Jack Green

2024

Brazilin is a Natural Product Inhibitor of the NLRP3 Inflammasome

Mcmahon, E., El Sayed, S., Green, J., Hoyle, C., Fitzpatrick, L., Jones, E., Corrie, E., Kelly, R., Challinor, M., Freeman, S., Bryce, R., Lawrence, C. B., Brough, D. & Kasher, P., 16 Feb 2024, In: iScience. 27, 2, 108968.

Research output: Contribution to journal › Article

Open Access

Discovery of an inhibitor of DNA-driven inflammation that preferentially targets the AIM2 inflammasome.

Green, J., El-Sharkawy, L., Roth, S., Zhu, J., Cao, J., Leach, A., Liesz, A., Freeman, S. & Brough, D., 19 May 2024, In: iScience. 26, 5, 106758.

Research output: Contribution to journal › Article › peer-review

Open Access

DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

Cao, J., Roth, S., Zhang, S., Kopczak, A., Mami, S., Asare, Y., Georgakis, M. K., Messerer, D., Horn, A., Shemer , R., Jacqmarcq, C., Picot, A., Green, J., Schlegl, C., Li, X., Tomas, L., Dutsch, A., Liman, T. G., Endres, M. & Wernsdorf, S. R. & 21 others, Fürle, C., Carofiglio, O., Zhu, J., Brough, D., Dichgans, M., Endres, M., Georgakis, M. K., Liman, T. G., Petzold, G. C., Spottke, A., Wunderlich, S., Zerr, I., Hornung, V., Dichgans, M., Vivien, D., Schulz, C., Dor, Y., Tiedt, S., Sager, H. B., Grosse, G. M. & Liesz, A., 7 Aug 2024, In: Nature .

Research output: Contribution to journal › Article › peer-review

Open Access

Lymphatic network drainage resolves cerebral oedema and facilitates recovery from experimental cerebral malaria

Haley, M., Barroso, R., Jasim, D., Haigh, M., Green, J., Dickie, B., Craig, A., Brough, D. & Couper, K., 28 May 2024, In: Cell Reports. 43, 5, 114217.

Research output: Contribution to journal › Article › peer-review

Open Access

Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions

Wellens, R., Tapia , V., Seoane Denicola, P., Bennett, H., Adamson, A., Coutts, G., Rivers-Auty, J., Lowe, M., Green, J., Lopez-Castejon, G., Brough, D. & Hoyle, C., 8 Aug 2024, In: Nature Communications. 15, 6750.

Research output: Contribution to journal › Article › peer-review

Open Access

The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome.

Gleeson, T. A., Kaiser, C., Lawrence, C. B., Brough, D., Allan, S. M. & Green, J. P., 22 May 2024, In: Disease Models & Mechanisms.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome

Lee, B., Hoyle, C., Wellens, R., Green, J. P., Martin-Sanchez, F., Williams, D. M., Matchett, B. J., Seoane, P. I., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M. & Brough, D., 21 Feb 2023, In: Science Signaling. 16, 773

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Phenolic and quinone methide nor-triterpenes as selective NLRP3 inflammasome inhibitors

Gonzalez Cofrade, L., Green, J. P., Cuadrado, I., Amesty, Á., Oramas-Royo, S., Brough, D., Estévez-Braun, A., Hortelano, S. & De-Las-Heras, B., 1 Mar 2023, In: Bioorganic Chemistry. 132, 106362.

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Open Access

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2022

Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages

Hoyle, C., Green, J., Allan, S. & Brough, D., 1 Apr 2022, In: Immunology. 165, 4

Research output: Contribution to journal › Article › peer-review

Open Access

Looking into the IL-1 of the storm: Are inflammasomes the link between immunothrombosis and hyperinflammation in cytokine storm syndromes?

Gleeson, T., Nordling, E., Kaiser, C., Lawrence, C. B., Brough, D., Green, J. & Allan, S., 24 Aug 2022, (Accepted/In press) In: Discovery Immunology.

