Holly Shiels, BSc, MSc, PhD

Search results

• 2015

  The Dynamic Nature of Hypertrophic and Fibrotic Remodeling of the Fish Ventricle.

  Keen, A. N., Fenna, A. J., McConnell, J. C., Sherratt, M. J., Gardner, P. & Shiels, H. A., 2015, In: Frontiers in Physiology. 6, 427.

  Research output: Contribution to journal › Article › peer-review

  • Heart 100%
  • Fish 85%
  • Ventricle of Heart 85%
  • Growth 71%
  • Heating 71%
• 2014

  Electrical excitability of the heart in a Chondrostei fish, the Siberian sturgeon (Acipenser baerii).

  Haworth, T. E., Haverinen, J., Shiels, H. A. & Vornanen, M., 1 Nov 2014, In: American journal of physiology. Regulatory, integrative and comparative physiology. 307, 9

  Research output: Contribution to journal › Article › peer-review

  • Fish 100%
  • Sturgeon 100%
  • Heart 80%
  • Myocyte 80%
  • Electrocardiogram 60%

• Rainbow trout provide the first experimental evidence for adherence to a distinct Strouhal number during animal oscillatory propulsion.

  Nudds, R. L., John, E. L., Keen, A. N. & Shiels, H. A., 1 Jul 2014, In: The Journal of Experimental Biology. 217, Pt 13, p. 2244-2249 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Tail 100%
  • Speed 66%
  • Propulsion 66%
  • Strouhal Number 66%
  • Animals 66%

• The calcium stored in the sarcoplasmic reticulum acts as a safety mechanism in rainbow trout heart.

  Cros, C., Salle, L., Warren, D. E., Shiels, H. A. & Brette, F., 5 Nov 2014, In: American journal of physiology. Regulatory, integrative and comparative physiology. 307, p. R1493-R1501

  Research output: Contribution to journal › Article › peer-review

  • Isoprenaline 100%
  • Egtazic Acid 60%
  • Ethylene Glycol 1,2 Bis(2 Aminophenyl) Ether N,n,n',n' Tetraacetic Acid 40%
  • Oncorhynchus mykiss 40%
  • Stress 40%

• The Sarcoplasmic Reticulum and the Evolution of the Vertebrate Heart.

  Shiels, H. A. & Galli, G. LJ., Nov 2014, In: Physiology. 29, 6, p. 456-469 13 p.

  Research output: Contribution to journal › Article › peer-review
• 2012

  Contractile properties of the axolotl ventricle at 17 and 21°C

  Wignall, F. & Shiels, H. A., Apr 2012, In: Journal of thermal biology. 37, 3, p. 230-235 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Responses 100%
  • Force 77%
  • Frequencies 66%
  • Temperature 44%
  • Starling 33%
• 2011

  Cardiac remodeling in fish: Strategies to maintain heart function during temperature change

  Klaiman, J. M., Fenna, A. J., Shiels, H. A., Macri, J. & Gillis, T. E., 2011, In: PLoS ONE. 6, 9, e24464.

  Research output: Contribution to journal › Article › peer-review

  • Males 100%
  • Myocardium 100%
  • Fish 100%
  • Cold Acclimatization 80%
  • Heart 60%

• Rainbow trout myocardium does not exhibit a slow inotropic response to stretch

  Patrick, S. M., White, E. & Shiels, H. A., Apr 2011, In: Journal of Experimental Biology. 214, 7, p. 1119-1122 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Force 100%
  • Oncorhynchus mykiss 50%
  • Starling 37%
  • Myocyte 37%
  • Myocardium 37%

• Temperature effects on Ca2+ cycling in scombrid cardiomyocytes: A phylogenetic comparison

  Galli, G. L. J., Lipnick, M. S., Shiels, H. A. & Block, B. A., Apr 2011, In: Journal of Experimental Biology. 214, 7, p. 1068-1076 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Temperature 100%
  • Yellowfin Tuna 80%
  • Mackerel 80%
  • Cardiac Muscle Cell 60%
  • Fish 40%

• The effect of stimulation frequency on the transmural ventricular monophasic action potential in yellowfin tuna Thunnus albacares

  Patrick, S. M., White, E., Brill, R. W. & Shiels, H. A., Feb 2011, In: Journal of Fish Biology. 78, 2, p. 651-658 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Action Potential 100%
  • Stimulation 75%
  • Action Potential Duration 50%
  • Ventricle of Heart 25%

