Research output per year
Research output per year
Personal profile
Research interests
Integrative and Environmental Physiology
Our research explores molecular and cellular mechanisms that impact cardiac function in response to environmental change and links these with altered organismal metabolism, locomotion and behaviour to determine the intersection of the cardiovascular system and the environment on fitness. We investigate the interplay between temperature and hypoxia on cardiac health working across species to identify conserved and fundamental biological pathways. Recent work has focused on the effects of air and water pollution on cardiac health using whole animal models (mice), tissue models (fish, sheep, mouse) and hiPSCs.
Biography
2021 - Present, Professor, Faculty of Biology, Medicine and Health, University of Manchester, UK.
2017 - 2021, Reader, Faculty of Biology, Medicine and Health, University of Manchester, UK.
2010 - 2017, Senior Lecturer (Associate Professor), Faculty of Life Sciences, University of Manchester, UK.
2004 - 2010, Lecturer (Assistant Professor), Faculty of Life Sciences, Universty of Manchester, UK.
2002 - 2004, NSERC Canada Post-Doctoral Fellow, School of Biomedical Sciences, University of Leeds, Leeds, UK.
2001 - 2002, Post-Doctoral Associate, Stanford University, Hopkins Marine, Station, Pacific Grove, Ca., USA.
1996 - 2001, PhD Physiology, Simon Fraser University, Canada.
1994 - 1996, MSc Physiology, Simon Fraser University, Canada.
1990 - 1994, BSc (hons) Biology, University of Western Ontario, Canada.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary President of the Fisheries Society of the British Isles
2023 → 2025
Fellow, The Physiological Society
2022 → …
Honorary Vice President, Fisheries Society of the British Isles
2021 → 2023
Director, Company of Biologists Ltd
2018 → 2028
Trustee, The Physiological Society
2015 → 2021
Fellow, Royal Society of Biology
2010 → …
Areas of expertise
- QP Physiology
- cardiology
- metabolism
- Environmental change
- pollution
- Thermal biology
- QL Zoology
- fish
- sharks
- environmental adaptation
- Environmental change
- Plastics
Research Beacons, Institutes and Platforms
- Sustainable Futures
- Lydia Becker Institute
- Christabel Pankhurst Institute
- Manchester Environmental Research Institute
- Healthier Futures
Keywords
- Environmental change
- Pollution
- Cardiac Physiology
- Thermal Biology
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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3-methyl-phenanthrene (3-MP) disrupts the electrical and contractile activity of the heart of the polar fish, navaga cod (Eleginus nawaga)
Filatova, T. S., Kuzmin, V. S., Dzhumaniiazova, I., Pustovit, O. B., Abramochkin, D. V. & Shiels, H. A., 19 Apr 2024, (E-pub ahead of print) In: Chemosphere. 142089.Research output: Contribution to journal › Article › peer-review
Open AccessFile26 Downloads (Pure) -
Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility
Tikhomirov, R., Oakley, R. H., Anderson, C., Xiang, Y., Al-Othman, S., Smith, M., Yaar, S., Torre, E., Li, J., Wilson, L. R., Goulding, D. R., Donaldson, I., Harno, E., Soattin, L., Shiels, H. A., Morris, G. M., Zhang, H., Boyett, M. R., Cidlowski, J. A. & Mesirca, P. & 2 others, , 10 May 2024, In: Circulation research. 134, 10, p. 1306-1326 21 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Cardiac thermal acclimation and adaption of the heart to extreme temperatures
Gillis, T. E., Shiels, H. A., Vornanen, M. & Gamperl, A. K., 22 Mar 2024, Encyclopedia of Fish Physiology. Alderman, S. L. & Gillis, T. E. (eds.). 2nd ed. Elsevier Australia, Vol. 2. p. 268-282 15 p.Research output: Chapter in Book/Conference proceeding › Chapter › peer-review
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Developmental plasticity of the cardiovascular system in oviparous vertebrates: effects of chronic hypoxia and interactive stressors in the context of climate change
Lock, M., Ripley, D., Smith, K., Mueller, C. A., Shiels, H., Crossley , D. A. & Galli, G., 1 Oct 2024, In: The Journal of Experimental Biology. 227, 20, jeb245530.Research output: Contribution to journal › Article › peer-review
Open Access -
Developmental programming of cardiac anoxia tolerance in turtles relies on Ca2+ cycling by the sarcoplasmic reticulum
Ruhr, I. M., Shiels, H., Crossley II, D. A. & Galli, G., 27 Aug 2024, (Accepted/In press) In: Journal of Experimental Biology.Research output: Contribution to journal › Article › peer-review
Projects
- 3 Finished
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BHF 4-Year PhD Studentship - University of Manchester (3rd Intake 2019 of 4th Scheme).
Cartwright, E. (PI), Abraham, S. (CoI), Allan, S. (CoI), Ashton, N. (CoI), Ballestrem, C. (CoI), Dibb, K. (CoI), Dobrzynski, H. (CoI), Eisner, D. (CoI), Galli, G. (CoI), Greenstein, A. (CoI), Heagerty, A. (CoI), Hentges, K. (CoI), Herbert, S. (CoI), Keavney, B. (CoI), Kitmitto, A. (CoI), Liu, W. (CoI), Oceandy, D. (CoI), Pinali, C. (CoI), Pinteaux, E. (CoI), Saiani, A. (CoI), Shiels, H. (CoI), Talavera, D. (CoI), Tomaszewski, M. (CoI), Trafford, A. (CoI), Venetucci, L. (CoI) & Wang, X. (CoI)
1/10/19 → 30/09/23
Project: Research
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BHF 4yr PhD Studentship - 2018 Intake.
