Hervé Boutin

2025

Early metabolic changes in the brain of Alzheimer's disease rats are driven by GLAST+ cells

Morrey, W. J., Ceyzériat, K., Amossé, Q., Badina, A. M., Dickie, B., Schiessl, I., Tsartsalis, S., Millet, P., Boutin, H. & Tournier, B. B., 7 Feb 2025, (E-pub ahead of print) In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 17 p., 0271678X251318923.

Research output: Contribution to journal › Article › peer-review

Open Access

MRI detects blood-brain barrier alterations in a rat model of Alzheimer’s disease and lung infection

Ohene, Y., Morrey, W. J., Powell , E., Smethers, K. F., Luka, N., South, K., Berks, M., Lawrence, C. B., Parker, G. J. M., Parkes, L. M., Boutin, H. & Dickie, B. R., 23 Jan 2025, (Accepted/In press) In: npj Imaging.

Research output: Contribution to journal › Article › peer-review

2024

Accumulation of Bioactive Lipid Species in LPS-Induced Neuroinflammation Models Analysed with Multi-Modal Mass Spectrometry Imaging

Razo, I. B., Shea, K., Allen, T.-J., Boutin, H., McMahon, A., Lockyer, N. & Hart, P. J., 8 Nov 2024, In: International Journal of Molecular Sciences. 25, 22

Research output: Contribution to journal › Article › peer-review

Optimizing SUV Analysis: A Multicenter Study on Preclinical FDG-PET/CT Highlights the Impact of Standardization

Kuntner, C., Alcaide, C., Anestis, D., Bankstahl, J. P., Boutin, H., Brasse, D., Elvas, F., Forster, D., Rouchota, M. G., Tavares, A., Teuter, M., Wanek, T., Zachhuber, L. & Mannheim, J. G., Aug 2024, In: Molecular Imaging and Biology. 26, 4, p. 668-679 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Quantitative Imaging of Regional Cerebral Protein Synthesis in Clinical Alzheimer's Disease by [¹¹C]Leucine PET

Herholz, K., McMahon, A., Thompson, J., Jones, M., Boutin, H., Gregory, J., Parker, C. A. & Hinz, R., 20 Nov 2024, In: Molecular Imaging and Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease

Mandolfo, O., Parker, H., Aguado, È., Ishikawa Learmonth, Y., Liao, A. Y., O'Leary, C., Ellison, S., Forte, G., Taylor, J., Wood, S., Searle, R., Holley, R. J., Boutin, H. & Bigger, B. W., 15 Jul 2024, In: EMBO Molecular Medicine. 16, 7, p. 1579-1602 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Filter exchange imaging with crusher gradient modelling detects increased blood-brain barrier water permeability in response to mild lung infection

Ohene, Y., Harris, W. J., Powell, E., Wycech, N. W., Smethers, K. F., Lasič, S., South, K., Coutts, G., Sharp, A., Lawrence, C. B., Boutin, H., Parker, G. J. M., Parkes, L. M. & Dickie, B. R., 1 Dec 2023, In: Fluids and Barriers of the CNS. 20, 1, 25.

Research output: Contribution to journal › Article › peer-review

Open Access

Virtual histology of Alzheimer's disease: Biometal entrapment within amyloid-β plaques allows for detection via X-ray phase-contrast imaging

Chourrout, M., Sandt, C., Weitkamp, T., Dučić, T., Meyronet, D., Baron, T., Klohs, J., Rama, N., Boutin, H., Singh, S., Olivier, C., Wiart, M., Brun, E., Bohic, S. & Chauveau, F., 15 Oct 2023, In: Acta Biomaterialia. 170, p. 260-272 13 p.

