2016 – current: Senior Lecturer, Faculty of Biology, Medicine and Health, University of Manchester.

2011 – 2016: Lecturer, Faculty of Life Sciences, University of Manchester.

2006 – 2011: Physical/Life Sciences Interface Independent Research Fellow, Faculty of Life Sciences, University of Manchester.

2003 – 2006: Postdoctoral Researcher, Kyoto University Bioinformatics Center (Japan).

1999 – 2003: PhD in Computer Engineering, Laval University (Canada).

1995 – 1999: Research Associate, Max-Planck Institute for Biochemistry (Germany).

1991 – 1994: Degree in Engineering, École Centrale Paris (France).

Pathways and biological systems modelling

Our research focuses on advancing bioinformatics and biological systems modelling, with a particular emphasis on networks and cellular dynamics. We integrate mathematics, computer science and systems biology to model, analyse and predict the behaviour of biological networks.

One major area of research is constraint-based analysis of metabolic networks, where we integrate large-scale multi-omics data to refine flux balance analysis tools. Our aim is to uncover emergent metabolic patterns, deepen our understanding of cellular mechanisms and develop robust predictive models applicable across diverse biological systems.

Another key focus is dynamic and integrative modelling of biological networks. By combining stochastic approaches, differential equations and machine learning, we capture the complexity of interactions between metabolism, gene regulation and cellular signalling. These models provide a general framework for studying a wide range of biological systems, with an emphasis on predicting emergent behaviours rather than specific applications.

Additionally, we apply network theory to analyse complex biological systems, such as protein-protein interactions and signalling pathways. Our goal is to develop algorithms that generate testable hypotheses from heterogeneous data, fostering a more systemic understanding of cellular processes.