Research output per year
Research output per year
Personal profile
Research interests
Integrative and Environmental Physiology
Our research explores molecular and cellular mechanisms that impact cardiac function in response to environmental change and links these with altered organismal metabolism, locomotion and behaviour to determine the intersection of the cardiovascular system and the environment on fitness. We investigate the interplay between temperature and hypoxia on cardiac health working across species to identify conserved and fundamental biological pathways. Recent work has focused on the effects of air and water pollution on cardiac health using whole animal models (mice), tissue models (fish, sheep, mouse) and hiPSCs.
Biography
2021 - Present, Professor, Faculty of Biology, Medicine and Health, University of Manchester, UK.
2017 - 2021, Reader, Faculty of Biology, Medicine and Health, University of Manchester, UK.
2010 - 2017, Senior Lecturer (Associate Professor), Faculty of Life Sciences, University of Manchester, UK.
2004 - 2010, Lecturer (Assistant Professor), Faculty of Life Sciences, Universty of Manchester, UK.
2002 - 2004, NSERC Canada Post-Doctoral Fellow, School of Biomedical Sciences, University of Leeds, Leeds, UK.
2001 - 2002, Post-Doctoral Associate, Stanford University, Hopkins Marine, Station, Pacific Grove, Ca., USA.
1996 - 2001, PhD Physiology, Simon Fraser University, Canada.
1994 - 1996, MSc Physiology, Simon Fraser University, Canada.
1990 - 1994, BSc (hons) Biology, University of Western Ontario, Canada.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Vice President, Fisheries Society of the British Isles
2021 → 2023
Director, Company of Biologists Ltd
2018 → 2028
Trustee, The Physiological Society
2015 → 2021
Fellow, Royal Society of Biology
2010 → …
Areas of expertise
- QP Physiology
- cardiology
- metabolism
- Environmental change
- pollution
- QL Zoology
- fish
- sharks
- environmental adaptation
- Environmental change
- Plastics
Research Beacons, Institutes and Platforms
- Sustainable Futures
- Lydia Becker Institute
- Christabel Pankhurst Institute
- Manchester Environmental Research Institute
Keywords
- Environmental change
Fingerprint
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Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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The air-breathing Alaska blackfish (Dallia pectoralis) suppresses brain mitochondrial reactive oxygen species to survive cold hypoxic winters
Galli, G. L. J., Shiels, H. A., White, E., Couturier, C. S. & Stecyk, J. A. W., 1 Feb 2023, In: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology . 276, 111355.Research output: Contribution to journal › Article › peer-review
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Absence of atrial smooth muscle in the heart of the loggerhead sea turtle (Caretta caretta): a re-evaluation of its role in diving physiology
Costello, L. M., García-párraga, D., Crespo-picazo, J. L., Codd, J. R., Shiels, H. A. & Joyce, W., 24 Oct 2022, In: Journal of Experimental Biology. 225, 20Research output: Contribution to journal › Article › peer-review
Open Access -
Adrenergic prolongation of action potential duration in rainbow trout myocardium via inhibition of the delayed rectifier potassium current, IKr.
Abramochkin, D. V., Haworth, T. E., Kuzmin, V. S., Dzhumaniiazova, I., Pustovit, K. B., Gacoin, M. & Shiels, H., 4 Feb 2022, (Accepted/In press) In: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology .Research output: Contribution to journal › Article › peer-review
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A revised perspective on the evolution of troponin I and troponin T gene families in vertebrates
Joyce, W., Ripley, D., Gillis, T. E., Coward Black, A., Shiels, H. & Hoffman, F. G., 5 Dec 2022, (Accepted/In press) In: Genome biology and evolution.Research output: Contribution to journal › Article › peer-review
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Avian cardiomyocyte architecture and what it reveals about the evolution of the vertebrate heart.
Shiels, H. A., 2 Apr 2022, (Accepted/In press) In: Royal Society of London. Philosophical Transactions B. Biological Sciences .Research output: Contribution to journal › Article › peer-review
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BHF 4-Year PhD Studentship - University of Manchester (3rd Intake 2019 of 4th Scheme).