Research output: Contribution to journal › Article › peer-review

LRRC8A is dispensable for a variety of microglial functions and response to acute stroke

Cook, J. R., Gray, A. L., Lemarchand, E., Schiessl, I., Green, J. P., Newland, M. C., Dyer, D. P., Brough, D. & Lawrence, C. B., 12 Feb 2022, In: GLIA.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

NLRP3 activation in response to disrupted endocytic traffic

Lee, B., Hoyle, C., Green, J., Wellens, R., Martín-Sánchez, F., Williams, D., Seoane Denicola, P., Bennett, H., Adamson, A., Lopez-Castejon, G., Lowe, M. & Brough, D., 16 Sept 2021, In: bioRxiv.

Research output: Contribution to journal › Article

Zinc status alters Alzheimer's disease progression through NLRP3-dependent inflammation

Lawrence, C. B., Rivers-Auty, J., Tapia Olivares, V., White, C., Daniels, M., Drinkall, S., Kennedy, P., Spence, H., Yu Shi, A., Green, J., Hoyle, C., Cook, J., Bradley, A., Mather, A., Peters, R., Tzeng, T.-C., Gordon, M. J., Beattie, J. H., Brough, D. & Lawrence, C. B., 31 Mar 2021, In: Journal of Neuroscience. 41 , 13, p. 3025–3038

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Bafilomycin A1 enhances NLRP3 inflammasome activation in human monocytes independent of lysosomal acidification

Yu Shi, A., Green, J., Wellens, R., Lopez-Castejon, G. & Brough, D., 3 Nov 2020, (E-pub ahead of print) In: The FEBS Journal.

Research output: Contribution to journal › Article › peer-review

Open Access

Inhibition of the NLRP3 inflammasome by HSP90 inhibitors

Nizami, S., Arunasalam, K., Green, J., Cook, J., Lawrence, C. B., Zarganes-Tzitzikas, T., Davis, J. B., Daniel, E. D. & Brough, D., 20 Sept 2020, In: Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation

Green, J., Swanton, T., Morris, L., El-Sharkawy, L., Cook, J., Yu Shi, A., Beswick, J., Adamson, A., Humphreys, N., Bryce, R., Freeman, S., Lawrence, C. B. & Brough, D., 20 Nov 2020, In: eLife. 2020, 9, e59704.

Research output: Contribution to journal › Article › peer-review

Open Access

Mechanisms of NLRP3 Priming in Inflammaging and Age Related Diseases

Gritsenko, A., Green, J., Brough, D. & Lopez-Castejon, G., 20 Aug 2020, (Accepted/In press) In: Cytokine and growth factor reviews.

Research output: Contribution to journal › Article › peer-review

Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl- channel modulation

Swanton, T., Beswick, J., Hammadi, H., Morris, L., Williams, D., De Cesco, S., El-sharkawy, L., Yu, S., Green, J., Davis, J., Lawrence, C., Brough, D. & Freeman, S., 12 Oct 2020, In: Chemical Science. 11, 43, p. 11720-11728 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes

Tapia, V. S., Daniels, M. J. D., Palazón-riquelme, P., Dewhurst, M., Luheshi, N. M., Rivers-auty, J., Green, J., Redondo-castro, E., Kaldis, P., Lopez-castejon, G. & Brough, D., 2019, In: Journal of Biological Chemistry. 294, 21, p. 8325-8335 11 p.

Research output: Contribution to journal › Article › peer-review

2018

Chloride regulates dynamic NLRP3-dependent ASC oligomerisation and inflammasome priming

Green, J., Yu, S., Martín-Sánchez, F., Pelegrin, P., Lopez-Castejon, G., Lawrence, C. B. & Brough, D., 2 Oct 2018, In: Proceedings of the National Academy of Sciences. 115, 40, p. E9371-E9380

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Open Access

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USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation

Palazón-Riquelme, P., Worboys, J. D., Green, J., Valera, A., Martín-Sánchez, F., Pellegrini, C., Brough, D. & López-Castejón, G., Oct 2018, In: EMBO reports. 19, 10, e44766.

Research output: Contribution to journal › Article › peer-review

Open Access

Jack Green

Research output

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