James Eales, PhD

Dr, Dr

  • Room 5.015 AV Hill Building, Upper Brook Street

    M13 9PT Manchester

Accepting PhD Students

Personal profile

Further information

Opportunities

PhD opportunities

3-year EPSRC and Industry funded PhD - An AI architecture for clinical molecular diagnostics from RNA-sequencing of urinary cells - Project co-supervised by Dr Abi Lay, Dr Sébastien Rubin. Student will have chance to spend up to 25% of time working with industrial partner (Qiagen).

3-year self-funded PhD - A deep-learning approach to genomic regulation of tissue-specific alternative splicing (open deadline)

Overview

I am a Lecturer in Cardiovascular Computational Biology interested in studying the biological impact of genetic, transcriptomic and epigenetic variation on human health using high-throughput sequencing technologies. I apply experimental approaches from the fields of multi-omics, deep-learning and data-science to answer research questions directly relevant to our understanding of biological disease processes. I have a special interest in translational research in cardiovascular medicine (hypertension, coronary artery disease) and nephrology (chronic kidney disease and renal histopathology) informed by genomics and transcriptomics.

I have been performing computational experiments for the large-scale analysis of genomics, transcriptomics, and epigenomics data for the last 10 years and have a particular interest in techniques for summarisation, visualisation and communication of high-dimensionality data for identifying causal disease genes. 

The work in my lab is funded by the British Heart Foundation, Translation Manchester and Health Innovation Manchester.

I have over 20 peer-reviewed publications, many in high-impact journals including Nature Genetics, the European Heart Journal, Nature Communications, Arteriosclerosis, Thrombosis and Vascular Biology and Journal of the American Society of Nephrology. I am also a recent reviewer for the European Heart Journal, Cardiovascular Research, Journal of Hypertension, Physiological Genomics, Journal of Human Hypertension and Scientific Reports. My work has over 1,500 citations and an H-index of 20.

I'm always happy to engage on twitter as well @EalesJames

 

My group

PhD Students

Yong Sun - PhD Student - Insights into mechanisms of chronic kidney disease from human tissue multi-omics - co-supervised with Prof Maciej Tomaszewski

Kate Campbell - PhD Student - Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture - co-supervised with Prof Andrew Trafford, Dr Kat Dibb, Prof Andreas Prokop.

Dr Sushant Saluja - Clinical PhD Student - Therapeutic targeting of blood pressure-associated kidney genes - co-supervised with Prof Maciej Tomaszewski

Maciej Drzal - PhD Student - Multi-omic profiling of the hypertensive kidney - co-supervised with Prof. Maciej Tomaszewski

David Scannali - PhD Student - Transcriptomics and epigenomics of chronic kidney disease - co-supervised with Dr Sabu Abraham, Dr Nick Ashton and Prof Maciej Tomaszewski

Collaborators

I also collaborate closely with the research groups of Prof Maciej Tomaszewski and Prof Bernard Keavney.

 

 

 

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Areas of expertise

  • QH301 Biology
  • QH426 Genetics

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