Research output: Contribution to journal › Article › peer-review

2022

Brain virtual histology with X-ray phase-contrast tomography Part II: 3D morphologies of amyloid-β plaques in Alzheimer's disease models

Chourrout, M., Roux, M., Boisvert, C., Gislard, C., Legland, D., Arganda-Carreras, I., Olivier, C., Peyrin, F., Boutin, H., Rama, N., Baron, T., Meyronet, D., Brun, E., Rositi, H., Wiart, M. & Chauveau, F., Mar 2022, In: Biomedical Optics Express. 13, 3, p. 1640-1653 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Brain virtual histology with X-ray phase-contrast tomography Part II:3D morphologies of amyloid- β plaques in Alzheimer's disease models.

Chourrout, M., Roux, M., Boisvert, C., Gislard, C., Legland, D., Arganda-Carreras, I., Olivier, C., Peyrin, F., Boutin, H., Rama, N., Baron, T., Meyronet, D., Brun, E., Rositi, H., Wiart, M. & Chauveau, F., 1 Mar 2022, In: Biomedical Optics Express. 13, 3, p. 1640-1653 14 p.

Research output: Contribution to journal › Article › peer-review

Measurement of Protein Synthesis Rate in Rat by [11C]Leucine PET Imaging: Application to the TgF344-AD Model of Alzheimer’s Disease

Bochicchio, D., Christie, L., Lawrence, C. B., Herholz, K., Parker, C. A., Hinz, R. & Boutin, H., 20 Dec 2022, (E-pub ahead of print) In: Molecular Imaging and Biology. 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantitative kinetic modelling and mapping of cerebral glucose transport and metabolism using glucoCESL MRI

Dickie, B. R., Jin, T., Wang, P., Hinz, R., Harris, W., Boutin, H., Parker, G. J. M., Parkes, L. M. & Matthews, J. C., 1 Nov 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 11, p. 2066-2079 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Retinal functional ultrasound imaging (rfUS) for assessing neurovascular alterations: a pilot study on a rat model of dementia

Morisset, C., Dizeux, A., Larrat, B., Selingue, E., Boutin, H., Picaud, S., Sahel, J.-A., Ialy-Radio, N., Pezet, S., Tanter, M. & Deffieux, T., 14 Nov 2022, In: Scientific Reports. 12, 1, 19515.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Alzheimer's disease pathology is associated with earlier alterations to blood-brain barrier water permeability compared with healthy ageing in TgF344-AD rats

Dickie, B. R., Boutin, H., Parker, G. J. M. & Parkes, L. M., 15 Mar 2021, In: NMR in Biomedicine. p. e4510

Research output: Contribution to journal › Article › peer-review

Open Access

Brain virtual histology with X-ray phase-contrast tomography Part II: 3D morphologies of amyloid-β plaques in Alzheimer’s disease models

Chourrout, M., Roux, M., Boisvert, C., Gislard, C., Legland, D., Arganda-Carreras, I., Olivier, C., Peyrin, F., Boutin, H., Rama, N., Baron, T., Meyronet, D., Brun, E., Rositi, H., Wiart, M. & Chauveau, F., 25 Mar 2021, In: bioRxiv.

Research output: Contribution to journal › Article › peer-review

Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies: A scoping review of clinical TSPO PET studies

Chauveau, F., Becker, G. & Boutin, H., Dec 2021, In: European Journal of Nuclear Medicine and Molecular Imaging. 49, 1, p. 201-220 20 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study: a collaborative multi-modal study

Chaney, A., Bochicchio, D., Vandesquille, M., Harte, M., Davies, K., Williams, S. R., Boutin, H. & et al., 3 May 2021, In: Theranostics. 11, 14, p. 6644-6667 24 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Spatiotemporal immunolocalisation of REST in the brain of healthy ageing and Alzheimer's disease rats

Mampay, M., Velasco-Estevez, M., Rolle, S. O., Chaney, A. M., Boutin, H., Dev, K. K., Moeendarbary, E. & Sheridan, G. K., 1 Jan 2021, In: FEBS open bio.

