Personal profile
Biography
Imogen was born and raised in the Scottish Borders before moving to Glasgow to completed her undergraduate degree at The University of Strathclyde (2009). From there she moved to The University of Cambridge, where she completed her PhD in the field of supramolecular chemistry with Prof Jonathan Nitschke in 2013. Following this she completed a post-doctoral appointment with Prof Stephen Lippard at Massachusetts Institute of Technology where she performed research into the mechanism of action of non-classical metalloanticancer agents. She joined the department as a Dame Kathleen Ollerenshaw Fellow in 2017.
Research interests
Proteins are the building blocks of life and their exquisite functionality is often tied to their fragile three-dimensional structure, which is governed through multiple weak intramolecular interactions. Materials capable of stabilizing and promoting these interactions therefore offer exciting possibilities to develop our fundamental understanding of biology, as well as presenting potential industrial and medicinal applications.
Our research interests lie at the interface of inorganic chemistry, materials science and biochemistry. Combining techniques developed in each of these disciplines we aim to (a) develop novel encapsulation solutions for biomolecules and (b) understand the interaction of biomolecules with synthetic constructs, with a specific focus on proteins.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 6 Clean Water and Sanitation
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Collaborations and top research areas from the last five years
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Development of an Automated Workflow for Screening the Assembly and Host–Guest Behavior of Metal‐Organic Cages Towards Accelerated Discovery
Basford, A. R., Bernardino, A. H., Teeuwen, P. C. P., Egleston, B. D., Humphreys, J., Jelfs, K. E., Nitschke, J. R., Riddell, I. A. & Greenaway, R. L., 7 Apr 2025, (E-pub ahead of print) In: Angewandte Chemie International Edition. e202424270.Research output: Contribution to journal › Article › peer-review
Open Access -
Encapsulation of Hydrophobic Pollutants within a Large Water-Soluble [Fe4L6]4- Cage
Wright, J., Whitehead, G., Pyzer-Knapp, E. O. & Riddell, I., 19 Feb 2025, In: Cell Reports Physical Science. 6, 2, 102404.Research output: Contribution to journal › Article › peer-review
Open Access -
Enhanced stability and reusability of recombinant silicatein upon biomimetic metal–organic framework crystallization
Zhang, T., Wang, X., Wright, J., Whitehead, G., Tidey, J. P., Wong, L. S. & Riddell, I., 7 Dec 2025, In: Chemical Science. 17, p. 3141-3147Research output: Contribution to journal › Article › peer-review
Open Access -
Protein and peptide confinement within metal–organic materials
Wright, J., Zhang, T., Wang, X. & Riddell, I., 14 May 2025, (E-pub ahead of print) In: Chemical Communications.Research output: Contribution to journal › Article › peer-review
Open Access -
Amino Functionality Enables Aqueous Synthesis of Carboxylic Acid-Based MOFs at Room Temperature by Biomimetic Crystallisation
Wang, X., Singh, S. P., Zhang, T., Andrews, R., Lizio, M. G., Whitehead, G. F. S. & Riddell, I. A., 14 May 2024, In: Inorganic Chemistry . 63, 21, p. 9801–9808Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 1 Finished
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Biomimetic Crystallization of Metal-Organic Materials for Protein Isolation and Stabilization
Riddell, I. (PI)
1/02/21 → 31/01/23
Project: Research
Prizes
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Rosalind Franklin Award Lecture for Physical Sciences and Mathematics
Riddell, I. (Recipient), 6 Sept 2017
Prize: Prize (including medals and awards)