• Warm fish with cold hearts: Thermal plasticity of excitation-contraction coupling in bluefin tuna

  Shiels, H. A., Di Maio, A., Thompson, S. & Block, B. A., 7 Jan 2011, In: Proceedings of the Royal Society B: Biological Sciences. 278, 1702, p. 18-27 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Temperature 100%
  • Fish 80%
  • Heart Function 60%
  • Plasticity 40%
  • Electron Microscopy 40%
• 2010

  Enhanced length-dependent Ca2+ activation in fish cardiomyocytes permits a large operating range of sarcomere lengths

  Patrick, S. M., Hoskins, A. C., Kentish, J. C., White, E., Shiels, H. A. & Cazorla, O., May 2010, In: Journal of molecular and cellular cardiology. 48, 5, p. 917-924 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Length 100%
  • Fish 83%
  • Tension 66%
  • Myocyte 66%
  • Sarcomere 58%

• Hypercapnic acidosis reduces contractile function in the ventricle of the armored catfish, pterygoplichthys pardalis

  Shiels, H. A., Santiago, D. A. & Galli, G. L. J., Mar 2010, In: Physiological and Biochemical Zoology. 83, 2, p. 366-375 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sarcoplasmic reticulum 100%
  • Acidosis 100%
  • Sarcoplasmic Reticulum 100%
  • Carbon Dioxide 60%
  • Calcium Ion 40%

• Mechano-electric feedback in the fish heart

  Patrick, S. M., White, E. & Shiels, H. A., 2010, In: PLoS ONE. 5, 5, e10548.

  Research output: Contribution to journal › Article › peer-review

  • Feedback System 100%
  • Fish 100%
  • Heart 80%
  • Salmonine 60%
  • Repolarization 60%

• The cellular force-frequency response in ventricular myocytes from the varanid lizard, Varanus exanthematicus

  Warren, D. E., Galli, G. L. J., Patrick, S. M. & Shiels, H. A., Mar 2010, In: AJP: Regulatory, Integrative and Comparative Physiology. 298, 3, p. R567-R574

  Research output: Contribution to journal › Article › peer-review

  • Calcium Ion 100%
  • Ventricle of Heart 57%
  • Myocyte 42%
  • Relaxation 42%
  • Lizard 42%
• 2009

  Ca2+ cycling in cardiomyocytes from a high-performance reptile, the varanid lizard (Varanus exanthematicus)

  Galli, G. L. J., Warren, D. E. & Shiels, H. A., Dec 2009, In: AJP: Regulatory, Integrative and Comparative Physiology. 297, 6, p. R1636-R1644

  Research output: Contribution to journal › Article › peer-review

  • Calcium Ion 100%
  • Reptile 85%
  • Lizard 71%
  • Myocyte 42%
  • Sarcoplasmic reticulum 42%

• Temperature acclimation has no effect on ryanodine receptor expression or subcellular localization in rainbow trout heart

  Birkedal, R., Christopher, J., Thistlethwaite, A. & Shiels, H. A., Oct 2009, In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology. 179, 8, p. 961-969 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Ryanodine Receptor 100%
  • Acclimation 35%
  • Calcium Ion 35%
  • Temperature 28%
  • Oncorhynchus mykiss 28%

• Temperature sensitivity of cardiac function in pelagic fishes with different vertical mobilities: Yellowfin tuna (thunnus albacares), bigeye tuna (Thunnus obesus), mahimahi (coryphaena hippurus), and swordfish (xiphias gladius)

  Galli, G., Galli, G. J., Shiels, H. A. & Brill, R. W., May 2009, In: Physiological and Biochemical Zoology. 82, 3, p. 280-290 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Yellowfin Tuna 100%
  • Mahi-Mahi 77%
  • Temperature 66%
  • Sarcoplasmic reticulum 44%
  • Muscle 33%
• 2008

  Cardiac survival in anoxia-tolerant vertebrates: An electrophysiological perspective

  Stecyk, J. A. W., Galli, G. L., Shiels, H. A. & Farrell, A. P., Nov 2008, In: Comparative Biochemistry and Physiology. Part C: Toxicology and Pharmacology. 148, 4, p. 339-354 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Anoxia 100%
  • Cellular Mechanism 33%
  • Vertebrate 33%
  • Crucian Carp 33%
  • Heart 22%

• Characterization of isolated ventricular myocytes from adult zebrafish (Danio rerio)