Cartwright, E., Abraham, S., Allan, S., Ashton, N., Ballestrem, C., Dibb, K., Dobrzynski, H., Eisner, D., Galli, G., Greenstein, A., Heagerty, A., Hentges, K., Herbert, S., Keavney, B., Kitmitto, A., Liu, W., Oceandy, D., Pinali, C., Pinteaux, E., Saiani, A., Shiels, H., Talavera, D., Tomaszewski, M., Trafford, A., Venetucci, L. & Wang, X.
1/10/19 → 30/09/23
Project: Research
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BHF 4-Year PhD Studentship Award - University of Manchester (1st Intake 2017 of 4th Scheme).
Cartwright, E., Abraham, S., Allan, S., Ballestrem, C., Boyett, M., Canfield, A., Dibb, K., Dobrzynski, H., Eisner, D., Galli, G., Heagerty, A., Hentges, K., Herbert, S., Holt, C., Humphries, M., Keavney, B., Kitmitto, A., Liu, W., Miller, C., Oceandy, D., Parry-Jones, A., Saiani, A., Sherratt, M., Shiels, H., Talavera, D., Tomaszewski, M., Trafford, A., Venetucci, L., Wang, X. & Zhang, Y.
1/10/17 → 30/09/21
Project: Research
Prizes
Activities
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Pint of Science Festival 2022
Jade Taylor (Organiser), Felicity Hunter (Organiser), Brendan Capey (Organiser), Josh Mouland (Participant), Alice Mortimer (Participant), Enrique Amaya (Participant), Maria Canal (Participant), Devin Simpkins (Participant), Holly Shiels (Participant), Rowan Green (Participant) & Giuseppe DAngelo (Participant)
9 May 2022 → 11 May 2022Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc
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Company of Biologists Ltd (External organisation)
Holly Shiels (Non-executive director)
10 Sep 2018Activity: Membership › Membership of professional association
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Company of Biologists Ltd (Publisher)
Holly Shiels (Other)
10 Sep 2018Activity: Publication peer-review and editorial work › Editorial work
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The Journal of Experimental Biology (Journal)
Holly Shiels (Editor)
1 Sep 2018 → 1 Sep 2025Activity: Publication peer-review and editorial work › Editorial work
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (Journal)
Holly Shiels (Editor)
2017 → 2021Activity: Publication peer-review and editorial work › Editorial work
Impacts
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Impact of the toxicity of crude oil on early fish life stages in the North Sea
Holly Shiels (Participant)
Impact: Environmental, Health and wellbeing
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Impacts arising from investigation of Deepwater Horizon crude oil spill effects on tunas
Holly Shiels (Participant) & Gina Galli (Participant)
Impact: Environmental, Economic, Health and wellbeing
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Linking air pollution to causes of cardiovascular problems to encourage reduction of pollution.
Holly Shiels (Participant)
Impact: Health and wellbeing, Environmental
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The Environment’s Effects on Health.
Holly Shiels (Participant)
Impact: Environmental, Health and wellbeing
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Press/Media
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Links to 31 news stories from 28 outlets on our research on: Polyaromatic hydrocarbons in pollution: a heart‐breaking matter
1/01/20
1 Media contribution
Press/Media: Research
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GULF NEWS: Air pollution linked to heart issues in humans, animals
16/12/19
1 item of Media coverage
Press/Media: Research
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Air pollution is breaking our hearts: Human and marine health is affected in similar ways
15/12/19
1 Media contribution
Press/Media: Research
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Press on research publication: Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles (Chelydra serpentina)
Gina Galli, Ilan Ruhr & Holly Shiels
27/06/19
1 item of Media coverage
Press/Media: Research
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Press on research publication: Developmental plasticity of cardiac anoxia-tolerance in juvenile common snapping turtles (Chelydra serpentina)
Gina Galli, Ilan Ruhr & Holly Shiels
26/06/19
1 item of Media coverage
Press/Media: Research