Research output: Contribution to journal › Article › peer-review

Open Access

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TSPO imaging in animal models of brain diseases

Van Camp, N., Lavisse, S., Roost, P., Gubinelli, F., Hillmer, A. & Boutin, H., 10 Jul 2021, In: European Journal of Nuclear Medicine and Molecular Imaging.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Evaluation of F-18-IAM6067 as a sigma-1 receptor PET tracer for neurodegeneration in vivo in rodents and in human tissue

Lepelletier, F.-X., Vandesquille, M., Asselin, M.-C., Prenant, C., Robinson, A. C., Mann, D. M. A., Green, M., Barnett, E., Banister, S. D., Mottinelli, M., Mesangeau, C., McCurdy, C. R., Fricke, I. B., Jacobs, A. H., Kassiou, M. & Boutin, H., 29 Jun 2020, In: Theranostics. 10, 18, p. 7938-7955 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA

Parker, H., Ellison, S. M., Holley, R. J., O'Leary, C., Liao, A., Asadi, J., Glover, E., Ghosh, A., Jones, S., Wilkinson, F. L., Brough, D., Pinteaux, E., Boutin, H. & Bigger, B. W., 6 Mar 2020, In: EMBO Molecular Medicine. 12, 3, e11185.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Early functional connectivity deficits and progressive microstructural alterations in the TgF344-AD rat model of Alzheimer's Disease: A longitudinal MRI study

Anckaerts, C., Blockx, I., Summer, P., Michael, J., Hamaide, J., Kreutzer, C., Boutin, H., Couillard-Després, S., Verhoye, M. & Van der Linden, A., Apr 2019, In: Neurobiology of disease. 124, p. 93-107 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Water-exchange MRI detects subtle blood-brain barrier breakdown in Alzheimer's disease rats

Dickie, B. R., Vandesquille, M., Ulloa, J., Boutin, H., Parkes, L. M. & Parker, G. J. M., 1 Jan 2019, In: NeuroImage. 184, p. 349-358

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

Infection augments expression of mechanosensing Piezo1 channels in amyloid plaque-reactive astrocytes

Velasco-Estevez, M., Mampay, M., Boutin, H., Chaney, A., Warn, P., Sharp, A., Burgess, E., Moeendarbary, E., Dev, K. K. & Sheridan, G. K., 2018, In: Frontiers in aging neuroscience. 10, OCT, 332.

Research output: Contribution to journal › Article › peer-review

Open Access

In vivo Molecular Imaging of Neuroinflammation in Alzheimer’s disease

Chaney, A., Williams, S. R. & Boutin, H., 2018, In: Journal of neurochemistry.

Research output: Contribution to journal › Article › peer-review

Open Access

Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe×PS1Δe9 transgenic mouse model of Alzheimer's disease

Chaney, A., Bauer, M., Bochicchio, D., Smigova, A., Kassiou, M., Davies, K. E., Williams, S. R. & Boutin, H., Feb 2018, In: Journal of neurochemistry. 144, 3, p. 318-335

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-modal imaging of long-term recovery post-stroke by positron emission tomography and matrix-assisted laser desorption/ionisation mass spectrometry

Henderson, F., Hart, P. J., Pradillo, J. M., Kassiou, M., Christie, L., Williams, K. J., Boutin, H. & McMahon, A., 14 Apr 2018, In: Rapid Communications in Mass Spectrometry. 32, 9, p. 721-729 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Comparative evaluation of three TSPO PET radiotracers in a LPS-induced model of mild neuroinflammation in rats.

Sridharan, S., Lepelletier, F.-X., Trigg, W., Banister , S., Reekie, T., Kassiou , M., Gerhard, A., Hinz, R. & Boutin, H., Feb 2017, In: Molecular Imaging and Biology. 19, 1, p. 77-89

Research output: Contribution to journal › Article › peer-review

Open Access

12 Downloads (Pure)

Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography.

Fairclough, M., Ellis, B., Boutin, H., Jones, A., Mcmahon, A., Alzabin, S., Gennari, A. & Prenant, C., Dec 2017, In: Applied Radiation and Isotopes. 130, p. 7-12 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Early changes in extracellular matrix in Alzheimer's disease.

