Hannah Harrison

2024

A novel preclinical model of the normal human breast

Wilby, A. J., Cabral, S., Zoghi, N., Howell, S. J., Farnie, G. & Harrison, H., 2 May 2024, In: Journal of Mammary Gland Biology and Neoplasia. 29, 1, 9.

Research output: Contribution to journal › Article › peer-review

Open Access

2022

The Prevention of Breast and Endometrial cancer using Total Diet Replacement (PROBE-TDR) Trial; Protocol for a Randomised Controlled Trial

Clarke, H., Harvie, M., Lombardelli, C., Krizak, S., Sellers, K., Harrison, H., Lim, Y. Y., Parkin, C., Patel, S., Issa, B., Maxwell, A., Wisley, J., Belcher, J., Clarke, R., Howell, T., Crosbie, E. & Howell, S., 19 Jul 2022, In: BMJ Open. 12, 7, e057161.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

A role for CBFβ in maintaining the metastatic phenotype of breast cancer cells

Ran, R., Harrison, H., Ariffin, N. S., Ayub, R., Pegg, H., Deng, W., Mastro, A., Ottewell, P. D., Mason, S. M., Blyth, K., Holen, I. & Shore, P., 31 Jan 2020, In: Oncogene. 39, p. 2624–2637 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer

walsh, C., Harrison, H., Harris, A. & Landberg, G., 21 Jul 2020, In: P L o S One. 15, 7, e0236187.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Hypoxia-induced secretion stimulates breast CSC regulatory signalling pathways

Harrison, H. & Landberg, G., 1 Aug 2019, In: Molecular Oncology.

Research output: Contribution to journal › Article › peer-review

Open Access

The RUNX Transcriptional Coregulator, CBFβ, Suppresses Migration of ER+ Breast Cancer Cells by Repressing ERα-Mediated Expression of the Migratory Factor TFF1

Pegg, H. J., Harrison, H., Rogerson, C. & Shore, P., 2019, In: Molecular Cancer Research.

Research output: Contribution to journal › Article › peer-review

2018

HIF1-alpha expressing cells induce a hypoxic-like response in neighbouring cancer cells

Harrison, H., Pegg, H., Thompson, J., Bates, C. & Shore, P., 2018, In: BMC Cancer. 18, 674

Research output: Contribution to journal › Article › peer-review

Open Access

Sortilin inhibition limits secretion induced progranulin dependent breast cancer progression and cancer stem cell expansion

Rhost, S., Hughes, E., Harrison, H., Rafnsdottir, S., Jacobsson, H., Gregersson, P., Magnusson, Y., Fitzpatrick, P., Andersson, D., Berger, K., Stahlberg, A. & Landberg, G., 20 Nov 2018, In: Breast Cancer Research.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Abstracts from the NIHR INVOLVE Conference 2017 : London, UK. 28 November 2017

Muir, D., Vat, L., Keller, M., Bell, T., Jørgensen, C., Eskildsen, N., Johnsen, A., Pandya-Wood, R., Blackburn, S., Day, R., Ingram, C., Hapeshi, J., Khan, S., Muir, D. & Harrison, H., 1 Jun 2017, In: Research Involvement and Engagement.

Research output: Contribution to journal › Article › peer-review

Robotic Mammosphere Assay for High-Throughput Screening in Triple-Negative Breast Cancer

Fitzpatrick, A. P., Akrap, N., Söderberg, E. M. V., Harrison, H., Thomson, G. J. & Landberg, G., 1 Aug 2017, In: SLAS Discovery. 22, 7, p. 827-836 10 p.

Research output: Contribution to journal › Article › peer-review

2016

Tissue Factor promotes breast cancer stem cell activity in vitro

Shaker, H., Harrison, H., Clarke, R., Landberg, G., Bundred, N., Versteeg, H. & Kirwan, C., 13 Dec 2016, In: Oncotarget. 8

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

Lamb, R., Harrison, H., Smith, D., Townsend, P. A., Jackson, T., Ozsvari, B., Martinez-Outschoorn, U. E., Pestell, R. G., Howell, A., Lisanti, M. P. & Sotgia, F., 10 Mar 2015, In: Oncotarget. 6, 7, p. 4585-4601

Research output: Contribution to journal › Article › peer-review

Open Access

2013

Contrasting Hypoxic Effects on Breast Cancer Stem Cell Hierarchy Is Dependent on ER-α Status

Harrison, H., Rogerson, L., Gregson, H. J., Brennan, K. R., Clarke, R. & Landberg, G., 15 Feb 2013, In: Cancer Research. 73, 4, p. 1420-1433 13 p.

