Research output per year
Research output per year
Personal profile
Overview
I am currently a PhD student at the University of Manchester, working in the lab of Dr Adam Hurlstone.
I graduated with a BSc (Hons) from the University of Birmingham in 2017. As part of my degree I worked in the lab of Dr Steven Lee, focusing on a project to engineer CAR T cells to target the tumour vasculature.
In 2018 I began an MRC-funded PhD at the University of Manchester under the supervision of Prof Paul Lorigan and Dr Adam Hurlstone. The aim of the project is to establish a pipeline in the lab for testing CAR T cells and other cellular therapies, alongside developing a zebrafish embryo-based platform for CAR T cell screening.
Research interests
My research interests focus on the use of immunotherapies in solid cancers. Specifically, I am researching the use of chimeric antigen receptor (CAR) T cells as a treatment for advanced melanoma. I am also interested in the development of novel models, and as such we are developing a zebrafish model for early stage screening of CAR T cell therapeutics in the context of melanoma.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Bachelor of Science, BMedSc Medical Studies and iBSc Clinical Sciences, University of Birmingham
19 Sep 2013 → 30 Jun 2016
Award Date: 30 Jun 2016
External positions
Clinical Trials Assistant, MAC Research Services Limited
1 Oct 2017 → 31 Aug 2018
Fingerprint
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Research output
- 2 Article
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Radiotherapy transiently reduces the sensitivity of cancer cells to lymphocyte cytotoxicity
Tuomela, K., Mukherjee, D., Ambrose, A., Harikrishnan, A., Mole, H., Hurlstone, A., Önfelt, B., Honeychurch, J. & Davis, D. M., 16 Dec 2021, (Accepted/In press) In: Proceedings of the National Academy of Sciences.Research output: Contribution to journal › Article › peer-review
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Systematic Roadmap for Cancer Drug Screening Using Zebrafish Embryo Xenograft Cancer Models: Melanoma Cell Line as a Case Study
Letrado, P., Mole, H., Montoya, M., Palacios, I., Barriuso, J., Hurlstone, A., Díez-martínez, R. & Oyarzabal, J., 23 Jul 2021, (E-pub ahead of print) In: Cancers. 13, 15, p. 3705Research output: Contribution to journal › Article › peer-review
Open Access
Activities
- 1 Participating in a conference, workshop, exhibition, performance, inquiry, course etc
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Trans-Atlantic Journeys in Cell and Gene Therapy
Holly Mole (Participant)
30 Nov 2020Activity: Participating in or organising event(s) › Participating in a conference, workshop, exhibition, performance, inquiry, course etc