Cartwright, E. (PI), Abraham, S. (CoI), Allan, S. (CoI), Ashton, N. (CoI), Ballestrem, C. (CoI), Boyett, M. (CoI), Dibb, K. (CoI), Dobrzynski, H. (CoI), Eisner, D. (CoI), Galli, G. (CoI), Greenstein, A. (CoI), Heagerty, A. (CoI), Hentges, K. (CoI), Herbert, S. (CoI), Keavney, B. (CoI), Kitmitto, A. (CoI), Liu, W. (CoI), Miller, C. (CoI), Oceandy, D. (CoI), Parry-Jones, A. (CoI), Saiani, A. (CoI), Sherratt, M. (CoI), Shiels, H. (CoI), Talavera, D. (CoI), Tomaszewski, M. (CoI), Trafford, A. (CoI), Venetucci, L. (CoI) & Wang, X. (CoI)
1/10/18 → 30/09/22
Project: Research
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BHF 4-Year PhD Studentship Award - University of Manchester (1st Intake 2017 of 4th Scheme).
Cartwright, E. (PI), Abraham, S. (CoI), Allan, S. (CoI), Ballestrem, C. (CoI), Boyett, M. (CoI), Canfield, A. (CoI), Dibb, K. (CoI), Dobrzynski, H. (CoI), Eisner, D. (CoI), Galli, G. (CoI), Heagerty, A. (CoI), Hentges, K. (CoI), Herbert, S. (CoI), Holt, C. (CoI), Humphries, M. (CoI), Keavney, B. (CoI), Kitmitto, A. (CoI), Liu, W. (CoI), Miller, C. (CoI), Oceandy, D. (CoI), Parry-Jones, A. (CoI), Saiani, A. (CoI), Sherratt, M. (CoI), Shiels, H. (CoI), Talavera, D. (CoI), Tomaszewski, M. (CoI), Trafford, A. (CoI), Venetucci, L. (CoI), Wang, X. (CoI) & Zhang, Y. (CoI)
1/10/17 → 30/09/21
Project: Research
Prizes
-
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Making a Difference Awards 2016
Webster, R. (Recipient) & Shiels, H. (Recipient), 2016
Prize: Prize (including medals and awards)
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Teaching Excellence Award 2016
Webster, R. (Recipient) & Shiels, H. (Recipient), 2016
Prize: Prize (including medals and awards)
Activities
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Pint of Science Festival 2022
Taylor, J. (Organiser), Hunter, F. (Organiser), Capey, B. (Organiser), Mouland, J. (Participant), Mortimer, A. (Participant), Amaya, E. (Participant), Canal, M. (Participant), Simpkins, D. (Participant), Shiels, H. (Participant), Green, R. (Participant) & DAngelo, G. (Participant)
9 May 2022 → 11 May 2022Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
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Company of Biologists Ltd (External organisation)
Shiels, H. (Non-executive director)
10 Sept 2018Activity: Membership › Membership of professional association › Research
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Company of Biologists Ltd (Publisher)
Shiels, H. (Other)
10 Sept 2018Activity: Publication peer-review and editorial work › Editorial work › Research
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The Journal of Experimental Biology (Journal)
Shiels, H. (Editor)
1 Sept 2018 → 1 Sept 2025Activity: Publication peer-review and editorial work › Editorial work › Research
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (Journal)
Shiels, H. (Editor)
2017 → 2021Activity: Publication peer-review and editorial work › Editorial work › Research
Impacts
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Impact of the toxicity of crude oil on early fish life stages in the North Sea
Shiels, H. (Corresponding participant)
Impact: Environmental, Health and wellbeing
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Impacts arising from investigation of Deepwater Horizon crude oil spill effects on tunas
Shiels, H. (Corresponding participant) & Galli, G. (Participant)
Impact: Environmental, Economic, Health and wellbeing
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Linking air pollution to causes of cardiovascular problems to encourage reduction of pollution.
Shiels, H. (Corresponding participant)
Impact: Health and wellbeing, Environmental
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The Environment’s Effects on Health.
Shiels, H. (Participant)
Impact: Environmental, Health and wellbeing
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Press/Media
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Fossil fuels responsible for heart arrhythmias in mammals
1/11/23
1 item of Media coverage
Press/Media: Research
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Links to 31 news stories from 28 outlets on our research on: Polyaromatic hydrocarbons in pollution: a heart‐breaking matter
1/01/20
1 Media contribution
Press/Media: Research
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GULF NEWS: Air pollution linked to heart issues in humans, animals
16/12/19
1 item of Media coverage
Press/Media: Research
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Air pollution is breaking our hearts: Human and marine health is affected in similar ways
15/12/19
1 Media contribution
Press/Media: Research
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Press on research publication: Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles (Chelydra serpentina)
Galli, G., Ruhr, I. & Shiels, H.
27/06/19
1 item of Media coverage
Press/Media: Research