., Wegner, S., Bano-Otalora, B., Petit, C., Gill, E., Logantha, S. J. R. J., Dobrzynski, H. & Ashton, N. & 10 others, Hart, G., Zhang, R., Zhang, H., Cartwright, E. J., Wisloff, U., Mangoni, M. E., Martins, P. A. D. C., Piggins, H. D., DiFrancesco, D. & Boyett, M. R., 1 May 2021, In: Heart Rhythm. 18, 5, p. 801-810 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Altered microRNA and mRNA profiles during heart failure in the human sinoatrial node

Dobrzynski, H., 29 Sept 2021, In: Scientific Reports. 11, 1

Research output: Contribution to journal › Article › peer-review

Open Access

Attenuation of inward rectifier potassium current contributes to the α1-adrenergic receptor-induced proarrhythmicity in the caval vein myocardium.

Dobrzynski, H., Apr 2021, In: Acta physiologica (Oxford, England).

Research output: Contribution to journal › Article › peer-review

Open Access

Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk

Pineda, S., Nikolova-Krstevski , V., Leimena, C., Atkinson, A., Altekoester , A.-K., Cox , C., Huttner, I., Ju, Y., Soka, M., Ohanian, M., Trivedi, G., Kalvakuri , S., Birker, K., Johnson , R., Molenaar, P., Kuchar, D., Allen, D., van Helden, D., Harvey , R. & Hill , A. & 5 others, Bodmer, R., Vogler , G., Dobrzynski, H., Ocorr, K. & Fatkin, D., 14 Apr 2021, In: Circulation: Genomic and precision medicine. e003144

Research output: Contribution to journal › Article › peer-review

Open Access

Further insights into the molecular complexity of the human sinus node - The role of 'novel' transcription factors and microRNAs

Aminu, A. J., Petkova, M., Atkinson, A. J., Yanni, J., Morris, A. D., Simms, R. T., Chen, W., Yin, Z., Kuniewicz, M., Holda, M. K., Kuzmin, V. S., Perde, F., Molenaar, P. & Dobrzynski, H., 1 Nov 2021, In: Progress in biophysics and molecular biology. 166, p. 86-104 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes

Mesirca, P., Nakao, S., Nissen, S. D., Forte, G., Anderson, C., Trussell, T., Li, J., Cox, C., Zi, M., Logantha, S. J. R., Yaar, S., Carstensen, H., Bidaud, I., Stuart, L., Soattin, L., Morris, G. M., da Costa Martins, P. A., Cartwright, E. J., Oceandy, D. & Mangoni, M. E. & 5 others, Jespersen, T., Buhl, R., Dobrzynski, H., Boyett, M. R. & D'Souza, A., 14 Apr 2021, In: Circulation research.

Research output: Contribution to journal › Article › peer-review

Micro-RNA 133a-3p induces repolarization abnormalities in atrial myocardium and modulates ventricular electrophysiology affecting ICa,L and Ito currents

Kuzmin, V. S., Ivanova, A. D., Filatova, T. S., Pustovit, K. B., Kobylina, A. A., Atkinson, A. J., Petkova, M., Voronkov, Y. I., Abramochkin, D. V. & Dobrzynski, H., 24 Jul 2021, In: European journal of pharmacology. 174369.

Research output: Contribution to journal › Article › peer-review

MiR-486-3p and MiR-938 –Important Inhibitors of Pacemaking Ion Channels and/or Markers of Immune Cells

Aminu, A., Petkova, M., Chen, W., Yin, Z., Kuzmin, V. S., Atkinson, A. & Dobrzynski, H., 2021, In: Applied Sciences.

Research output: Contribution to journal › Article › peer-review

Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit

Logantha, S. J. R. J., Cai, X. J., Yanni, J., Jones, C. B., Stephenson, R. S., Stuart, L., Quigley, G., Monfredi, O., Nakao, S., Oh, I. Y., Starborg, T., Kitmitto, A., Vohra, A., Hutcheon, R. C., Corno, A. F., Jarvis, J. C., Dobrzynski, H., Boyett, M. R. & Hart, G., 1 Jul 2021, In: Circulation. Heart Failure. 14, 7, p. 800-816 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Remodelling of the Purkinje network in congestive heart failure in the rabbit

Logantha, S., Cai, X., Yanni Gerges, J., Jones, C. B., Stephenson, R. S., Stuart, L., Quigley, G., Monfredi, O., Nakao, S., Oh, I.-Y., Starborg, T., Kitmitto, A., Vohra, A., Hutcheon, R. C., Corno, A. F., Jarvis, J. C., Dobrzynski, H., Boyett, M. & Hart, G., 4 May 2021, (Accepted/In press) In: Circulation: Heart Failure.