  Brette, F., Luxan, G., Cros, C., Dixey, H., Wilson, C. & Shiels, H. A., 12 Sep 2008, In: Biochemical and Biophysical Research Communications. 374, 1, p. 143-146 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Zebra Fish 100%
  • Myocyte 85%
  • Adult 28%
  • Species 14%
  • Cells 14%

• The Frank-Starling mechanism in vertebrate cardiac myocytes

  Shiels, H. A. & White, E., Jul 2008, In: Journal of Experimental Biology. 211, 13, p. 2005-2013 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Myocyte 100%
  • Length 80%
  • Fish 40%
  • Starling Law 40%
  • Heart 40%
• 2007

  High [Na+]i in cardiomyocytes from rainbow trout

  Birkedal, R. & Shiels, H. A., Aug 2007, In: AJP: Regulatory, Integrative and Comparative Physiology. 293, 2, p. R861-R866

  Research output: Contribution to journal › Article › peer-review

  • Sodium Ion 100%
  • Calcium Ion 33%
  • Oncorhynchus mykiss 33%
  • Cardiomyocyte 26%
  • Temperature 26%

• Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat

  Shiels, H., O'Connell, A., Qureshi, M. A., Howarth, F. C., White, E. & Calaghan, S., Jan 2007, In: Molecular and Cellular Biochemistry. 294, 1-2, p. 173-180 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Microtubule 100%
  • Myocyte 88%
  • Streptozocin 88%
  • Streptozotocin 88%
  • Calcium Ion 66%
• 2006

  Calcium flux in turtle ventricular myocytes

  Galli, G. L. J., Taylor, E. W. & Shiels, H. A., 2006, In: AJP: Regulatory, Integrative and Comparative Physiology. 291, 6, p. R1781-R1789

  Research output: Contribution to journal › Article › peer-review

  • Myocyte 100%
  • Turtles 83%
  • Calcium Channel 66%
  • Sarcoplasmic reticulum 50%
  • Cells 16%

• Sarcolemmal ion currents and sarcoplasmic reticulum Ca2+ content in ventricular myocytes from the cold stenothermic fish, the burbot (Lota lota)

  Shiels, H. A., Paajanen, V. & Vornanen, M., Aug 2006, In: Journal of Experimental Biology. 209, 16, p. 3091-3100 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Myocyte 100%
  • Fish 80%
  • Heart 40%
  • Acclimation 40%
  • Lota lota 40%

• The cellular basis for enhanced volume-modulated cardiac output in fish hearts

  Shiels, H. A., Calaghan, S. C. & White, E., 2006, In: Journal of General Physiology. 128, 1, p. 37-44 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Fish 100%
  • Cardiac Output 31%
  • Heart Output 31%
  • Heart 25%
  • Length 25%

• The role of the sarcoplasmic reticulum in the generation of high heart rates and blood pressures in reptiles

  Galli, G. L. J., Gesser, H., Taylor, E. W., Shiels, H. A. & Wang, T., May 2006, In: Journal of Experimental Biology. 209, 10, p. 1956-1963 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Sarcoplasmic reticulum 100%
  • Species 100%
  • Tissues 83%
  • Heart Rate 83%
  • Ryanodine 66%

• Three-dimensional mitochondrial arrangement in ventricular myocytes: From chaos to order

  Birkedal, R., Shiels, H. A. & Vendelin, M., Dec 2006, In: American Journal of Physiology: Cell Physiology. 291, 6, p. C1148-C1158

  Research output: Contribution to journal › Article › peer-review

  • Mitochondria 100%
  • Mitochondrion 100%
  • Rat 66%
  • Salmonine 66%
  • Muscle Cell 50%
• 2005

  Temporal and spatial properties of cellular Ca2+ flux in trout ventricular myocytes

  Shiels, H. A. & White, E., Jun 2005, In: AJP: Regulatory, Integrative and Comparative Physiology. 288, 6, p. R1756-R1766

  Research output: Contribution to journal › Article › peer-review

  • Myocyte 100%
  • Cells 50%
  • Trout 41%
  • Sarcoplasmic reticulum 25%
  • Oncorhynchus mykiss 25%
• 2004

  Electrophysiological properties of the L-type Ca(2+) current in cardiomyocytes from bluefin tuna and Pacific mackerel.