Research output: Contribution to journal › Article › peer-review

Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling

Harrison, H., Simões, B. M., Rogerson, L., Howell, S. J., Landberg, G. & Clarke, R. B., 8 Mar 2013, In: Breast Cancer Research. 15, 2, R21.

Research output: Contribution to journal › Article › peer-review

Targeting treatment-resistant breast cancer stem cells with FKBPL and Its peptide derivative, AD-01, via the CD44 pathway

McClements, L., Yakkundi, A., Papaspyropoulos, A., Harrison, H., Ablett, M. P., Jithesh, P. V., McKeen, H. D., Bennett, R., Donley, C., Kissenpfennig, A., McIntosh, S., McCarthy, H. O., O'Neill, E., Clarke, R. B. & Robson, T., 15 Jul 2013, In: Clinical Cancer Research. 19, 14, p. 3881-3893 12 p.

Research output: Contribution to journal › Article › peer-review

2012

A detailed mammosphere assay protocol for the quantification of breast stem cell activity

Shaw, F. L., Harrison, H., Spence, K., Ablett, M. P., Simões, B. M., Farnie, G. & Clarke, R. B., Jun 2012, In: Journal of Mammary Gland Biology and Neoplasia. 17, 2, p. 111-117 6 p.

Research output: Contribution to journal › Article › peer-review

2011

Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: An experimentally supported mathematical model

Agur, Z., Kirnasovsky, O. U., Vasserman, G., Tencer-Hershkowicz, L., Kogan, Y., Harrison, H., Lamb, R. & Clarke, R. B., 2011, In: PLoS ONE. 6, 9, e24225.

Research output: Contribution to journal › Article › peer-review

2010

Breast cancer stem cells: something out of notching?

Harrison, H., Farnie, G., Brennan, K. R. & Clarke, R. B., 15 Nov 2010, In: Cancer Research. 70, 22, p. 8973-8976 3 p.

Research output: Contribution to journal › Article › peer-review

Disruption of a Quorum Sensing mechanism triggers tumorigenesis: A simple discrete model corroborated by experiments in mammary cancer stem cells

Agur, Z., Kogan, Y., Levi, L., Harrison, H., Lamb, R., Kirnasovsky, O. U. & Clarke, R. B., 20 Apr 2010, In: Biology Direct. 5, 20.

Research output: Contribution to journal › Article › peer-review

Irradiated Blm-deficient mice are a highly tumor prone model for analysis of a broad spectrum of hematologic malignancies

Warren, M., Chung, Y. J., Howat, W. J., Harrison, H., McGinnis, R., Hao, X., McCafferty, J., Fredrickson, T. N., Bradley, A. & Morse, H. C., Feb 2010, In: Leukemia Research. 34, 2, p. 210-220 10 p.

Research output: Contribution to journal › Article › peer-review

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor

Harrison, H., Farnie, G., Howell, S. J., Rock, R. E., Stylianou, S., Brennan, K. R., Bundred, N. J. & Clarke, R. B., 15 Jan 2010, In: Cancer Research. 70, 2, p. 709-718 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2008

Loss of Rassf1a cooperates with ApcMin to accelerate intestinal tumourigenesis

Van Der Weyden, L., Arends, M. J., Dovey, O. M., Harrison, H. L., Lefebvre, G., Conte, N., Gergely, F. V., Bradley, A. & Adams, D. J., 24 Jul 2008, In: Oncogene. 27, 32, p. 4503-4508 5 p.

Research output: Contribution to journal › Article › peer-review

2007

Mammary development, carcinomas and progesterone: role of Wnt signalling.

Lamb, R., Harrison, H. & Clarke, R. B., 2007, In: Ernst Schering Foundation symposium proceedings. 1, p. 1-23 22 p.

Research output: Contribution to journal › Article › peer-review

2004

A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization

Harrison, H., Chung, Y. J., Jonkers, J., Kitson, H., Fiegler, H., Humphray, S., Scott, C., Hunt, S., Yu, Y., Nishijima, I., Velds, A., Holstege, H., Carter, N. & Bradley, A., Jan 2004, In: Genome research. 14, 1, p. 188-196 8 p.

Research output: Contribution to journal › Article › peer-review

Hannah Harrison, BSc, PhD

Research output

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