Research output: Contribution to journal › Article › peer-review

Repolarizing potassium currents in working myocardium of Japanese quail: novel translational model for cardiac electrophysiology

Filatova, T. S., Abramochkin, D., Pavlova, N. S., Pustovit, K. B., Konovalova, O. P., Kuzmin, V. S. & Dobrzynski, H., 6 Feb 2021, (Accepted/In press) In: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology .

Research output: Contribution to journal › Article › peer-review

Structural and Functional Properties of Subsidiary Atrial Pacemakers in a Goat Model of Sinus Node Disease

Soattin, L., Borbas, Z., Caldwell, J., Prendergast, B., Vohra, A., Saeed, Y., Hoschtitzky, A., Yanni, J., Atkinson, A., Logantha, S. J., Borbas, B., Garratt, C., Morris, G. M. & Dobrzynski, H., 4 Mar 2021, In: Frontiers in Physiology. 12, p. 592229 592229.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Common arterial trunk in a cat: a high-resolution morphological analysis with micro-computed tomography

Nakao, S., Atkinson, A. J., Motomochi, T., Fukunaga, D. & Dobrzynski, H., 21 Dec 2020, In: Journal of Veterinary Cardiology. 34, p. 8-15

Research output: Contribution to journal › Article › peer-review

Open Access

File

113 Downloads (Pure)

Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node

Petkova, M., Atkinson, A. J., Yanni, J., Stuart, L., Aminu, A. J., Perde, F., Molenaar, P., Fedorov, V. V. & Dobrzynski, H., 16 Oct 2020, In: Journal of the American Heart Association. 9, 20, p. e016590

Research output: Contribution to journal › Article › peer-review

Open Access

Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Li, N., Kalyanasundaram, A., Hansen, B. J., Artiga, E. J., Sharma, R., Abudulwahed, S. H., Helfrich, K. M., Rozenberg, G., Wu, P.-J., Zakharkin, S., Gyorke, S., Janssen, P., Whitson, B. A., Mokadam, N. A., Biesiadecki, B. J., Accornero, F., Hummel, J. D., Jichao Zhao, J., Mohler, P. J. & Dobrzynski, H. & 1 others, Fedorov, V. V., 24 Jan 2020, In: Nature Communications. 11, 1, p. 512 512.

Research output: Contribution to journal › Article › peer-review

Open Access

Silencing miR-370-3p rescues funny current and sinus node function in heart failure

Yanni Gerges, J., D'Souza, A., Wang, Y., Li, N., Hansen, B. J., Zakharkin, S., Smith, M., Hayward, C., Whitson, B. A., Mohler, P. J., Janssen, P. M. L., Zeef, L., Choudhury, M., Zi, M., Cai, X., Logantha, S., Nakao, S., Atkinson, A., Petkova, M. & Doris, U. & 8 others, Ariyaratnam, J., Cartwright, E., Griffiths-Jones, S., Hart, G., Federov, V. V., Oceandy, D., Dobrzynski, H. & Boyett, M., 9 Jul 2020, In: Scientific Reports. 10, 11279.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

A sexy approach to pacemaking: differences in function and molecular make up of the sinoatrial node

Doris, U., Kharche, S., Petkova, M., Borbas, B., Logantha, S., Fedorenko, O., Maczewski, M., MacKiewicz, U., Zhang, Y., Chahal, A., D'Souza, A., Atkinson, A., Dobrzynski, H. & Yanni, J., 10 Apr 2019, In: Histology and histopathology.

Research output: Contribution to journal › Article › peer-review

Open Access

Circadian rhythm of cardiac electrophysiology, arrhythmogenesis, and the underlying mechanisms

Black, N., D'Souza, A., Wang, Y., Piggins, H., Dobrzynski, H., Morris, G. & Boyett, M. R., Feb 2019, In: Heart Rhythm. 16, 2, p. 298-307 10 p.

Research output: Contribution to journal › Article › peer-review

Electrical conduction system remodelling in streptozotocin-induced diabetes mellitus rat heart

Zhang, Y., Wang, Y., Yanni Gerges, J., Quereshi, M. A., Logantha, S., Al Adhamn, S., Boyett, M., Gardiner, N., Sun, H., Howarth, F. C. & Dobrzynski, H., 2019, In: Frontiers in Physiology. 10, p. 1 15 p., 826.