  Shiels, HA., Blank, JM., Farrell, AP. & Block, BA., 2004, In: American Journal of Physiology. 286, 4

  Research output: Contribution to journal › Article › peer-review
• 2003

  Acute temperature change modulates the response of ICa to adrenergic stimulation in fish cardiomyocytes

  Shiels, H. A., Vornanen, M. & Farrell, A. P., Nov 2003, In: Physiological and Biochemical Zoology. 76, 6, p. 816-824 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Temperature 100%
  • Adrenergic Stimulation 83%
  • Fish 33%
  • Oncorhynchus mykiss 33%
  • Cell Membrane 16%
• 2002

  Effects of temperature on intracellular Ca2+ in trout atrial myocytes.

  Shiels, HA., Vornanen, M. & Farrell, AP., 2002, In: The Journal of Experimental Biology. 205, Pt 23

  Research output: Contribution to journal › Article › peer-review

• Plasticity of excitation-contraction coupling in fish cardiac myocytes

  Vornanen, M., Shiels, H. A. & Farrell, A. P., 2002, In: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology . 132, 4, p. 827-846 19 p.

  Research output: Contribution to journal › Article › peer-review

• Temperature dependence of cardiac sarcoplasmic reticulum function in rainbow trout myocytes

  Shiels, H. A., Vornanen, M. & Farrell, A. P., Dec 2002, In: Journal of Experimental Biology. 205, 23, p. 3631-3639 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Sarcoplasmic reticulum 100%
  • Temperature 77%
  • Action Potential 44%
  • Pulse Rate 44%
  • Oncorhynchus mykiss 44%

• The force-frequency relationship in fish hearts - A review

  Shiels, H. A., Vornanen, M. & Farrell, A. P., 2002, In: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology . 132, 4, p. 811-826 15 p.

  Research output: Contribution to journal › Article › peer-review
• 2000

  A comparison of myocardial beta-adrenoreceptor density and ligand binding affinity among selected teleost fishes.

  Olsson, HI., Yee, N., Shiels, HA., Brauner, C. & Farrell, AP., 2000, In: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 170, 7

  Research output: Contribution to journal › Article › peer-review

• Temperature-dependence of L-type Ca(2+) channel current in atrial myocytes from rainbow trout.

  Shiels, HA., Vornanen, M. & Farrell, AP., 2000, In: The Journal of Experimental Biology. 203

  Research output: Contribution to journal › Article › peer-review

• The effect of ryanodine on isometric tension development in isolated ventricular trabeculae from Pacific mackerel (Scomber japonicus)

  Shiels, H. A. & Farrell, A. P., Mar 2000, In: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology . 125, 3, p. 331-341 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Ion 100%
  • Ryanodine 71%
  • Sarcoplasmic reticulum 57%
  • Ventricle of Heart 57%
  • Mackerel 57%
• 1999

  The sarcoplasmic reticulum plays a major role in isometric contraction in atrial muscle of yellowfin tuna

  Shiels, H. A., Freund, E. V., Farrell, A. P. & Block, B. A., Apr 1999, In: Journal of Experimental Biology. 202, 7, p. 881-890 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Yellowfin Tuna 100%
  • Calcium Ion 80%
  • Sarcoplasmic reticulum 80%
  • Tuna 80%
  • Atrium 40%
• 1998

  Effects of temperature, adrenaline and ryanodine on power production in rainbow trout Oncorhynchus mykiss ventricular trabeculae

  Shiels, H. A., Stevens, E. D. & Farrell, A. P., Oct 1998, In: Journal of Experimental Biology. 201, 19, p. 2701-2710 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Temperature 100%
  • Oncorhynchus mykiss 88%
  • Sarcolemma 44%
  • Sarcoplasmic reticulum 33%
  • Rainbows 33%
• 1997

  The effect of temperature and adrenaline on the relative importance of the sarcoplasmic reticulum in contributing Ca2+ to force development in isolated ventricular trabeculae from rainbow trout

  Shiels, H. A. & Farrell, A. P., Jun 1997, In: Journal of Experimental Biology. 200, 11, p. 1607-1621 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Sarcoplasmic reticulum 100%
  • Temperature 93%
  • Ryanodine 50%
  • Oncorhynchus mykiss 43%
  • Epinephrine 31%
• 1996

  Maximum cardiac performance of rainbow trout (Oncorhynchus mykiss) at temperatures approaching their upper lethal limit

  Farrell, A. P., Gamperl, A. K., Hicks, J. M. T., Shiels, H. A. & Jain, K. E., Mar 1996, In: Journal of Experimental Biology. 199, 3, p. 663-672 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Temperature 100%
  • Heart Rate 46%
  • Oncorhynchus mykiss 46%
  • Epinephrine 38%
  • Trout 30%