Personal profile
Biography
I am a Lecturer in Clinical Pharmaceutical Science in the Division of Pharmacy and Optometry. With my background in Pharmacy, I combine expertise in biochemistry and pharmacology to study the mechanisms of diseases caused by mitochondrial dysfunction.
I studied Pharmacy at the University of Nottingham, I became fascinated by the intricate molecular pathways that link metabolic dysfunction to the progression of diseases. My experience working in the pharmaceutical industry and hospital pharmacy led my interest towards applying scientific research to developing therapeutic interventions. I completed my PhD under the supervision of Professor Mike Murphy at the MRC Mitochondrial Biology Unit, University of Cambridge. My PhD research focused on developing novel inhibitors of the mitochondrial enzyme succinate dehydrogenase, a key player in cellular energy production and key node in a number of diseases.
During my PhD, I became interested in translating my work, as it was relevant for treating ischaemia/reperfusion injury during heart attacks and inflammation. I carried out postdoctoral research at the University of Cambridge, working with Professor Thomas Krieg in the Department of Medicine. Here, I undertook work to understand the precise mechanisms of damage occurring in ischaemia/reperfusion injury and developed a novel therapeutic approach to combat this, which has shown to be effective in pre-clinical models of heart attack, ischaemic stroke and organ transplantation.
In January 2025, I took up my current Lectureship at the University of Manchester, to start my research program focused on understanding the role of mitochondrial metabolism and redox status in disease and identifying new therapeutic targets.
Research interests
- Mitochondrial function in compromised oxygen environments
- Mitochondrial metabolism and redox status driving disease
- Mitochondria-targeted drug delivery
- Mitochondrial metabolite signalling
Education/Academic qualification
Doctor of Philosophy, University of Cambridge
Master of Pharmacy, University of Nottingham
Areas of expertise
- RM Therapeutics. Pharmacology
- RS Pharmacy and materia medica
- QP Physiology
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 4 Quality Education
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SDG 10 Reduced Inequalities
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Collaborations and top research areas from the last five years
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Mitochondrial succinate transport is required for cardiac ischemia/reperfusion injury
Pala, L., Torres-López, M., Caldwell, S. T., Valadares, J., Smith, E. M., Hammond, K. L., Sauchanka, O., Abe, J., Krieg, T., Hartley, R. C., Murphy, M. P. & Prag, H., 28 Jan 2026, In: Cardiovascular research.Research output: Contribution to journal › Article › peer-review
Open Access -
Immunomodulation by AZD1656 reverses cardiac dysfunction, metabolic remodelling and reduces infarct size in type 2 diabetic cardiomyopathy
Anderson, S., Karlstaedt, A., Chen, J., O'Riordan, C., Barnes, M., Staka, Z., Albee, L., Garrod-Ketchley, C., Vithanachchi, S., Prag, H., Cvetko, F., Thiemermann, C., Lewis, A. J., Murphy, M. P., Smith, D. M., Henson, S., Tyler, D. & Aksentijevic, D., 11 Apr 2025, bioRxiv, 28 p.Research output: Preprint/Working paper › Preprint
Open Access -
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning
Hernandez-Resendiz, S., Vilskersts, R., Aluja, D., Andreadou, I., Bencsik, P., Dambrova, M., Efentakis, P., Gao, F., Giricz, Z., Inserte, J., Kelly-Laubscher, R., Kiss, A., Krieg, T., Kwak, B. R., Lecour, S., Lopaschuk, G., Mączewski, M., Waszkiewicz, M., Oknińska, M. & Pagliaro, P. & 7 others, , 12 Mar 2025, In: Basic Research in Cardiology.Research output: Contribution to journal › Article › peer-review
Open Access -
Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischemic stroke
Lee, J. J., Prag, H. A., Chary, K., Abe, J., Uno, S., Sorby-Adams, A., Yu, C. S., Sauchanka, O., Mottahedin, A., Kaggie, J. D., Gallagher, F. A., Murphy, M. P. & Krieg, T., 1 Aug 2025, In: Cardiovascular research. 121, 9, p. 1407-1418 12 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Optical Brain Pulse Monitoring for Detection of Large Vessel Occlusion Stroke in a Sheep Model
Sharkey, J. M., Teo, E. J., Chung, S. W., Grace, S. A., Hellerstedt, J., Petautschnig, S., Prag, H. A., Turner, R. J., Krieg, T., Murphy, M. P., Sorby-Adams, A. & Dixon, B., 5 Feb 2025, bioRxiv.Research output: Preprint/Working paper › Preprint