Research output: Contribution to journal › Article › peer-review

Open Access

Mechanistic insights from targeted molecular profiling of repolarization alternans in the intact human heart

Orini, M., Yanni, J., Taggart, P., Hanson, B., Hayward, M., Smith, A., Zhang, H., Colman, M., Jones, G., Jie, X., Dobrzynski, H., Boyett, M. R. & Lambiase, P. D., 1 Jun 2019, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 21, 6, p. 981-989 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sinus node-like pacemaker mechanisms regulate ectopic pacemaker activity in the adult rat atrioventricular ring

Logantha, S. J. R. J., Kharche, S. R., Zhang, Y., Atkinson, A. J., Hao, G., Boyett, M. R. & Dobrzynski, H., 13 Aug 2019, In: Scientific Reports. 9, 11781.

Research output: Contribution to journal › Article › peer-review

Open Access

Supraventricular Arrhythmias in Athletes: Basic Mechanisms and New Directions

D'Souza, A., Trussell, T., Morris, G. M., Dobrzynski, H. & Boyett, M. R., 1 Sept 2019, In: Physiology. 34, 5, p. 314-326 13 p.

Research output: Contribution to journal › Article › peer-review

2018

Structural and functional remodeling of the atrioventricular node with aging in rats: The role of hyperpolarization-activated cyclic nucleotide-gated and ryanodine 2 channels

Saeed, Y., Temple, I. P., Borbas, Z., Atkinson, A., Yanni Gerges, J., Maczewski, M., Mackiewicz, U., Aly, M., Logantha, S., Garratt, C. & Dobrzynski, H., 2018, In: Heart Rhythm.

Research output: Contribution to journal › Article › peer-review

Open Access

TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome

Choudhury, M., Black, N., Alghamdi, A., D'Souza, A., Wang, R., Yanni Gerges, J., Dobrzynski, H., Kingston, P., Zhang, H., Boyett, M. & Morris, G., 26 Sept 2018, In: The Journal of Physiology. 596, 24, p. 6141-6155 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The Pattern of mRNA Expression Is Changed in Sinoatrial Node from Goto-Kakizaki Type 2 Diabetic Rat Heart

Howarth, F. C., Qureshi, M. A., Jayaprakash, P., Parekh, K., Oz, M., Dobrzynski, H. & Adrian, T. E., 2018, In: Journal of Diabetes Research. 2018, 8454078.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Altered profile of mRNA expression in atrioventricular node of streptozotocin-induced diabetic rats

Howarth, F. C., Parekh, K., Jayaprakash, P., Inbaraj, E. S., Oz, M., Dobrzynski, H. & Adrian, T. E., Oct 2017, In: Molecular Medicine Reports. 16, 4, p. 3720-3730 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

A Sexy Approach to Pacemaking

Doris, U., Logantha, S., Petkova, M., Zhang, Y., Kharche, S., Dobrzynski, H. & Yanni, J., 3 Feb 2017, In: BIOPHYSICAL JOURNAL. 112, 3, p. 403A-403A

Research output: Contribution to journal › Meeting Abstract › peer-review

Computational assessment of the functional role of sinoatrial node exit pathways in the human heart.

Kharche, S., Vigmond, E., Efimov, I. & Dobrzynski, H., 5 Sept 2017, In: PLoS ONE.

Research output: Contribution to journal › Article › peer-review

Open Access

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling

Stephenson, R. S., Atkinson, A., Kottas, P., Perde, F., Jafarzadeh, F., Bateman, M., Iaizzo, P. A., Zhao, J., Zhang, H., Anderson, R. H., Jarvis, J. C. & Dobrzynski, H., 2017, In: Scientific Reports. 7, 7188.

Research output: Contribution to journal › Article › peer-review

Open Access

Mechanism underlying impaired cardiac pacemaking rhythm during ischemia: A simulation study

Bai, X., Wang, K., Yuan, Y., Li, Q., Dobrzynski, H., Boyett, M. R., Hancox, J. C. & Zhang, H., 2017, In: Chaos. 27, 9, 093934.