Lepelletier, F.-X., Mann, D., Robinson, A., Pinteaux, E. & Boutin, H., Feb 2017, In: Neuropathology and Applied Neurobiology. 43, 2, p. 167-182

Research output: Contribution to journal › Article › peer-review

FTIR imaging of the molecular burden around Aβ deposits in an early-stage 3-Tg-APP-PSP1-TAU mouse model of Alzheimer's disease

Surowka, A. D., Pilling, M., Henderson, A., Boutin, H., Christie, L., Szczerbowska-Boruchowska, M. & Gardner, P., 7 Jan 2017, In: Analyst. 142, 1, p. 156-168

Research output: Contribution to journal › Article › peer-review

Open Access

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Mass spectrometry imaging shows major derangements in neurogranin and in purine metabolism in the triple-knockout 3×Tg Alzheimer mouse model

Esteve, C., Jones, E. A., Kell, D. B., Boutin, H. & McDonnell, L. A., 2017, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 7, p. 747-754

Research output: Contribution to journal › Article › peer-review

Open Access

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Reparative effects of interleukin-1receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia

Pradillo, J., Murray, K., Coutts, G., Moraga, A., Oroz-Gonjar, F., Boutin, H., Moro, M. A., Ignacio, L. M., Rothwell, N. & Allan, S., Mar 2017, In: Brain, Behavior, and Immunity. 61, p. 117-126 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

A new technique for the radiolabelling of mixed leukocytes with zirconium-89 for inflammation imaging with positron emission tomography

Fairclough, M., Prenant, C., Ellis, B., Boutin, H., Mcmahon, A., Brown, G., Locatelli, P. & Jones, A., 15 Jun 2016, In: Journal of Labelled Compounds and Radiopharmaceuticals. 59, 7, p. 261 296 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Automation of [18F]fluoroacetaldehyde synthesis: application to a recombinant human interleukin-1 receptor antagonist (rhIL-1RA)

Morris, O., Mcmahon, A., Boutin, H., Grigg, J. & Prenant, C., 6 Apr 2016, In: Journal of Labelled Compounds and Radiopharmaceuticals. 59, 7, p. 277-283

Research output: Contribution to journal › Article › peer-review

Open Access

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Development & Automation of a novel [18F]F prosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Morris, O., Gregory, J., Kadirvel, M., Henderson, F., Blykers, A., McMahon, A., Taylor, M., Allsop, D., Allan, S., Grigg, J., Boutin, H. & Prenant, C., 1 Oct 2016, In: Applied Radiation and Isotopes. 116, p. 120–127 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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EFFECT OF DELAYED ADMINISTRATION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST ON NEUROGENESIS AFTER EXPERIMENTAL STROKE IN YOUNG/ AGED RATS

Pradillo, J., Murray, K. N., Moraga, A., Boutin, H., Coutts, G., Moro, M. A., Lizasoain, I., Rothwell, N. J. & Allan, S. M., Jun 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, p. 223-224

Research output: Contribution to journal › Article › peer-review

Thickness of functionalized graphene oxide sheets plays critical role in tissue accumulation and urinary excretion: a pilot PET/CT study

Jasim, D., Boutin, H., Fairclough, M., Ménard-Moyon, C., Prenant, C., Bianco, A. & Kostarelos, K., Sept 2016, In: Applied Materials Today . 4, p. 24-30 7 p.

Research output: Contribution to journal › Article › peer-review

2015

Development and application of an [18F] anti-amyloid peptide radiotracer

Morris, O., Gregory, J., Blykers, A., Allsop, D., Taylor, M., Allan, S., McMahon, A., Boutin, H. & Prenant, C., 1 Oct 2015, In: European Journal of Nuclear Medicine. 42, Supplement 1, p. S144 1 p.

