Research output per year
Research output per year
Personal profile
Overview
I am a Lecturer in Cardiovascular Computational Biology interested in studying the biological impact of genetic and epigenetic variation on human health using high-throughput sequencing technologies (multi-omics, data-science methods and biomedical imaging data. I have a special interest in translational research in cardiovascular medicine (hypertension, coronary artery disease) and nephrology (chronic kidney disease and renal histology) informed by genomics and transcriptomics.
I have been performing computational experiments for the large-scale analysis of genomics, transcriptomics, and epigenomics data for the last 10 years and have a particular interest in techniques for summarisation, visualisation and communication of high-dimensionality data for identifying causal disease genes.
I am principal investigator on two translational grants, current co-investigator on two British Heart Foundation project grants and one Kidney Research UK grant and I have previously secured, as principal investigator, two grants for enterprise projects.
I have over 20 recent publications, many in high-impact journals including Nature Genetics, the European Heart Journal, Nature Communications, Arteriosclerosis, Thrombosis and Vascular Biology and Journal of the American Society of Nephrology. I am also a recent reviewer for the European Heart Journal, Cardiovascular Research, Journal of Hypertension, Physiological Genomics, Journal of Human Hypertension and Scientific Reports.
I am an active member of the communications committee of the International Society of Hypertension.
I'm always happy to engage on twitter as well @EalesJames
My group
David Scannali - PhD Student - Transcriptomics and epigenomics of chronic kidney disease - co-supervised with Dr Sabu Abraham, Dr Nick Ashton and Prof Maciej Tomaszewski
Maciej Drzal - PhD Student - Multi-omic profiling of the hypertensive kidney - co-supervised with Prof. Maciej Tomaszewski
Dr Sushant Saluja - Clinical PhD Student - Therapeutic targeting of blood pressure-associated kidney genes - co-supervised with Prof Maciej Tomaszewski
Kate Campbell - PhD Student - Drosophila based screening to replace mammalian systems to identify the functional role of candidate genes in controlling muscle dyadic architecture - co-supervised with Prof Andrew Trafford, Dr Kat Dibb, Prof Andreas Prokop.
I also collaborate closely with the research groups of Prof Maciej Tomaszewski and Prof Bernard Keavney.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Areas of expertise
- QH301 Biology
- QH426 Genetics
Fingerprint
Dive into the research topics where James Eales is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney
Eales, J., Jiang, X., Xu, X., Saluja, S., Akbarov, A., Cano-Gomez, E., McNulty, M. T., Finan, C., Guo, H., Wystrychowski, W., Szulinska, M., Thomas, H., Pramanik, S., Chopade, S., Prestes, P. R., Wise, I., Evangelou, E., Salehi, M., Shakanti, Y., Ekholm, M., & 30 others, 6 May 2021, In: Nature Genetics. 53, 5, p. 630–637 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile54 Downloads (Pure) -
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney
Jiang, X., Eales, J. M., Scannali, D., Nazgiewicz, A., Prestes, P., Maier, M., Denniff, M., Xu, X., Saluja, S., Cano-Gamez, E., Wystrychowski, W., Szulinska, M., Antczak, A., Byars, S., Skrypnik, D., Glyda, M., Król, R., Zywiec, J., Zukowska-Szczechowska, E., Burrell, L. M., & 13 others, 27 Oct 2020, In: European Heart Journal . 41, 48, p. 4580-4588 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study
Matías-García, P., Wilson, R., Guo, Q., Zaghlool, S., Eales, J., Xu, X., Charchar, F., Dormer, J., Maalmi, H., Schlosser, P., Elhadad, M., Nano, J., Sharma, S., Peters, A., Fornoni, A., Mook-Kanamori, D., Winkelmann, J., Danesh, J., Di Angelantonio, E., Ouwehand, W., & 16 others, Jul 2021, In: Journal of the American Society of Nephrology : JASN. 32, 7, p. 1747-1763 17 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile112 Downloads (Pure) -
Towards Faster Gene Expression Prediction via Dimensionality Reduction and Feature Selection
Watts, J., Allen, E., Mitoubsi, A., Khojandi, A., Eales, J. & Papamarkou, T., 11 Apr 2023, (Accepted/In press) 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
-
Adapting Random Forests to Predict Obesity-Associated Gene Expression
Watts, J., Allen, E., Mitoubsi, A., Khojandi, A., Eales, J., Jalali-Najafabadi, F. & Papamarkou, T., 8 Sep 2022, p. 4407-4410. 4 p.Research output: Contribution to conference › Paper › peer-review