Research output: Contribution to journal › Article › peer-review

Open Access

Targeting miR-423-5p Reverses Exercise Training-Induced HCN4 Channel Remodeling and Sinus Bradycardia

D'Souza, A., Pearman, C. M., Wang, Y., Nakao, S., Logantha, S. J. R. J., Cox, C., Bennett, H., Zhang, Y., Johnsen, A. B., Linscheid, N., Poulsen, P. C., Elliott, J., Coulson, J., McPhee, J., Robertson, A., Da Costa Martins, P. A., Kitmitto, A., Wisløff, U., Cartwright, E. J. & Monfredi, O. & 5 others, Lundby, A., Dobrzynski, H., Oceandy, D., Morris, G. M. & Boyett, M. R., 13 Oct 2017, In: Circulation research. 121, 9, p. 1058-1068 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

3D anatomical reconstruction of human cardiac conduction system and simulation of bundle branch block after TAVI procedure

Atkinson, A. J., Kharche, S. R., Bateman, M. G., Iaizzo, P. A. & Dobrzynski, H., 2016, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS.

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Atrioventricular node dysfunction and ion channel transcriptome in pulmonary hypertension

Temple, I., Logantha, S., Absi, M., Zhang, Y., Pervolaraki, E., Yanni Gerges, J., Atkinson, A., Petkova, M., Quigley, G., Castro, S., Drinkhill, M. J., Schneider, H., Monfredi, O., Cartwright, E., Yamanushi, T. T., Mahadevan, V. S., Gurney, A., White, E., Zhang, H. & Hart, G. & 2 others, Boyett, M. & Dobrzynski, H., 15 Dec 2016, In: Circulation: Arrhythmia and Electrophysiology. 9, e003432.

Research output: Contribution to journal › Article › peer-review

Open Access

File

329 Downloads (Pure)

Bradycardia in Hypothyroidism is Caused by Intrinsic Remodelling of the Sinus Node

Logantha, S. J. R. J., Ozbeyli, D., Yanni, J., D'souza, A., Dobrzynski, H., Cakir, O. K. & Boyett, M. R., Sept 2016, In: Acta Physiologica. 218, p. 26-26

Research output: Contribution to journal › Meeting Abstract › peer-review

Ca2+-clock-dependent pacemaking in the sinus node is impaired in mice with a cardiac specific reduction in SERCA2 abundance

Logantha, S. J. R. J., Stokke, M. K., Atkinson, A. J., Kharche, S. R., Parveen, S., Saeed, Y., Sjaastad, I., Sejersted, O. M. & Dobrzynski, H., 2 Jun 2016, In: Frontiers in Physiology. 7, 197.

Research output: Contribution to journal › Article › peer-review

Open Access

Expression of connexin 43, ion channels and Ca2+-handling proteins in rat pulmonary vein cardiomyocytes

Xiao, Y., Cai, X., Atkinson, A., Logantha, S., Boyett, M. & Dobrzynski, H., 2016, In: Experimental and Therapeutic Medicine.

Research output: Contribution to journal › Article › peer-review

Insights from echocardiography, magnetic resonance imaging, and microcomputed tomography relative to the mid-myocardial left ventricular echogenic zone

Agger, P., Stephenson, R. S., Dobrzynski, H., Atkinson, A., Iaizzo, P. A., Anderson, R. H., Jarvis, J. C., Allan, S. L., Partridge, J. B., Zhao, J., Zhang, H. & MacIver, D. H., 2016, In: Echocardiography. 33, 10, p. 1546-1556 11 p.

Research output: Contribution to journal › Article › peer-review

Sinus node-like pacemaker phenotype is the basis of ectopic activity originating in atrioventricular rings

Logantha, S., Atkinson, A., Kharche, S. & Dobrzynski, H., 11 Nov 2016, In: Circulation. 134, p. A18556

Research output: Contribution to journal › Meeting Abstract › peer-review

2015

Adverse remodelling of the cardiac conduction system (CCS) in heart failure could be the result of up and down regulation of microRNAs

Yanni Gerges, J., Zeef, L., Zi, M., Cai, X., Logantha, S., Li, J., Cartwright, E., Dobrzynski, H., Hart, G. & Boyett, M., 2015.

Research output: Contribution to conference › Abstract

Changes in the expression of connexins and Ca2+-handling proteins at the Purkinje-ventricular junction in a rabbit model of heart failure

Naruka, V., Cai, X., Yanni Gerges, J., Jones, C. B., Li, J., Vohra, A., Hart, G., Boyett, M., Dobrzynski, H. & Logantha, S., 2015.

Research output: Contribution to conference › Abstract › peer-review

Open Access

Halina Dobrzynski

Research output

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