Research output: Contribution to journal › Article › peer-review

Development of a cell labelling technique using zirconium-89 for inflammation imaging with positron emission tomography (PET)

Fairclough, M., Ellis, B., Brown, G., Boutin, H., McMahon, A., Gennari, A., Jones, A. & Prenant, C., 1 Oct 2015, In: European Journal of Nuclear Medicine. 42, 1, p. S499-S500

Research output: Contribution to journal › Article › peer-review

TSPO imaging in stroke: from animal models to human subjects

Boutin, H. & Pinborg, P., 30 Sept 2015, In: Clinical and Translational Imaging. 3, 6, p. 423-435

Research output: Contribution to journal › Article › peer-review

2014

18F-GE-180: a novel TSPO radiotracer compared to 11C-R-PK11195 in a preclinical model of stroke

Boutin, H., Murray, K., Pradillo, J., Maroy, R., Smigova, A., Gerhard, A., Jones, P. & Trigg, W., 29 Oct 2014, (E-pub ahead of print) In: European Journal of Nuclear Medicine and Molecular Imaging. 42, 3, p. 503-511 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Radiolabelling of an anti-amyloid peptide with 6-(2-[18F]Fluoroethoxy)-2-cyanobenzothiazole

Morris, O., Boutin, H., McMahon, A., Allan, S., Taylor, M., Allsop, D., Kadirvel, M. & Prenant, C., Oct 2014, In: European Journal of Nuclear Medicine and Molecular Imaging. 41, 2 Supplement, p. S199-S199

Research output: Contribution to journal › Article › peer-review

Radiolabelling of an anti-amyloid peptide with 6-(2-[18F]Fluoroethoxy)-2-cyanobenzothiazole

Morris, O., Boutin, H., McMahon, A., Allan, S., Taylor, M., Allsop, D., Kadirvel, M. & Prenant, C., 1 Oct 2014, In: European Journal of Nuclear Medicine. 41, Supplement 2, p. S199 OP169.

Research output: Contribution to journal › Article › peer-review

2013

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats

Boutin, H., Prenant, C., Maroy, R., Galea, J., Greenhalgh, A. D., Smigova, A., Cawthorne, C., Julyan, P., Wilkinson, S. M., Banister, S. D., Brown, G., Herholz, K., Kassiou, M. & Rothwell, N. J., 13 Feb 2013, In: PLoS ONE. 8, 2, e56441.

Research output: Contribution to journal › Article › peer-review

[C-11]PK13168 and [C-11]PK13162, two PK11195 analogues labelled at their carbamate function using [C-11]phosgene

Thominiaux, C., Demphel, S., Damont, A., Boutin, H., Rooney, T., Tavitian, B. & Dolle, F., May 2013, In: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 56, p. S293-S293

Research output: Contribution to journal › Article › peer-review

2012

Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

Pradillo, J. M., Denes, A., Greenhalgh, A. D., Boutin, H., Drake, C., McColl, B. W., Barton, E., Proctor, S. D., Russell, J. C., Rothwell, N. J. & Allan, S. M., Sept 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 9, p. 1810-1819 9 p.

Research output: Contribution to journal › Article › peer-review

Noninvasive molecular imaging of neuroinflammation

Boutin, H., Jacobs, A. H. & Tavitian, B., Jul 2012, In: Journal of Cerebral Blood Flow and Metabolism. 32, 7, p. 1393-1415 22 p.

Research output: Contribution to journal › Article › peer-review

2011

Assessing the contribution of inflammation in models of Alzheimer's disease

Johnston, H., Boutin, H. & Allan, S. M., Aug 2011, In: Biochemical Society Transactions. 39, 4, p. 886-890 4 p.

Research output: Contribution to journal › Article › peer-review

Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [ 18F]-IL1RA and PET imaging in rats

Cawthorne, C., Prenant, C., Smigova, A., Julyan, P., Maroy, R., Herholz, K., Rothwell, N. & Boutin, H., Feb 2011, In: British Journal of Pharmacology. 162, 3, p. 659-672 13 p.

Research output: Contribution to journal › Article › peer-review

Hervé Boutin, PhD

Research output

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