Personal profile


Post-doctoral scientist in the Division of Diabetes, Endocrinology and Gastroenterology


My current work in Dr Karen Piper Hanley’s group at the University of Manchester aims to identify mechanisms that regulate the pathological deposition of extracellular matrix components by hepatic stellate cells (HSC) during liver fibrosis. Collaboration with Professor Derek Mann’s group at Newcastle University allowed me to learn how to isolate primary HSC and establish this technique in Manchester. We have since used culture activation of HSC as a model to identify novel targets and upstream signalling mechanisms for the transcription factor SRY (sex determining region Y)-box 9 (SOX9) during fibrosis. To support this work I was awarded a Manchester BRC travel scholarship to visit Professor Scott Friedman’s laboratory at Mount Sinai Medical Centre, New York. This was a unique opportunity to work with a world leader in liver fibrosis, and allowed me to gain valuable experience of in vivo surgical techniques for the study of liver fibrosis. This included bile duct ligation & partial hepatectomy, which we are now using to study the effects of abolishing Sox9 expression during liver fibrosis in vivo.

My collaborations

Supervisors: Karen Piper Hanley & Neil Hanley

Memberships of committees and professional bodies


Biochemical Society

Methodological knowledge

  • (Primary) cell and tissue culture
  • Immunocytochemistry, immunohistochemistry and live imaging techniques
  • Western blotting and immunoprecipitation
  • Confocal microscopy
  • PCR
  • qRT-PCR
  • ELISA based assays
  • Transfections
  • ChIP
  • Luciferase assays


  • BSc(Hons) Leeds University 2002
  • PhD University of Manchester 2006
  • Associate Fellow, Higher Education Academy 2014

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being


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Collaborations and top research areas from the last five years

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